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Entry version 167 (07 Oct 2020)
Sequence version 1 (01 Jul 1993)
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Protein

Malate synthase 1

Gene

MLS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Malate synthase which takes part in the glyoxylate cycle (PubMed:1454530). MLS1 activity is essential for cells to grow on oleic acid as a sole carbon source (PubMed:11846793). Two steps of the glyoxylate cycle take place in the cytosol, the splitting of isocitrate into succinate and glyoxylate, and the dehydrogenation of malate to oxaloacetate (PubMed:1454530). However, the formation of malate from glyoxylate and acetyl-CoA undertaken MLS1, occurs in the peroxisomes when cells are grown on oleic acid (Probable). The source of acetyl-CoA being either peroxisomal when breaking down fatty acids, or cytosolic when extra-cellular two-carbon substrates are used, therefore, although not strictly essential, the peroxisomal localization of MLS1 appears to be advantageous for cells growing on oleic acid, in that acetyl-CoA production and utilization are thereby intimately compartmentalized together to increase efficiency (Probable).1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glyoxylate cycle

This protein is involved in step 2 of the subpathway that synthesizes (S)-malate from isocitrate.By similarity
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Isocitrate lyase (ICL1)
  2. Malate synthase 1 (MLS1)
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei177Proton acceptorBy similarity1
Active sitei457Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • malate synthase activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:YNL117W-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00703;UER00720

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Malate synthase 11 Publication (EC:2.3.3.9By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLS11 Publication
Ordered Locus Names:YNL117W
ORF Names:N1921
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XIV

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YNL117W

Saccharomyces Genome Database

More...
SGDi
S000005061, MLS1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Strongly decreases the growth rate on ethanol or acetate medium.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi552 – 554Missing : Impairs the peroxisomal localitation and leads to both nuclear and cytosolic localization. 1 Publication3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001668641 – 554Malate synthase 1Add BLAST554

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P30952

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P30952

PRoteomics IDEntifications database

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PRIDEi
P30952

Consortium for Top Down Proteomics

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TopDownProteomicsi
P30952

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is sensitive to carbon catabolite repression, but nearly insensitive to nitrogen catabolite repression.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PEX9.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
35709, 40 interactors

Protein interaction database and analysis system

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IntActi
P30952, 9 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YNL117W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P30952, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30952

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi552 – 554SKL peroxisome targeting motif1 Publication3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the malate synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1261, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000174673

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_018928_3_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30952

KEGG Orthology (KO)

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KOi
K01638

Identification of Orthologs from Complete Genome Data

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OMAi
GWHMVDN

Family and domain databases

Conserved Domains Database

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CDDi
cd00727, malate_synt_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011076, Malate_synth-like_sf
IPR006252, Malate_synthA
IPR001465, Malate_synthase
IPR019830, Malate_synthase_CS

The PANTHER Classification System

More...
PANTHERi
PTHR42902, PTHR42902, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01274, Malate_synthase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001363, Malate_synth, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51645, SSF51645, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01344, malate_syn_A, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00510, MALATE_SYNTHASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30952-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKVSLDNVK LLVDVDKEPF FKPSSTTVGD ILTKDALEFI VLLHRTFNNK
60 70 80 90 100
RKQLLENRQV VQKKLDSGSY HLDFLPETAN IRNDPTWQGP ILAPGLINRS
110 120 130 140 150
TEITGPPLRN MLINALNAPV NTYMTDFEDS ASPTWNNMVY GQVNLYDAIR
160 170 180 190 200
NQIDFDTPRK SYKLNGNVAN LPTIIVRPRG WHMVEKHLYV DDEPISASIF
210 220 230 240 250
DFGLYFYHNA KELIKLGKGP YFYLPKMEHH LEAKLWNDVF CVAQDYIGIP
260 270 280 290 300
RGTIRATVLI ETLPAAFQME EIIYQLRQHS SGLNCGRWDY IFSTIKRLRN
310 320 330 340 350
DPNHILPNRN QVTMTSPFMD AYVKRLINTC HRRGVHAMGG MAAQIPIKDD
360 370 380 390 400
PAANEKAMTK VRNDKIRELT NGHDGSWVAH PALAPICNEV FINMGTPNQI
410 420 430 440 450
YFIPENVVTA ANLLETKIPN GEITTEGIVQ NLDIGLQYME AWLRGSGCVP
460 470 480 490 500
INNLMEDAAT AEVSRCQLYQ WVKHGVTLKD TGEKVTPELT EKILKEQVER
510 520 530 540 550
LSKASPLGDK NKFALAAKYF LPEIRGEKFS EFLTTLLYDE IVSTKATPTD

