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Protein

5-hydroxytryptamine receptor 1F

Gene

HTR1F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.3 Publications

GO - Molecular functioni

  • G-protein coupled serotonin receptor activity Source: MGI
  • neurotransmitter receptor activity Source: GO_Central
  • serotonin binding Source: MGI

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
  • chemical synaptic transmission Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1F
Short name:
5-HT-1F
Short name:
5-HT1F
Alternative name(s):
Serotonin receptor 1F
Gene namesi
Name:HTR1F
Synonyms:HTR1EL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000179097.5
HGNCiHGNC:5292 HTR1F
MIMi182134 gene
neXtProtiNX_P30939

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 50Helical; Name=1By similarityAdd BLAST21
Topological domaini51 – 60CytoplasmicBy similarity10
Transmembranei61 – 83Helical; Name=2By similarityAdd BLAST23
Topological domaini84 – 97ExtracellularBy similarityAdd BLAST14
Transmembranei98 – 118Helical; Name=3By similarityAdd BLAST21
Topological domaini119 – 140CytoplasmicBy similarityAdd BLAST22
Transmembranei141 – 161Helical; Name=4By similarityAdd BLAST21
Topological domaini162 – 178ExtracellularBy similarityAdd BLAST17
Transmembranei179 – 201Helical; Name=5By similarityAdd BLAST23
Topological domaini202 – 290CytoplasmicBy similarityAdd BLAST89
Transmembranei291 – 311Helical; Name=6By similarityAdd BLAST21
Topological domaini312 – 329ExtracellularBy similarityAdd BLAST18
Transmembranei330 – 350Helical; Name=7By similarityAdd BLAST21
Topological domaini351 – 366CytoplasmicBy similarityAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3355
OpenTargetsiENSG00000179097
PharmGKBiPA29553

Chemistry databases

ChEMBLiCHEMBL1805
DrugBankiDB00216 Eletriptan
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB01221 Ketamine
DB00247 Methysergide
DB06148 Mianserin
DB00952 Naratriptan
DB00953 Rizatriptan
DB00669 Sumatriptan
DB13025 Tiapride
DB00315 Zolmitriptan
GuidetoPHARMACOLOGYi5

Polymorphism and mutation databases

BioMutaiHTR1F
DMDMi398967

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689371 – 3665-hydroxytryptamine receptor 1FAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30939
PRIDEiP30939
ProteomicsDBi54747

PTM databases

iPTMnetiP30939
PhosphoSitePlusiP30939

Expressioni

Gene expression databases

BgeeiENSG00000179097
CleanExiHS_HTR1F
GenevisibleiP30939 HS

Organism-specific databases

HPAiHPA005555

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322924

Chemistry databases

BindingDBiP30939

Structurei

3D structure databases

ProteinModelPortaliP30939
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 108Agonist bindingBy similarity10
Regioni306 – 310Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi120 – 122DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi343 – 347NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP30939
KOiK04153
OMAiNVCEKCK
OrthoDBiEOG091G06VI
PhylomeDBiP30939
TreeFamiTF316350

Family and domain databases

CDDicd15334 7tmA_5-HT1F, 1 hit
InterProiView protein in InterPro
IPR000450 5HT1F_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF34 PTHR24247:SF34, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV
60 70 80 90 100
TRKLHHPANY LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL
110 120 130 140 150
SVDITCCTCS ILHLSAIALD RYRAITDAVE YARKRTPKHA GIMITIVWII
160 170 180 190 200
SVFISMPPLF WRHQGTSRDD ECIIKHDHIV STIYSTFGAF YIPLALILIL
210 220 230 240 250
YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS VSTSYVLEKS
260 270 280 290 300
LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG
310 320 330 340 350
AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF
360
NEDFKKAFQK LVRCRC
Length:366
Mass (Da):41,709
Last modified:July 1, 1993 - v1
Checksum:i16EA80344793B54F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05597 Genomic DNA Translation: AAA36605.1
L04962 Genomic DNA Translation: AAA36646.1
AF498981 mRNA Translation: AAM21128.1
AC119733 Genomic DNA No translation available.
BC069125 mRNA Translation: AAH69125.1
CCDSiCCDS2920.1
PIRiA47321
RefSeqiNP_000857.1, NM_000866.4
NP_001309137.1, NM_001322208.1
NP_001309138.1, NM_001322209.1
NP_001309139.1, NM_001322210.1
XP_005264808.1, XM_005264751.3
XP_011531966.1, XM_011533664.2
UniGeneiHs.248136

Genome annotation databases

EnsembliENST00000319595; ENSP00000322924; ENSG00000179097
GeneIDi3355
KEGGihsa:3355
UCSCiuc062lsi.1 human

Similar proteinsi

Entry informationi

Entry namei5HT1F_HUMAN
AccessioniPrimary (citable) accession number: P30939
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 20, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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