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Protein

Gonadotropin-releasing hormone receptor

Gene

Gnrhr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

  • cellular response to gonadotropin-releasing hormone Source: GO_Central
  • circadian rhythm Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: RGD
  • negative regulation of cell proliferation Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gonadotropin-releasing hormone receptor
Short name:
GnRH receptor
Short name:
GnRH-R
Gene namesi
Name:Gnrhr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70513 Gnrhr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 58Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini59 – 77CytoplasmicSequence analysisAdd BLAST19
Transmembranei78 – 97Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini98 – 115ExtracellularSequence analysisAdd BLAST18
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 164CytoplasmicSequence analysisAdd BLAST27
Transmembranei165 – 184Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini185 – 211ExtracellularSequence analysisAdd BLAST27
Transmembranei212 – 231Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini232 – 280CytoplasmicSequence analysisAdd BLAST49
Transmembranei281 – 299Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini300 – 305ExtracellularSequence analysis6
Transmembranei306 – 325Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini326 – 327CytoplasmicSequence analysis2

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3066
GuidetoPHARMACOLOGYi256

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694911 – 327Gonadotropin-releasing hormone receptorAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30969

PTM databases

iPTMnetiP30969
PhosphoSitePlusiP30969

Expressioni

Inductioni

Expression oscillates in a diurnal and melatonin-dependent fashion in the preoptic area (POA) region in the hypothalamus, with maximal expression attained during the dark phase of the light/dark cycle.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi249567, 2 interactors
STRINGi10116.ENSRNOP00000002755

Chemistry databases

BindingDBiP30969

Structurei

3D structure databases

ProteinModelPortaliP30969
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000251590
HOVERGENiHBG009082
InParanoidiP30969
KOiK04280
PhylomeDBiP30969

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001658 GphnRH_fam_rcpt
IPR027982 GphnRH_rcpt
PANTHERiPTHR24241:SF22 PTHR24241:SF22, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00529 GNADOTRPHINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANNASLEQD QNHCSAINNS IPLTQGKLPT LTLSGKIRVT VTFFLFLLST
60 70 80 90 100
AFNASFLVKL QRWTQKRKKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG EFLCKVLSYL KLFSMYAPAF MMVVISLDRS LAVTQPLAVQ
160 170 180 190 200
SKSKLERSMT SLAWILSIVF AGPQLYIFRM IYLADGSGPA VFSQCVTHCS
210 220 230 240 250
FPQWWHEAFY NFFTFSCLFI IPLLIMLICN AKIIFALTRV LHQDPRKLQL
260 270 280 290 300
NQSKNNIPRA RLRTLKMTVA FGTSFVICWT PYYVLGIWYW FDPEMLNRVS
310 320
EPVNHFFFLF AFLNPCFDPL IYGYFSL
Length:327
Mass (Da):37,748
Last modified:February 1, 1994 - v2
Checksum:i86A2CA1A2C9F1BE4
GO

Sequence cautioni

The sequence AAA41265 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184A → V in CAA48776 (PubMed:1338727).Curated1
Sequence conflicti184A → V in AAB26420 (PubMed:1338727).Curated1
Sequence conflicti272G → A in AAA41265 (PubMed:7916600).Curated1
Sequence conflicti272G → A in CAA54083 (PubMed:8185587).Curated1
Sequence conflicti272G → A in AAC60671 (PubMed:7764374).Curated1
Sequence conflicti272G → A in AAB58038 (Ref. 7) Curated1
Sequence conflicti311A → G in CAA48776 (PubMed:1338727).Curated1
Sequence conflicti311A → G in AAB26420 (PubMed:1338727).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S59525 mRNA Translation: AAB26420.1
X68980 mRNA Translation: CAA48776.1
U00935 mRNA Translation: AAC27349.1
L25053 mRNA Translation: AAA41265.1 Different initiation.
L07646 mRNA Translation: AAA41274.1
X76635 mRNA Translation: CAA54083.1
S68578 mRNA Translation: AAC60671.1
U92471, U92469, U92470 Genomic DNA Translation: AAB58038.1
PIRiI60169
RefSeqiNP_112300.2, NM_031038.3
UniGeneiRn.112595

Genome annotation databases

GeneIDi81668
KEGGirno:81668
UCSCiRGD:70513 rat

Similar proteinsi

Entry informationi

Entry nameiGNRHR_RAT
AccessioniPrimary (citable) accession number: P30969
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: February 1, 1994
Last modified: February 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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