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Protein

Chitinase-3-like protein 1

Gene

CHI3L1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity).By similarity1 Publication

Caution

Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141ChitooligosaccharideBy similarity1
Binding sitei263ChitooligosaccharideBy similarity1
Binding sitei352ChitooligosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial
Biological processApoptosis, Inflammatory response
LigandLectin

Protein family/group databases

CAZyiGH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase-3-like protein 1
Alternative name(s):
39 kDa whey protein
Cartilage glycoprotein 39
Short name:
CGP-39
Short name:
GP-39
Chitinase-like protein 1
Short name:
CLP-1
SPC-40
Signal-processing protein
Gene namesi
Name:CHI3L1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000004278722 – 383Chitinase-3-like protein 1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 511 Publication
Glycosylationi60N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi300 ↔ 3641 Publication
Glycosylationi367N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP30922
PeptideAtlasiP30922
PRIDEiP30922

PTM databases

iPTMnetiP30922

Expressioni

Tissue specificityi

Mammary secretions collected during the non-lactating period.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024253

Structurei

Secondary structure

1383
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 29Combined sources7
Helixi30 – 34Combined sources5
Helixi37 – 39Combined sources3
Helixi43 – 45Combined sources3
Turni48 – 50Combined sources3
Beta strandi52 – 62Combined sources11
Beta strandi65 – 67Combined sources3
Helixi73 – 81Combined sources9
Helixi82 – 85Combined sources4
Beta strandi91 – 97Combined sources7
Helixi103 – 111Combined sources9
Helixi113 – 130Combined sources18
Beta strandi133 – 138Combined sources6
Turni144 – 146Combined sources3
Helixi147 – 164Combined sources18
Helixi165 – 167Combined sources3
Beta strandi173 – 179Combined sources7
Helixi182 – 188Combined sources7
Helixi191 – 195Combined sources5
Beta strandi199 – 204Combined sources6
Beta strandi211 – 215Combined sources5
Helixi237 – 246Combined sources10
Helixi251 – 253Combined sources3
Beta strandi254 – 270Combined sources17
Beta strandi277 – 281Combined sources5
Turni286 – 288Combined sources3
Beta strandi293 – 295Combined sources3
Helixi296 – 302Combined sources7
Turni303 – 305Combined sources3
Beta strandi307 – 311Combined sources5
Turni312 – 315Combined sources4
Beta strandi316 – 321Combined sources6
Beta strandi324 – 327Combined sources4
Helixi331 – 343Combined sources13
Beta strandi347 – 352Combined sources6
Helixi354 – 356Combined sources3
Beta strandi359 – 361Combined sources3
Beta strandi363 – 366Combined sources4
Helixi371 – 382Combined sources12

3D structure databases

ProteinModelPortaliP30922
SMRiP30922
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30922

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 71Chitooligosaccharide bindingBy similarity2
Regioni97 – 100Chitooligosaccharide bindingBy similarity4
Regioni204 – 207Chitooligosaccharide bindingBy similarity4
Regioni324 – 338Important for AKT1 activation and IL8 productionBy similarityAdd BLAST15

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
HOGENOMiHOG000111109
HOVERGENiHBG011684
InParanoidiP30922
KOiK17523

Family and domain databases

Gene3Di3.10.50.10, 1 hit
InterProiView protein in InterPro
IPR028538 CHI3L1
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR11177:SF202 PTHR11177:SF202, 1 hit
PfamiView protein in Pfam
PF00704 Glyco_hydro_18, 1 hit
SMARTiView protein in SMART
SM00636 Glyco_18, 1 hit
SUPFAMiSSF51445 SSF51445, 2 hits
SSF54556 SSF54556, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30922-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRAAHTGF VVLVLLQSCA AYKLICYYTS WSQYREGDGS CFPDAIDPFL
60 70 80 90 100
CTHVIYSFAN ISNNEIDTWE WNDVTLYDTL NTLKNRNPNL KTLLSVGGWN
110 120 130 140 150
FGSQRFSKIA SKTQSRRTFI KSVPPFLRTH GFDGLDLAWL YPGWRDKRHL
160 170 180 190 200
TTLVKEMKAE FVREAQAGTE QLLLSAAVPA GKIAIDRGYD IAQISRHLDF
210 220 230 240 250
ISLLTYDFHG AWRQTVGHHS PLFRGQEDAS SDRFSNADYA VSYMLRLGAP
260 270 280 290 300
ANKLVMGIPT FGRSYTLASS KTDVGAPISG PGIPGQFTKE KGILAYYEIC
310 320 330 340 350
DFLHGATTHR FRDQQVPYAT KGNQWVAYDD QESVKNKARY LKNRQLAGAM
360 370 380
VWALDLDDFR GTFCGQNLTF PLTSAIKDVL ARV
Length:383
Mass (Da):43,032
Last modified:November 8, 2005 - v3
Checksum:i391561804C371A10
GO

Sequence cautioni

The sequence AAX46682 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25I → V in AAB64304 (Ref. 4) Curated1
Sequence conflicti104Q → E in AAP41220 (Ref. 2) Curated1
Sequence conflicti164E → G in AAB64304 (Ref. 4) Curated1
Sequence conflicti179P → T in AAP41220 (Ref. 2) Curated1
Sequence conflicti211A → G in AAP41220 (Ref. 2) Curated1
Sequence conflicti214Q → G in AAP41220 (Ref. 2) Curated1
Sequence conflicti226 – 232QEDASSD → NSDGSS in AAP41220 (Ref. 2) Curated7
Sequence conflicti271 – 273KTD → STR in AAP41220 (Ref. 2) Curated3
Sequence conflicti307T → I in AAX46682 (PubMed:16305752).Curated1
Sequence conflicti369T → A in AAX46682 (PubMed:16305752).Curated1
Sequence conflicti382R → E in AAX46682 (PubMed:16305752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021835 mRNA Translation: AAX46682.1 Different initiation.
AY291312 mRNA Translation: AAP41220.2
AF011373 mRNA Translation: AAB64304.1
PIRiA27682
RefSeqiNP_001073688.1, NM_001080219.1
UniGeneiBt.60417

Genome annotation databases

GeneIDi286869
KEGGibta:286869

Similar proteinsi

Entry informationi

Entry nameiCH3L1_BOVIN
AccessioniPrimary (citable) accession number: P30922
Secondary accession number(s): O18949, Q58CW2, Q7YSE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 8, 2005
Last modified: February 28, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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