C-C motif chemokine 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• CCR1 chemokine receptor binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis."
    Ness T.L., Carpenter K.J., Ewing J.L., Gerard C.J., Hogaboam C.M., Kunkel S.L.
    J. Immunol. 173:6938-6948(2004) [PubMed] [Europe PMC] [Abstract]
• CCR5 chemokine receptor binding Source: BHF-UCL
• CCR chemokine receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemoattractant activity Source: MGI
• chemokine activity Source: BHF-UCL
• chemokine receptor antagonist activity Source: BHF-UCL
• chemokine receptor binding Source: MGI
• heparin binding Source: MGI
• identical protein binding Source: MGI
• phosphatidylinositol phospholipase C activity Source: MGI
• phospholipase activator activity Source: MGI
• protein homodimerization activity Source: BHF-UCL
• protein kinase activity Source: MGI
• protein self-association Source: BHF-UCL
• receptor signaling protein tyrosine kinase activator activity Source: BHF-UCL

GO - Biological processⁱ

• activation of phospholipase D activity Source: BHF-UCL
• calcium ion transport Source: MGI
• cell-cell signaling Source: BHF-UCL
• cellular calcium ion homeostasis Source: MGI
• cellular response to fibroblast growth factor stimulus Source: Ensembl
• cellular response to interferon-gamma Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic cyclic compound Source: MGI
• cellular response to tumor necrosis factor Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine-mediated signaling pathway Source: UniProtKB
• eosinophil chemotaxis Source: BHF-UCL
• exocytosis Source: MGI
• G protein-coupled receptor signaling pathway Source: UniProtKB
• inflammatory response Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer."
    Hu B., Elinav E., Huber S., Strowig T., Hao L., Hafemann A., Jin C., Wunderlich C., Wunderlich T., Eisenbarth S.C., Flavell R.A.
    Proc. Natl. Acad. Sci. U.S.A. 110:9862-9867(2013) [PubMed] [Europe PMC] [Abstract]
• leukocyte cell-cell adhesion Source: BHF-UCL
• lipopolysaccharide-mediated signaling pathway Source: MGI
• lymphocyte chemotaxis Source: MGI
• MAPK cascade Source: MGI
• monocyte chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation by host of viral transcription Source: MGI
• negative regulation of cell death Source: MGI
• negative regulation of G protein-coupled receptor signaling pathway Source: MGI
• negative regulation of macrophage apoptotic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection."
    Tyner J.W., Uchida O., Kajiwara N., Kim E.Y., Patel A.C., O'Sullivan M.P., Walter M.J., Schwendener R.A., Cook D.N., Danoff T.M., Holtzman M.J.
    Nat. Med. 11:1180-1187(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neuron death Source: MGI
• negative regulation of T cell apoptotic process Source: BHF-UCL
• negative regulation of viral genome replication Source: BHF-UCL
• neutrophil activation Source: BHF-UCL
• neutrophil chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of angiogenesis Source: MGI
• positive regulation of calcium ion transport Source: MGI
• positive regulation of cell adhesion Source: BHF-UCL
• positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
• positive regulation of cell migration Source: MGI
• positive regulation of cellular biosynthetic process Source: BHF-UCL
• positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Influenza virus infection aggravates stroke outcome."
    Muhammad S., Haasbach E., Kotchourko M., Strigli A., Krenz A., Ridder D.A., Vogel A.B., Marti H.H., Al-Abed Y., Planz O., Schwaninger M.
    Stroke 42:783-791(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of defense response to virus by host Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection."
    Tyner J.W., Uchida O., Kajiwara N., Kim E.Y., Patel A.C., O'Sullivan M.P., Walter M.J., Schwendener R.A., Cook D.N., Danoff T.M., Holtzman M.J.
    Nat. Med. 11:1180-1187(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epithelial cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer."
    Hu B., Elinav E., Huber S., Strowig T., Hao L., Hafemann A., Jin C., Wunderlich C., Wunderlich T., Eisenbarth S.C., Flavell R.A.
    Proc. Natl. Acad. Sci. U.S.A. 110:9862-9867(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ERK1 and ERK2 cascade Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of fever generation Source: MGI
• positive regulation of gene expression Source: MGI
• positive regulation of GTPase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of homotypic cell-cell adhesion Source: BHF-UCL
• positive regulation of macrophage chemotaxis Source: BHF-UCL
• positive regulation of mast cell chemotaxis Source: MGI
• positive regulation of monocyte chemotaxis Source: BHF-UCLInferred from direct assayⁱ
  • "Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes."
    Laubli H., Spanaus K.S., Borsig L.
    Blood 114:4583-4591(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of natural killer cell chemotaxis Source: MGI
• positive regulation of neuron differentiation Source: MGI
• positive regulation of osteoclast differentiation Source: MGI
• positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
• positive regulation of phosphorylation Source: BHF-UCL
• positive regulation of smooth muscle cell migration Source: BHF-UCL
• positive regulation of smooth muscle cell proliferation Source: BHF-UCL
• positive regulation of T cell apoptotic process Source: BHF-UCL
• positive regulation of T cell chemotaxis Source: BHF-UCL
• positive regulation of T cell migration Source: MGIInferred from sequence orthologyⁱ
  • "CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration."
    Chiang Y.J., Ho K.C., Sun C.T., Chiu J.J., Lee F.J., Liao F., Yang-Yen H.F., Yen J.J.
    PLoS ONE 8:e61761-e61761(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell proliferation Source: MGI
• positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
• protein kinase B signaling Source: MGI
• pseudopodium assembly Source: MGI
• regulation of insulin secretion Source: UniProtKB
• regulation of neuron death Source: UniProtKB
• regulation of T cell activation Source: BHF-UCL
• response to cytokine Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes."
    Heeger P., Wolf G., Meyers C., Sun M.J., O'Farrell S.C., Krensky A.M., Neilson E.G.
    Kidney Int. 41:220-225(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• response to interferon-gamma Source: MGI
• response to toxic substance Source: MGI
• response to tumor necrosis factor Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes."
    Heeger P., Wolf G., Meyers C., Sun M.J., O'Farrell S.C., Krensky A.M., Neilson E.G.
    Kidney Int. 41:220-225(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• T-helper 1 cell diapedesis Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• CCR1 chemokine receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis."
    Ness T.L., Carpenter K.J., Ewing J.L., Gerard C.J., Hogaboam C.M., Kunkel S.L.
    J. Immunol. 173:6938-6948(2004) [PubMed] [Europe PMC] [Abstract]
• CCR5 chemokine receptor binding Source: BHF-UCL
• CCR chemokine receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemoattractant activity Source: MGI
• chemokine activity Source: BHF-UCL
• chemokine receptor antagonist activity Source: BHF-UCL
• chemokine receptor binding Source: MGI
• identical protein binding Source: MGI
• protein homodimerization activity Source: BHF-UCL
• protein self-association Source: BHF-UCL

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY 
        60         70         80         90 
FYTSSKCSNL AVVFVTRRNR QVCANPEKKW VQEYINYLEM S          

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references