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Protein

Serine--pyruvate aminotransferase

Gene

AGXT

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
L-alanine + glyoxylate = pyruvate + glycine.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei360SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Serine--pyruvate aminotransferase (EC:2.6.1.51)
Short name:
SPT
Alternative name(s):
Alanine--glyoxylate aminotransferase (EC:2.6.1.44)
Short name:
AGT
Gene namesi
Name:AGXT
Synonyms:AGT1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001502381 – 392Serine--pyruvate aminotransferaseAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei209N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei225N6-acetyllysine; alternateBy similarity1
Modified residuei225N6-succinyllysine; alternateBy similarity1
Modified residuei234N6-acetyllysineBy similarity1
Modified residuei312N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000022506

Structurei

3D structure databases

ProteinModelPortaliP31030
SMRiP31030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi390 – 392Microbody targeting signal3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2862 Eukaryota
COG0075 LUCA
HOGENOMiHOG000171815
HOVERGENiHBG006907
InParanoidiP31030
KOiK00830

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR024169 SP_NH2Trfase/AEP_transaminase
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF000524 SPT, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

Sequencei

Sequence statusi: Complete.

P31030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRQLLVAP PEALRKPLCT PHRLLLGPGP SNLPPRVLAA GGLQMIGHMH
60 70 80 90 100
EEMYQVMDEI KQGIQYAFQT RNALTLAVSG SGHCALETAL FNLLEPGDAF
110 120 130 140 150
LVGANGIWGQ RAAEVGERIG ARVHPMIKDP GSHYTLQEVE ECLAQHKPVL
160 170 180 190 200
LFLTHGESST GVLQPLDGFG ELCHRYKCLL LVDSVASLGG APIYMDQQGI
210 220 230 240 250
DVLYSGSQKA LNAPPGTSLI SFSDKAKSKI YARKTKPFSF YMDVQLLANI
260 270 280 290 300
WGCDGKPRMY HHTTPVIGIF ALRESLALLV EQGLEKSWQR HREVAQHLYR
310 320 330 340 350
RLQELGLQLF VKDPALRLPT VTTVIVPASY RWRDIVSYVM HHFGIEITGG
360 370 380 390
LGPSADKVLR IGLLGCNATR ENVDRLATAL REALQHCAQS QL
Length:392
Mass (Da):43,148
Last modified:July 1, 1993 - v1
Checksum:i5261DD14564582D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84647 mRNA Translation: AAA31158.1
PIRiS24155
RefSeqiNP_001075778.1, NM_001082309.1
UniGeneiOcu.1825

Genome annotation databases

GeneIDi100009147
KEGGiocu:100009147

Similar proteinsi

Entry informationi

Entry nameiSPYA_RABIT
AccessioniPrimary (citable) accession number: P31030
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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