LSKL
Length:554
Mass (Da):62,791
Last modified:July 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98E698E86E59C480
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti118A → T in strain: Awamori-1, AKU-4011, K1, K5, NRIC 23, NRIC 1413 and NRIC 1685. 1 Publication1
Natural varianti199I → V in strain: Pasteur Red. 1 Publication1
Natural varianti217G → C in strain: YJM326. 1 Publication1
Natural varianti253T → S in strain: Levuline ALS, Lalvin CY-3079, Cote des Blancs, I14, M1, M11, M12, M13, M15, M2, M20, M21, M22, M24, M29, M3, M30, M31, M32, M33, M34, M4, M5, M6, M7, M8, M9, NRRL Y-1438, NRRL YB-1952, NRRL Y-2411, Pasteur Red, UCD 51, UCD 2120, UCD 175, UCD 529, UCD 765, UCD 781, UCD 820, UCD 762, YJM269, YJM270, YJM308, YJM326, YJM434 and YJM1129. 2 Publications1
Natural varianti310N → D in strain: SK1, V1-09, YJM269, YJM270, YJM280, YJM320, YJM326, YJM339, YJM627 and YJM1129. 1 Publication1
Natural varianti541I → V in strain: YJM269 and YJM270. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X64407 Genomic DNA Translation: CAA45750.1
EF125216 Genomic DNA Translation: ABN58540.1
EF125217 Genomic DNA Translation: ABN58549.1
EF125218 Genomic DNA Translation: ABN58558.1
EF125219 Genomic DNA Translation: ABN58567.1
EF125220 Genomic DNA Translation: ABN58575.1
EF125221 Genomic DNA Translation: ABN58585.1
EF125222 Genomic DNA Translation: ABN58594.1
EF125223 Genomic DNA Translation: ABN58603.1
EF125224 Genomic DNA Translation: ABN58612.1
EF125225 Genomic DNA Translation: ABN58621.1
EF125226 Genomic DNA Translation: ABN58630.1
EF125228 Genomic DNA Translation: ABN58648.1
Z69382 Genomic DNA Translation: CAA93390.1
Z71393 Genomic DNA Translation: CAA95997.1
AY942279 Genomic DNA Translation: AAY22671.1
AY942280 Genomic DNA Translation: AAY22672.1
AY942281 Genomic DNA Translation: AAY22673.1
AY942282 Genomic DNA Translation: AAY22674.1
AY942283 Genomic DNA Translation: AAY22675.1
AY942284 Genomic DNA Translation: AAY22676.1
AY942285 Genomic DNA Translation: AAY22677.1
AY942286 Genomic DNA Translation: AAY22678.1
AY942287 Genomic DNA Translation: AAY22679.1
AY942288 Genomic DNA Translation: AAY22680.1
AY942289 Genomic DNA Translation: AAY22681.1
AY942290 Genomic DNA Translation: AAY22682.1
AY942291 Genomic DNA Translation: AAY22683.1
AY942292 Genomic DNA Translation: AAY22684.1
AY942293 Genomic DNA Translation: AAY22685.1
AY942294 Genomic DNA Translation: AAY22686.1
AY942295 Genomic DNA Translation: AAY22687.1
AY942296 Genomic DNA Translation: AAY22688.1
AY942297 Genomic DNA Translation: AAY22689.1
AY942298 Genomic DNA Translation: AAY22690.1
