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Protein

Neurotensin receptor type 1

Gene

NTSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:8381365, PubMed:21725197, PubMed:23140271). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed:21725197).3 Publications

GO - Molecular functioni

  • G protein-coupled neurotensin receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: ProtInc
  • identical protein binding Source: IntAct
  • protein heterodimerization activity Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • protein N-terminus binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP30989

Protein family/group databases

TCDBi9.A.14.1.14 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 1
Short name:
NT-R-1
Short name:
NTR1
Alternative name(s):
High-affinity levocabastine-insensitive neurotensin receptor
NTRH
Gene namesi
Name:NTSR1
Synonyms:NTRR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101188.4
HGNCiHGNC:8039 NTSR1
MIMi162651 gene
neXtProtiNX_P30989

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67ExtracellularBy similarityAdd BLAST67
Transmembranei68 – 88Helical; Name=1By similarityAdd BLAST21
Topological domaini89 – 102CytoplasmicBy similarityAdd BLAST14
Transmembranei103 – 122Helical; Name=2By similarityAdd BLAST20
Topological domaini123 – 142ExtracellularBy similarityAdd BLAST20
Transmembranei143 – 164Helical; Name=3By similarityAdd BLAST22
Topological domaini165 – 184CytoplasmicBy similarityAdd BLAST20
Transmembranei185 – 205Helical; Name=4By similarityAdd BLAST21
Topological domaini206 – 234ExtracellularBy similarityAdd BLAST29
Transmembranei235 – 259Helical; Name=5By similarityAdd BLAST25
Topological domaini260 – 303CytoplasmicBy similarityAdd BLAST44
Transmembranei304 – 325Helical; Name=6By similarityAdd BLAST22
Topological domaini326 – 343ExtracellularBy similarityAdd BLAST18
Transmembranei344 – 364Helical; Name=7By similarityAdd BLAST21
Topological domaini365 – 418CytoplasmicBy similarityAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi381C → S: Abolishes palmitoylation; when associated with S-383. 1 Publication1
Mutagenesisi383C → S: Abolishes palmitoylation; when associated with S-381. 1 Publication1

Organism-specific databases

DisGeNETi4923
OpenTargetsiENSG00000101188
PharmGKBiPA31821

Chemistry databases

ChEMBLiCHEMBL4123
GuidetoPHARMACOLOGYi309

Polymorphism and mutation databases

BioMutaiNTSR1
DMDMi62297312

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699461 – 418Neurotensin receptor type 1Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi141 ↔ 224PROSITE-ProRule annotation
Lipidationi381S-palmitoyl cysteine1 Publication1
Lipidationi383S-palmitoyl cysteine1 Publication1

Post-translational modificationi

N-glycosylated.1 Publication
Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP30989
PaxDbiP30989
PeptideAtlasiP30989
PRIDEiP30989
ProteomicsDBi54755

PTM databases

iPTMnetiP30989
PhosphoSitePlusiP30989
SwissPalmiP30989

Expressioni

Tissue specificityi

Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain.2 Publications

Gene expression databases

BgeeiENSG00000101188 Expressed in 55 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_NTSR1
GenevisibleiP30989 HS

Organism-specific databases

HPAiHPA050299

Interactioni

Subunit structurei

Interacts (palmitoylated form) with GNA11.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110977, 1 interactor
DIPiDIP-60977N
IntActiP30989, 1 interactor
STRINGi9606.ENSP00000359532

Chemistry databases

BindingDBiP30989

Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP30989
SMRiP30989
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni321 – 344Neurotensin bindingBy similarityAdd BLAST24

Domaini

The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembrane regions TM6 and TM7.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000231271
HOVERGENiHBG098285
InParanoidiP30989
KOiK04211
OMAiVPMLFTM
OrthoDBiEOG091G0Q6E
PhylomeDBiP30989
TreeFamiTF337167

