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UniProtKB - P30957 (RYR2_RABIT)

Entry version 155 (25 May 2022)
Sequence version 3 (05 Oct 2010)
Previous versions | rss
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Protein

Ryanodine receptor 2

Gene

RYR2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity).

The calcium channel activity is modulated by formation of heterotetramers with RYR3.

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Channel activity is modulated by the alkaloid ryanodine that binds to the open Ca-release channel with high affinity and maintains the channel in an open conformation. Channel activity is regulated by calmodulin (CALM). The calcium release channel is activated by calcium ions and ATP. Channel activity is inhibited by magnesium ions (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Developmental protein, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ryanodine receptor 2
Short name:
RYR-2
Short name:
RyR2
Alternative name(s):
Cardiac muscle ryanodine receptor
Cardiac muscle ryanodine receptor-calcium release channel
Cardiac muscle-type ryanodine receptor
Type 2 ryanodine receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RYR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOryctolagus cuniculus (Rabbit)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9986 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001811 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4282CytoplasmicSequence analysisAdd BLAST4282
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4283 – 4303HelicalSequence analysisAdd BLAST21
Transmembranei4505 – 4525HelicalSequence analysisAdd BLAST21
Transmembranei4582 – 4602HelicalSequence analysisAdd BLAST21
Transmembranei4732 – 4752HelicalSequence analysisAdd BLAST21
Transmembranei4771 – 4791HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei4822 – 4831Pore-formingBy similarity10
Transmembranei4852 – 4872HelicalSequence analysisAdd BLAST21
Topological domaini4873 – 4969CytoplasmicSequence analysisAdd BLAST97

Keywords - Cellular componenti

Membrane, Sarcoplasmic reticulum

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193621 – 4969Ryanodine receptor 2Add BLAST4969

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1341PhosphoserineBy similarity1
Modified residuei1869PhosphoserineBy similarity1
Modified residuei2031Phosphoserine; by PKABy similarity1
Modified residuei2370PhosphoserineBy similarity1
Modified residuei2698PhosphoserineBy similarity1
Modified residuei2798PhosphoserineBy similarity1
Modified residuei2809Phosphoserine; by CaMK2D and PKA1 Publication1
Modified residuei2812PhosphoserineBy similarity1
Modified residuei2815Phosphoserine; by CaMK2DBy similarity1
Modified residuei2948PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2809 and Ser-2815 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca2+ levels.1 Publication
Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.By similarity

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30957

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart and brain.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. Can also form heterotetramers with RYR1 and RYR3.

Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca2+ leaks.

Interacts with CALM and S100A1; these interactions regulate channel activity.

Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1.

Interacts directly with FKBP1B, PKA, PP1 and PP2A (By similarity).

Interacts with SELENON (PubMed:18713863). In cardiac muscles, identified in a complex, composed of FSD2, CMYA5 and RYR2 (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P30957, 1 interactor

Molecular INTeraction database

More...MINTi		P30957

STRING: functional protein association networks

More...STRINGi		9986.ENSOCUP00000016860

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P30957

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30957

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 165MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini172 – 217MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini225 – 280MIR 3PROSITE-ProRule annotationAdd BLAST56
Domaini286 – 345MIR 4PROSITE-ProRule annotationAdd BLAST60
Domaini351 – 408MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini599 – 809B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST211
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati853 – 9661Add BLAST114
Repeati967 – 10802Add BLAST114
Domaini1025 – 1222B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST198
Domaini1357 – 1562B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST206
Repeati2693 – 28113Add BLAST119
Repeati2813 – 29264Add BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni853 – 29264 X approximate repeatsAdd BLAST2074
Regioni1855 – 1886DisorderedSequence analysisAdd BLAST32
Regioni2355 – 2380DisorderedSequence analysisAdd BLAST26
Regioni3582 – 3611Interaction with CALMBy similarityAdd BLAST30
Regioni4211 – 4231DisorderedSequence analysisAdd BLAST21
Regioni4337 – 4362DisorderedSequence analysisAdd BLAST26
Regioni4419 – 4470DisorderedSequence analysisAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4413 – 4446Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1868 – 1886Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi4213 – 4231Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi4341 – 4362Basic and acidic residuesSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR2 subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2243, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30957

