UniProtKB - P30874 (SSR2_HUMAN)
Somatostatin receptor type 2
SSTR2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 89 | Important for ligand binding | 1 |
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- PDZ domain binding Source: UniProtKB
- peptide binding Source: GO_Central
- somatostatin receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
- cellular response to estradiol stimulus Source: GO_Central
- cellular response to glucocorticoid stimulus Source: GO_Central
- cerebellum development Source: Ensembl
- forebrain development Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- negative regulation of cell population proliferation Source: ProtInc
- neuropeptide signaling pathway Source: GO_Central
- peristalsis Source: Ensembl
- regulation of muscle contraction Source: Ensembl
- response to starvation Source: Ensembl
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P30874 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P30874 |
SIGNORi | P30874 |
Names & Taxonomyi
Protein namesi | Recommended name: Somatostatin receptor type 2Short name: SS-2-R Short name: SS2-R Short name: SS2R Alternative name(s): SRIF-1 |
Gene namesi | Name:SSTR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11331, SSTR2 |
MIMi | 182452, gene |
neXtProti | NX_P30874 |
VEuPathDBi | HostDB:ENSG00000180616.8 |
Subcellular locationi
Plasma membrane
Other locations
Note: Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Cytosol
- cytosol Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 43 | ExtracellularSequence analysisAdd BLAST | 43 | |
Transmembranei | 44 – 67 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 68 – 78 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 79 – 103 | Helical; Name=2Sequence analysisAdd BLAST | 25 | |
Topological domaini | 104 – 118 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 119 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 139 – 161 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 162 – 181 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 182 – 207 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 208 – 229 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 230 – 253 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 254 – 278 | Helical; Name=6Sequence analysisAdd BLAST | 25 | |
Topological domaini | 279 – 288 | ExtracellularSequence analysis | 10 | |
Transmembranei | 289 – 303 | Helical; Name=7Sequence analysisAdd BLAST | 15 | |
Topological domaini | 304 – 369 | CytoplasmicSequence analysisAdd BLAST | 66 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 89 | D → A: Expression levels reduced by 60%. 1 Publication | 1 | |
Mutagenesisi | 89 | D → L: Expression levels reduced by 80%. 1 Publication | 1 | |
Mutagenesisi | 89 | D → R: Slightly reduced expression levels. Remains localized in membrane. Abolishes ligand binding and G protein-mediated calcium release. 1 Publication | 1 | |
Mutagenesisi | 139 | D → A: Expression levels reduced by 50%. Significantly reduced ligand binding capacity but increased affinity. Reduced G protein-mediated cAMP release but no effect on G-protein mediated calcium release. 1 Publication | 1 | |
Mutagenesisi | 139 | D → N: Expression levels reduced by 40%. No significant change in ligand binding capacity or affinity. Reduced G protein-mediated cAMP signaling but no effect on G protein-mediated calcium release. 1 Publication | 1 | |
Mutagenesisi | 140 | R → A: Slightly reduced expression levels. No significant change in ligand binding capacity or affinity. No significant change in G protein-mediated cAMP or calcium release. 1 Publication | 1 | |
Mutagenesisi | 140 | R → E: Almost abolishes expression. Abolishes membrane localization. 1 Publication | 1 | |
Mutagenesisi | 140 | R → L: Slightly reduced expression levels. Significantly reduced ligand binding capacity but increased affinity. Reduced G protein-mediated cAMP release but no effect on G protein-mediated calcium release. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 6752 |
OpenTargetsi | ENSG00000180616 |
PharmGKBi | PA36155 |
Miscellaneous databases
Pharosi | P30874, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1804 |
DrugBanki | DB13925, Dotatate gallium Ga-68 DB15494, Edotreotide gallium Ga-68 DB06791, Lanreotide DB13985, Lutetium Lu 177 dotatate DB06663, Pasireotide DB09099, Somatostatin DB04894, Vapreotide |
DrugCentrali | P30874 |
GuidetoPHARMACOLOGYi | 356 |
Genetic variation databases
BioMutai | SSTR2 |
DMDMi | 401126 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070120 | 1 – 369 | Somatostatin receptor type 2Add BLAST | 369 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 22 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 115 ↔ 193 | PROSITE-ProRule annotation | ||
Lipidationi | 328 | S-palmitoyl cysteineSequence analysis | 1 | |
Modified residuei | 341 | PhosphoserineBy similarity | 1 | |
Modified residuei | 343 | PhosphoserineBy similarity | 1 | |
Modified residuei | 348 | PhosphoserineBy similarity | 1 | |
Modified residuei | 353 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 354 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
jPOSTi | P30874 |
MassIVEi | P30874 |
PaxDbi | P30874 |
PeptideAtlasi | P30874 |
PRIDEi | P30874 |
ProteomicsDBi | 54743 [P30874-1] 54744 [P30874-2] |
PTM databases
GlyGeni | P30874, 4 sites |
iPTMneti | P30874 |
PhosphoSitePlusi | P30874 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000180616, Expressed in subventricular zone (inner) (primate) and 150 other tissues |
Genevisiblei | P30874, HS |
Organism-specific databases
HPAi | ENSG00000180616, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization.
Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface.
Interacts (via C-terminus) with SHANK1 (via PDZ domain).
3 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- PDZ domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112630, 7 interactors |
CORUMi | P30874 |
IntActi | P30874, 2 interactors |
MINTi | P30874 |
STRINGi | 9606.ENSP00000350198 |
Chemistry databases
BindingDBi | P30874 |
Miscellaneous databases
RNActi | P30874, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000156544 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P30874 |
OMAi | CLKKVGG |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P30874 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR002074, Somatstn_rcpt_2 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00588, SOMATOSTTN2R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDMADEPLNG SHTWLSIPFD LNGSVVSTNT SNQTEPYYDL TSNAVLTFIY
60 70 80 90 100
FVVCIIGLCG NTLVIYVILR YAKMKTITNI YILNLAIADE LFMLGLPFLA
110 120 130 140 150
MQVALVHWPF GKAICRVVMT VDGINQFTSI FCLTVMSIDR YLAVVHPIKS
160 170 180 190 200
AKWRRPRTAK MITMAVWGVS LLVILPIMIY AGLRSNQWGR SSCTINWPGE
210 220 230 240 250
SGAWYTGFII YTFILGFLVP LTIICLCYLF IIIKVKSSGI RVGSSKRKKS
260 270 280 290 300
EKKVTRMVSI VVAVFIFCWL PFYIFNVSSV SMAISPTPAL KGMFDFVVVL
310 320 330 340 350
TYANSCANPI LYAFLSDNFK KSFQNVLCLV KVSGTDDGER SDSKQDKSRL
360
NETTETQRTL LNGDLQTSI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 | I → T in BAG36594 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 122 | D → N in BAG36594 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 356 | T → A in BAG36594 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001922 | 332 – 369 | VSGTD…LQTSI → VDNSKSGEEGSCLDMIFRNN KNRKK in isoform B. CuratedAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81830 Genomic DNA Translation: AAA58248.1 AY236542 Genomic DNA Translation: AAO92064.1 AF184174 Genomic DNA Translation: AAF42809.1 AF184174 Genomic DNA Translation: AAF42810.1 AB065911 Genomic DNA Translation: BAC06126.1 AK290745 mRNA Translation: BAF83434.1 AK313866 mRNA Translation: BAG36594.1 BT019926 mRNA Translation: AAV38729.1 BC000256 mRNA Translation: AAH00256.1 BC009522 mRNA Translation: AAH09522.1 BC019610 mRNA Translation: AAH19610.1 BC095495 mRNA Translation: AAH95495.1 |
CCDSi | CCDS11691.1 [P30874-1] |
PIRi | B41795 |
RefSeqi | NP_001041.1, NM_001050.2 [P30874-1] |
Genome annotation databases
Ensembli | ENST00000357585; ENSP00000350198; ENSG00000180616 [P30874-1] |
GeneIDi | 6752 |
KEGGi | hsa:6752 |
UCSCi | uc002jje.4, human [P30874-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81830 Genomic DNA Translation: AAA58248.1 AY236542 Genomic DNA Translation: AAO92064.1 AF184174 Genomic DNA Translation: AAF42809.1 AF184174 Genomic DNA Translation: AAF42810.1 AB065911 Genomic DNA Translation: BAC06126.1 AK290745 mRNA Translation: BAF83434.1 AK313866 mRNA Translation: BAG36594.1 BT019926 mRNA Translation: AAV38729.1 BC000256 mRNA Translation: AAH00256.1 BC009522 mRNA Translation: AAH09522.1 BC019610 mRNA Translation: AAH19610.1 BC095495 mRNA Translation: AAH95495.1 |
CCDSi | CCDS11691.1 [P30874-1] |
PIRi | B41795 |
RefSeqi | NP_001041.1, NM_001050.2 [P30874-1] |
3D structure databases
SMRi | P30874 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112630, 7 interactors |
CORUMi | P30874 |
IntActi | P30874, 2 interactors |
MINTi | P30874 |
STRINGi | 9606.ENSP00000350198 |
Chemistry databases
BindingDBi | P30874 |
ChEMBLi | CHEMBL1804 |
DrugBanki | DB13925, Dotatate gallium Ga-68 DB15494, Edotreotide gallium Ga-68 DB06791, Lanreotide DB13985, Lutetium Lu 177 dotatate DB06663, Pasireotide DB09099, Somatostatin DB04894, Vapreotide |
DrugCentrali | P30874 |
GuidetoPHARMACOLOGYi | 356 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P30874, 4 sites |
iPTMneti | P30874 |
PhosphoSitePlusi | P30874 |
Genetic variation databases
BioMutai | SSTR2 |
DMDMi | 401126 |
Proteomic databases
jPOSTi | P30874 |
MassIVEi | P30874 |
PaxDbi | P30874 |
PeptideAtlasi | P30874 |
PRIDEi | P30874 |
ProteomicsDBi | 54743 [P30874-1] 54744 [P30874-2] |
Protocols and materials databases
ABCDi | P30874, 9 sequenced antibodies |
Antibodypediai | 1548, 369 antibodies |
DNASUi | 6752 |
Genome annotation databases
Ensembli | ENST00000357585; ENSP00000350198; ENSG00000180616 [P30874-1] |
GeneIDi | 6752 |
KEGGi | hsa:6752 |
UCSCi | uc002jje.4, human [P30874-1] |
Organism-specific databases
CTDi | 6752 |
DisGeNETi | 6752 |
GeneCardsi | SSTR2 |
HGNCi | HGNC:11331, SSTR2 |
HPAi | ENSG00000180616, Tissue enhanced (brain) |
MIMi | 182452, gene |
neXtProti | NX_P30874 |
OpenTargetsi | ENSG00000180616 |
PharmGKBi | PA36155 |
VEuPathDBi | HostDB:ENSG00000180616.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000156544 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P30874 |
OMAi | CLKKVGG |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P30874 |
TreeFami | TF315737 |
Enzyme and pathway databases
PathwayCommonsi | P30874 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P30874 |
SIGNORi | P30874 |
Miscellaneous databases
BioGRID-ORCSi | 6752, 2 hits in 872 CRISPR screens |
ChiTaRSi | SSTR2, human |
GeneWikii | Somatostatin_receptor_2 |
GenomeRNAii | 6752 |
Pharosi | P30874, Tclin |
PROi | PR:P30874 |
RNActi | P30874, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180616, Expressed in subventricular zone (inner) (primate) and 150 other tissues |
Genevisiblei | P30874, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR002074, Somatstn_rcpt_2 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00588, SOMATOSTTN2R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SSR2_HUMAN | |
Accessioni | P30874Primary (citable) accession number: P30874 Secondary accession number(s): A8K3Y0 Q9BWH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 10, 2021 | |
This is version 186 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries