UniProtKB - P30968 (GNRHR_HUMAN)
Protein
Gonadotropin-releasing hormone receptor
Gene
GNRHR
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
GO - Molecular functioni
- gonadotropin-releasing hormone receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- peptide binding Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
- multicellular organism development Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P30968 |
Reactomei | R-HSA-375281, Hormone ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P30968 |
Protein family/group databases
TCDBi | 9.A.14.10.1, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Gonadotropin-releasing hormone receptorShort name: GnRH receptor Short name: GnRH-R |
Gene namesi | Name:GNRHR Synonyms:GRHR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000109163.6 |
HGNCi | HGNC:4421, GNRHR |
MIMi | 138850, gene |
neXtProti | NX_P30968 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 58 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 59 – 77 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 78 – 97 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 98 – 115 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 116 – 137 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 138 – 164 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 165 – 184 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 185 – 212 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 213 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 233 – 281 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 282 – 300 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 301 – 306 | ExtracellularSequence analysis | 6 | |
Transmembranei | 307 – 326 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 327 – 328 | CytoplasmicSequence analysis | 2 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Hypogonadotropic hypogonadism 7 with or without anosmia (HH7)12 Publications
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in GNRHR as well as in other HH-associated genes including FGFR1 (PubMed:23643382).1 Publication
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019311 | 10 | N → K in HH7; is able to bind GnRH but with a reduced affinity in vitro. 1 PublicationCorresponds to variant dbSNP:rs104893843EnsemblClinVar. | 1 | |
Natural variantiVAR_072970 | 18 | N → S in HH7. 1 PublicationCorresponds to variant dbSNP:rs774317793Ensembl. | 1 | |
Natural variantiVAR_072971 | 37 | I → S in HH7. 1 PublicationCorresponds to variant dbSNP:rs886907903Ensembl. | 1 | |
Natural variantiVAR_069960 | 83 | L → V in HH7; the patient also carries a mutation in FGFR1. 1 PublicationCorresponds to variant dbSNP:rs1391808526Ensembl. | 1 | |
Natural variantiVAR_072972 | 90 | E → D in HH7. 1 Publication | 1 | |
Natural variantiVAR_019312 | 90 | E → K in HH7; virtual abolition of GnRH agonist binding and agonist-stimulated phosphoinositide turnover; impairs GnRHR-effector coupling. 2 PublicationsCorresponds to variant dbSNP:rs104893844EnsemblClinVar. | 1 | |
Natural variantiVAR_019313 | 106 | Q → R in HH7; some patients also carry mutations in FGFR1; decreases but does not eliminate GnRH binding. 6 PublicationsCorresponds to variant dbSNP:rs104893836EnsemblClinVar. | 1 | |
Natural variantiVAR_019314 | 129 | A → D in HH7; complete loss of function. 2 PublicationsCorresponds to variant dbSNP:rs104893838EnsemblClinVar. | 1 | |
Natural variantiVAR_019315 | 139 | R → H in HH7; completely eliminates detectable GnRH-binding activity and prevents GnRH-induced stimulation of inositol phosphate accumulation in vitro. 2 PublicationsCorresponds to variant dbSNP:rs104893842EnsemblClinVar. | 1 | |
Natural variantiVAR_072973 | 146 | P → S in HH7. 1 PublicationCorresponds to variant dbSNP:rs144900788EnsemblClinVar. | 1 | |
