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Protein

Leukocyte antigen CD37

Gene

Cd37

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte antigen CD37
Alternative name(s):
CD_antigen: CD37
Gene namesi
Name:Cd37
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62035 Cd37

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 59ExtracellularSequence analysisAdd BLAST21
Transmembranei60 – 74HelicalSequence analysisAdd BLAST15
Topological domaini75 – 85CytoplasmicSequence analysisAdd BLAST11
Transmembranei86 – 111HelicalSequence analysisAdd BLAST26
Topological domaini112 – 241ExtracellularSequence analysisAdd BLAST130
Transmembranei242 – 266HelicalSequence analysisAdd BLAST25
Topological domaini267 – 281CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192111 – 281Leukocyte antigen CD37Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP31053
PRIDEiP31053

PTM databases

PhosphoSitePlusiP31053

Expressioni

Tissue specificityi

B-lymphocytes.

Gene expression databases

GenevisibleiP31053 RN

Interactioni

Subunit structurei

Interacts with SCIMP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059092

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP31053
KOiK06475
OrthoDBiEOG091G0H71
PhylomeDBiP31053

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 2 hits
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P31053-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAQESCLSL IKYFLFVFNL FFFVLGGLIF CFGTWILIDK TSFVSFVGLS
60 70 80 90 100
FVPLQTWSKV LSVSGVLTMA LALLGCVGAL KELRCLLGLY FGMLLLLFAT
110 120 130 140 150
QITLGILIST QRVRLERRVQ ELVLRTIQSY RTNPDETAAE ESWDYAQFQL
160 170 180 190 200
RCCGWQSPRD WNKAQMLKAN GSEELFVPCS CYNSTATNDS SGFDKLFLSQ
210 220 230 240 250
LSRLGPRAKL RQTADICALP AKAHIYREGC ARSLQKWLHN NIISIVGICL
260 270 280
GVGLLELGFM TLSIFLCRNL DHVYDRLARY R
Length:281
Mass (Da):31,750
Last modified:July 1, 1993 - v1
Checksum:iA3462D23E824AA1C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0H2UI08A0A0H2UI08_RAT
Tetraspanin
Cd37
304Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53517 mRNA Translation: CAA37596.1
BC059144 mRNA Translation: AAH59144.1
PIRiB47629
RefSeqiNP_058820.1, NM_017124.1
UniGeneiRn.2357

Genome annotation databases

GeneIDi29185
KEGGirno:29185
UCSCiRGD:62035 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53517 mRNA Translation: CAA37596.1
BC059144 mRNA Translation: AAH59144.1
PIRiB47629
RefSeqiNP_058820.1, NM_017124.1
UniGeneiRn.2357

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059092

PTM databases

PhosphoSitePlusiP31053

Proteomic databases

PaxDbiP31053
PRIDEiP31053

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29185
KEGGirno:29185
UCSCiRGD:62035 rat

Organism-specific databases

CTDi951
RGDi62035 Cd37

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP31053
KOiK06475
OrthoDBiEOG091G0H71
PhylomeDBiP31053

Miscellaneous databases

PROiPR:P31053

Gene expression databases

GenevisibleiP31053 RN

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 2 hits
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD37_RAT
AccessioniPrimary (citable) accession number: P31053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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