UniProtKB - P30882 (CCL5_MOUSE)
C-C motif chemokine 5
Ccl5
Functioni
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
By similarityGO - Molecular functioni
- CCR1 chemokine receptor binding Source: BHF-UCL
- CCR5 chemokine receptor binding Source: BHF-UCL
- CCR chemokine receptor binding Source: GO_Central
- chemoattractant activity Source: MGI
- chemokine activity Source: BHF-UCL
- chemokine receptor antagonist activity Source: BHF-UCL
- chemokine receptor binding Source: MGI
- heparin binding Source: MGI
- identical protein binding Source: MGI
- phosphatidylinositol phospholipase C activity Source: MGI
- phospholipase activator activity Source: MGI
- protein homodimerization activity Source: BHF-UCL
- protein kinase activity Source: MGI
- protein self-association Source: BHF-UCL
- receptor signaling protein tyrosine kinase activator activity Source: BHF-UCL
GO - Biological processi
- activation of phospholipase D activity Source: BHF-UCL
- calcium ion transport Source: MGI
- cell-cell signaling Source: BHF-UCL
- cellular calcium ion homeostasis Source: MGI
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to organic cyclic compound Source: MGI
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: UniProtKB
- eosinophil chemotaxis Source: BHF-UCL
- exocytosis Source: MGI
- G protein-coupled receptor signaling pathway Source: UniProtKB
- inflammatory response Source: MGI
- leukocyte cell-cell adhesion Source: BHF-UCL
- lipopolysaccharide-mediated signaling pathway Source: MGI
- lymphocyte chemotaxis Source: MGI
- MAPK cascade Source: MGI
- monocyte chemotaxis Source: GO_Central
- negative regulation by host of viral transcription Source: MGI
- negative regulation of cell death Source: MGI
- negative regulation of G protein-coupled receptor signaling pathway Source: MGI
- negative regulation of macrophage apoptotic process Source: BHF-UCL
- negative regulation of neuron death Source: MGI
- negative regulation of T cell apoptotic process Source: BHF-UCL
- negative regulation of viral genome replication Source: BHF-UCL
- neutrophil activation Source: BHF-UCL
- neutrophil chemotaxis Source: GO_Central
- positive regulation of angiogenesis Source: MGI
- positive regulation of calcium ion transport Source: MGI
- positive regulation of cell adhesion Source: BHF-UCL
- positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
- positive regulation of cell migration Source: MGI
- positive regulation of cellular biosynthetic process Source: BHF-UCL
- positive regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
- positive regulation of defense response to virus by host Source: BHF-UCL
- positive regulation of epithelial cell proliferation Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of fever generation Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of homotypic cell-cell adhesion Source: BHF-UCL
- positive regulation of macrophage chemotaxis Source: BHF-UCL
- positive regulation of mast cell chemotaxis Source: MGI
- positive regulation of monocyte chemotaxis Source: BHF-UCL
- positive regulation of natural killer cell chemotaxis Source: MGI
- positive regulation of neuron differentiation Source: MGI
- positive regulation of osteoclast differentiation Source: MGI
- positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
- positive regulation of phosphorylation Source: BHF-UCL
- positive regulation of smooth muscle cell migration Source: BHF-UCL
- positive regulation of smooth muscle cell proliferation Source: BHF-UCL
- positive regulation of T cell apoptotic process Source: BHF-UCL
- positive regulation of T cell chemotaxis Source: BHF-UCL
- positive regulation of T cell migration Source: MGI
- positive regulation of T cell proliferation Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- protein kinase B signaling Source: MGI
- pseudopodium assembly Source: MGI
- regulation of insulin secretion Source: UniProtKB
- regulation of neuron death Source: UniProtKB
- regulation of T cell activation Source: BHF-UCL
- response to cytokine Source: MGI
- response to interferon-gamma Source: MGI
- response to toxic substance Source: MGI
- response to tumor necrosis factor Source: MGI
- T-helper 1 cell diapedesis Source: MGI
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 5Alternative name(s): MuRantes SIS-delta Small-inducible cytokine A5 T-cell-specific protein RANTES |
Gene namesi | Name:Ccl5 Synonyms:Scya5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98262, Ccl5 |
VEuPathDBi | HostDB:ENSMUSG00000035042 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000005179 | 24 – 91 | C-C motif chemokine 5Add BLAST | 68 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 57 | By similarity | ||
