CD28

Functionⁱ

Possibly involved in T-cell activation.By similarity

GO - Molecular functionⁱ

protease binding Source: Ensembl
protein kinase binding Source: Ensembl
SH3/SH2 adaptor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic signaling pathway Source: Ensembl
immune response Source: InterPro
negative regulation of gene expression Source: Ensembl
negative thymic T cell selection Source: Ensembl
positive regulation of alpha-beta T cell proliferation Source: Ensembl
positive regulation of inflammatory response to antigenic stimulus Source: Ensembl
positive regulation of interleukin-10 production Source: Ensembl
positive regulation of interleukin-2 biosynthetic process Source: Ensembl
positive regulation of interleukin-4 production Source: Ensembl
positive regulation of isotype switching to IgG isotypes Source: Ensembl
positive regulation of mitotic nuclear division Source: Ensembl
positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
positive regulation of protein kinase B signaling Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of regulatory T cell differentiation Source: Ensembl
regulatory T cell differentiation Source: Ensembl
T cell costimulation Source: Ensembl
T cell receptor signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-GGA-1257604 PIP3 activates AKT signaling R-GGA-389356 CD28 co-stimulation R-GGA-389357 CD28 dependent PI3K/Akt signaling R-GGA-389359 CD28 dependent Vav1 pathway R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Reactomeⁱ

R-GGA-1257604 PIP3 activates AKT signaling
R-GGA-389356 CD28 co-stimulation
R-GGA-389357 CD28 dependent PI3K/Akt signaling
R-GGA-389359 CD28 dependent Vav1 pathway
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-cell-specific surface glycoprotein CD28 homolog Alternative name(s): CHT28
Gene namesⁱ	Name:CD28
Organismⁱ	Gallus gallus (Chicken)
Taxonomic identifierⁱ	9031 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
Proteomesⁱ	UP000000539 Componentⁱ: Chromosome 7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	14 – 149	ExtracellularSequence analysisAdd BLAST	136
Transmembraneⁱ	150 – 174	HelicalSequence analysisAdd BLAST	25
Topological domainⁱ	175 – 221	CytoplasmicSequence analysisAdd BLAST	47

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 13	Sequence analysisAdd BLAST		13
ChainⁱPRO_0000014656	14 – 221	T-cell-specific surface glycoprotein CD28 homologAdd BLAST		208

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	33	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	40 ↔ 111	By similarity
Glycosylationⁱ	41	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	45	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	66 ↔ 85	By similarity
Glycosylationⁱ	71	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	100	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	128	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P31043
PRIDEⁱ	P31043

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSGALG00000008669 Expressed in 8 organ(s), highest expression level in spleen

Bgeeⁱ

ENSGALG00000008669 Expressed in 8 organ(s), highest expression level in spleen

Interactionⁱ

Subunit structureⁱ

Monomer.

GO - Molecular functionⁱ

protease binding Source: Ensembl
protein kinase binding Source: Ensembl
SH3/SH2 adaptor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000014099

STRINGⁱ

9031.ENSGALP00000014099

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P31043
SMRⁱ	P31043
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 137	Ig-like V-typeAdd BLAST		110

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IXMM Eukaryota ENOG410Z063 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063873
HOGENOMⁱ	HOG000276892
HOVERGENⁱ	HBG004094
InParanoidⁱ	P31043
KEGG Orthology (KO) More...KOⁱ	K06470
OMAⁱ	PTRRHYQ
Database of Orthologous Groups More...OrthoDBⁱ	1222373at2759
PhylomeDBⁱ	P31043
TreeFamⁱ	TF335679

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR008093 CD28 IPR040216 CTLA4/CD28 IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013106 Ig_V-set
PANTHERⁱ	PTHR11494 PTHR11494, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15910 V-set_2, 1 hit
PRINTSⁱ	PR01717 CD28ANTIGEN
SUPFAMⁱ	SSF48726 SSF48726, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P31043-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLGILVVLCL IPAADVTENK ILVAQRPLLI VANRTATLVC NYTYNGTGKE 
        60         70         80         90        100
FRASLHKGTD SAVEVCFISW NMTKINSNSN KEFNCRGIHD KDKVIFNLWN 
       110        120        130        140        150
MSASQTDIYF CKIEAMYPPP YVYNEKSNGT VIHVRETPIQ TQEPESATSY 
       160        170        180        190        200
WVMVAVTGLL GFYSMLITAV FIIYRQKSKR NRYRQSDYMN MTPRHPPHQK 
       210        220 
NKGYPSYAPT RDYTAYRSWQ P

