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Protein

40S ribosomal protein S2

Gene

RpS2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a specific developmental role during oogenesis and a general role in protein synthesis as a component of the small ribosomal subunit.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • multicellular organism development Source: UniProtKB-KW
  • oogenesis Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, Ribosomal protein
Biological processDifferentiation, Oogenesis

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-3214858 RMTs methylate histone arginines
R-DME-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DME-72649 Translation initiation complex formation
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-DME-72702 Ribosomal scanning and start codon recognition
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-8876725 Protein methylation
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S2
Alternative name(s):
Protein strings of pearls
Gene namesi
Name:RpS2
Synonyms:sop
ORF Names:CG5920
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0004867 RpS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001316791 – 26740S ribosomal protein S2Add BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP31009
PRIDEiP31009

PTM databases

iPTMnetiP31009

Expressioni

Gene expression databases

BgeeiFBgn0004867
ExpressionAtlasiP31009 baseline and differential
GenevisibleiP31009 DM

Interactioni

Protein-protein interaction databases

BioGridi60403, 27 interactors
DIPiDIP-18767N
IntActiP31009, 25 interactors
MINTiP31009
STRINGi7227.FBpp0079500

Structurei

3D structure databases

ProteinModelPortaliP31009
SMRiP31009
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 148S5 DRBMPROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0877 Eukaryota
COG0098 LUCA
GeneTreeiENSGT00390000001433
InParanoidiP31009
KOiK02981
OMAiEDCYTQS
OrthoDBiEOG091G0LPC
PhylomeDBiP31009

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR000851 Ribosomal_S5
IPR005324 Ribosomal_S5_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005711 Ribosomal_S5_euk/arc
IPR013810 Ribosomal_S5_N
IPR018192 Ribosomal_S5_N_CS
PANTHERiPTHR13718 PTHR13718, 1 hit
PfamiView protein in Pfam
PF00333 Ribosomal_S5, 1 hit
PF03719 Ribosomal_S5_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
TIGRFAMsiTIGR01020 uS5_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00585 RIBOSOMAL_S5, 1 hit
PS50881 S5_DSRBD, 1 hit

Sequencei

Sequence statusi: Complete.

P31009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEAPARSG FRGGFGSRGG RGGRGRGRGR WARGRGKEDS KEWVPVTKLG
60 70 80 90 100
RLVREGKIKS LEEIYLYSLP IKEFEIIDFF LGSSLKDEVL KIMPVQKQTR
110 120 130 140 150
AGQRTRFKAF VAIGDNNGHI GLGVKCSKEV ATAIRGAIIL AKLSVVPVRR
160 170 180 190 200
GYWGNKIGKP HTVPCKVTGK CGSVSVRLIP APRGTGIVSA PVPKKLLTMA
210 220 230 240 250
GIEDCYTSAR GSTGTLGNFA KATYAAIAKT YAYLTPDLWK EMPLGSTPYQ
260
AYSDFLSKPT PRLHADA
Length:267
Mass (Da):28,900
Last modified:February 1, 1995 - v2
Checksum:iADA22CD28F100743
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 20GG → PP in CAA48872 (PubMed:8441641).Curated2
Sequence conflicti194K → R in CAA48872 (PubMed:8441641).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01334 mRNA Translation: AAC34198.1
U01335 Genomic DNA Translation: AAA87053.1
X69120 mRNA Translation: CAA48872.1
AE014134 Genomic DNA Translation: AAF52822.1
AY094799 mRNA Translation: AAM11152.1
PIRiS30395
RefSeqiNP_001260303.1, NM_001273374.2
NP_001285785.1, NM_001298856.1
NP_476874.1, NM_057526.5
UniGeneiDm.3451

Genome annotation databases

EnsemblMetazoaiFBtr0079905; FBpp0079500; FBgn0004867
FBtr0330682; FBpp0303531; FBgn0004867
FBtr0345436; FBpp0311561; FBgn0004867
GeneIDi34309
KEGGidme:Dmel_CG5920

Similar proteinsi

Entry informationi

Entry nameiRS2_DROME
AccessioniPrimary (citable) accession number: P31009
Secondary accession number(s): Q9VL74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1995
Last modified: July 18, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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