Family and domain databases

Conserved Domains Database

More...CDDi		cd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00795, RYANODINER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30957-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGGEGEDE IQFLRTDDEV VLQCTATIHK EQQKLCLAAE GFGNRLCFLE 
        60         70         80         90        100
STSNSKNVPP DLSICTFVLE QSLLVRALQE MLANTVEKSE GQVDVEKWKF 
       110        120        130        140        150
MMKTAQGGGH RTLLYGHAIL LRHSYSGMYL CCLSTSRSST DKLAFDVGLQ 
       160        170        180        190        200
EDTTGEACWW TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHLSYGNGS 
       210        220        230        240        250
LHVDAAFQQT LWSVAPISSG SEAAQGYLIG GDVLRLLHGH MDECLTVPSG 
       260        270        280        290        300
EHGEEQRRTV HYEGGAVSVH ARSLWRLETL RVAWSGSHIR WGQPFRLRHV 
       310        320        330        340        350
TTGKYLSLME DKNLLLMDKE KADVKSTAFT FRSSKEKLDG GVRKEVDGMG 
       360        370        380        390        400
TSEIKYGDSI CYIQHVDTGL WLTYQSVDVK SVRMGSIQRK AIMHHEGHMD 
       410        420        430        440        450
DGLNLSRSQH EESRTARVIR STVFLFNRFI RGLDALSKKA KASSVDLPIE 
       460        470        480        490        500
SVSLSLQDLI GYFHPPDEHL EHEDKQNRLR ALKNRQNLFQ EEGMINLVLE 
       510        520        530        540        550
CIDRLHVYSS AAHFADVAGR EAGESWKSIL NSLYELLAAL IRGNRKNCAQ 
       560        570        580        590        600
FSGSLDWLIS RLERLEASSG ILEVLHCVLV ESPEALNIIK EGHIKSIISL 
       610        620        630        640        650
LDKHGRNHKV LDVLCSLCVC HGVAVRSNQH LICDNLLPGR DLLLQTRLVN 
       660        670        680        690        700
HVSSMRPNIF LGVSEGSAQY KKWYYELMVD HTEPFVTAEA THLRVGWAST 
       710        720        730        740        750
EGYSPYPGGG EEWGGNGVGD DLFSYGFDGL HLWSGCIART VSSPNQHLLR 
       760        770        780        790        800
TDDVISCCLD LSAPSISFRI NGQPVQGMFE NFNIDGLFFP VVSFSAGIKV 
       810        820        830        840        850
RFLLGGRHGE FKFLPPPGYA PCYEAVLPKE KLKVEHSREY KQERTYTRDL 
       860        870        880        890        900
LGPTVSLTQA AFTPIPVDTS QIVLPPHLER IREKLAENIH ELWVMNKIEL 
       910        920        930        940        950
GWQYGPVRDD NKRQHPCLVE FSKLPEQERN YNLQMSLETL KTLLALGCHV 
       960        970        980        990       1000
GISDEHAEEK VKKMKLPKNY QLTSGYKPAP MDLSFIKLTP SQEAMVDKLA 
      1010       1020       1030       1040       1050
ENAHNVWARD RIRQGWTYGI QQDVKNRRNP RLVPYTLLDD RTKKSNKDSL 
      1060       1070       1080       1090       1100
REAVRTLLGY GYNLEAPDQD HAARAEVCSG TGERFRIFRA EKTYAVKAGR 
      1110       1120       1130       1140       1150
WYFEFEAVTS GDMRVGWSRP GCQPDQELGS DERAFAFDGF KAQRWHQGNE 
      1160       1170       1180       1190       1200
HYGRSWQAGD VVGCMVDMNE HTMMFTLNGE ILLDDSGSEL AFKDFDVGDG 
      1210       1220       1230       1240       1250
FIPVCSLGVA QVGRMNFGKD VSTLKYFTIC GLQEGYEPFA VNTNRDITMW 
      1260       1270       1280       1290       1300
LSKRLPQFLQ VPSNHEHIEV TRIDGTIDSS PCLKVTQKSF GSQNSNTDIM 
      1310       1320       1330       1340       1350
FYRLSMPIEC AEVFSKTVPG GLPGAGLFGP KNDLEDYDAD SDFEVLMKTA 
      1360       1370       1380       1390       1400
HGHLVPDRVD KDKETTKAEF NNHKDYAQEK PSRLKQRFLL RRTKPDYSTS 
      1410       1420       1430       1440       1450
HSARLTEDVL ADDRDDYDFL MQTSTYYYSV RIFPGQEPAN VWVGWITSDF 
      1460       1470       1480       1490       1500
HQYDTGFDLD RVRTVTVTLG DEKGKVHESI KRSNCYMVCA GESMSPGQGR 
      1510       1520       1530       1540       1550
NNNGLEIGCV VDAASGLLTF IANGKELSTY YQVEPSTKLF PAVFAQATSP 
      1560       1570       1580       1590       1600
NVFQFELGRI KNVMPLSAGL FKSEHKNPVP QCPPRLHVQF LSHVLWSRMP 
      1610       1620       1630       1640       1650
NQFLKVDVSR ISERQGWLVQ CLDPLQFMSL HIPEENRSVD ILELTEQEEL 
