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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDHA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225).1 Publication1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).1 Publication
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDHB), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei275FADBy similarity1
Binding sitei296SubstrateBy similarity1
Binding sitei308SubstrateBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei340Proton acceptorBy similarity1
Binding sitei407SubstrateBy similarity1
Binding sitei440FADBy similarity1
Binding sitei451SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi68 – 73FADBy similarity6
Nucleotide bindingi91 – 106FADBy similarityAdd BLAST16
Nucleotide bindingi456 – 457FADBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • electron transfer activity Source: GO_Central
  • flavin adenine dinucleotide binding Source: GO_Central
  • succinate dehydrogenase (ubiquinone) activity Source: UniProtKB
  • succinate dehydrogenase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:ENSG00000073578-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-611105 Respiratory electron transport
R-HSA-71403 Citric acid cycle (TCA cycle)

SIGNOR Signaling Network Open Resource

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SIGNORi
P31040

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00223;UER01006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.11 Publication)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
Fp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDHA
Synonyms:SDH2, SDHF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000073578.16

Human Gene Nomenclature Database

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HGNCi
HGNC:10680 SDHA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600857 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P31040

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex II deficiency (MT-C2D)
The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Disease descriptionA disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome.
See also OMIM:252011
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_016879555G → E in MT-C2D and CMD1GG. 2 PublicationsCorresponds to variant dbSNP:rs137852768EnsemblClinVar.1
Leigh syndrome (LS)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.
See also OMIM:256000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074022189C → G in LS; decrease in succinate dehydrogenase activity. 1 Publication1
Natural variantiVAR_016878524A → V in LS. 1 PublicationCorresponds to variant dbSNP:rs137852767EnsemblClinVar.1
Natural variantiVAR_002449554R → W in LS. 1 PublicationCorresponds to variant dbSNP:rs9809219EnsemblClinVar.1
Cardiomyopathy, dilated 1GG (CMD1GG)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:613642
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016879555G → E in MT-C2D and CMD1GG. 2 PublicationsCorresponds to variant dbSNP:rs137852768EnsemblClinVar.1
Paragangliomas 5 (PGL5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.
See also OMIM:614165
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065975589R → W in PGL5; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs387906780EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Leigh syndrome, Primary mitochondrial disease, Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
6389

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
SDHA

MalaCards human disease database

More...
MalaCardsi
SDHA
MIMi252011 phenotype
256000 phenotype
613642 phenotype
614165 phenotype

Open Targets

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OpenTargetsi
ENSG00000073578

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
154 Familial isolated dilated cardiomyopathy
44890 Gastrointestinal stromal tumor
29072 Hereditary pheochromocytoma-paraganglioma
3208 Isolated succinate-CoQ reductase deficiency
255241 Leigh syndrome with leukodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35605

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5758

Drug and drug target database

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DrugBanki
DB04657 Carboxin
DB00139 Succinic acid
DB04795 Thenoyltrifluoroacetone
DB08689 UBIQUINONE-1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SDHA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1169337

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 42MitochondrionBy similarityAdd BLAST42
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001033543 – 664Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99Tele-8alpha-FAD histidineBy similarity1
Modified residuei167N6-acetyllysineBy similarity1
Modified residuei179N6-acetyllysine; alternateCombined sources1
Modified residuei179N6-succinyllysine; alternateBy similarity1
Modified residuei182N6-acetyllysineBy similarity1
Modified residuei215Phosphotyrosine; by SRC1 Publication1
Modified residuei250N6-acetyllysine; alternateBy similarity1
Modified residuei250N6-succinyllysine; alternateBy similarity1
Modified residuei335N6-acetyllysine; alternateCombined sources1
Modified residuei335N6-succinyllysine; alternateBy similarity1
Modified residuei480N6-acetyllysineBy similarity1
Modified residuei485N6-acetyllysine; alternateBy similarity1
Modified residuei485N6-succinyllysine; alternateBy similarity1
Modified residuei498N6-acetyllysine; alternateBy similarity1
Modified residuei498N6-succinyllysine; alternateBy similarity1
Modified residuei517N6-acetyllysineBy similarity1
Modified residuei538N6-acetyllysine; alternateBy similarity1
Modified residuei538N6-succinyllysine; alternateBy similarity1
Modified residuei541N6-acetyllysineCombined sources1
Modified residuei547N6-acetyllysine; alternateBy similarity1
Modified residuei547N6-succinyllysine; alternateBy similarity1
Modified residuei550N6-acetyllysineBy similarity1
Modified residuei598N6-acetyllysineBy similarity1
Modified residuei608N6-acetyllysineCombined sources1
Modified residuei615N6-succinyllysineBy similarity1
Modified residuei624N6-acetyllysineBy similarity1
Modified residuei636N6-acetyllysineBy similarity1
Modified residuei647N6-acetyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation.1 Publication
Acetylated. Deacetylated by SIRT3.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P31040

