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Protein

Neurotensin/neuromedin N

Gene

NTS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionVasoactive

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP30990

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:NTS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000133636.10
HGNCiHGNC:8038 NTS
MIMi162650 gene
neXtProtiNX_P30990

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4922
OpenTargetsiENSG00000133636
PharmGKBiPA31820

Polymorphism and mutation databases

BioMutaiNTS
DMDMi2828196

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001952224 – 148Large neuromedin NAdd BLAST125
PeptideiPRO_0000019523144 – 148Neuromedin N5
PeptideiPRO_0000019524151 – 163NeurotensinAdd BLAST13
PeptideiPRO_0000019525166 – 170Tail peptideSequence analysis5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Pyrrolidone carboxylic acid1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP30990
PaxDbiP30990
PeptideAtlasiP30990
PRIDEiP30990
ProteomicsDBi54756

PTM databases

iPTMnetiP30990
PhosphoSitePlusiP30990

Miscellaneous databases

PMAP-CutDBiP30990

Expressioni

Gene expression databases

BgeeiENSG00000133636 Expressed in 119 organ(s), highest expression level in adrenal gland
CleanExiHS_NTS
ExpressionAtlasiP30990 baseline and differential
GenevisibleiP30990 HS

Organism-specific databases

HPAiHPA026664

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NTSR1P309892EBI-6655799,EBI-6655774

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110976, 2 interactors
DIPiDIP-60978N
IntActiP30990, 3 interactors
STRINGi9606.ENSP00000256010

Chemistry databases

BindingDBiP30990

Structurei

Secondary structure

1170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP30990
SMRiP30990
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30990

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDE Eukaryota
ENOG410YV74 LUCA
GeneTreeiENSGT00640000091574
HOGENOMiHOG000113770
HOVERGENiHBG003785
InParanoidiP30990
KOiK05235
OMAiLTNMYTS
OrthoDBiEOG091G0PRU
PhylomeDBiP30990
TreeFamiTF330765

Family and domain databases

InterProiView protein in InterPro
IPR008055 NeurotensiN
PANTHERiPTHR15356 PTHR15356, 1 hit
PfamiView protein in Pfam
PF07421 Pro-NT_NN, 1 hit
PRINTSiPR01668 NEUROTENSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016590 NeurotensiN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P30990-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAGMKIQLV CMLLLAFSSW SLCSDSEEEM KALEADFLTN MHTSKISKAH
60 70 80 90 100
VPSWKMTLLN VCSLVNNLNS PAEETGEVHE EELVARRKLP TALDGFSLEA
110 120 130 140 150
MLTIYQLHKI CHSRAFQHWE LIQEDILDTG NDKNGKEEVI KRKIPYILKR
160 170
QLYENKPRRP YILKRDSYYY
Length:170
Mass (Da):19,795
Last modified:November 1, 1997 - v2
Checksum:i66E2E146DA08E3C7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1X6G3V1X6_HUMAN
Neurotensin, isoform CRA_a
NTS hCG_21128
95Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91618 mRNA Translation: AAB50564.1
BC010918 mRNA Translation: AAH10918.1
S47339 Genomic DNA Translation: AAB23934.1
CCDSiCCDS9029.1
PIRiI58190
RefSeqiNP_006174.1, NM_006183.4
UniGeneiHs.80962

Genome annotation databases

EnsembliENST00000256010; ENSP00000256010; ENSG00000133636
GeneIDi4922
KEGGihsa:4922

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Neurotensin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91618 mRNA Translation: AAB50564.1
BC010918 mRNA Translation: AAH10918.1
S47339 Genomic DNA Translation: AAB23934.1
CCDSiCCDS9029.1
PIRiI58190
RefSeqiNP_006174.1, NM_006183.4
UniGeneiHs.80962

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNENMR-A152-163[»]
2LNFNMR-A152-163[»]
2LNGNMR-A152-163[»]
2LYWNMR-B152-163[»]
2OYVNMR-A152-163[»]
2OYWNMR-A152-163[»]
3F6KX-ray2.00N151-163[»]
4PO7X-ray2.66N/P151-163[»]
5LUZX-ray2.70C/D/P/Q151-163[»]
ProteinModelPortaliP30990
SMRiP30990
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110976, 2 interactors
DIPiDIP-60978N
IntActiP30990, 3 interactors
STRINGi9606.ENSP00000256010

Chemistry databases

BindingDBiP30990

PTM databases

iPTMnetiP30990
PhosphoSitePlusiP30990

Polymorphism and mutation databases

BioMutaiNTS
DMDMi2828196

Proteomic databases

EPDiP30990
PaxDbiP30990
PeptideAtlasiP30990
PRIDEiP30990
ProteomicsDBi54756

Protocols and materials databases

DNASUi4922
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256010; ENSP00000256010; ENSG00000133636
GeneIDi4922
KEGGihsa:4922

Organism-specific databases

CTDi4922
DisGeNETi4922
EuPathDBiHostDB:ENSG00000133636.10
GeneCardsiNTS
HGNCiHGNC:8038 NTS
HPAiHPA026664
MIMi162650 gene
neXtProtiNX_P30990
OpenTargetsiENSG00000133636
PharmGKBiPA31820
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKDE Eukaryota
ENOG410YV74 LUCA
GeneTreeiENSGT00640000091574
HOGENOMiHOG000113770
HOVERGENiHBG003785
InParanoidiP30990
KOiK05235
OMAiLTNMYTS
OrthoDBiEOG091G0PRU
PhylomeDBiP30990
TreeFamiTF330765

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP30990

Miscellaneous databases

ChiTaRSiNTS human
EvolutionaryTraceiP30990
GeneWikiiNeurotensin
GenomeRNAii4922
PMAP-CutDBiP30990
PROiPR:P30990
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133636 Expressed in 119 organ(s), highest expression level in adrenal gland
CleanExiHS_NTS
ExpressionAtlasiP30990 baseline and differential
GenevisibleiP30990 HS

Family and domain databases

InterProiView protein in InterPro
IPR008055 NeurotensiN
PANTHERiPTHR15356 PTHR15356, 1 hit
PfamiView protein in Pfam
PF07421 Pro-NT_NN, 1 hit
PRINTSiPR01668 NEUROTENSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016590 NeurotensiN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEUT_HUMAN
AccessioniPrimary (citable) accession number: P30990
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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