CHRNB4

Functionⁱ

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	82	Key residue that facilitates effective access of the conotoxin BuIA to the channel binding siteBy similarity		1
Siteⁱ	134	Key residue for a low dissociation (K(off)) from the conotoxin BuIABy similarity		1

GO - Molecular functionⁱ

acetylcholine binding Source: Ensembl
acetylcholine-gated cation-selective channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18387948
acetylcholine receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8906617
ligand-gated ion channel activity
Source: DFLAT
Traceable author statementⁱ
- 20438829
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

action potential Source: Ensembl
behavioral response to nicotine Source: Ensembl
chemical synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transport
Source: UniProtKB
Traceable author statementⁱ
- 8906617
locomotory behavior Source: Ensembl
nervous system process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuromuscular synaptic transmission
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil degranulation Source: Reactome
positive regulation of transmission of nerve impulse Source: Ensembl
protein heterooligomerization Source: Ensembl
regulation of membrane potential
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of neurotransmitter secretion
Source: UniProtKB
Non-traceable author statementⁱ
- 11742001
regulation of smooth muscle contraction Source: Ensembl
response to nicotine
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 8906617
smooth muscle contraction Source: Ensembl
synaptic transmission, cholinergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
synaptic transmission involved in micturition
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11450844

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal acetylcholine receptor subunit beta-4
Gene namesⁱ	Name:CHRNB4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117971.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1964 CHRNB4
MIMⁱ	118509 gene
neXtProtⁱ	NX_P30926

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 236	ExtracellularSequence analysisAdd BLAST	215
Transmembraneⁱ	237 – 257	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	258 – 265	CytoplasmicSequence analysis	8
Transmembraneⁱ	266 – 286	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	287 – 298	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	299 – 319	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	320 – 460	CytoplasmicSequence analysisAdd BLAST	141
Transmembraneⁱ	461 – 481	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	482 – 498	ExtracellularSequence analysisAdd BLAST	17

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1143
Open Targets More...OpenTargetsⁱ	ENSG00000117971
PharmGKBⁱ	PA26496

Chemistry databases

ChEMBLⁱ	CHEMBL3885595
Drug and drug target database More...DrugBankⁱ	DB00514 Dextromethorphan DB00898 Ethanol DB00674 Galantamine DB01227 Levomethadyl Acetate DB00184 Nicotine DB01090 Pentolinium

Polymorphism and mutation databases

BioMutaⁱ	CHRNB4
DMDMⁱ	2506129

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000000389	22 – 498	Neuronal acetylcholine receptor subunit beta-4Add BLAST		477

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	36	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	93	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	138	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	153 ↔ 167	By similarity
Glycosylationⁱ	166	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P30926
PaxDbⁱ	P30926
PRIDEⁱ	P30926
ProteomicsDBⁱ	54746

PTM databases

iPTMnetⁱ	P30926
PhosphoSitePlusⁱ	P30926

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000117971 Expressed in 66 organ(s), highest expression level in right testis
CleanExⁱ	HS_CHRNB4
ExpressionAtlasⁱ	P30926 baseline and differential
Genevisibleⁱ	P30926 HS

Interactionⁱ

Subunit structureⁱ

Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-4 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly (PubMed:16120769). Interacts with LYPD6 (PubMed:27344019). The pentamer alpha3-beta-4 interacts with the conotoxin BuIA (By similarity). The heteropentamer composed of alpha-3 and beta-4 subunits interacts with the alpha-conotoxin ImI (PubMed:15609996).By similarity3 Publications

GO - Molecular functionⁱ

protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107565, 77 interactors
ComplexPortalⁱ	CPX-210 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4 CPX-213 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 CPX-2190 Neuronal nicotinic acetylcholine receptor complex, alpha2-beta4 CPX-2200 Neuronal nicotinic acetylcholine receptor complex, alpha3-beta4 CPX-2203 Neuronal nicotinic acetylcholine receptor complex, alpha4-beta4
CORUMⁱ	P30926
IntActⁱ	P30926, 2 interactors
STRINGⁱ	9606.ENSP00000261751

Chemistry databases

BindingDBⁱ

P30926

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P30926
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006757
HOVERGENⁱ	HBG003756
InParanoidⁱ	P30926
KEGG Orthology (KO) More...KOⁱ	K04815
OMAⁱ	FMKRPEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P30926
TreeFamⁱ	TF315605

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P30926-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS 
        60         70         80         90        100
SQLISIKLQL SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV 
       110        120        130        140        150
NILRIPAKRI WLPDIVLYNN ADGTYEVSVY TNLIVRSNGS VLWLPPAIYK 
       160        170        180        190        200
SACKIEVKYF PFDQQNCTLK FRSWTYDHTE IDMVLMTPTA SMDDFTPSGE 
       210        220        230        240        250
WDIVALPGRR TVNPQDPSYV DVTYDFIIKR KPLFYTINLI IPCVLTTLLA 
       260        270        280        290        300
ILVFYLPSDC GEKMTLCISV LLALTFFLLL ISKIVPPTSL DVPLIGKYLM 
       310        320        330        340        350
FTMVLVTFSI VTSVCVLNVH HRSPSTHTMA PWVKRCFLHK LPTFLFMKRP 
       360        370        380        390        400
GPDSSPARAF PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP 
       410        420        430        440        450
AGSTPVAIPR DFWLRSSGRF RQDVQEALEG VSFIAQHMKN DDEDQSVVED 
       460        470        480        490 
WKYVAMVVDR LFLWVFMFVC VLGTVGLFLP PLFQTHAASE GPYAAQRD

Length:498

Mass (Da):56,380

Last modified:November 1, 1997 - v2

Checksum:ⁱ0D48AB203F3FD03E

GO

Isoform 2 (identifier: P30926-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
120-217: NADGTYEVSV...GRRTVNPQDP → KSLRTGSTWL...GKDGGLGCPL
218-498: Missing.

« Hide

        10         20         30         40         50
MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS 
        60         70         80         90        100
SQLISIKLQL SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV 
       110        120        130        140        150
NILRIPAKRI WLPDIVLYNK SLRTGSTWLW WWTGCSCGCS CLCASWALWG 
       160        170        180        190        200
SSYRPSSRPM QLLRGPTLPS VTEGPLGCGV RGCEWPGGHF AASFWVVADE 
       210        220        230 
ALSKYVSIGH QPHQTSHSRG TGKDGGLGCP L

Show »

Length:231

Mass (Da):25,862

Checksum:ⁱ4182D0886DD041BE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H3BU02	H3BU02_HUMAN		Neuronal acetylcholine receptor sub... Neuronal acetylcholine receptor subunit beta-4	CHRNB4	66	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	72 – 73	EQ → DE in CAA48336 (PubMed:1330682).Curated		2
Sequence conflictⁱ	121	Missing in CAC34819 (Ref. 4) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048174	91	T → I. Corresponds to variant dbSNP:rs12914008Ensembl.	1
Natural variantⁱVAR_013241	136	R → W1 PublicationCorresponds to variant dbSNP:rs141876090Ensembl.	1
Natural variantⁱVAR_013242	140	S → G1 PublicationCorresponds to variant dbSNP:rs56218866Ensembl.	1
Natural variantⁱVAR_013243	467	M → V1 PublicationCorresponds to variant dbSNP:rs61737502Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046674	120 – 217	NADGT…NPQDP → KSLRTGSTWLWWWTGCSCGC SCLCASWALWGSSYRPSSRP MQLLRGPTLPSVTEGPLGCG VRGCEWPGGHFAASFWVVAD EALSKYVSIGHQPHQTSHSR GTGKDGGLGCPL in isoform 2. 1 PublicationAdd BLAST		98
Alternative sequenceⁱVSP_046675	218 – 498	Missing in isoform 2. 1 PublicationAdd BLAST		281

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U62439 mRNA Translation: AAB40117.1 U48861 mRNA Translation: AAA92123.1 Y08416 mRNA Translation: CAA69693.1 AJ306454 AJ306459 Genomic DNA Translation: CAC34819.1 AF306329 AF306328 Genomic DNA Translation: AAL02062.1 AC022748 Genomic DNA No translation available. AC067863 Genomic DNA No translation available. BC096080 mRNA Translation: AAH96080.1 BC096081 mRNA Translation: AAH96081.1 BC096083 mRNA Translation: AAH96083.1 BC096082 mRNA Translation: AAH96082.1 AF453877 Genomic DNA Translation: AAL57840.1 X68275 mRNA Translation: CAA48336.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10306.1 [P30926-1] CCDS58392.1 [P30926-2]
PIRⁱ	G02421
NCBI Reference Sequences More...RefSeqⁱ	NP_000741.1, NM_000750.3 [P30926-1] NP_001243496.1, NM_001256567.1 [P30926-2]
UniGeneⁱ	Hs.624178

Genome annotation databases

Ensemblⁱ	ENST00000261751; ENSP00000261751; ENSG00000117971 [P30926-1] ENST00000412074; ENSP00000416386; ENSG00000117971 [P30926-2]
GeneIDⁱ	1143
KEGGⁱ	hsa:1143
UCSC genome browser More...UCSCⁱ	uc002bed.2 human [P30926-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30926	CHRNB4 isoform 6		PANTR		498	UniRef90_P30926
Uncharacterized protein		PANPA		498
CHRNB4 isoform 1		PONAB		498
Cholinergic receptor nicotinic beta 4 subunit		GORGO		498
Uncharacterized protein		RHIBE		492
+33
P30926-2	Cholinergic receptor nicotinic beta 4 subunit		CALJA		232	UniRef90_P30926-2
CHRNB4 isoform 5		PANTR		231
Uncharacterized protein		PANPA		231
CHRNB4 isoform 2		PONAB		231
UPI0004F06002		CALJA		277

Protein	Similar proteins		Species	Score	Length	Source
P30926	Neuronal acetylcholine receptor subunit beta-2 (Fragment)		CARAU		459	UniRef50_P30926
Neuronal acetylcholine receptor subunit beta-4 (Fragment)		CHICK		470
Neuronal acetylcholine receptor subunit beta-4		MOUSE		495
Neuronal acetylcholine receptor subunit beta-4	)	RAT		495
Neuronal acetylcholine receptor subunit beta-4		BOVIN		496
+604
P30926-2	Cholinergic receptor nicotinic beta 4 subunit		CALJA		232	UniRef50_P30926-2
CHRNB4 isoform 5		PANTR		231
Uncharacterized protein		PANPA		231
CHRNB4 isoform 2		PONAB		231
UPI00048B849B		RABIT		238
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U62439 mRNA Translation: AAB40117.1 U48861 mRNA Translation: AAA92123.1 Y08416 mRNA Translation: CAA69693.1 AJ306454 AJ306459 Genomic DNA Translation: CAC34819.1 AF306329 AF306328 Genomic DNA Translation: AAL02062.1 AC022748 Genomic DNA No translation available. AC067863 Genomic DNA No translation available. BC096080 mRNA Translation: AAH96080.1 BC096081 mRNA Translation: AAH96081.1 BC096083 mRNA Translation: AAH96083.1 BC096082 mRNA Translation: AAH96082.1 AF453877 Genomic DNA Translation: AAL57840.1 X68275 mRNA Translation: CAA48336.1
CCDSⁱ	CCDS10306.1 [P30926-1] CCDS58392.1 [P30926-2]
PIRⁱ	G02421
RefSeqⁱ	NP_000741.1, NM_000750.3 [P30926-1] NP_001243496.1, NM_001256567.1 [P30926-2]
UniGeneⁱ	Hs.624178

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ASG	model	-	B/D/E	262-284	[»]
ProteinModelPortalⁱ	P30926
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107565, 77 interactors
ComplexPortalⁱ	CPX-210 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha5-beta4 CPX-213 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4 CPX-2190 Neuronal nicotinic acetylcholine receptor complex, alpha2-beta4 CPX-2200 Neuronal nicotinic acetylcholine receptor complex, alpha3-beta4 CPX-2203 Neuronal nicotinic acetylcholine receptor complex, alpha4-beta4
CORUMⁱ	P30926
IntActⁱ	P30926, 2 interactors
STRINGⁱ	9606.ENSP00000261751

Chemistry databases

BindingDBⁱ	P30926
ChEMBLⁱ	CHEMBL3885595
DrugBankⁱ	DB00514 Dextromethorphan DB00898 Ethanol DB00674 Galantamine DB01227 Levomethadyl Acetate DB00184 Nicotine DB01090 Pentolinium

PTM databases

iPTMnetⁱ	P30926
PhosphoSitePlusⁱ	P30926

Polymorphism and mutation databases

BioMutaⁱ	CHRNB4
DMDMⁱ	2506129

Proteomic databases

EPDⁱ	P30926
PaxDbⁱ	P30926
PRIDEⁱ	P30926
ProteomicsDBⁱ	54746

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000261751; ENSP00000261751; ENSG00000117971 [P30926-1] ENST00000412074; ENSP00000416386; ENSG00000117971 [P30926-2]
GeneIDⁱ	1143
KEGGⁱ	hsa:1143
UCSCⁱ	uc002bed.2 human [P30926-1]

Organism-specific databases

CTDⁱ	1143
DisGeNETⁱ	1143
EuPathDBⁱ	HostDB:ENSG00000117971.11
GeneCardsⁱ	CHRNB4
HGNCⁱ	HGNC:1964 CHRNB4
MIMⁱ	118509 gene
neXtProtⁱ	NX_P30926
OpenTargetsⁱ	ENSG00000117971
PharmGKBⁱ	PA26496
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3645 Eukaryota ENOG410XQGR LUCA
GeneTreeⁱ	ENSGT00760000118930
HOGENOMⁱ	HOG000006757
HOVERGENⁱ	HBG003756
InParanoidⁱ	P30926
KOⁱ	K04815
OMAⁱ	FMKRPEN
OrthoDBⁱ	EOG091G0R20
PhylomeDBⁱ	P30926
TreeFamⁱ	TF315605

Enzyme and pathway databases

Reactomeⁱ	R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors
R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	CHRNB4 human
GeneWikiⁱ	CHRNB4
GenomeRNAiⁱ	1143
Protein Ontology More...PROⁱ	PR:P30926
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117971 Expressed in 66 organ(s), highest expression level in right testis
CleanExⁱ	HS_CHRNB4
ExpressionAtlasⁱ	P30926 baseline and differential
Genevisibleⁱ	P30926 HS

Family and domain databases

Gene3Dⁱ	2.70.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR006202 Neur_chan_lig-bd IPR036734 Neur_chan_lig-bd_sf IPR006201 Neur_channel IPR036719 Neuro-gated_channel_TM_sf IPR006029 Neurotrans-gated_channel_TM IPR018000 Neurotransmitter_ion_chnl_CS IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERⁱ	PTHR18945 PTHR18945, 1 hit
Pfamⁱ	View protein in Pfam PF02931 Neur_chan_LBD, 1 hit PF02932 Neur_chan_memb, 1 hit
PRINTSⁱ	PR00254 NICOTINICR PR00252 NRIONCHANNEL
SUPFAMⁱ	SSF63712 SSF63712, 1 hit SSF90112 SSF90112, 1 hit
TIGRFAMsⁱ	TIGR00860 LIC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACHB4_HUMAN
Accessionⁱ	P30926Primary (citable) accession number: P30926 Secondary accession number(s): A4FTX5 , E9PHE8, Q16607, Q4VBA5, Q8WXC8, Q9BQR4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

UniProtKB

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UniRef

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Supporting data

UniProtKB - P30926 (ACHB4_HUMAN)

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Neuronal acetylcholine receptor subunit beta-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