Disulfide bondi | 34 ↔ 73 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P30882 |
PRIDEi | P30882 |
ProteomicsDBi | 281333 |
PTM databases
PhosphoSitePlusi | P30882 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000035042, Expressed in blood and 135 other tissues |
ExpressionAtlasi | P30882, baseline and differential |
Genevisiblei | P30882, MM |
Interactioni
GO - Molecular functioni
- CCR1 chemokine receptor binding Source: BHF-UCL
- CCR5 chemokine receptor binding Source: BHF-UCL
- CCR chemokine receptor binding Source: GO_Central
- chemoattractant activity Source: MGI
- chemokine activity Source: BHF-UCL
- chemokine receptor antagonist activity Source: BHF-UCL
- chemokine receptor binding Source: MGI
- identical protein binding Source: MGI
- protein homodimerization activity Source: BHF-UCL
- protein self-association Source: BHF-UCL
Protein-protein interaction databases
IntActi | P30882, 4 interactors |
STRINGi | 10090.ENSMUSP00000039600 |
Miscellaneous databases
RNActi | P30882, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P30882 |
SMRi | P30882 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S8D1, Eukaryota |
GeneTreei | ENSGT01000000214365 |
HOGENOMi | CLU_141716_4_2_1 |
InParanoidi | P30882 |
OMAi | CCFAYLS |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P30882 |
TreeFami | TF334888 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MKISAAALTI ILTAAALCTP APASPYGSDT TPCCFAYLSL ALPRAHVKEY
60 70 80 90
FYTSSKCSNL AVVFVTRRNR QVCANPEKKW VQEYINYLEM S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | T → A in AAB22330 (PubMed:1376260).Curated | 1 | |
Sequence conflicti | 41 | A → E in AAA40029 (PubMed:1375672).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77747 mRNA Translation: AAA40029.1 S37648 mRNA Translation: AAB22330.1 U02298 Unassigned DNA Translation: AAA18302.1 X70675 Genomic DNA Translation: CAA50011.1 AF065944 mRNA Translation: AAC17511.1 AF065945 mRNA Translation: AAC17512.1 AF065946 mRNA Translation: AAC17513.1 AF065947 mRNA Translation: AAC17514.1 AF128187 mRNA Translation: AAF22528.1 AB051897 Genomic DNA Translation: BAB18731.1 AK003101 mRNA Translation: BAB22566.1 BC033508 mRNA Translation: AAH33508.1 |
CCDSi | CCDS36254.1 |
PIRi | I48875, A46539 |
RefSeqi | NP_038681.2, NM_013653.3 |
Genome annotation databases
Ensembli | ENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042 |
GeneIDi | 20304 |
KEGGi | mmu:20304 |
UCSCi | uc007kpi.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77747 mRNA Translation: AAA40029.1 S37648 mRNA Translation: AAB22330.1 U02298 Unassigned DNA Translation: AAA18302.1 X70675 Genomic DNA Translation: CAA50011.1 AF065944 mRNA Translation: AAC17511.1 AF065945 mRNA Translation: AAC17512.1 AF065946 mRNA Translation: AAC17513.1 AF065947 mRNA Translation: AAC17514.1 AF128187 mRNA Translation: AAF22528.1 AB051897 Genomic DNA Translation: BAB18731.1 AK003101 mRNA Translation: BAB22566.1 BC033508 mRNA Translation: AAH33508.1 |
CCDSi | CCDS36254.1 |
PIRi | I48875, A46539 |
RefSeqi | NP_038681.2, NM_013653.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YAM | NMR | - | A/B | 24-91 | [»] | |
AlphaFoldDBi | P30882 | |||||
SMRi | P30882 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P30882, 4 interactors |
STRINGi | 10090.ENSMUSP00000039600 |
PTM databases
PhosphoSitePlusi | P30882 |
Proteomic databases
PaxDbi | P30882 |
PRIDEi | P30882 |
ProteomicsDBi | 281333 |
Protocols and materials databases
DNASUi | 20304 |
Genome annotation databases
Ensembli | ENSMUST00000035938; ENSMUSP00000039600; ENSMUSG00000035042 |
GeneIDi | 20304 |
KEGGi | mmu:20304 |
UCSCi | uc007kpi.2, mouse |
Organism-specific databases
CTDi | 6352 |
MGIi | MGI:98262, Ccl5 |
VEuPathDBi | HostDB:ENSMUSG00000035042 |
Phylogenomic databases
eggNOGi | ENOG502S8D1, Eukaryota |
GeneTreei | ENSGT01000000214365 |
HOGENOMi | CLU_141716_4_2_1 |
InParanoidi | P30882 |
OMAi | CCFAYLS |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P30882 |
TreeFami | TF334888 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 20304, 2 hits in 77 CRISPR screens |
PROi | PR:P30882 |
RNActi | P30882, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035042, Expressed in blood and 135 other tissues |
ExpressionAtlasi | P30882, baseline and differential |
Genevisiblei | P30882, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL5_MOUSE | |
Accessioni | P30882Primary (citable) accession number: P30882 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families