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Protein

T-cell-specific surface glycoprotein CD28 homolog

Gene

CD28

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Possibly involved in T-cell activation.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-GGA-1257604 PIP3 activates AKT signaling
R-GGA-389356 CD28 co-stimulation
R-GGA-389357 CD28 dependent PI3K/Akt signaling
R-GGA-389359 CD28 dependent Vav1 pathway
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell-specific surface glycoprotein CD28 homolog
Alternative name(s):
CHT28
Gene namesi
Name:CD28
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 149ExtracellularSequence analysisAdd BLAST136
Transmembranei150 – 174HelicalSequence analysisAdd BLAST25
Topological domaini175 – 221CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Sequence analysisAdd BLAST13
ChainiPRO_000001465614 – 221T-cell-specific surface glycoprotein CD28 homologAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi40 ↔ 111By similarity
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi66 ↔ 85By similarity
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP31043
PRIDEiP31043

Expressioni

Gene expression databases

BgeeiENSGALG00000008669 Expressed in 8 organ(s), highest expression level in spleen

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014099

Structurei

3D structure databases

ProteinModelPortaliP31043
SMRiP31043
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 137Ig-like V-typeAdd BLAST110

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXMM Eukaryota
ENOG410Z063 LUCA
GeneTreeiENSGT00530000063873
HOGENOMiHOG000276892
HOVERGENiHBG004094
InParanoidiP31043
KOiK06470
OMAiVNGNYSH
OrthoDBiEOG091G0IGY
PhylomeDBiP31043
TreeFamiTF335679

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008093 CD28
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF15910 V-set_2, 1 hit
PRINTSiPR01717 CD28ANTIGEN
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31043-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGILVVLCL IPAADVTENK ILVAQRPLLI VANRTATLVC NYTYNGTGKE
60 70 80 90 100
FRASLHKGTD SAVEVCFISW NMTKINSNSN KEFNCRGIHD KDKVIFNLWN
110 120 130 140 150
MSASQTDIYF CKIEAMYPPP YVYNEKSNGT VIHVRETPIQ TQEPESATSY
160 170 180 190 200
WVMVAVTGLL GFYSMLITAV FIIYRQKSKR NRYRQSDYMN MTPRHPPHQK
210 220
NKGYPSYAPT RDYTAYRSWQ P
Length:221
Mass (Da):25,401
Last modified:July 1, 1993 - v1
Checksum:i60245A3D493CF109
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67915 mRNA Translation: CAA48114.1
PIRiI50619 S25168
RefSeqiNP_990642.1, NM_205311.1
UniGeneiGga.723

Genome annotation databases

EnsembliENSGALT00000014115; ENSGALP00000014099; ENSGALG00000008669
GeneIDi396249
KEGGigga:396249

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67915 mRNA Translation: CAA48114.1
PIRiI50619 S25168
RefSeqiNP_990642.1, NM_205311.1
UniGeneiGga.723

3D structure databases

ProteinModelPortaliP31043
SMRiP31043
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000014099

Proteomic databases

PaxDbiP31043
PRIDEiP31043

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000014115; ENSGALP00000014099; ENSGALG00000008669
GeneIDi396249
KEGGigga:396249

Organism-specific databases

CTDi940

Phylogenomic databases

eggNOGiENOG410IXMM Eukaryota
ENOG410Z063 LUCA
GeneTreeiENSGT00530000063873
HOGENOMiHOG000276892
HOVERGENiHBG004094
InParanoidiP31043
KOiK06470
OMAiVNGNYSH
OrthoDBiEOG091G0IGY
PhylomeDBiP31043
TreeFamiTF335679

Enzyme and pathway databases

ReactomeiR-GGA-1257604 PIP3 activates AKT signaling
R-GGA-389356 CD28 co-stimulation
R-GGA-389357 CD28 dependent PI3K/Akt signaling
R-GGA-389359 CD28 dependent Vav1 pathway
R-GGA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Miscellaneous databases

PROiPR:P31043

Gene expression databases

BgeeiENSGALG00000008669 Expressed in 8 organ(s), highest expression level in spleen

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR008093 CD28
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF15910 V-set_2, 1 hit
PRINTSiPR01717 CD28ANTIGEN
SUPFAMiSSF48726 SSF48726, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD28_CHICK
AccessioniPrimary (citable) accession number: P31043
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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