Length:221

Mass (Da):25,401

Last modified:July 1, 1993 - v1

Checksum:ⁱ60245A3D493CF109

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X67915 mRNA Translation: CAA48114.1
PIRⁱ	I50619 S25168
NCBI Reference Sequences More...RefSeqⁱ	NP_990642.1, NM_205311.1
UniGeneⁱ	Gga.723

Genome annotation databases

Ensemblⁱ	ENSGALT00000014115; ENSGALP00000014099; ENSGALG00000008669
GeneIDⁱ	396249
KEGGⁱ	gga:396249

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P31043	Uncharacterized protein		COLVI		221	UniRef90_P31043
Uncharacterized protein		CALSU		221
UPI0007779BAC		COTJA		221

Protein	Similar proteins		Species	Score	Length	Source
P31043	Uncharacterized protein		COLVI		221	UniRef50_P31043
Uncharacterized protein		CALSU		221
T-cell-specific surface glycoprotein CD28 (Fragment)		NESNO		209
T-cell-specific surface glycoprotein CD28 (Fragment)		CALAN		209
Uncharacterized protein		SARHA		244
+96

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X67915 mRNA Translation: CAA48114.1
PIRⁱ	I50619 S25168
RefSeqⁱ	NP_990642.1, NM_205311.1
UniGeneⁱ	Gga.723

3D structure databases

ProteinModelPortalⁱ	P31043
SMRⁱ	P31043
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000014099

STRINGⁱ

9031.ENSGALP00000014099

Proteomic databases

PaxDbⁱ	P31043
PRIDEⁱ	P31043

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSGALT00000014115; ENSGALP00000014099; ENSGALG00000008669
GeneIDⁱ	396249
KEGGⁱ	gga:396249

Organism-specific databases

CTDⁱ	940

CTDⁱ

940

Phylogenomic databases

eggNOGⁱ	ENOG410IXMM Eukaryota ENOG410Z063 LUCA
GeneTreeⁱ	ENSGT00530000063873
HOGENOMⁱ	HOG000276892
HOVERGENⁱ	HBG004094
InParanoidⁱ	P31043
KOⁱ	K06470
OMAⁱ	PTRRHYQ
OrthoDBⁱ	1222373at2759
PhylomeDBⁱ	P31043
TreeFamⁱ	TF335679

Enzyme and pathway databases

Reactomeⁱ	R-GGA-1257604 PIP3 activates AKT signaling R-GGA-389356 CD28 co-stimulation R-GGA-389357 CD28 dependent PI3K/Akt signaling R-GGA-389359 CD28 dependent Vav1 pathway R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Reactomeⁱ

R-GGA-1257604 PIP3 activates AKT signaling
R-GGA-389356 CD28 co-stimulation
R-GGA-389357 CD28 dependent PI3K/Akt signaling
R-GGA-389359 CD28 dependent Vav1 pathway
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P31043

PROⁱ

PR:P31043

Gene expression databases

Bgeeⁱ	ENSGALG00000008669 Expressed in 8 organ(s), highest expression level in spleen

Bgeeⁱ

ENSGALG00000008669 Expressed in 8 organ(s), highest expression level in spleen

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR008093 CD28 IPR040216 CTLA4/CD28 IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013106 Ig_V-set
PANTHERⁱ	PTHR11494 PTHR11494, 1 hit
Pfamⁱ	View protein in Pfam PF15910 V-set_2, 1 hit
PRINTSⁱ	PR01717 CD28ANTIGEN
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD28_CHICK
Accessionⁱ	P31043Primary (citable) accession number: P31043
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	July 1, 1993
	Last modified:	January 16, 2019
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P31043 (CD28_CHICK)

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T-cell-specific surface glycoprotein CD28 homolog

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