UniProtKB - P30843 (BASR_ECOLI)
Protein
Transcriptional regulatory protein BasR
Gene
basR
Organism
Escherichia coli (strain K12)
Status
Functioni
Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS loci, all involved in resistance to polymyxin (By similarity).By similarity
Miscellaneous
The activity of the BasR protein is in some natural isolates, but not in strain K12, controlled at a post-transcriptional level by the PmrD protein under low Mg2+ concentration conditions.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 124 – 218 | OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST | 95 |
GO - Molecular functioni
- DNA-binding transcription activator activity Source: GO_Central
- phosphorelay response regulator activity Source: EcoCyc
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- phosphorelay signal transduction system Source: EcoCyc
- regulation of transcription, DNA-templated Source: EcoCyc
- response to antibiotic Source: UniProtKB-KW
- response to iron(III) ion Source: EcoCyc
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Antibiotic resistance, Transcription, Transcription regulation, Two-component regulatory system |
Enzyme and pathway databases
BioCyci | EcoCyc:BASR-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional regulatory protein BasR |
Gene namesi | Name:basR Synonyms:pmrA Ordered Locus Names:b4113, JW4074 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: GO_Central
Other locations
- protein-DNA complex Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081023 | 1 – 222 | Transcriptional regulatory protein BasRAdd BLAST | 222 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 51 | 4-aspartylphosphatePROSITE-ProRule annotation | 1 |
Post-translational modificationi
Phosphorylated by BasS.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P30843 |
PaxDbi | P30843 |
PRIDEi | P30843 |
Expressioni
Inductioni
The eptA-basRS operon is positively autoregulated by BasR under high iron or aluminum concentration conditions.By similarity
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 4263083, 7 interactors |
DIPi | DIP-9201N |
IntActi | P30843, 5 interactors |
STRINGi | 511145.b4113 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 116 | Response regulatoryPROSITE-ProRule annotationAdd BLAST | 115 |
Phylogenomic databases
eggNOGi | COG0745, Bacteria |
HOGENOMi | CLU_000445_30_1_6 |
InParanoidi | P30843 |
PhylomeDBi | P30843 |
Family and domain databases
CDDi | cd00383, trans_reg_C, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR001867, OmpR/PhoB-type_DNA-bd IPR016032, Sig_transdc_resp-reg_C-effctor IPR001789, Sig_transdc_resp-reg_receiver IPR039420, WalR-like IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR48111, PTHR48111, 1 hit |
Pfami | View protein in Pfam PF00072, Response_reg, 1 hit PF00486, Trans_reg_C, 1 hit |
SMARTi | View protein in SMART SM00448, REC, 1 hit SM00862, Trans_reg_C, 1 hit |
SUPFAMi | SSF46894, SSF46894, 1 hit SSF52172, SSF52172, 1 hit |
PROSITEi | View protein in PROSITE PS51755, OMPR_PHOB, 1 hit PS50110, RESPONSE_REGULATORY, 1 hit |
i Sequence
Sequence statusi: Complete.