Natural variantiVAR_019316 | 168 | S → R in HH7; complete loss of the receptor-mediated signaling response. 1 PublicationCorresponds to variant dbSNP:rs104893840EnsemblClinVar. | 1 | |
Natural variantiVAR_019317 | 171 | A → T in HH7; complete loss of ligand binding and receptor activation; specific receptor binding of radioisotope-labeled GnRH ligand is undetectable in transfected cells. 1 PublicationCorresponds to variant dbSNP:rs74452732EnsemblClinVar. | 1 | |
Natural variantiVAR_019318 | 217 | S → R in HH7; altered hormone binding. 1 PublicationCorresponds to variant dbSNP:rs104893839EnsemblClinVar. | 1 | |
Natural variantiVAR_019319 | 262 | R → Q in HH7; unknown pathological significance; some patients also carry mutations in FGFR1; minimal effects upon receptor affinity but expression decreased; altered activation of phospholipase C. 6 PublicationsCorresponds to variant dbSNP:rs104893837EnsemblClinVar. | 1 | |
Natural variantiVAR_072974 | 266 | L → R in HH7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148499544Ensembl. | 1 | |
Natural variantiVAR_019320 | 284 | Y → C in HH7; minimal effects upon receptor affinity but receptor expression decreased. 1 PublicationCorresponds to variant dbSNP:rs28933074EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutation, Hypogonadotropic hypogonadismOrganism-specific databases
DisGeNETi | 2798 |
GeneReviewsi | GNRHR |
MalaCardsi | GNRHR |
MIMi | 146110, phenotype |
OpenTargetsi | ENSG00000109163 |
Orphaneti | 432, Normosmic congenital hypogonadotropic hypogonadism |
PharmGKBi | PA28800 |
Miscellaneous databases
Pharosi | P30968, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1855 |
DrugBanki | DB00106, Abarelix DB06719, Buserelin DB00050, Cetrorelix DB01406, Danazol DB06699, Degarelix DB11979, Elagolix DB06785, Ganirelix DB11619, Gestrinone DB00644, Gonadorelin DB00014, Goserelin DB06788, Histrelin DB00007, Leuprolide DB00666, Nafarelin DB06494, Sufugolix DB05624, Teverelix DB06825, Triptorelin |
DrugCentrali | P30968 |
GuidetoPHARMACOLOGYi | 256 |
Polymorphism and mutation databases
BioMutai | GNRHR |
DMDMi | 399777 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069487 | 1 – 328 | Gonadotropin-releasing hormone receptorAdd BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 18 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 114 ↔ 196 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P30968 |
PaxDbi | P30968 |
PeptideAtlasi | P30968 |
PRIDEi | P30968 |
ProteomicsDBi | 54750 [P30968-1] 54751 [P30968-2] |
PTM databases
GlyGeni | P30968, 2 sites |
PhosphoSitePlusi | P30968 |
Expressioni
Tissue specificityi
Pituitary, ovary, testis, breast and prostate but not in liver and spleen.
Gene expression databases
Bgeei | ENSG00000109163, Expressed in adrenal tissue and 96 other tissues |
Genevisiblei | P30968, HS |
Organism-specific databases
HPAi | ENSG00000109163, Tissue enriched (pituitary) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 109060, 4 interactors |
IntActi | P30968, 4 interactors |
MINTi | P30968 |
STRINGi | 9606.ENSP00000226413 |
Chemistry databases
BindingDBi | P30968 |
Miscellaneous databases
RNActi | P30968, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222270 |
HOGENOMi | CLU_009579_15_2_1 |
InParanoidi | P30968 |
OMAi | SEPVNHF |
OrthoDBi | 858238at2759 |
PhylomeDBi | P30968 |
TreeFami | TF106499 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001658, GphnRH_fam_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00529, GNADOTRPHINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P30968-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MANSASPEQN QNHCSAINNS IPLMQGNLPT LTLSGKIRVT VTFFLFLLSA
60 70 80 90 100
TFNASFLLKL QKWTQKKEKG KKLSRMKLLL KHLTLANLLE TLIVMPLDGM
110 120 130 140 150
WNITVQWYAG ELLCKVLSYL KLFSMYAPAF MMVVISLDRS LAITRPLALK
160 170 180 190 200
SNSKVGQSMV GLAWILSSVF AGPQLYIFRM IHLADSSGQT KVFSQCVTHC
210 220 230 240 250