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P31040

MaxQB - The MaxQuant DataBase

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MaxQBi
P31040

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P31040

PeptideAtlas

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PeptideAtlasi
P31040

PRoteomics IDEntifications database

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PRIDEi
P31040

ProteomicsDB human proteome resource

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ProteomicsDBi
54758

Consortium for Top Down Proteomics

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TopDownProteomicsi
P31040-1 [P31040-1]

2D gel databases

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00305166

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P31040

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P31040

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P31040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000073578 Expressed in 95 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

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CleanExi
HS_SDHA

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P31040 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P31040 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034929
HPA041981
HPA064582

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD (By similarity). Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (PubMed:19628817). Interacts with TRAP1 (PubMed:23747254).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112290, 227 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-561 Mitochondrial respiratory chain complex II

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P31040

Database of interacting proteins

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DIPi
DIP-45851N

Protein interaction database and analysis system

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IntActi
P31040, 149 interactors

Molecular INTeraction database

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MINTi
P31040

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264932

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P31040

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P31040

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2403 Eukaryota
COG1053 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00910000144277

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000160475

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001461

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P31040

KEGG Orthology (KO)

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KOi
K00234

Identification of Orthologs from Complete Genome Data

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OMAi
GDSPWEH

Database of Orthologous Groups

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OrthoDBi
507784at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P31040

TreeFam database of animal gene trees

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TreeFami
TF300763

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.50.50.60, 1 hit
3.90.700.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg

Pfam protein domain database

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Pfami
View protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 1 hit
SSF56425 SSF56425, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P31040-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MSGVRGLSRL LSARRLALAK AWPTVLQTGT RGFHFTVDGN KRASAKVSDS
60 70 80 90 100
ISAQYPVVDH EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT
110 120 130 140 150
VAAQGGINAA LGNMEEDNWR WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV
160 170 180 190 200
VELENYGMPF SRTEDGKIYQ RAFGGQSLKF GKGGQAHRCC CVADRTGHSL
210 220 230 240 250
LHTLYGRSLR YDTSYFVEYF ALDLLMENGE CRGVIALCIE DGSIHRIRAK
260 270 280 290 300
NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI
310 320 330 340 350
YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE
360 370 380 390 400
IREGRGCGPE KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI
410 420 430 440 450
PVLPTVHYNM GGIPTNYKGQ VLRHVNGQDQ IVPGLYACGE AACASVHGAN
460 470 480 490 500
RLGANSLLDL VVFGRACALS IEESCRPGDK VPPIKPNAGE ESVMNLDKLR
510 520 530 540 550
FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS KLYGDLKHLK
560 570 580 590 600
TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKVR
610 620 630 640 650
IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVGTGKVTLE YRPVIDKTLN
660
EADCATVPPA IRSY
Length:664
Mass (Da):72,692
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i180B664E3FFD0B34
GO
Isoform 2 (identifier: P31040-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-152: Missing.

Note: No experimental confirmation available.
Show »
Length:616
Mass (Da):67,300
Checksum:i7F3417D2C871A210
GO
Isoform 3 (identifier: P31040-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-270: Missing.