P30843-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKILIVEDDT LLLQGLILAA QTEGYACDSV TTARMAEQSL EAGHYSLVVL
60 70 80 90 100
DLGLPDEDGL HFLARIRQKK YTLPVLILTA RDTLTDKIAG LDVGADDYLV
110 120 130 140 150
KPFALEELHA RIRALLRRHN NQGESELIVG NLTLNMGRRQ VWMGGEELIL
160 170 180 190 200
TPKEYALLSR LMLKAGSPVH REILYNDIYN WDNEPSTNTL EVHIHNLRDK
210 220
VGKARIRTVR GFGYMLVANE EN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | S → T (PubMed:8282725).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 29 | S → G in strain: ECOR 1, ECOR 10, ECOR 11, ECOR 12, ECOR 13, ECOR 14, ECOR 15, ECOR 16, ECOR 17, ECOR 18, ECOR 19, ECOR 2, ECOR 20, ECOR 21, ECOR 22, ECOR 24, ECOR 25, ECOR 26, ECOR 27, ECOR 3, ECOR 30, ECOR 33, ECOR 34, ECOR 35, ECOR 36, ECOR 37, ECOR 38, ECOR 4, ECOR 40, ECOR 41, ECOR 42, ECOR 43, ECOR 44, ECOR 45, ECOR 46, ECOR 47, ECOR 48, ECOR 5, ECOR 50, ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 6, ECOR 60, ECOR 61, ECOR 62, ECOR 63, ECOR 64, ECOR 65, ECOR 66, ECOR 67, ECOR 68, ECOR 69, ECOR 7, ECOR 70, ECOR 71, ECOR 72, ECOR 8 and ECOR 9. | 1 | |
Natural varianti | 31 | T → S in strain: ECOR 35, ECOR 36, ECOR 38, ECOR 40, ECOR 41, ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 60, ECOR 61, ECOR 62, ECOR 63 and ECOR 64, ECOR 65 and ECOR 66. | 1 | |
Natural varianti | 128 | I → N in strain: ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 60, ECOR 61, ECOR 62, ECOR 63 and ECOR 64. | 1 | |
Natural varianti | 129 | V → L in strain: ECOR 19. | 1 | |
Natural varianti | 144 | G → S in strain: ECOR 44, ECOR 48, ECOR 50, ECOR 51, ECOR 52, ECOR 53, ECOR 54, ECOR 55, ECOR 56, ECOR 57, ECOR 59, ECOR 60, ECOR 61, ECOR 62, ECOR 63, ECOR 64 and ECOR 72. | 1 | |
Natural varianti | 207 | R → P in strain: ECOR 27. | 1 | |
Natural varianti | 214 | Y → F in strain: ECOR 27. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14055 Genomic DNA Translation: BAA03143.1 AY725270 Genomic DNA Translation: AAV92717.1 AY725271 Genomic DNA Translation: AAV92718.1 AY725272 Genomic DNA Translation: AAV92719.1 AY725273 Genomic DNA Translation: AAV92720.1 AY725274 Genomic DNA Translation: AAV92721.1 AY725275 Genomic DNA Translation: AAV92722.1 AY725276 Genomic DNA Translation: AAV92723.1 AY725277 Genomic DNA Translation: AAV92724.1 AY725278 Genomic DNA Translation: AAV92725.1 AY725279 Genomic DNA Translation: AAV92726.1 AY725280 Genomic DNA Translation: AAV92727.1 AY725281 Genomic DNA Translation: AAV92728.1 AY725282 Genomic DNA Translation: AAV92729.1 AY725283 Genomic DNA Translation: AAV92730.1 AY725284 Genomic DNA Translation: AAV92731.1 AY725285 Genomic DNA Translation: AAV92732.1 AY725286 Genomic DNA Translation: AAV92733.1 AY725287 Genomic DNA Translation: AAV92734.1 AY725288 Genomic DNA Translation: AAV92735.1 AY725289 Genomic DNA Translation: AAV92736.1 AY725290 Genomic DNA Translation: AAV92737.1 AY725291 Genomic DNA Translation: AAV92738.1 AY725292 Genomic DNA Translation: AAV92739.1 AY725293 Genomic DNA Translation: AAV92740.1 AY725294 Genomic DNA Translation: AAV92741.1 AY725295 Genomic DNA Translation: AAV92742.1 AY725296 Genomic DNA Translation: AAV92743.1 AY725297 Genomic DNA Translation: AAV92744.1 AY725298 Genomic DNA Translation: AAV92745.1 AY725299 Genomic DNA Translation: AAV92746.1 AY725300 Genomic DNA Translation: AAV92747.1 AY725301 Genomic DNA Translation: AAV92748.1 AY725302 Genomic DNA Translation: AAV92749.1 AY725303 Genomic DNA Translation: AAV92750.1 AY725304 Genomic DNA Translation: AAV92751.1 AY725305 Genomic DNA Translation: AAV92752.1 AY725306 Genomic DNA Translation: AAV92753.1 AY725307 Genomic DNA Translation: AAV92754.1 AY725308 Genomic DNA Translation: AAV92755.1 AY725309 Genomic DNA Translation: AAV92756.1 AY725310 Genomic DNA Translation: AAV92757.1 AY725311 Genomic DNA Translation: AAV92758.1 AY725312 Genomic DNA Translation: AAV92759.1 AY725313 Genomic DNA Translation: AAV92760.1 AY725314 Genomic DNA Translation: AAV92761.1 AY725315 Genomic DNA Translation: AAV92762.1 AY725316 Genomic DNA Translation: AAV92763.1 AY725317 Genomic DNA Translation: AAV92764.1 AY725318 Genomic DNA Translation: AAV92765.1 AY725319 Genomic DNA Translation: AAV92766.1 AY725320 Genomic DNA Translation: AAV92767.1 AY725321 Genomic DNA Translation: AAV92768.1 AY725322 Genomic DNA Translation: AAV92769.1 AY725323 Genomic DNA Translation: AAV92770.1 AY725324 Genomic DNA Translation: AAV92771.1 AY725325 Genomic DNA Translation: AAV92772.1 AY725326 Genomic DNA Translation: AAV92773.1 AY725327 Genomic DNA Translation: AAV92774.1 AY725328 Genomic DNA Translation: AAV92775.1 AY725329 Genomic DNA Translation: AAV92776.1 AY725330 Genomic DNA Translation: AAV92777.1 AY725331 Genomic DNA Translation: AAV92778.1 AY725332 Genomic DNA Translation: AAV92779.1 AY725333 Genomic DNA Translation: AAV92780.1 U14003 Genomic DNA Translation: AAA97012.1 U00096 Genomic DNA Translation: AAC77074.1 AP009048 Genomic DNA Translation: BAE78115.1 |
PIRi | H65220 |
RefSeqi | NP_418537.1, NC_000913.3 WP_000697919.1, NZ_STEB01000014.1 WP_000697926.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC77074; AAC77074; b4113 BAE78115; BAE78115; BAE78115 |
GeneIDi | 948631 |
KEGGi | ecj:JW4074 eco:b4113 |
PATRICi | fig|1411691.4.peg.2587 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D14055 Genomic DNA Translation: BAA03143.1 AY725270 Genomic DNA Translation: AAV92717.1 AY725271 Genomic DNA Translation: AAV92718.1 AY725272 Genomic DNA Translation: AAV92719.1 AY725273 Genomic DNA Translation: AAV92720.1 AY725274 Genomic DNA Translation: AAV92721.1 AY725275 Genomic DNA Translation: AAV92722.1 AY725276 Genomic DNA Translation: AAV92723.1 AY725277 Genomic DNA Translation: AAV92724.1 AY725278 Genomic DNA Translation: AAV92725.1 AY725279 Genomic DNA Translation: AAV92726.1 AY725280 Genomic DNA Translation: AAV92727.1 AY725281 Genomic DNA Translation: AAV92728.1 AY725282 Genomic DNA Translation: AAV92729.1 AY725283 Genomic DNA Translation: AAV92730.1 AY725284 Genomic DNA Translation: AAV92731.1 AY725285 Genomic DNA Translation: AAV92732.1 AY725286 Genomic DNA Translation: AAV92733.1 AY725287 Genomic DNA Translation: AAV92734.1 AY725288 Genomic DNA Translation: AAV92735.1 AY725289 Genomic DNA Translation: AAV92736.1 AY725290 Genomic DNA Translation: AAV92737.1 AY725291 Genomic DNA Translation: AAV92738.1 AY725292 Genomic DNA Translation: AAV92739.1 AY725293 Genomic DNA Translation: AAV92740.1 AY725294 Genomic DNA Translation: AAV92741.1 AY725295 Genomic DNA Translation: AAV92742.1 AY725296 Genomic DNA Translation: AAV92743.1 AY725297 Genomic DNA Translation: AAV92744.1 AY725298 Genomic DNA Translation: AAV92745.1 AY725299 Genomic DNA Translation: AAV92746.1 AY725300 Genomic DNA Translation: AAV92747.1 AY725301 Genomic DNA Translation: AAV92748.1 AY725302 Genomic