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Protein

Aldehyde dehydrogenase, dimeric NADP-preferring

Gene

ALDH3A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).By similarityCurated

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei30PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, dimeric NADP-preferring (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 3
Aldehyde dehydrogenase family 3 member A1
Corneal 15.8 kDa protein
Corneal protein 54
Short name:
bCP54
Transparentin
Gene namesi
Name:ALDH3A1
Synonyms:ALDH3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000056469‹1 – ›239Aldehyde dehydrogenase, dimeric NADP-preferringAdd BLAST›239

Proteomic databases

PaxDbiP30907

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028125

Structurei

3D structure databases

ProteinModelPortaliP30907
SMRiP30907
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2456 Eukaryota
COG1012 LUCA
HOGENOMiHOG000271515
HOVERGENiHBG050483
InParanoidiP30907

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit

Sequencei

Sequence statusi: Fragment.

P30907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NPHYVDKDRD LDIACRRIAW GKFMNSGQTC VAPDYILCDP SIQSQVVEKL
60 70 80 90 100
KKSLKEFYGE DAKKSRDYGR IINSRHFQRV MGLLEGQKVA YGGTGDATTR
110 120 130 140 150
YIAPTILTDV DPESPVMQEE VFGPVLPIMC VRSLEEAIQF ITQREKPLAL
160 170 180 190 200
YVFSPNDKVI KKMIAETSSG GVTANDVVVH ISVHSLPYGG VGDSGMGSYH
210 220 230
GRKSFETFSH RRSCLVRPLL NEETLKARYP RARPICPDT
Length:239
Mass (Da):26,743
Last modified:November 1, 1997 - v2
Checksum:i16BD07206287716C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2391

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51969 mRNA Translation: AAB24736.2
M37384 mRNA Translation: AAA30468.1
PIRiPS0412
T01406
UniGeneiBt.13116

Entry informationi

Entry nameiAL3A1_BOVIN
AccessioniPrimary (citable) accession number: P30907
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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