AY942299 Genomic DNA Translation: AAY22691.1
AY942300 Genomic DNA Translation: AAY22692.1
AY942301 Genomic DNA Translation: AAY22693.1
AY942302 Genomic DNA Translation: AAY22694.1
AY942303 Genomic DNA Translation: AAY22695.1
AY942304 Genomic DNA Translation: AAY22696.1
AY942305 Genomic DNA Translation: AAY22697.1
AY942306 Genomic DNA Translation: AAY22698.1
AY942307 Genomic DNA Translation: AAY22699.1
AY942308 Genomic DNA Translation: AAY22700.1
AY942309 Genomic DNA Translation: AAY22701.1
AY942310 Genomic DNA Translation: AAY22702.1
AY942311 Genomic DNA Translation: AAY22703.1
AY942312 Genomic DNA Translation: AAY22704.1
AY942313 Genomic DNA Translation: AAY22705.1
AY942314 Genomic DNA Translation: AAY22706.1
AY942315 Genomic DNA Translation: AAY22707.1
AY942316 Genomic DNA Translation: AAY22708.1
AY942317 Genomic DNA Translation: AAY22709.1
AY942318 Genomic DNA Translation: AAY22710.1
AY942319 Genomic DNA Translation: AAY22711.1
AY942320 Genomic DNA Translation: AAY22712.1
AY942321 Genomic DNA Translation: AAY22713.1
AY942322 Genomic DNA Translation: AAY22714.1
AY942323 Genomic DNA Translation: AAY22715.1
AY942324 Genomic DNA Translation: AAY22716.1
AY942325 Genomic DNA Translation: AAY22717.1
AY942326 Genomic DNA Translation: AAY22718.1
AY942327 Genomic DNA Translation: AAY22719.1
AY942328 Genomic DNA Translation: AAY22720.1
AY942329 Genomic DNA Translation: AAY22721.1
AY942330 Genomic DNA Translation: AAY22722.1
AY942331 Genomic DNA Translation: AAY22723.1
AY942332 Genomic DNA Translation: AAY22724.1
AY942333 Genomic DNA Translation: AAY22725.1
AY942334 Genomic DNA Translation: AAY22726.1
AY942335 Genomic DNA Translation: AAY22727.1
AY942336 Genomic DNA Translation: AAY22728.1
AY942337 Genomic DNA Translation: AAY22729.1
AY942338 Genomic DNA Translation: AAY22730.1
AY942339 Genomic DNA Translation: AAY22731.1
AY942340 Genomic DNA Translation: AAY22732.1
AY942341 Genomic DNA Translation: AAY22733.1
AY942342 Genomic DNA Translation: AAY22734.1
AY942343 Genomic DNA Translation: AAY22735.1
AY942344 Genomic DNA Translation: AAY22736.1
AY942345 Genomic DNA Translation: AAY22737.1
AY942346 Genomic DNA Translation: AAY22738.1
AY942347 Genomic DNA Translation: AAY22739.1
AY942348 Genomic DNA Translation: AAY22740.1
AY942349 Genomic DNA Translation: AAY22741.1
AY942350 Genomic DNA Translation: AAY22742.1
AY942351 Genomic DNA Translation: AAY22743.1
AY942352 Genomic DNA Translation: AAY22744.1
AY942353 Genomic DNA Translation: AAY22745.1
AY942354 Genomic DNA Translation: AAY22746.1
AY942355 Genomic DNA Translation: AAY22747.1
BK006947 Genomic DNA Translation: DAA10431.1

Protein sequence database of the Protein Information Resource

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PIRi
S26645

NCBI Reference Sequences

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RefSeqi
NP_014282.1, NM_001182955.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YNL117W_mRNA; YNL117W; YNL117W

Database of genes from NCBI RefSeq genomes

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GeneIDi
855606

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
sce:YNL117W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64407 Genomic DNA Translation: CAA45750.1
EF125216 Genomic DNA Translation: ABN58540.1
EF125217 Genomic DNA Translation: ABN58549.1
EF125218 Genomic DNA Translation: ABN58558.1
EF125219 Genomic DNA Translation: ABN58567.1
EF125220 Genomic DNA Translation: ABN58575.1
EF125221 Genomic DNA Translation: ABN58585.1
EF125222 Genomic DNA Translation: ABN58594.1
EF125223 Genomic DNA Translation: ABN58603.1
EF125224 Genomic DNA Translation: ABN58612.1
EF125225 Genomic DNA Translation: ABN58621.1
EF125226 Genomic DNA Translation: ABN58630.1
EF125228 Genomic DNA Translation: ABN58648.1
Z69382 Genomic DNA Translation: CAA93390.1
Z71393 Genomic DNA Translation: CAA95997.1
AY942279 Genomic DNA Translation: AAY22671.1
AY942280 Genomic DNA Translation: AAY22672.1
AY942281 Genomic DNA Translation: AAY22673.1
AY942282 Genomic DNA Translation: AAY22674.1
AY942283 Genomic DNA Translation: AAY22675.1
AY942284 Genomic DNA Translation: AAY22676.1
AY942285 Genomic DNA Translation: AAY22677.1
AY942286 Genomic DNA Translation: AAY22678.1
AY942287 Genomic DNA Translation: AAY22679.1
AY942288 Genomic DNA Translation: AAY22680.1
AY942289 Genomic DNA Translation: AAY22681.1
AY942290 Genomic DNA Translation: AAY22682.1
AY942291 Genomic DNA Translation: AAY22683.1
AY942292 Genomic DNA Translation: AAY22684.1
AY942293 Genomic DNA Translation: AAY22685.1
AY942294 Genomic DNA Translation: AAY22686.1
AY942295 Genomic DNA Translation: AAY22687.1
AY942296 Genomic DNA Translation: AAY22688.1
AY942297 Genomic DNA Translation: AAY22689.1
AY942298 Genomic DNA Translation: AAY22690.1
AY942299 Genomic DNA Translation: AAY22691.1
AY942300 Genomic DNA Translation: AAY22692.1
AY942301 Genomic DNA Translation: AAY22693.1
AY942302 Genomic DNA Translation: AAY22694.1
AY942303 Genomic DNA Translation: AAY22695.1
AY942304 Genomic DNA Translation: AAY22696.1
AY942305 Genomic DNA Translation: AAY22697.1
AY942306 Genomic DNA Translation: AAY22698.1
AY942307 Genomic DNA Translation: AAY22699.1
AY942308 Genomic DNA Translation: AAY22700.1
AY942309 Genomic DNA Translation: AAY22701.1
AY942310 Genomic DNA Translation: AAY22702.1
AY942311 Genomic DNA Translation: AAY22703.1
AY942312 Genomic DNA Translation: AAY22704.1
AY942313 Genomic DNA Translation: AAY22705.1
AY942314 Genomic DNA Translation: AAY22706.1
AY942315 Genomic DNA Translation: AAY22707.1
AY942316 Genomic DNA Translation: AAY22708.1
AY942317 Genomic DNA Translation: AAY22709.1
AY942318 Genomic DNA Translation: AAY22710.1
AY942319 Genomic DNA Translation: AAY22711.1
AY942320 Genomic DNA Translation: AAY22712.1
AY942321 Genomic DNA Translation: AAY22713.1
AY942322 Genomic DNA Translation: AAY22714.1
AY942323 Genomic DNA Translation: AAY22715.1
AY942324 Genomic DNA Translation: AAY22716.1
AY942325 Genomic DNA Translation: AAY22717.1
AY942326 Genomic DNA Translation: AAY22718.1
AY942327 Genomic DNA Translation: AAY22719.1
AY942328 Genomic DNA Translation: AAY22720.1
AY942329 Genomic DNA Translation: AAY22721.1
AY942330 Genomic DNA Translation: AAY22722.1
AY942331 Genomic DNA Translation: AAY22723.1
AY942332 Genomic DNA Translation: AAY22724.1
AY942333 Genomic DNA Translation: AAY22725.1
AY942334 Genomic DNA Translation: AAY22726.1
AY942335 Genomic DNA Translation: AAY22727.1
AY942336 Genomic DNA Translation: AAY22728.1
AY942337 Genomic DNA Translation: AAY22729.1
AY942338 Genomic DNA Translation: AAY22730.1
AY942339 Genomic DNA Translation: AAY22731.1
AY942340 Genomic DNA Translation: AAY22732.1
AY942341 Genomic DNA Translation: AAY22733.1
AY942342 Genomic DNA Translation: AAY22734.1
AY942343 Genomic DNA Translation: AAY22735.1
AY942344 Genomic DNA Translation: AAY22736.1
AY942345 Genomic DNA Translation: AAY22737.1
AY942346 Genomic DNA Translation: AAY22738.1
AY942347 Genomic DNA Translation: AAY22739.1
AY942348 Genomic DNA Translation: AAY22740.1
AY942349 Genomic DNA Translation: AAY22741.1
AY942350 Genomic DNA Translation: AAY22742.1
AY942351 Genomic DNA Translation: AAY22743.1
AY942352 Genomic DNA Translation: AAY22744.1
AY942353 Genomic DNA Translation: AAY22745.1
AY942354 Genomic DNA Translation: AAY22746.1
AY942355 Genomic DNA Translation: AAY22747.1
BK006947 Genomic DNA Translation: DAA10431.1
PIRiS26645
RefSeqiNP_014282.1, NM_001182955.1

3D structure databases

SMRiP30952
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi35709, 40 interactors
IntActiP30952, 9 interactors
STRINGi4932.YNL117W

Proteomic databases

MaxQBiP30952
PaxDbiP30952
PRIDEiP30952
TopDownProteomicsiP30952

Genome annotation databases

EnsemblFungiiYNL117W_mRNA; YNL117W; YNL117W
GeneIDi855606
KEGGisce:YNL117W

Organism-specific databases

EuPathDBiFungiDB:YNL117W
SGDiS000005061, MLS1

Phylogenomic databases

eggNOGiKOG1261, Eukaryota
GeneTreeiENSGT00940000174673
HOGENOMiCLU_018928_3_0_1
InParanoidiP30952
KOiK01638
OMAiGWHMVDN

Enzyme and pathway databases

UniPathwayiUPA00703;UER00720
BioCyciMetaCyc:YNL117W-MONOMER

Miscellaneous databases

Protein Ontology

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PROi
PR:P30952
RNActiP30952, protein

Family and domain databases

CDDicd00727, malate_synt_A, 1 hit
InterProiView protein in InterPro
IPR011076, Malate_synth-like_sf
IPR006252, Malate_synthA
IPR001465, Malate_synthase
IPR019830, Malate_synthase_CS
PANTHERiPTHR42902, PTHR42902, 1 hit
PfamiView protein in Pfam
PF01274, Malate_synthase, 1 hit
PIRSFiPIRSF001363, Malate_synth, 1 hit
SUPFAMiSSF51645, SSF51645, 1 hit
TIGRFAMsiTIGR01344, malate_syn_A, 1 hit
PROSITEiView protein in PROSITE
PS00510, MALATE_SYNTHASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLS1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30952
Secondary accession number(s): B0KZR8
, B0KZS7, B0KZU5, B0KZY1, B0L026, D6W165, Q4KQ64, Q4KQ91, Q4KQC3, Q4KQC4, Q4KQC8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 7, 2020
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome XIV
    Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
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