UniProtKB - P30946 (HS90A_RABIT)
Heat shock protein HSP 90-alpha
HSP90AA1
Functioni
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 51 | ATPBy similarity | 1 | |
Binding sitei | 93 | ATPBy similarity | 1 | |
Binding sitei | 112 | ATPBy similarity | 1 | |
Binding sitei | 138 | ATP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 376 | ATPBy similarity | 1 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB
- phosphoprotein binding Source: AgBase
- unfolded protein binding Source: InterPro
GO - Biological processi
- protein folding Source: InterPro
- response to antibiotic Source: AgBase
- response to cold Source: AgBase
- response to heat Source: AgBase
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein HSP 90-alpha |
Gene namesi | Name:HSP90AA1 Synonyms:HSPCA |
Organismi | Oryctolagus cuniculus (Rabbit) |
Taxonomic identifieri | 9986 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
- Melanosome By similarity
Nucleus
- nucleus Source: AgBase
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: AgBase
- melanosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000409818 | 2 – 694 | Heat shock protein HSP 90-alphaBy similarityAdd BLAST | 693 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 5 | Phosphothreonine; by PRKDC1 Publication | 1 | |
Modified residuei | 7 | Phosphothreonine; by PRKDC1 Publication | 1 | |
Modified residuei | 58 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 84 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 231 | PhosphoserineBy similarity | 1 | |
Modified residuei | 249 | PhosphoserineBy similarity | 1 | |
Modified residuei | 289 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 419 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 429 | PhosphoserineBy similarity | 1 | |
Modified residuei | 434 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 452 | PhosphoserineBy similarity | 1 | |
Modified residuei | 465 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 468 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 547 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 560 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 603 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, S-nitrosylation, Ubl conjugationPTM databases
iPTMneti | P30946 |
Interactioni
Subunit structurei
Homodimer (By similarity). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (PubMed:9195923).
Forms a complex containing HSP90AA1, TSC1 and TSC2; TSC1 is required to recruit TCS2 to the complex (By similarity). The closed form interacts (via the middle domain and TPR repeat-binding motif) with co-chaperone TSC1 (via C-terminus) (By similarity).
Interacts with TOM34 (By similarity).
Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (By similarity).
Interacts with CHORDC1 and DNAJC7 (By similarity).
Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (By similarity).
Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (By similarity). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (By similarity).
Interacts with KSR1 (By similarity).
Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity (By similarity). May interact with NWD1 (By similarity).
Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity (By similarity).
Interacts with co-chaperone AHSA1 (phosphorylated on 'Tyr-223'); the interaction activates HSP90AA1 ATPase activity and results in the dissociation of TSC1 from HSP90AA1 (By similarity).
Interacts with FLCN in the presence of FNIP1 (By similarity).
Interacts with HSP70, STIP1 and PTGES3 (By similarity).
Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase.
Interacts with SGTA (via TPR repeats) (By similarity).
Interacts with TTC1 (via TPR repeats) (By similarity).
Interacts with HSF1 in an ATP-dependent manner (By similarity).
Interacts with MET; the interaction suppresses MET kinase activity (By similarity).
Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity (By similarity).
Interacts with HIF1A, KEAP1 and RHOBTB2 (By similarity).
Interacts with HIF1A, KEAP1 and RHOBTB2 (By similarity).
Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities (By similarity).
Interacts with STUB1 and SMAD3 (By similarity).
Interacts with HSP90AB1; interaction is constitutive (By similarity).
Interacts with HECTD1 (via N-terminus) (By similarity).
Interacts with NR3C1 (via domain NR LBD) and NR1D1 (via domain NR LBD) (By similarity).
Interacts with NLPR12.
Interacts with PDCL3 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- phosphoprotein binding Source: AgBase
- unfolded protein binding Source: InterPro
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000001106 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 9 – 236 | Interaction with NR3C1By similarityAdd BLAST | 228 | |
Regioni | 258 – 578 | Interaction with NR3C1By similarityAdd BLAST | 321 | |
Regioni | 261 – 694 | Interaction with FLCN and FNIP1By similarityAdd BLAST | 434 | |
Regioni | 261 – 582 | Interaction with FNIP2 and TSC1By similarityAdd BLAST | 322 | |
Regioni | 590 – 693 | Interaction with NR1D1By similarityAdd BLAST | 104 | |
Regioni | 644 – 694 | Required for homodimerizationBy similarityAdd BLAST | 51 | |
Regioni | 690 – 694 | Essential for interaction with SMYD3, TSC1 and STIP1/HOPBy similarity | 5 | |
Regioni | 691 – 694 | Essential for interaction with SGTA and TTC1By similarity | 4 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 685 – 694 | TPR repeat-bindingBy similarity | 10 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0019, Eukaryota |
InParanoidi | P30946 |
TreeFami | TF300686 |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS00298, HSP90, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS
60 70 80 90 100
NSSDALDKIR YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK
110 120 130 140 150
ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVGFYS AYLVAEKVTV
160 170 180 190 200
ITKHNDDEQY AWESSAGGSF TVRTDAGEPM GRGTKVVLHL KEDQTEYLEE
210 220 230 240 250
RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAKQPDD KPEIEDVGSD
260 270 280 290 300
EEEEEKKDGD IDQEELNKTK PIWTRNPDDI TNEEYGEFYK SLTNDWEDHL
310 320 330 340 350
AVKHFSVEGQ LEFRALLFVP RRAPFDLFEN RKKKNNIKLY VRRVFIMDNC
360 370 380 390 400
EELIPEYLNF IRGVVDSEDL PLNISREMLQ QSKILKVIRK NLVKKCLELF
410 420 430 440 450
TELAEDKENY KKFYEQFSKN IKLGIHEDSQ NRKKLSELLR YYTSASGDEM
460 470 480 490 500
VSLKDYCTRM KENQKHIYYI TGETKDQVAN SAFVERLRKH GLEVIYMIEP
510 520 530 540 550
IDEYCVQQLK EFEGKTLVSV TKEGLELTKF ENLCKIMKDI LEKKVEKVVV
560 570 580 590 600
SNRLVTSPCC IVTSTYGWTA NMERIMKAQA LRDNSTMGYM AAKKHLEVNP
610 620 630 640 650
DHSIIETLRQ KAEADKNDKS VKDLVILLYE TALLSSGFSL EDPQTHANRI
660 670 680 690
YRMIKLGLGI DEDDPTADDT AAAVTEEMPP LEGDDDTSRM EEVD
Sequence databases
PIRi | A34461 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A34461 |
3D structure databases
BMRBi | P30946 |
SMRi | P30946 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9986.ENSOCUP00000001106 |
PTM databases
iPTMneti | P30946 |
Phylogenomic databases
eggNOGi | KOG0019, Eukaryota |
InParanoidi | P30946 |
TreeFami | TF300686 |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS00298, HSP90, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HS90A_RABIT | |
Accessioni | P30946Primary (citable) accession number: P30946 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | June 28, 2011 | |
Last modified: | October 7, 2020 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families