Family and domain databases

CDDicd15355 7tmA_NTSR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003985 NT1_rcpt
IPR003984 NT_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01479 NEUROTENSINR
PR01480 NEUROTENSN1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30989-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLNSSAPGT PGTPAADPFQ RAQAGLEEAL LAPGFGNASG NASERVLAAP
60 70 80 90 100
SSELDVNTDI YSKVLVTAVY LALFVVGTVG NTVTAFTLAR KKSLQSLQST
110 120 130 140 150
VHYHLGSLAL SDLLTLLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA
160 170 180 190 200
CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA
210 220 230 240 250
VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVVIQVN TFMSFIFPMV
260 270 280 290 300
VISVLNTIIA NKLTVMVRQA AEQGQVCTVG GEHSTFSMAI EPGRVQALRH
310 320 330 340 350
GVRVLRAVVI AFVVCWLPYH VRRLMFCYIS DEQWTPFLYD FYHYFYMVTN
360 370 380 390 400
ALFYVSSTIN PILYNLVSAN FRHIFLATLA CLCPVWRRRR KRPAFSRKAD
410
SVSSNHTLSS NATRETLY
Length:418
Mass (Da):46,259
Last modified:March 29, 2005 - v2
Checksum:i471AD1C49D29C2C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti200A → T in CAA49675 (PubMed:8381365).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05932872A → V. Corresponds to variant dbSNP:rs11698783Ensembl.1
Natural variantiVAR_049424275Q → H. Corresponds to variant dbSNP:rs35373650Ensembl.1
Natural variantiVAR_020071304V → I. Corresponds to variant dbSNP:rs2273075Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70070 mRNA Translation: CAA49675.1
AY429106 mRNA Translation: AAR07901.1
AL035669 Genomic DNA No translation available.
AL357033 Genomic DNA No translation available.
CCDSiCCDS13502.1
PIRiS29506
RefSeqiNP_002522.2, NM_002531.2
UniGeneiHs.590869

Genome annotation databases

EnsembliENST00000370501; ENSP00000359532; ENSG00000101188
GeneIDi4923
KEGGihsa:4923
UCSCiuc002ydf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Neurotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70070 mRNA Translation: CAA49675.1
AY429106 mRNA Translation: AAR07901.1
AL035669 Genomic DNA No translation available.
AL357033 Genomic DNA No translation available.
CCDSiCCDS13502.1
PIRiS29506
RefSeqiNP_002522.2, NM_002531.2
UniGeneiHs.590869

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LYWNMR-A321-344[»]
ProteinModelPortaliP30989
SMRiP30989
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110977, 1 interactor
DIPiDIP-60977N
IntActiP30989, 1 interactor
STRINGi9606.ENSP00000359532

Chemistry databases

BindingDBiP30989
ChEMBLiCHEMBL4123
GuidetoPHARMACOLOGYi309

Protein family/group databases

TCDBi9.A.14.1.14 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiP30989
PhosphoSitePlusiP30989
SwissPalmiP30989

Polymorphism and mutation databases

BioMutaiNTSR1
DMDMi62297312

Proteomic databases

MaxQBiP30989
PaxDbiP30989
PeptideAtlasiP30989
PRIDEiP30989
ProteomicsDBi54755

Protocols and materials databases

DNASUi4923
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370501; ENSP00000359532; ENSG00000101188
GeneIDi4923
KEGGihsa:4923
UCSCiuc002ydf.3 human

Organism-specific databases

CTDi4923
DisGeNETi4923
EuPathDBiHostDB:ENSG00000101188.4
GeneCardsiNTSR1
HGNCiHGNC:8039 NTSR1
HPAiHPA050299
MIMi162651 gene
neXtProtiNX_P30989
OpenTargetsiENSG00000101188
PharmGKBiPA31821
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000231271
HOVERGENiHBG098285
InParanoidiP30989
KOiK04211
OMAiVPMLFTM
OrthoDBiEOG091G0Q6E
PhylomeDBiP30989
TreeFamiTF337167

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP30989

Miscellaneous databases

GeneWikiiNeurotensin_receptor_1
GenomeRNAii4923
PROiPR:P30989
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101188 Expressed in 55 organ(s), highest expression level in muscle layer of sigmoid colon
CleanExiHS_NTSR1
GenevisibleiP30989 HS

Family and domain databases

CDDicd15355 7tmA_NTSR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR003985 NT1_rcpt
IPR003984 NT_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01479 NEUROTENSINR
PR01480 NEUROTENSN1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNTR1_HUMAN
AccessioniPrimary (citable) accession number: P30989
Secondary accession number(s): Q9H4H1, Q9H4T5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: March 29, 2005
Last modified: November 7, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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