UniProtKB - P30873 (SSR1_MOUSE)
Protein
Somatostatin receptor type 1
Gene
Sstr1
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- somatostatin receptor activity Source: MGI
GO - Biological processi
- cellular response to estradiol stimulus Source: GO_Central
- cellular response to leukemia inhibitory factor Source: MGI
- cerebellum development Source: Ensembl
- forebrain development Source: Ensembl
- glutamate receptor signaling pathway Source: MGI
- G protein-coupled receptor signaling pathway Source: MGI
- neuropeptide signaling pathway Source: MGI
- response to starvation Source: Ensembl
- spermatogenesis Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Somatostatin receptor type 1Short name: SS-1-R Short name: SS1-R Short name: SS1R Alternative name(s): SRIF-2 |
Gene namesi | Name:Sstr1 Synonyms:Smstr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98327, Sstr1 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- membrane Source: MGI
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 56 | ExtracellularSequence analysisAdd BLAST | 56 | |
Transmembranei | 57 – 84 | Helical; Name=1Sequence analysisAdd BLAST | 28 | |
Topological domaini | 85 – 94 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 95 – 120 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 121 – 131 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 132 – 153 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 154 – 175 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 176 – 196 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 219 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 220 – 244 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 245 – 270 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 271 – 296 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 297 – 303 | ExtracellularSequence analysis | 7 | |
Transmembranei | 304 – 327 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 328 – 391 | CytoplasmicSequence analysisAdd BLAST | 64 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4242 |
DrugCentrali | P30873 |
GuidetoPHARMACOLOGYi | 355 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070117 | 1 – 391 | Somatostatin receptor type 1Add BLAST | 391 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 44 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 48 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 130 ↔ 208 | PROSITE-ProRule annotation | ||
Lipidationi | 339 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P30873 |
PRIDEi | P30873 |
PTM databases
GlyGeni | P30873, 3 sites |
iPTMneti | P30873 |
PhosphoSitePlusi | P30873 |
SwissPalmi | P30873 |
Expressioni
Tissue specificityi
Jejunum and stomach.
Gene expression databases
Bgeei | ENSMUSG00000035431, Expressed in Ammon's horn and 71 other tissues |
ExpressionAtlasi | P30873, baseline and differential |
Genevisiblei | P30873, MM |
Interactioni
Binary interactionsi
P30873
With | #Exp. | IntAct |
---|---|---|
Dlg4 [Q62108] | 3 | EBI-7665262,EBI-300895 |
Protein-protein interaction databases
IntActi | P30873, 2 interactors |
MINTi | P30873 |
STRINGi | 10090.ENSMUSP00000106299 |
Chemistry databases
BindingDBi | P30873 |
Miscellaneous databases
RNActi | P30873, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161442 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P30873 |
OMAi | CYILIIA |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P30873 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001116, Somatstn_rcpt_1 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00587, SOMATOSTTN1R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P30873-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFPNGTASSP SSSPSPSPGS CGEGACSRGP GSGAADGMEE PGRNASQNGT
60 70 80 90 100
LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL
110 120 130 140 150
AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV
160 170 180 190 200
LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA
210 220 230 240 250
NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM
260 270 280 290 300
RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD
310 320 330 340 350
DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP
360 370 380 390
VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCASRIST L
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81831 Genomic DNA Translation: AAA58255.1 |
CCDSi | CCDS36456.1 |
PIRi | C41795 |
RefSeqi | NP_033242.1, NM_009216.3 XP_006515697.1, XM_006515634.3 |
Genome annotation databases
Ensembli | ENSMUST00000044299; ENSMUSP00000037045; ENSMUSG00000035431 ENSMUST00000110671; ENSMUSP00000106299; ENSMUSG00000035431 |
GeneIDi | 20605 |
KEGGi | mmu:20605 |
UCSCi | uc007npu.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M81831 Genomic DNA Translation: AAA58255.1 |
CCDSi | CCDS36456.1 |
PIRi | C41795 |
RefSeqi | NP_033242.1, NM_009216.3 XP_006515697.1, XM_006515634.3 |
3D structure databases
SMRi | P30873 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P30873, 2 interactors |
MINTi | P30873 |
STRINGi | 10090.ENSMUSP00000106299 |
Chemistry databases
BindingDBi | P30873 |
ChEMBLi | CHEMBL4242 |
DrugCentrali | P30873 |
GuidetoPHARMACOLOGYi | 355 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P30873, 3 sites |
iPTMneti | P30873 |
PhosphoSitePlusi | P30873 |
SwissPalmi | P30873 |
Proteomic databases
PaxDbi | P30873 |
PRIDEi | P30873 |
Protocols and materials databases
Antibodypediai | 4061, 415 antibodies |
DNASUi | 20605 |
Genome annotation databases
Ensembli | ENSMUST00000044299; ENSMUSP00000037045; ENSMUSG00000035431 ENSMUST00000110671; ENSMUSP00000106299; ENSMUSG00000035431 |
GeneIDi | 20605 |
KEGGi | mmu:20605 |
UCSCi | uc007npu.1, mouse |
Organism-specific databases
CTDi | 6751 |
MGIi | MGI:98327, Sstr1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000161442 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P30873 |
OMAi | CYILIIA |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P30873 |
TreeFami | TF315737 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-418594, G alpha (i) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 20605, 1 hit in 17 CRISPR screens |
PROi | PR:P30873 |
RNActi | P30873, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000035431, Expressed in Ammon's horn and 71 other tissues |
ExpressionAtlasi | P30873, baseline and differential |
Genevisiblei | P30873, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001116, Somatstn_rcpt_1 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00587, SOMATOSTTN1R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SSR1_MOUSE | |
Accessioni | P30873Primary (citable) accession number: P30873 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries