We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P30936 (SSR3_RAT)
Protein
Somatostatin receptor type 3
Gene
Sstr3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
2 PublicationsGO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- signaling receptor binding Source: RGD
- somatostatin receptor activity Source: InterPro
GO - Biological processi
- cellular response to estradiol stimulus Source: RGD
- cellular response to glucocorticoid stimulus Source: RGD
- cerebellum development Source: RGD
- forebrain development Source: RGD
- neuropeptide signaling pathway Source: GO_Central
- response to starvation Source: RGD
- spermatogenesis Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-418594, G alpha (i) signalling events R-RNO-5620922, BBSome-mediated cargo-targeting to cilium |
Names & Taxonomyi
Protein namesi | Recommended name: Somatostatin receptor type 3Short name: SS-3-R Short name: SS3-R Short name: SS3R Alternative name(s): SSR-28 |
Gene namesi | Name:Sstr3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620308, Sstr3 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Note: Internalized into endoplasmic vesicles upon somatostatin-stimulation.
Plasma Membrane
- ciliary membrane Source: RGD
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: RGD
Other locations
- cilium Source: RGD
- cytoplasm Source: RGD
- neuron projection Source: GO_Central
- non-motile cilium Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 45 | ExtracellularSequence analysisAdd BLAST | 45 | |
Transmembranei | 46 – 71 | Helical; Name=1Sequence analysisAdd BLAST | 26 | |
Topological domaini | 72 – 81 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 82 – 103 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 104 – 118 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 119 – 140 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 141 – 162 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 163 – 182 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 183 – 206 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 207 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 26 | |
Topological domaini | 233 – 266 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 267 – 288 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 289 – 302 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 303 – 325 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 326 – 428 | CytoplasmicSequence analysisAdd BLAST | 103 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 341 | S → A: Impaired internalization after somatostatin binding. 1 Publication | 1 | |
Mutagenesisi | 346 | S → A: Impaired internalization after somatostatin binding. 1 Publication | 1 | |
Mutagenesisi | 351 | S → A: Impaired internalization after somatostatin binding. 1 Publication | 1 | |
Mutagenesisi | 357 | T → A: Reduced basal and somatostatin-induced phosphorylation. Impaired internalization after somatostatin binding. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3340 |
DrugCentrali | P30936 |
GuidetoPHARMACOLOGYi | 357 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070126 | 1 – 428 | Somatostatin receptor type 3Add BLAST | 428 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 18 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 117 ↔ 192 | PROSITE-ProRule annotation | ||
Modified residuei | 341 | Phosphoserine1 Publication | 1 | |
Modified residuei | 346 | Phosphoserine1 Publication | 1 | |
Modified residuei | 351 | Phosphoserine1 Publication | 1 | |
Modified residuei | 357 | Phosphothreonine1 Publication | 1 |
Post-translational modificationi
Phosphorylated. Phosphorylation increases upon somatostatin binding.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P30936 |
PTM databases
GlyGeni | P30936, 2 sites |
iPTMneti | P30936 |
PhosphoSitePlusi | P30936 |
Expressioni
Tissue specificityi
Densely expressed in cerebellum and at moderate levels in the amygdala, cortex, striatum, spleen, liver and pituitary.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000007332, Expressed in thymus and 21 other tissues |
Genevisiblei | P30936, RN |
Interactioni
Subunit structurei
Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function.
1 PublicationGO - Molecular functioni
- signaling receptor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 251061, 1 interactor |
STRINGi | 10116.ENSRNOP00000009612 |
Chemistry databases
BindingDBi | P30936 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 343 – 428 | DisorderedSequence analysisAdd BLAST | 86 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 355 – 369 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 381 – 428 | Polar residuesSequence analysisAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000162038 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P30936 |
OMAi | VRAPSCQ |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P30936 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001856, Somatstn_rcpt_3 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00589, SOMATOSTTN3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P30936-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVTYPSSV PTTLDPGNAS SAWPLDTSLG NASAGTSLAG LAVSGILISL
60 70 80 90 100
VYLVVCVVGL LGNSLVIYVV LRHTSSPSVT SVYILNLALA DELFMLGLPF
110 120 130 140 150
LAAQNALSYW PFGSLMCRLV MAVDGINQFT SIFCLTVMSV DRYLAVVHPT
160 170 180 190 200
RSARWRTAPV ARMVSAAVWV ASAVVVLPVV VFSGVPRGMS TCHMQWPEPA
210 220 230 240 250
AAWRTAFIIY TAALGFFGPL LVICLCYLLI VVKVRSTTRR VRAPSCQWVQ
260 270 280 290 300
APACQRRRRS ERRVTRMVVA VVALFVLCWM PFYLLNIVNV VCPLPEEPAF
310 320 330 340 350
FGLYFLVVAL PYANSCANPI LYGFLSYRFK QGFRRILLRP SRRVRSQEPG
360 370 380 390 400
SGPPEKTEEE EDEEEEERRE EEERRMQRGQ EMNGRLSQIA QPGPSGQQQR
410 420
PCTGTAKEQQ LLPQEATAGD KASTLSHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63574 mRNA Translation: CAA45130.1 |
PIRi | S30508 |
RefSeqi | NP_598206.1, NM_133522.1 XP_006242028.1, XM_006241966.2 |
Genome annotation databases
Ensembli | ENSRNOT00000009612; ENSRNOP00000009612; ENSRNOG00000007332 |
GeneIDi | 171044 |
KEGGi | rno:171044 |
UCSCi | RGD:620308, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63574 mRNA Translation: CAA45130.1 |
PIRi | S30508 |
RefSeqi | NP_598206.1, NM_133522.1 XP_006242028.1, XM_006241966.2 |
3D structure databases
SMRi | P30936 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 251061, 1 interactor |
STRINGi | 10116.ENSRNOP00000009612 |
Chemistry databases
BindingDBi | P30936 |
ChEMBLi | CHEMBL3340 |
DrugCentrali | P30936 |
GuidetoPHARMACOLOGYi | 357 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P30936, 2 sites |
iPTMneti | P30936 |
PhosphoSitePlusi | P30936 |
Proteomic databases
PaxDbi | P30936 |
Genome annotation databases
Ensembli | ENSRNOT00000009612; ENSRNOP00000009612; ENSRNOG00000007332 |
GeneIDi | 171044 |
KEGGi | rno:171044 |
UCSCi | RGD:620308, rat |
Organism-specific databases
CTDi | 6753 |
RGDi | 620308, Sstr3 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000162038 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P30936 |
OMAi | VRAPSCQ |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P30936 |
TreeFami | TF315737 |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-418594, G alpha (i) signalling events R-RNO-5620922, BBSome-mediated cargo-targeting to cilium |
Miscellaneous databases
PROi | PR:P30936 |
Gene expression databases
Bgeei | ENSRNOG00000007332, Expressed in thymus and 21 other tissues |
Genevisiblei | P30936, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001856, Somatstn_rcpt_3 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00589, SOMATOSTTN3R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SSR3_RAT | |
Accessioni | P30936Primary (citable) accession number: P30936 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families