Note: No experimental confirmation available.
Show »
Length:519
Mass (Da):56,650
Checksum:i608A48ACFF596F2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFM5D6RFM5_HUMAN
Succinate dehydrogenase [ubiquinone...
SDHA
583Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1I3A0A087X1I3_HUMAN
Succinate dehydrogenase [ubiquinone...
SDHA
519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8X1H0Y8X1_HUMAN
Succinate dehydrogenase [ubiquinone...
SDHA
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8S2H0Y8S2_HUMAN
Succinate dehydrogenase [ubiquinone...
SDHA
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REB7D6REB7_HUMAN
Succinate dehydrogenase [ubiquinone...
SDHA
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92228 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA37886 differs from that shown. Differs extensively from that shown.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti356G → D in AAD51006 (PubMed:10746566).Curated1
Sequence conflicti398E → D in AAD51006 (PubMed:10746566).Curated1
Sequence conflicti591A → T in AAD51006 (PubMed:10746566).Curated1
Sequence conflicti596D → G in AAD51006 (PubMed:10746566).Curated1
Sequence conflicti600R → Q in AAD51006 (PubMed:10746566).Curated1
Sequence conflicti618F → L in BAG58722 (PubMed:14702039).Curated1
Sequence conflicti640E → G in AAD51006 (PubMed:10746566).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04921433F → V. Corresponds to variant dbSNP:rs1061518Ensembl.1
Natural variantiVAR_04921538D → V1 PublicationCorresponds to variant dbSNP:rs34635677EnsemblClinVar.1
Natural variantiVAR_074022189C → G in LS; decrease in succinate dehydrogenase activity. 1 Publication1
Natural variantiVAR_049216240E → Q. Corresponds to variant dbSNP:rs1041946Ensembl.1
Natural variantiVAR_059307333V → I. Corresponds to variant dbSNP:rs1062468Ensembl.1
Natural variantiVAR_016878524A → V in LS. 1 PublicationCorresponds to variant dbSNP:rs137852767EnsemblClinVar.1
Natural variantiVAR_002449554R → W in LS. 1 PublicationCorresponds to variant dbSNP:rs9809219EnsemblClinVar.1
Natural variantiVAR_016879555G → E in MT-C2D and CMD1GG. 2 PublicationsCorresponds to variant dbSNP:rs137852768EnsemblClinVar.1
Natural variantiVAR_065975589R → W in PGL5; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs387906780EnsemblClinVar.1
Natural variantiVAR_071037629Y → F3 PublicationsCorresponds to variant dbSNP:rs6960EnsemblClinVar.1
Natural variantiVAR_049217657V → I1 PublicationCorresponds to variant dbSNP:rs6962EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055077105 – 152Missing in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_055078126 – 270Missing in isoform 3. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D30648 mRNA Translation: BAA06332.1
L21936 mRNA Translation: AAA20683.1
AF171030
, AF171017, AF171018, AF171019, AF171020, AF171021, AF171022, AF171023, AF171024, AF171025, AF171026, AF171027, AF171028, AF171029 Genomic DNA Translation: AAD51006.1
AK291311 mRNA Translation: BAF84000.1
AK295937 mRNA Translation: BAG58722.1
AB208991 mRNA Translation: BAD92228.1 Different initiation.
AC021087 Genomic DNA No translation available.
CH471235 Genomic DNA Translation: EAW50983.1
BC001380 mRNA Translation: AAH01380.1
BC041016 mRNA Translation: AAH41016.1
X53943 mRNA Translation: CAA37886.1 Sequence problems.
S79641 Genomic DNA Translation: AAB35332.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3853.1 [P31040-1]
CCDS77992.1 [P31040-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JX0336
S21302

NCBI Reference Sequences

More...
RefSeqi
NP_001281261.1, NM_001294332.1 [P31040-2]
NP_004159.2, NM_004168.3 [P31040-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.440475

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264932; ENSP00000264932; ENSG00000073578 [P31040-1]
ENST00000510361; ENSP00000427703; ENSG00000073578 [P31040-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6389

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6389

UCSC genome browser

More...
UCSCi
uc003jao.5 human [P31040-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

