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Protein

Ribonuclease R

Gene

rnr

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity). Required for the expression of virulence genes on the large plasmid of S.flexneri at the post-transcriptional level.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease, RNA-binding
Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease RUniRule annotation (EC:3.1.13.1UniRule annotation)
Short name:
RNase RUniRule annotation
Alternative name(s):
Protein VacB
Gene namesi
Name:rnrUniRule annotation
Synonyms:vacB
Ordered Locus Names:SF4334, S4602
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001664111 – 813Ribonuclease RAdd BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei544N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP30851
SMRiP30851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini644 – 725S1 motifUniRule annotationAdd BLAST82

Sequence similaritiesi

Belongs to the RNR ribonuclease family. RNase R subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C40 Bacteria
COG0557 LUCA
HOGENOMiHOG000071120
KOiK12573

Family and domain databases

HAMAPiMF_01895 RNase_R, 1 hit
InterProiView protein in InterPro
IPR011129 CSD
IPR012340 NA-bd_OB-fold
IPR013223 RNase_B_OB_dom
IPR022966 RNase_II/R_CS
IPR004476 RNase_II/RNase_R
IPR011805 RNase_R
IPR013668 RNase_R_HTH_12
IPR022967 S1_dom
IPR003029 S1_domain
PfamiView protein in Pfam
PF08461 HTH_12, 1 hit
PF08206 OB_RNB, 2 hits
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 4 hits
TIGRFAMsiTIGR00358 3_prime_RNase, 1 hit
TIGR02063 RNase_R, 1 hit
PROSITEiView protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

P30851-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQDPFQERE AEKYANPIPS REFILEHLTK REKPASRDEL AVELHIEGEE
60 70 80 90 100
QLEGLRRRLR AMERDGQLVF TRRQCYALPE RLDLVKGTVI GHRDGYGFLR
110 120 130 140 150
VEGRKDDLYL SSEQMKTCIH GDQVLAQPLG ADRKGRREAR IVRVLVPKTS
160 170 180 190 200
QIVGRYFTEA GVGFVVPDDS RLSFDILIPP DQIMGARMGF VVVVELTQRP
210 220 230 240 250
TRRTKAVGKI VEVLGDNMGT GMAVDIALRT HEIPYIWPQA VEQQVAGLKE
260 270 280 290 300
EVPEEAKAGR VDLRDLPLVT IDGEDARDFD DAVYCEKKRG GGWRLWVAIA
310 320 330 340 350
DVSYYVRPPT PLDREARNRG TSVYFPSQVI PMLPEVLSNG LCSLNPQVDR
360 370 380 390 400
LCMVCEMTVS SKGRLTGYKF YEAVMSSHAR LTYTKVWHIL QGDQDLREQY
410 420 430 440 450
APLVKHLEEL HNLYKVLDKA REERGGISFE SEEAKFIFNA ERRIERIEQT
460 470 480 490 500
QRNDAHKLIE ECMILANISA ARFVEKAKEP ALFRIHDKPS TEAITSFRSV
510 520 530 540 550
LAELGLELPG GNKPEPRDYA ELLESVADRP DAEMLQTMLL RSMKQAIYDP
560 570 580 590 600
ENRGHFGLAL QSYAHFTSPI RRYPDLTLHR AIKYLLAKEQ GHQGNTTETG
610 620 630 640 650
GYHYSMEEML QLGQHCSMAE RRADEATRDV ADWLKCDFML DQVGNVFKGV
660 670 680 690 700
ISSVTGFGFF VRLDDLFIDG LVHVSSLDND YYRFDQVGQR LMGESSGQTY
710 720 730 740 750
RLGDRVEVRV EAVNMDERKI DFSLISSERA PRNVGKTARE KAKKGDAGKK
760 770 780 790 800
GGKRCQVGKK VNFEPDSAFR GEKKTKPKAA KKDARKAKKP SAKTQKIAAA
810
TKAKRAAKKK VAE
Length:813
Mass (Da):92,066
Last modified:January 10, 2003 - v4
Checksum:i759B6D1B40C24494
GO

Sequence cautioni

The sequence AAN45751 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP19534 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA01777 differs from that shown. Several sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti520 – 521AE → GQ in BAA01777 (PubMed:1400189).Curated2
Sequence conflicti624D → E in BAA01777 (PubMed:1400189).Curated1
Sequence conflicti628R → G in BAA01777 (PubMed:1400189).Curated1
Sequence conflicti718R → A in BAA01777 (PubMed:1400189).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN45751.1 Different initiation.
AE014073 Genomic DNA Translation: AAP19534.1 Different initiation.
D11024 Genomic DNA Translation: BAA01777.1 Frameshift.
RefSeqiNP_710044.3, NC_004337.2
WP_000076311.1, NZ_QDEA01000093.1

Genome annotation databases

EnsemblBacteriaiAAN45751; AAN45751; SF4334
AAP19534; AAP19534; S4602
GeneIDi1025395
KEGGisfl:SF4334
sfx:S4602
PATRICifig|198214.7.peg.5108

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN45751.1 Different initiation.
AE014073 Genomic DNA Translation: AAP19534.1 Different initiation.
D11024 Genomic DNA Translation: BAA01777.1 Frameshift.
RefSeqiNP_710044.3, NC_004337.2
WP_000076311.1, NZ_QDEA01000093.1

3D structure databases

ProteinModelPortaliP30851
SMRiP30851
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN45751; AAN45751; SF4334
AAP19534; AAP19534; S4602
GeneIDi1025395
KEGGisfl:SF4334
sfx:S4602
PATRICifig|198214.7.peg.5108

Phylogenomic databases

eggNOGiENOG4105C40 Bacteria
COG0557 LUCA
HOGENOMiHOG000071120
KOiK12573

Family and domain databases

HAMAPiMF_01895 RNase_R, 1 hit
InterProiView protein in InterPro
IPR011129 CSD
IPR012340 NA-bd_OB-fold
IPR013223 RNase_B_OB_dom
IPR022966 RNase_II/R_CS
IPR004476 RNase_II/RNase_R
IPR011805 RNase_R
IPR013668 RNase_R_HTH_12
IPR022967 S1_dom
IPR003029 S1_domain
PfamiView protein in Pfam
PF08461 HTH_12, 1 hit
PF08206 OB_RNB, 2 hits
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00357 CSP, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 4 hits
TIGRFAMsiTIGR00358 3_prime_RNase, 1 hit
TIGR02063 RNase_R, 1 hit
PROSITEiView protein in PROSITE
PS01175 RIBONUCLEASE_II, 1 hit
PS50126 S1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNR_SHIFL
AccessioniPrimary (citable) accession number: P30851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 10, 2003
Last modified: October 10, 2018
This is version 135 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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