      1660       1670       1680       1690       1700
LKFHYHTLRL YSAVCALGNH RVAHALCSHV DEPQLLYAIE NKYMPGLLRT 
      1710       1720       1730       1740       1750
GYYDLLIDIH LSSYATARLM MNNEFIVPMT EETKSITLFP DENKKHGLPG 
      1760       1770       1780       1790       1800
IGLSTSLRPR MQFSSPSFVS INNECYQYSP EFPLDILKAK TIQMLTEAVK 
      1810       1820       1830       1840       1850
EGSLHGRDPV GGTTEFLFVP LIKLFYTLLI MGIFHNEDLR HILQLIEPSV 
      1860       1870       1880       1890       1900
FKDAATPEEE GDTLEEEPSV EDTKLEGAGE EEAKVGKRPK EGLLQMKLPE 
      1910       1920       1930       1940       1950
PVKLQMCLLL QYLCDCQVRH RIEAIVAFSD DFVAKLQDNQ RFRYNEVMQA 
      1960       1970       1980       1990       2000
LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKSECPCPE EIRDQLLDFH 
      2010       2020       2030       2040       2050
EDLMTHCGIE LDEDGSLDGN SDLTIRGRLL SLVEKVTYLK KKQTEKPVES 
      2060       2070       2080       2090       2100
DSRKSSTLQQ LISETMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR 
      2110       2120       2130       2140       2150
ALPKTYTING VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM 
      2160       2170       2180       2190       2200
NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEITFP KMVANCCRFL 
      2210       2220       2230       2240       2250
CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPAMRGSTPL DVAAASVMDN 
      2260       2270       2280       2290       2300
NELALALREP DLEKVVVRYL AGCGLQSCQM LVSKGYPDIG WNPVEGERYL 
      2310       2320       2330       2340       2350
DFLRFAVFCN GESVEENANV VVRLLIRRPE CFGPALRGEG GNGLLAAMEE 
      2360       2370       2380       2390       2400
AIKIAEDPSR DGPSPTSGSS KTLDTEEEED DTIHMGNAIM TFYAALIDLL 
      2410       2420       2430       2440       2450
GRCAPEMHLI HAGKGEAIRI RSILRSLIPL GDLVGVISIA FQMPTIAKDG 
      2460       2470       2480       2490       2500
NVVEPDMSAG FCPDHKAAMV LFLDRVYGIE VQDFLLHLLE VGFLPDLRAA 
      2510       2520       2530       2540       2550
ASLDTAALSA TDMALALNRY LCTAVLPLLT RCAPLFAGTE HHASLIDSLL 
      2560       2570       2580       2590       2600
HTVYRLSKGC SLTKAQRDSI EVCLLSICGQ LRPSMMQHLL RRLVFDVPLL 
      2610       2620       2630       2640       2650
NEHAKMPLKL LTNHYERCWK YYCLPGGWGN FGAASEEELH LSRKLFWGIF 
      2660       2670       2680       2690       2700
DALSQKKYEQ ELFKLALPCL SAVAGALPPD YMESNYVSMM EKQSSMDSEG 
      2710       2720       2730       2740       2750
NFNPQPVDTS NIIIPEKLEY FINKYAEHSH DKWSMDKLAN GWIYGEIYSD 
      2760       2770       2780       2790       2800
SSKIQPLMKP YKLLSEKEKE IYRWPIKESL KTMLAWGWRI ERTREGDSMA 
      2810       2820       2830       2840       2850
LYNRTRRISQ TSQVSVDAAH GYSPRAIDMS NVTLSRDLHA MAEMMAENYH 
      2860       2870       2880       2890       2900
NIWAKKKKLE LESKGGGNHP LLVPYDTLTA KEKAKDREKA QDILKFLQIN 
      2910       2920       2930       2940       2950
GYAVSRGFKD LELDTPSIEK RFAYSFLQQL IRYVDEAHQY ILEFDGGSRS 
      2960       2970       2980       2990       3000
KGEHFPYEQE IKFFAKVVLP LIDQYFKNHR LYFLSAASRP LCSGGHASNK 
      3010       3020       3030       3040       3050
EKEMVTSLFC KLGVLVRHRI SLFGNDATSI VNCLHILGQT LDARTVMKTG 
      3060       3070       3080       3090       3100
LESVKSALRA FLDNAAEDLE KTMENLKQGQ FTHTRNQPRG VTQIINYTTV 
      3110       3120       3130       3140       3150
ALLPMLSSLF EHIGQHQFGE DLILEDVQVS CYRILTSLYA LGTSKSIYVE 
      3160       3170       3180       3190       3200
RQRSALGECL AAFAGAFPVA FLETHLNKHN IYSIYNTKSS RERAALSLPA 
      3210       3220       3230       3240       3250
NVEDVCPNIP SLEKLMEEIV ELAESGIRYT QMPHVMEVIL PMLCSYMSRW 
      3260       3270       3280       3290       3300
WEHGPESNPG RAEMCCTALN SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL 
      3310       3320       3330       3340       3350
AVFSQPIINK VKPQLLKTHF LPLMEKLKKK AAMVVSEEDH LKAEARGDMS 
      3360       3370       3380       3390       3400
EAELLILDEF TTLARDLYAF YPLLIRFVDY NRAKWLKEPT PEAEELFRMV 
      3410       3420       3430       3440       3450
AEVFIYWSKS HNFKREEQNF VVQNEINNMS FLITDTKSKM SKAAVSDQER 
      3460       3470       3480       3490       3500
KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN ICAPGDQELI ALAKNRFSLK 
      3510       3520       3530       3540       3550
ATEDEVRDII RNNIHLQGKL EDPAIRWQMA LYKDLPNRTE ETSDPEKTVE 
      3560       3570       3580       3590       3600
RVLDIANVLF HLEQKSKFIG RRYYNLVEHP QRSKKAVWHK LLSKQRKRAV 
      3610       3620       3630       3640       3650
VACFRMAPLY NLPRHRAVNL FLQGYEKSWI ETEEHYFEDK LIEDLAKPGA 
      3660       3670       3680       3690       3700
EPPEEDEVTK RVDPLHQLIL LFSRTALTEK CKLEEDFLYM AYADIMAKSC 
      3710       3720       3730       3740       3750
HDEEDDDGEE EVKSFEEKEM EKQKLLYQQA RLHDRGAAEM VLQTISASKG 
      3760       3770       3780       3790       3800
ETGPMVAATL KLGIAILNGG NSTVQQKMLD YLKEKKDVGF FQSLAGLMQS 
      3810       3820       3830       3840       3850
CSVLDLNAFE RQNKAEGLGM VTEEGSGEKV LQDDEFTCDL FRFLQLLCEG 
      3860       3870       3880       3890       3900
HNSDFQNYLR TQTGNNTTVN IIISTVDYLL RVQESISDFY WYYSGKDVID 
      3910       3920       3930       3940       3950
EQGQRNFSKA IQVAKQVFNT LTEYIQGPCT GNQQSLAHSR LWDAVVGFLH 
      3960       3970       3980       3990       4000
VFAHMQMKLS QDSSQIELLK ELMDLQKDMV VMLLSMLEGN VVNGTIGKQM 
      4010       4020       4030       4040       4050
VDMLVESSNN VEMILKFFDM FLKLKDLTSS DTFKEYDPDG KGIISKRDFH 
      4060       4070       4080       4090       4100
KAMESHKHYT QSETEFLLSC AETDENETLD YEEFVKRFHE PAKDIGFNVA 
      4110       4120       4130       4140       4150
VLLTNLSEHM PNDTRLQTFL ELAESVLNYF QPFLGRIEIM GSAKRIERVY 
      4160       4170       4180       4190       4200
FEISESSRTQ WEKPQVKESK RQFIFDVVNE GGEKEKMELF VNFCEDTIFE 
      4210       4220       4230       4240       4250
MQLAAQISES DLNERSANKE ESEKERPEEQ GPKMGFFSVL TVRSALFALR 
      4260       4270       4280       4290       4300
YNILTLMRML SLKSLKKQMK KMKKMTVKDM VTAFFSSYWS IFMTLLHFVA 
      4310       4320       4330       4340       4350
SVFRGFFRIV CSLLLGGSLV EGAKKIKVAE LLANMPDPTQ DEVRGDGEEG 
      4360       4370       4380       4390       4400
ERKPMETTLP SEDLTDLKEL TEESDLLSDI FGLDLKREGG QYKLIPHNPN 
      4410       4420       4430       4440       4450
AGLSDLMSNP VLIPEEQEKF QEQKTKEEEK EEKEETKSEP EKAEGEDGEK 
      4460       4470       4480       4490       4500
EEKVKEDKGK QKLRQLHTHR YGEPEVPESA FWKKIIAYQQ KLLNYLARNF 
      4510       4520       4530       4540       4550
YNMRMLALFV AFAINFILLF YKVSTSSVVE GKELPSRSTS ENAKVTTSLD 
      4560       4570       4580       4590       4600
SSSHRIIAVH YVLEESSGYM EPTLRILAIL HTVISFFCII GYYCLKVPLV 
      4610       4620       4630       4640       4650
IFKREKEVAR KLEFDGLYIT EQPSEDDIKG QWDRLVINTQ SFPNNYWDKF 
      4660       4670       4680       4690       4700
VKRKVMDKYG EFYGRDRISE LLGMDKAALD FSDAREKKKP KKDSSLSAVL 
      4710       4720       4730       4740       4750
NSIDVKYQMW KLGVVFTDNS FLYLAWYMTM SILGHYNNFF FAAHLLDIAM 
      4760       4770       4780       4790       4800
GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED 
      4810       4820       4830       4840       4850
GDTPDMKCDD MLTCYMFHMY VGVRAGGGIG DEIEDPAGDE YEIYRIIFDI 
      4860       4870       4880       4890       4900
TFFFFVIVIL LAIIQGLIID AFGELRDQQE QVKEDMETKC FICGIGNDYF 
      4910       4920       4930       4940       4950
DTVPHGFETH TLQEHNLANY LFFLMYLINK DETEHTGQES YVWKMYQERC 
      4960 
WEFFPAGDCF RKQYEDQLN
Length:4,969
Mass (Da):565,073
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF6E0684B974BB4D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M59743 mRNA Translation: AAA31179.1

Protein sequence database of the Protein Information Resource

More...PIRi		A37113

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59743 mRNA Translation: AAA31179.1
PIRiA37113

3D structure databases

BMRBiP30957
SMRiP30957
ModBaseiSearch...

Protein-protein interaction databases

IntActiP30957, 1 interactor
MINTiP30957
STRINGi9986.ENSOCUP00000016860

PTM databases

iPTMnetiP30957

Phylogenomic databases

eggNOGiKOG2243, Eukaryota
InParanoidiP30957

Family and domain databases

CDDicd12877, SPRY1_RyR, 1 hit
cd12878, SPRY2_RyR, 1 hit
cd12879, SPRY3_RyR, 1 hit
Gene3Di2.60.120.920, 3 hits
InterProiView protein in InterPro
IPR001870, B30.2/SPRY
IPR043136, B30.2/SPRY_sf
IPR013320, ConA-like_dom_sf
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR014821, Ins145_P3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR013333, Ryan_recept
IPR003032, Ryanodine_rcpt
IPR009460, Ryanrecept_TM4-6
IPR035910, RyR/IP3R_RIH_dom_sf
IPR035761, SPRY1_RyR
IPR035764, SPRY2_RyR
IPR035762, SPRY3_RyR
IPR003877, SPRY_dom
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF06459, RR_TM4-6, 1 hit
PF01365, RYDR_ITPR, 2 hits
PF02026, RyR, 4 hits
PF00622, SPRY, 3 hits
PRINTSiPR00795, RYANODINER
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SM00449, SPRY, 3 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF47473, SSF47473, 1 hit
SSF49899, SSF49899, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50188, B302_SPRY, 3 hits
PS50919, MIR, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRYR2_RABIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30957
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 5, 2010
Last modified: May 25, 2022
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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