DNA Translation: AAV92749.1 AY725303 Genomic DNA Translation: AAV92750.1 AY725304 Genomic DNA Translation: AAV92751.1 AY725305 Genomic DNA Translation: AAV92752.1 AY725306 Genomic DNA Translation: AAV92753.1 AY725307 Genomic DNA Translation: AAV92754.1 AY725308 Genomic DNA Translation: AAV92755.1 AY725309 Genomic DNA Translation: AAV92756.1 AY725310 Genomic DNA Translation: AAV92757.1 AY725311 Genomic DNA Translation: AAV92758.1 AY725312 Genomic DNA Translation: AAV92759.1 AY725313 Genomic DNA Translation: AAV92760.1 AY725314 Genomic DNA Translation: AAV92761.1 AY725315 Genomic DNA Translation: AAV92762.1 AY725316 Genomic DNA Translation: AAV92763.1 AY725317 Genomic DNA Translation: AAV92764.1 AY725318 Genomic DNA Translation: AAV92765.1 AY725319 Genomic DNA Translation: AAV92766.1 AY725320 Genomic DNA Translation: AAV92767.1 AY725321 Genomic DNA Translation: AAV92768.1 AY725322 Genomic DNA Translation: AAV92769.1 AY725323 Genomic DNA Translation: AAV92770.1 AY725324 Genomic DNA Translation: AAV92771.1 AY725325 Genomic DNA Translation: AAV92772.1 AY725326 Genomic DNA Translation: AAV92773.1 AY725327 Genomic DNA Translation: AAV92774.1 AY725328 Genomic DNA Translation: AAV92775.1 AY725329 Genomic DNA Translation: AAV92776.1 AY725330 Genomic DNA Translation: AAV92777.1 AY725331 Genomic DNA Translation: AAV92778.1 AY725332 Genomic DNA Translation: AAV92779.1 AY725333 Genomic DNA Translation: AAV92780.1 U14003 Genomic DNA Translation: AAA97012.1 U00096 Genomic DNA Translation: AAC77074.1 AP009048 Genomic DNA Translation: BAE78115.1 |
PIRi | H65220 |
RefSeqi | NP_418537.1, NC_000913.3 WP_000697919.1, NZ_STEB01000014.1 WP_000697926.1, NZ_LN832404.1 |
3D structure databases
SMRi | P30843 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263083, 7 interactors |
DIPi | DIP-9201N |
IntActi | P30843, 5 interactors |
STRINGi | 511145.b4113 |
Proteomic databases
jPOSTi | P30843 |
PaxDbi | P30843 |
PRIDEi | P30843 |
Genome annotation databases
EnsemblBacteriai | AAC77074; AAC77074; b4113 BAE78115; BAE78115; BAE78115 |
GeneIDi | 948631 |
KEGGi | ecj:JW4074 eco:b4113 |
PATRICi | fig|1411691.4.peg.2587 |
Organism-specific databases
EchoBASEi | EB1572 |
Phylogenomic databases
eggNOGi | COG0745, Bacteria |
HOGENOMi | CLU_000445_30_1_6 |
InParanoidi | P30843 |
PhylomeDBi | P30843 |
Enzyme and pathway databases
BioCyci | EcoCyc:BASR-MONOMER |
Miscellaneous databases
PROi | PR:P30843 |
Family and domain databases
CDDi | cd00383, trans_reg_C, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR011006, CheY-like_superfamily IPR001867, OmpR/PhoB-type_DNA-bd IPR016032, Sig_transdc_resp-reg_C-effctor IPR001789, Sig_transdc_resp-reg_receiver IPR039420, WalR-like IPR036388, WH-like_DNA-bd_sf |
PANTHERi | PTHR48111, PTHR48111, 1 hit |
Pfami | View protein in Pfam PF00072, Response_reg, 1 hit PF00486, Trans_reg_C, 1 hit |
SMARTi | View protein in SMART SM00448, REC, 1 hit SM00862, Trans_reg_C, 1 hit |
SUPFAMi | SSF46894, SSF46894, 1 hit SSF52172, SSF52172, 1 hit |
PROSITEi | View protein in PROSITE PS51755, OMPR_PHOB, 1 hit PS50110, RESPONSE_REGULATORY, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BASR_ECOLI | |
Accessioni | P30843Primary (citable) accession number: P30843 Secondary accession number(s): Q2M6J1 Q5MNH0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | August 29, 2003 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |