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Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase iron-sulfur subunit (sdhB), Succinate dehydrogenase flavoprotein subunit (sdhA)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei225FADBy similarity1
Binding sitei246SubstrateBy similarity1
Binding sitei258SubstrateBy similarity1
Active sitei290Proton acceptorBy similarity1
Binding sitei357SubstrateBy similarity1
Binding sitei391FADBy similarity1
Binding sitei402SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 23FADBy similarity6
Nucleotide bindingi41 – 56FADBy similarityAdd BLAST16
Nucleotide bindingi407 – 408FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-130-MONOMER
UniPathwayiUPA00223; UER01005

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1By similarity)
Gene namesi
Name:sdhA
Ordered Locus Names:RP128
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586571 – 596Succinate dehydrogenase flavoprotein subunitAdd BLAST596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PRIDEiP31038

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.By similarity

Protein-protein interaction databases

STRINGi272947.RP128

Structurei

3D structure databases

ProteinModelPortaliP31038
SMRiP31038
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108J01 Bacteria
COG1053 LUCA
HOGENOMiHOG000160475
KOiK00239
OMAiGDSPWEH

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P31038-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAYNIIHH KFDVVVVGAG GAGLRSAFGM AKEGLNTACI TKIFPTRSHT
60 70 80 90 100
VAAQGGISAA LGNMGEDDWR WHMYDTVKGS DWLGDQDAIE YMCKNAPDAI
110 120 130 140 150
LELEHYGVPF SRTVDGKIYQ RPFGGMTTEY GKGKAAQRTC AAADRTGHAI
160 170 180 190 200
LHTLYQQSLK HKVQFFIEYF AIDLLMEDGE CRGVVAWNLD DGSLHCFRAH
210 220 230 240 250
NVVLATGGYG RAYFSATSAH TCTGDGGGMV IRAGLPLQDM EFVQFHPTGI
260 270 280 290 300
YSAGCLITEG ARGEGGYLVN ANGERFMERY APAAKDLASR DVVSRAMTIE
310 320 330 340 350
IREGRGVGEH KDHVFLHLNH LSPEILHRRL PGISETAKIF AGVDVTKDPI
360 370 380 390 400
PVLPTVHYNM GGIPTNYQGQ VIIKDGKNHN SIVNGIMAIG EAACVSVHGA
410 420 430 440 450
NRLGSNSLLD LVVFGRSSAL KAAELIKPAS PHKPLQKETL EKIINRFDKV
460 470 480 490 500
RYANGNILVA DLRLKMQRTM QSHVSVFRTQ KLLDEGVGMI SEIRNRYKDI
510 520 530 540 550
KINDKSLIWN SDLVEALELD NLLDQALVTV CSAAARKESR GAHAREDYPD
560 570 580 590
RNDRDWIKHT LSSIDDSGKV VLDYKPVTLT TLTDAISAIP PVKRVY
Length:596
Mass (Da):65,445
Last modified:July 1, 1993 - v1
Checksum:iE5CAA5DFE9426EC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88696 Unassigned DNA Translation: AAA16097.1
U02603 Unassigned DNA Translation: AAA18327.1
AJ235270 Genomic DNA Translation: CAA14597.1
PIRiJN0895
RefSeqiNP_220520.1, NC_000963.1
WP_004597170.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA14597; CAA14597; CAA14597
GeneIDi883752
KEGGirpr:RP128
PATRICifig|272947.5.peg.130

Similar proteinsi

Entry informationi

Entry nameiSDHA_RICPR
AccessioniPrimary (citable) accession number: P31038
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Rickettsia prowazekii
    Rickettsia prowazekii (strain Madrid E): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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