TCA Cycle Gene Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30648 mRNA Translation: BAA06332.1
L21936 mRNA Translation: AAA20683.1
AF171030
, AF171017, AF171018, AF171019, AF171020, AF171021, AF171022, AF171023, AF171024, AF171025, AF171026, AF171027, AF171028, AF171029 Genomic DNA Translation: AAD51006.1
AK291311 mRNA Translation: BAF84000.1
AK295937 mRNA Translation: BAG58722.1
AB208991 mRNA Translation: BAD92228.1 Different initiation.
AC021087 Genomic DNA No translation available.
CH471235 Genomic DNA Translation: EAW50983.1
BC001380 mRNA Translation: AAH01380.1
BC041016 mRNA Translation: AAH41016.1
X53943 mRNA Translation: CAA37886.1 Sequence problems.
S79641 Genomic DNA Translation: AAB35332.1
CCDSiCCDS3853.1 [P31040-1]
CCDS77992.1 [P31040-2]
PIRiJX0336
S21302
RefSeqiNP_001281261.1, NM_001294332.1 [P31040-2]
NP_004159.2, NM_004168.3 [P31040-1]
UniGeneiHs.440475

3D structure databases

ProteinModelPortaliP31040
SMRiP31040
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112290, 227 interactors
ComplexPortaliCPX-561 Mitochondrial respiratory chain complex II
CORUMiP31040
DIPiDIP-45851N
IntActiP31040, 149 interactors
MINTiP31040
STRINGi9606.ENSP00000264932

Chemistry databases

ChEMBLiCHEMBL5758
DrugBankiDB04657 Carboxin
DB00139 Succinic acid
DB04795 Thenoyltrifluoroacetone
DB08689 UBIQUINONE-1

PTM databases

iPTMnetiP31040
PhosphoSitePlusiP31040
SwissPalmiP31040

Polymorphism and mutation databases

BioMutaiSDHA
DMDMi1169337

2D gel databases

REPRODUCTION-2DPAGEiIPI00305166

Proteomic databases

EPDiP31040
jPOSTiP31040
MaxQBiP31040
PaxDbiP31040
PeptideAtlasiP31040
PRIDEiP31040
ProteomicsDBi54758
TopDownProteomicsiP31040-1 [P31040-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6389
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264932; ENSP00000264932; ENSG00000073578 [P31040-1]
ENST00000510361; ENSP00000427703; ENSG00000073578 [P31040-2]
GeneIDi6389
KEGGihsa:6389
UCSCiuc003jao.5 human [P31040-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6389
DisGeNETi6389
EuPathDBiHostDB:ENSG00000073578.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SDHA
GeneReviewsiSDHA

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0120996
HGNCiHGNC:10680 SDHA
HPAiCAB034929
HPA041981
HPA064582
MalaCardsiSDHA
MIMi252011 phenotype
256000 phenotype
600857 gene
613642 phenotype
614165 phenotype
neXtProtiNX_P31040
OpenTargetsiENSG00000073578
Orphaneti154 Familial isolated dilated cardiomyopathy
44890 Gastrointestinal stromal tumor
29072 Hereditary pheochromocytoma-paraganglioma
3208 Isolated succinate-CoQ reductase deficiency
255241 Leigh syndrome with leukodystrophy
PharmGKBiPA35605

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
GeneTreeiENSGT00910000144277
HOGENOMiHOG000160475
HOVERGENiHBG001461
InParanoidiP31040
KOiK00234
OMAiGDSPWEH
OrthoDBi507784at2759
PhylomeDBiP31040
TreeFamiTF300763

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01006

BioCyciMetaCyc:ENSG00000073578-MONOMER
ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-71403 Citric acid cycle (TCA cycle)
SIGNORiP31040

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SDHA human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SDHA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6389

Protein Ontology

More...
PROi
PR:P31040

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000073578 Expressed in 95 organ(s), highest expression level in apex of heart
CleanExiHS_SDHA
ExpressionAtlasiP31040 baseline and differential
GenevisibleiP31040 HS

Family and domain databases

Gene3Di3.50.50.60, 1 hit
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 1 hit
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDHA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P31040
Secondary accession number(s): A8K5J6
, B4DJ60, E9PBJ5, Q16395, Q59GW8, Q8IW48, Q9UMY5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1995
Last modified: January 16, 2019
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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