SFSQWWHQAF YNFFTFSCLF IIPLFIMLIC NAKIIFTLTR VLHQDPHELQ
260 270 280 290 300
LNQSKNNIPR ARLKTLKMTV AFATSFTVCW TPYYVLGIWY WFDPEMLNRL
310 320
SDPVNHFFFL FAFLNPCFDP LIYGYFSL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 247 | H → T in CAB17082 (PubMed:10366411).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019311 | 10 | N → K in HH7; is able to bind GnRH but with a reduced affinity in vitro. 1 PublicationCorresponds to variant dbSNP:rs104893843EnsemblClinVar. | 1 | |
Natural variantiVAR_072970 | 18 | N → S in HH7. 1 PublicationCorresponds to variant dbSNP:rs774317793Ensembl. | 1 | |
Natural variantiVAR_072971 | 37 | I → S in HH7. 1 PublicationCorresponds to variant dbSNP:rs886907903Ensembl. | 1 | |
Natural variantiVAR_069960 | 83 | L → V in HH7; the patient also carries a mutation in FGFR1. 1 PublicationCorresponds to variant dbSNP:rs1391808526Ensembl. | 1 | |
Natural variantiVAR_072972 | 90 | E → D in HH7. 1 Publication | 1 | |
Natural variantiVAR_019312 | 90 | E → K in HH7; virtual abolition of GnRH agonist binding and agonist-stimulated phosphoinositide turnover; impairs GnRHR-effector coupling. 2 PublicationsCorresponds to variant dbSNP:rs104893844EnsemblClinVar. | 1 | |
Natural variantiVAR_019313 | 106 | Q → R in HH7; some patients also carry mutations in FGFR1; decreases but does not eliminate GnRH binding. 6 PublicationsCorresponds to variant dbSNP:rs104893836EnsemblClinVar. | 1 | |
Natural variantiVAR_019314 | 129 | A → D in HH7; complete loss of function. 2 PublicationsCorresponds to variant dbSNP:rs104893838EnsemblClinVar. | 1 | |
Natural variantiVAR_019315 | 139 | R → H in HH7; completely eliminates detectable GnRH-binding activity and prevents GnRH-induced stimulation of inositol phosphate accumulation in vitro. 2 PublicationsCorresponds to variant dbSNP:rs104893842EnsemblClinVar. | 1 | |
Natural variantiVAR_072973 | 146 | P → S in HH7. 1 PublicationCorresponds to variant dbSNP:rs144900788EnsemblClinVar. | 1 | |
Natural variantiVAR_019316 | 168 | S → R in HH7; complete loss of the receptor-mediated signaling response. 1 PublicationCorresponds to variant dbSNP:rs104893840EnsemblClinVar. | 1 | |
Natural variantiVAR_019317 | 171 | A → T in HH7; complete loss of ligand binding and receptor activation; specific receptor binding of radioisotope-labeled GnRH ligand is undetectable in transfected cells. 1 PublicationCorresponds to variant dbSNP:rs74452732EnsemblClinVar. | 1 | |
Natural variantiVAR_019318 | 217 | S → R in HH7; altered hormone binding. 1 PublicationCorresponds to variant dbSNP:rs104893839EnsemblClinVar. | 1 | |
Natural variantiVAR_019319 | 262 | R → Q in HH7; unknown pathological significance; some patients also carry mutations in FGFR1; minimal effects upon receptor affinity but expression decreased; altered activation of phospholipase C. 6 PublicationsCorresponds to variant dbSNP:rs104893837EnsemblClinVar. | 1 | |
Natural variantiVAR_072974 | 266 | L → R in HH7; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs148499544Ensembl. | 1 | |
Natural variantiVAR_019320 | 284 | Y → C in HH7; minimal effects upon receptor affinity but receptor expression decreased. 1 PublicationCorresponds to variant dbSNP:rs28933074EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001914 | 176 – 328 | YIFRM…GYFSL → PLHHPSFHHADLQCKNHLHP DTGPSSGPPRTTTESVQEQY TKSTAEDSKNDGCICHFIYC LLDSLLCPRNLVLV in isoform 2. 1 PublicationAdd BLAST | 153 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03380 mRNA Translation: AAA35918.1 L07949 mRNA Translation: AAA35917.1 S60587 mRNA Translation: AAB26287.1 S77472 mRNA Translation: AAB33884.1 AF001952, AF001950, AF001951 Genomic DNA Translation: AAB71348.1 Z81148 mRNA Translation: CAB03541.1 AY392011 mRNA Translation: AAR92228.1 BC113546 mRNA Translation: AAI13547.1 Z99995 Genomic DNA Translation: CAB17082.1 |
CCDSi | CCDS3517.1 [P30968-1] CCDS47064.1 [P30968-2] |
PIRi | JC1353 |
RefSeqi | NP_000397.1, NM_000406.2 [P30968-1] NP_001012781.1, NM_001012763.1 [P30968-2] |
Genome annotation databases
Ensembli | ENST00000226413; ENSP00000226413; ENSG00000109163 [P30968-1] ENST00000420975; ENSP00000397561; ENSG00000109163 [P30968-2] |
GeneIDi | 2798 |
KEGGi | hsa:2798 |
UCSCi | uc003hdm.4, human [P30968-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L03380 mRNA Translation: AAA35918.1 L07949 mRNA Translation: AAA35917.1 S60587 mRNA Translation: AAB26287.1 S77472 mRNA Translation: AAB33884.1 AF001952, AF001950, AF001951 Genomic DNA Translation: AAB71348.1 Z81148 mRNA Translation: CAB03541.1 AY392011 mRNA Translation: AAR92228.1 BC113546 mRNA Translation: AAI13547.1 Z99995 Genomic DNA Translation: CAB17082.1 |
CCDSi | CCDS3517.1 [P30968-1] CCDS47064.1 [P30968-2] |
PIRi | JC1353 |
RefSeqi | NP_000397.1, NM_000406.2 [P30968-1] NP_001012781.1, NM_001012763.1 [P30968-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109060, 4 interactors |
IntActi | P30968, 4 interactors |
MINTi | P30968 |
STRINGi | 9606.ENSP00000226413 |
Chemistry databases
BindingDBi | P30968 |
ChEMBLi | CHEMBL1855 |
DrugBanki | DB00106, Abarelix DB06719, Buserelin DB00050, Cetrorelix DB01406, Danazol DB06699, Degarelix DB11979, Elagolix DB06785, Ganirelix DB11619, Gestrinone DB00644, Gonadorelin DB00014, Goserelin DB06788, Histrelin DB00007, Leuprolide DB00666, Nafarelin DB06494, Sufugolix DB05624, Teverelix DB06825, Triptorelin |
DrugCentrali | P30968 |
GuidetoPHARMACOLOGYi | 256 |
Protein family/group databases
TCDBi | 9.A.14.10.1, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P30968, 2 sites |
PhosphoSitePlusi | P30968 |
Polymorphism and mutation databases
BioMutai | GNRHR |
DMDMi | 399777 |
Proteomic databases
EPDi | P30968 |
PaxDbi | P30968 |
PeptideAtlasi | P30968 |
PRIDEi | P30968 |
ProteomicsDBi | 54750 [P30968-1] 54751 [P30968-2] |
Protocols and materials databases
ABCDi | P30968, 2 sequenced antibodies |
Antibodypediai | 12675, 417 antibodies |
DNASUi | 2798 |
Genome annotation databases
Ensembli | ENST00000226413; ENSP00000226413; ENSG00000109163 [P30968-1] ENST00000420975; ENSP00000397561; ENSG00000109163 [P30968-2] |
GeneIDi | 2798 |
KEGGi | hsa:2798 |
UCSCi | uc003hdm.4, human [P30968-1] |
Organism-specific databases
CTDi | 2798 |
DisGeNETi | 2798 |
EuPathDBi | HostDB:ENSG00000109163.6 |
GeneCardsi | GNRHR |
GeneReviewsi | GNRHR |
HGNCi | HGNC:4421, GNRHR |
HPAi | ENSG00000109163, Tissue enriched (pituitary) |
MalaCardsi | GNRHR |
MIMi | 138850, gene 146110, phenotype |
neXtProti | NX_P30968 |
OpenTargetsi | ENSG00000109163 |
Orphaneti | 432, Normosmic congenital hypogonadotropic hypogonadism |
PharmGKBi | PA28800 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222270 |
HOGENOMi | CLU_009579_15_2_1 |
InParanoidi | P30968 |
OMAi | SEPVNHF |
OrthoDBi | 858238at2759 |
PhylomeDBi | P30968 |
TreeFami | TF106499 |
Enzyme and pathway databases
PathwayCommonsi | P30968 |
Reactomei | R-HSA-375281, Hormone ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P30968 |
Miscellaneous databases
BioGRID-ORCSi | 2798, 0 hits in 839 CRISPR screens |
GeneWikii | GNRHR |
GenomeRNAii | 2798 |
Pharosi | P30968, Tclin |
PROi | PR:P30968 |
RNActi | P30968, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109163, Expressed in adrenal tissue and 96 other tissues |
Genevisiblei | P30968, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001658, GphnRH_fam_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00529, GNADOTRPHINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNRHR_HUMAN | |
Accessioni | P30968Primary (citable) accession number: P30968 Secondary accession number(s): O75793, Q14D13, Q92644 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 194 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries