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Protein

Lipocalin-1

Gene

LCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.

GO - Molecular functioni

  • chloride ion binding Source: CAFA
  • cysteine-type endopeptidase inhibitor activity Source: ProtInc
  • signaling receptor binding Source: UniProtKB
  • small molecule binding Source: InterPro
  • zinc ion binding Source: CAFA

GO - Biological processi

  • long-chain fatty acid transport Source: Reactome
  • proteolysis Source: ProtInc
  • response to stimulus Source: UniProtKB-KW
  • retina homeostasis Source: UniProtKB
  • sensory perception of taste Source: UniProtKB-KW

Keywordsi

Biological processSensory transduction, Taste, Transport

Enzyme and pathway databases

ReactomeiR-HSA-804914 Transport of fatty acids

Chemistry databases

SwissLipidsiSLP:000001525

Names & Taxonomyi

Protein namesi
Recommended name:
Lipocalin-1
Alternative name(s):
Tear lipocalin
Short name:
Tlc
Tear prealbumin
Short name:
TP
von Ebner gland protein
Short name:
VEG protein
Gene namesi
Name:LCN1
Synonyms:VEGP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000160349.9
HGNCiHGNC:6525 LCN1
MIMi151675 gene
neXtProtiNX_P31025

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3933
OpenTargetsiENSG00000160349
PharmGKBiPA30308

Protein family/group databases

Allergomei3990 Hom s TL

Polymorphism and mutation databases

BioMutaiLCN1
DMDMi401346

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000001797419 – 176Lipocalin-1Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi79 ↔ 171

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP31025
MaxQBiP31025
PaxDbiP31025
PeptideAtlasiP31025
PRIDEiP31025
ProteomicsDBi54757
TopDownProteomicsiP31025

2D gel databases

UCD-2DPAGEiP31025

PTM databases

iPTMnetiP31025
PhosphoSitePlusiP31025

Expressioni

Tissue specificityi

Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.

Gene expression databases

BgeeiENSG00000160349
CleanExiHS_LCN1
ExpressionAtlasiP31025 baseline and differential
GenevisibleiP31025 HS

Interactioni

Subunit structurei

Homodimer (By similarity). Binds to LMBR1L which may mediate its endocytosis.By similarity

GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi110125, 22 interactors
IntActiP31025, 7 interactors
STRINGi9606.ENSP00000263598

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 27Combined sources3
Beta strandi33 – 42Combined sources10
Beta strandi44 – 46Combined sources3
Beta strandi49 – 54Combined sources6
Beta strandi57 – 61Combined sources5
Turni63 – 65Combined sources3
Beta strandi67 – 73Combined sources7
Beta strandi75 – 78Combined sources4
Beta strandi80 – 88Combined sources9
Beta strandi94 – 97Combined sources4
Helixi98 – 100Combined sources3
Beta strandi102 – 108Combined sources7
Beta strandi111 – 113Combined sources3
Beta strandi114 – 121Combined sources8
Beta strandi128 – 139Combined sources12
Helixi145 – 154Combined sources10
Beta strandi160 – 163Combined sources4

3D structure databases

ProteinModelPortaliP31025
SMRiP31025
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31025

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1KM Eukaryota
ENOG4111BH9 LUCA
GeneTreeiENSGT00440000033563
HOGENOMiHOG000231562
HOVERGENiHBG101411
InParanoidiP31025
OMAiSGKWYLK
OrthoDBiEOG091G0PIH
PhylomeDBiP31025
TreeFamiTF338197

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002450 von_Ebner_gland
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01175 VNEBNERGLAND
SUPFAMiSSF50814 SSF50814, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31025-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLLLAVSL GLIAALQAHH LLASDEEIQD VSGTWYLKAM TVDREFPEMN
60 70 80 90 100
LESVTPMTLT TLEGGNLEAK VTMLISGRCQ EVKAVLEKTD EPGKYTADGG
110 120 130 140 150
KHVAYIIRSH VKDHYIFYCE GELHGKPVRG VKLVGRDPKN NLEALEDFEK
160 170
AAGARGLSTE SILIPRQSET CSPGSD
Length:176
Mass (Da):19,250
Last modified:July 1, 1993 - v1
Checksum:i0DDBF124C8C78CB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62418 mRNA Translation: CAA44284.1
M90424 mRNA Translation: AAA61845.1
X67647 mRNA Translation: CAA47889.1
L14927 Genomic DNA Translation: AAA18633.1
AL161452 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW88156.1
BC065721 mRNA Translation: AAH65721.1
BC074925 mRNA Translation: AAH74925.1
BC074926 mRNA Translation: AAH74926.1
CCDSiCCDS6991.1
PIRiA44029 LCHUL
RefSeqiNP_001239546.1, NM_001252617.1
NP_001239547.1, NM_001252618.1
NP_001239548.1, NM_001252619.1
NP_002288.1, NM_002297.3
UniGeneiHs.530311

Genome annotation databases

EnsembliENST00000263598; ENSP00000263598; ENSG00000160349
ENST00000371781; ENSP00000360846; ENSG00000160349
GeneIDi3933
KEGGihsa:3933
UCSCiuc004cfz.3 human

Similar proteinsi

Entry informationi

Entry nameiLCN1_HUMAN
AccessioniPrimary (citable) accession number: P31025
Secondary accession number(s): Q5T8A1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 18, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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