UniProtKB - P31043 (CD28_CHICK)
Protein
T-cell-specific surface glycoprotein CD28 homolog
Gene
CD28
Organism
Gallus gallus (Chicken)
Status
Functioni
Possibly involved in T-cell activation.By similarity
GO - Biological processi
- immune response Source: InterPro
- immune system process Source: GO_Central
- positive regulation of T cell proliferation Source: GO_Central
- T cell activation Source: GO_Central
- T cell costimulation Source: GO_Central
- T cell receptor signaling pathway Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: T-cell-specific surface glycoprotein CD28 homologAlternative name(s): CHT28 |
Gene namesi | Name:CD28 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Other locations
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- spanning component of plasma membrane Source: AgBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 14 – 149 | ExtracellularSequence analysisAdd BLAST | 136 | |
Transmembranei | 150 – 174 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 175 – 221 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 13 | Sequence analysisAdd BLAST | 13 | |
ChainiPRO_0000014656 | 14 – 221 | T-cell-specific surface glycoprotein CD28 homologAdd BLAST | 208 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 33 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 40 ↔ 111 | By similarity | ||
Glycosylationi | 41 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 45 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 66 ↔ 85 | By similarity | ||
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 128 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P31043 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000008669, Expressed in granulocyte and 9 other tissues |
Interactioni
Subunit structurei
Monomer.
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000014099 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 137 | Ig-like V-typeAdd BLAST | 110 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SAVP, Eukaryota |
HOGENOMi | CLU_085095_1_0_1 |
InParanoidi | P31043 |
OMAi | HQLQFHS |
OrthoDBi | 1222373at2759 |
PhylomeDBi | P31043 |
TreeFami | TF335679 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR008093, CD28 IPR040216, CTLA4/CD28 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
PANTHERi | PTHR11494, PTHR11494, 1 hit |
Pfami | View protein in Pfam PF15910, V-set_2, 1 hit |
PRINTSi | PR01717, CD28ANTIGEN |
SUPFAMi | SSF48726, SSF48726, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P31043-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGILVVLCL IPAADVTENK ILVAQRPLLI VANRTATLVC NYTYNGTGKE
60 70 80 90 100
FRASLHKGTD SAVEVCFISW NMTKINSNSN KEFNCRGIHD KDKVIFNLWN
110 120 130 140 150
MSASQTDIYF CKIEAMYPPP YVYNEKSNGT VIHVRETPIQ TQEPESATSY
160 170 180 190 200
WVMVAVTGLL GFYSMLITAV FIIYRQKSKR NRYRQSDYMN MTPRHPPHQK
210 220
NKGYPSYAPT RDYTAYRSWQ P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X67915 mRNA Translation: CAA48114.1 |
PIRi | I50619, S25168 |
RefSeqi | NP_990642.1, NM_205311.1 |
Genome annotation databases
GeneIDi | 396249 |
KEGGi | gga:396249 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X67915 mRNA Translation: CAA48114.1 |
PIRi | I50619, S25168 |
RefSeqi | NP_990642.1, NM_205311.1 |
3D structure databases
SMRi | P31043 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000014099 |
Proteomic databases
PaxDbi | P31043 |
Genome annotation databases
GeneIDi | 396249 |
KEGGi | gga:396249 |
Organism-specific databases
CTDi | 940 |
Phylogenomic databases
eggNOGi | ENOG502SAVP, Eukaryota |
HOGENOMi | CLU_085095_1_0_1 |
InParanoidi | P31043 |
OMAi | HQLQFHS |
OrthoDBi | 1222373at2759 |
PhylomeDBi | P31043 |
TreeFami | TF335679 |
Miscellaneous databases
PROi | PR:P31043 |
Gene expression databases
Bgeei | ENSGALG00000008669, Expressed in granulocyte and 9 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR008093, CD28 IPR040216, CTLA4/CD28 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
PANTHERi | PTHR11494, PTHR11494, 1 hit |
Pfami | View protein in Pfam PF15910, V-set_2, 1 hit |
PRINTSi | PR01717, CD28ANTIGEN |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD28_CHICK | |
Accessioni | P31043Primary (citable) accession number: P31043 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |