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Protein

C-C motif chemokine 5

Gene

Ccl5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 5
Alternative name(s):
MuRantes
SIS-delta
Small-inducible cytokine A5
T-cell-specific protein RANTES
Gene namesi
Name:Ccl5
Synonyms:Scya5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98262 Ccl5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000517924 – 91C-C motif chemokine 5Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP30882
PRIDEiP30882

PTM databases

PhosphoSitePlusiP30882

Expressioni

Tissue specificityi

T-cell and macrophage specific.

Gene expression databases

BgeeiENSMUSG00000035042 Expressed in 105 organ(s), highest expression level in blood
CleanExiMM_CCL5
ExpressionAtlasiP30882 baseline and differential
GenevisibleiP30882 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ccl17F6R5P44EBI-20314992,EBI-20561031

GO - Molecular functioni

Protein-protein interaction databases

IntActiP30882, 4 interactors
STRINGi10090.ENSMUSP00000039600

Structurei

3D structure databases

ProteinModelPortaliP30882
SMRiP30882
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XH Eukaryota
ENOG410ZUYI LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP30882
KOiK12499
OMAiCCFAYLS
OrthoDBiEOG091G14Y2
PhylomeDBiP30882
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR030595 CCL5
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PTHR12015:SF82 PTHR12015:SF82, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P30882-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY
60 70 80 90
FYTSSKCSNL AVVFVTRRNR QVCANPEKKW VQEYINYLEM S
Length:91
Mass (Da):10,071
Last modified:June 1, 1994 - v2
Checksum:i5DFD66F4684FE1C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19T → A in AAB22330 (PubMed:1376260).Curated1
Sequence conflicti41A → E in AAA40029 (PubMed:1375672).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77747 mRNA Translation: AAA40029.1
S37648 mRNA Translation: AAB22330.1
U02298 Unassigned DNA Translation: AAA18302.1
X70675 Genomic DNA Translation: CAA50011.1
AF065944 mRNA Translation: AAC17511.1
AF065945 mRNA Translation: AAC17512.1
AF065946 mRNA Translation: AAC17513.1
AF065947 mRNA Translation: AAC17514.1
AF128187 mRNA Translation: AAF22528.1
AB051897 Genomic DNA Translation: BAB18731.1
AK003101 mRNA Translation: BAB22566.1
BC033508 mRNA Translation: AAH33508.1
CCDSiCCDS36254.1
PIRiI48875 A46539
RefSeqiNP_038681.2, NM_013653.3
UniGeneiMm.284248

Genome annotation databases

EnsembliENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042
GeneIDi20304
KEGGimmu:20304
UCSCiuc007kpi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77747 mRNA Translation: AAA40029.1
S37648 mRNA Translation: AAB22330.1
U02298 Unassigned DNA Translation: AAA18302.1
X70675 Genomic DNA Translation: CAA50011.1
AF065944 mRNA Translation: AAC17511.1
AF065945 mRNA Translation: AAC17512.1
AF065946 mRNA Translation: AAC17513.1
AF065947 mRNA Translation: AAC17514.1
AF128187 mRNA Translation: AAF22528.1
AB051897 Genomic DNA Translation: BAB18731.1
AK003101 mRNA Translation: BAB22566.1
BC033508 mRNA Translation: AAH33508.1
CCDSiCCDS36254.1
PIRiI48875 A46539
RefSeqiNP_038681.2, NM_013653.3
UniGeneiMm.284248

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YAMNMR-A/B24-91[»]
ProteinModelPortaliP30882
SMRiP30882
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP30882, 4 interactors
STRINGi10090.ENSMUSP00000039600

PTM databases

PhosphoSitePlusiP30882

Proteomic databases

PaxDbiP30882
PRIDEiP30882

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042
GeneIDi20304
KEGGimmu:20304
UCSCiuc007kpi.2 mouse

Organism-specific databases

CTDi6352
MGIiMGI:98262 Ccl5

Phylogenomic databases

eggNOGiENOG410J0XH Eukaryota
ENOG410ZUYI LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP30882
KOiK12499
OMAiCCFAYLS
OrthoDBiEOG091G14Y2
PhylomeDBiP30882
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P30882
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035042 Expressed in 105 organ(s), highest expression level in blood
CleanExiMM_CCL5
ExpressionAtlasiP30882 baseline and differential
GenevisibleiP30882 MM

Family and domain databases

InterProiView protein in InterPro
IPR030595 CCL5
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PTHR12015:SF82 PTHR12015:SF82, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL5_MOUSE
AccessioniPrimary (citable) accession number: P30882
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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