UniProtKB - P30838 (AL3A1_HUMAN)

BLAST

>sp|P30838|AL3A1_HUMAN Aldehyde dehydrogenase, dimeric NADP-preferring OS=Homo sapiens OX=9606 GN=ALDH3A1 PE=1 SV=3
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH

Align
Format
Add to basket Added to basket
History
Entry version 175 (12 Sep 2018)
Sequence version 3 (02 Nov 2010)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Aldehyde dehydrogenase, dimeric NADP-preferring

Gene

ALDH3A1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).By similarityCurated1 Publication

Catalytic activityⁱ

An aldehyde + NAD(P)⁺ + H₂O = a carboxylate + NAD(P)H.2 Publications

Kineticsⁱ

Has a high Km for acetaldehyde.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	210	1 Publication		1
Active siteⁱ	244	1 Publication		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	188 – 193	NAD or NADPBy similarity		6

GO - Molecular functionⁱ

3-chloroallyl aldehyde dehydrogenase activity Source: Ensembl
alcohol dehydrogenase (NADP+) activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1737758
aldehyde dehydrogenase (NAD) activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1737758
aldehyde dehydrogenase [NAD(P)+] activity Source: Reactome
benzaldehyde dehydrogenase (NAD+) activity
Source: CACAO
Inferred from direct assayⁱ
- 4015840

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular aldehyde metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 1737758
oxidation-reduction process
Source: UniProtKB
Inferred from direct assayⁱ
- 1737758
xenobiotic metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD, NADP

Enzyme and pathway databases

BRENDAⁱ	1.2.1.5 2681
Reactomeⁱ	R-HSA-211945 Phase I - Functionalization of compounds
SABIO-RKⁱ	P30838

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aldehyde dehydrogenase, dimeric NADP-preferring (EC:1.2.1.52 Publications) Alternative name(s): ALDHIII Aldehyde dehydrogenase 3 Aldehyde dehydrogenase family 3 member A1
Gene namesⁱ	Name:ALDH3A1 Synonyms:ALDH3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108602.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:405 ALDH3A1
MIMⁱ	100660 gene
neXtProtⁱ	NX_P30838

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	244	C → S: Abolishes activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	218
Open Targets More...OpenTargetsⁱ	ENSG00000108602
PharmGKBⁱ	PA24697

Chemistry databases

ChEMBLⁱ	CHEMBL3578
Drug and drug target database More...DrugBankⁱ	DB00157 NADH

Polymorphism and mutation databases

BioMutaⁱ	ALDH3A1
DMDMⁱ	311033473

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000056470	2 – 453	Aldehyde dehydrogenase, dimeric NADP-preferringAdd BLAST		452

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	178	N6-acetyllysineCombined sources	1
Modified residueⁱ	194	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P30838
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P30838
PaxDbⁱ	P30838
PeptideAtlas More...PeptideAtlasⁱ	P30838
PRIDEⁱ	P30838
ProteomicsDBⁱ	54741

PTM databases

iPTMnetⁱ	P30838
PhosphoSitePlusⁱ	P30838

Expressionⁱ

Tissue specificityⁱ

High levels in stomach, esophagus and lung; low level in the liver and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000108602 Expressed in 141 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_ALDH3A1
ExpressionAtlasⁱ	P30838 baseline and differential
Genevisibleⁱ	P30838 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB045957 HPA051150 HPA063783

HPAⁱ

CAB045957
HPA051150
HPA063783

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
POT1	Q9NUX5	2	EBI-3905126,EBI-752420

With

Entry

#Exp.

IntAct

Notes

POT1

Q9NUX5

EBI-3905126,EBI-752420

Protein-protein interaction databases

BioGridⁱ	106720, 20 interactors
IntActⁱ	P30838, 5 interactors
STRINGⁱ	9606.ENSP00000225740

Chemistry databases

BindingDBⁱ

P30838

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	3 – 16	Combined sources	14
Turnⁱ	17 – 20	Combined sources	4
Helixⁱ	23 – 39	Combined sources	17
Helixⁱ	41 – 52	Combined sources	12
Helixⁱ	56 – 61	Combined sources	6
Helixⁱ	64 – 82	Combined sources	19
Helixⁱ	91 – 93	Combined sources	3
Beta strandⁱ	96 – 104	Combined sources	9
Beta strandⁱ	106 – 111	Combined sources	6
Beta strandⁱ	114 – 116	Combined sources	3
Helixⁱ	119 – 130	Combined sources	12
Beta strandⁱ	134 – 138	Combined sources	5
Beta strandⁱ	141 – 143	Combined sources	3
Helixⁱ	144 – 157	Combined sources	14
Turnⁱ	160 – 162	Combined sources	3
Helixⁱ	170 – 176	Combined sources	7
Beta strandⁱ	182 – 188	Combined sources	7
Helixⁱ	190 – 201	Combined sources	12
Turnⁱ	202 – 204	Combined sources	3
Beta strandⁱ	207 – 210	Combined sources	4
Beta strandⁱ	216 – 219	Combined sources	4
Helixⁱ	225 – 237	Combined sources	13
Helixⁱ	238 – 241	Combined sources	4
Beta strandⁱ	249 – 252	Combined sources	4
Helixⁱ	254 – 256	Combined sources	3
Helixⁱ	257 – 272	Combined sources	16
Helixⁱ	276 – 278	Combined sources	3
Helixⁱ	288 – 298	Combined sources	11
Beta strandⁱ	301 – 305	Combined sources	5
Turnⁱ	311 – 314	Combined sources	4
Beta strandⁱ	319 – 323	Combined sources	5
Helixⁱ	329 – 331	Combined sources	3
Beta strandⁱ	337 – 344	Combined sources	8
Helixⁱ	348 – 357	Combined sources	10
Beta strandⁱ	362 – 367	Combined sources	6
Helixⁱ	371 – 380	Combined sources	10
Beta strandⁱ	384 – 389	Combined sources	6
Helixⁱ	393 – 395	Combined sources	3
Helixⁱ	406 – 408	Combined sources	3
Helixⁱ	416 – 421	Combined sources	6
Beta strandⁱ	423 – 430	Combined sources	8
Helixⁱ	437 – 442	Combined sources	6
Beta strandⁱ	443 – 445	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P30838
SMRⁱ	P30838
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P30838

EvolutionaryTraceⁱ

P30838

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2456 Eukaryota COG1012 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000002825
HOGENOMⁱ	HOG000271515
HOVERGENⁱ	HBG050483
InParanoidⁱ	P30838
KEGG Orthology (KO) More...KOⁱ	K00129
OMAⁱ	QKLPEWA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05HC
PhylomeDBⁱ	P30838
TreeFamⁱ	TF314264

Family and domain databases

Gene3Dⁱ	3.40.309.10, 1 hit 3.40.605.10, 2 hits
InterProⁱ	View protein in InterPro IPR016161 Ald_DH/histidinol_DH IPR016163 Ald_DH_C IPR016160 Ald_DH_CS_CYS IPR029510 Ald_DH_CS_GLU IPR016162 Ald_DH_N IPR015590 Aldehyde_DH_dom IPR012394 Aldehyde_DH_NAD(P)
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00171 Aldedh, 1 hit
PIRSFⁱ	PIRSF036492 ALDH, 1 hit
SUPFAMⁱ	SSF53720 SSF53720, 1 hit
PROSITEⁱ	View protein in PROSITE PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

P30838-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA 
        60         70         80         90        100
DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI 
       110        120        130        140        150
HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNSVVLKPS ELSENMASLL 
       160        170        180        190        200
ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA 
       210        220        230        240        250
AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI 
       260        270        280        290        300
LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG 
       310        320        330        340        350
QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE 
       360        370        380        390        400
AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL 
       410        420        430        440        450
PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM 

TQH

Length:453

Mass (Da):50,395

Last modified:November 2, 2010 - v3

Checksum:ⁱD35C488A022FAACA

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A8MYB8	A8MYB8_HUMAN	Aldehyde dehydrogenase, dimeric NAD... Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	389	Annotation score:
I3L3I9	I3L3I9_HUMAN	Aldehyde dehydrogenase, dimeric NAD... Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	380	Annotation score:
C9JMC5	C9JMC5_HUMAN	Aldehyde dehydrogenase, dimeric NAD... Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	372	Annotation score:
C9JKT2	C9JKT2_HUMAN	Aldehyde dehydrogenase, dimeric NAD... Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	259	Annotation score:
E9PNN6	E9PNN6_HUMAN	Aldehyde dehydrogenase, dimeric NAD... Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	396	Annotation score:
I3L1H6	I3L1H6_HUMAN	Aldehyde dehydrogenase, dimeric NAD... Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	131	Annotation score:
I3L3W9	I3L3W9_HUMAN	Aldehyde dehydrogenase, dimeric NAD... Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	74	Annotation score:
I3L4E5	I3L4E5_HUMAN	Aldehyde dehydrogenase, dimeric NAD... Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	119	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	12	R → P in AAB46377 (PubMed:1737758).Curated	1
Sequence conflictⁱ	12	R → P in AAB26658 (PubMed:8493892).Curated	1
Sequence conflictⁱ	27	I → F in AAA51696 (Ref. 1) Curated	1
Sequence conflictⁱ	170	V → L AA sequence (PubMed:2037078).Curated	1
Sequence conflictⁱ	436	D → E AA sequence (PubMed:2037078).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018981	134	S → A5 PublicationsCorresponds to variant dbSNP:rs887241Ensembl.	1
Natural variantⁱVAR_018982	309	G → E. Corresponds to variant dbSNP:rs3744692Ensembl.	1
Natural variantⁱVAR_011303	329	P → A in allele ALDH3A1*2. 1 PublicationCorresponds to variant dbSNP:rs2228100Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74542 mRNA Translation: AAA51696.1 M77477 mRNA Translation: AAB46377.1 S61044 mRNA Translation: AAB26658.1 BT007102 mRNA Translation: AAP35766.1 AK292193 mRNA Translation: BAF84882.1 AK314584 mRNA Translation: BAG37160.1 AC005722 Genomic DNA No translation available. CH471212 Genomic DNA Translation: EAW50909.1 BC004370 mRNA Translation: AAH04370.1 BC008892 mRNA Translation: AAH08892.1 BC021194 mRNA Translation: AAH21194.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11212.1
PIRⁱ	A42584
NCBI Reference Sequences More...RefSeqⁱ	NP_000682.3, NM_000691.4 NP_001128639.1, NM_001135167.1 NP_001128640.1, NM_001135168.1
UniGeneⁱ	Hs.531682

Genome annotation databases

Ensemblⁱ	ENST00000225740; ENSP00000225740; ENSG00000108602 ENST00000444455; ENSP00000388469; ENSG00000108602 ENST00000457500; ENSP00000411821; ENSG00000108602
GeneIDⁱ	218
KEGGⁱ	hsa:218
UCSC genome browser More...UCSCⁱ	uc002gwj.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30838	Aldehyde dehydrogenase, dimeric NADP-preferring (Fragment)		HUMAN		372	UniRef100_P30838
Aldehyde dehydrogenase, dimeric NADP-preferring		HUMAN		380

Protein	Similar proteins		Species	Score	Length	Source
P30838	Aldehyde dehydrogenase, dimeric NADP-preferring (Fragment)		HUMAN		372	UniRef90_P30838
Aldehyde dehydrogenase		CERAT		480
Aldehyde dehydrogenase		MACFA		480
Aldehyde dehydrogenase		MACNE		480
Aldehyde dehydrogenase		RHIRO		480
+52

Protein	Similar proteins		Species	Score	Length	Source
P30838	Aldehyde dehydrogenase, dimeric NADP-preferring (Fragment)		HUMAN		372	UniRef50_P30838
Aldehyde dehydrogenase		MACFA		480
Aldehyde dehydrogenase		MACNE		480
Aldehyde dehydrogenase		CERAT		480
Aldehyde dehydrogenase		PAPAN		480
+54

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74542 mRNA Translation: AAA51696.1 M77477 mRNA Translation: AAB46377.1 S61044 mRNA Translation: AAB26658.1 BT007102 mRNA Translation: AAP35766.1 AK292193 mRNA Translation: BAF84882.1 AK314584 mRNA Translation: BAG37160.1 AC005722 Genomic DNA No translation available. CH471212 Genomic DNA Translation: EAW50909.1 BC004370 mRNA Translation: AAH04370.1 BC008892 mRNA Translation: AAH08892.1 BC021194 mRNA Translation: AAH21194.1
CCDSⁱ	CCDS11212.1
PIRⁱ	A42584
RefSeqⁱ	NP_000682.3, NM_000691.4 NP_001128639.1, NM_001135167.1 NP_001128640.1, NM_001135168.1
UniGeneⁱ	Hs.531682

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3SZA	X-ray	1.48	A/B	1-453	[»]
	3SZB	X-ray	1.51	A/B	1-453	[»]
	4H80	X-ray	2.50	A/B/C/D/E/F/G/H	1-453	[»]
	4L1O	X-ray	2.30	A/B	1-453	[»]
	4L2O	X-ray	1.94	A/B/E/G	1-453	[»]
ProteinModelPortalⁱ	P30838
SMRⁱ	P30838
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106720, 20 interactors
IntActⁱ	P30838, 5 interactors
STRINGⁱ	9606.ENSP00000225740

Chemistry databases

BindingDBⁱ	P30838
ChEMBLⁱ	CHEMBL3578
DrugBankⁱ	DB00157 NADH

PTM databases

iPTMnetⁱ	P30838
PhosphoSitePlusⁱ	P30838

Polymorphism and mutation databases

BioMutaⁱ	ALDH3A1
DMDMⁱ	311033473

Proteomic databases

EPDⁱ	P30838
MaxQBⁱ	P30838
PaxDbⁱ	P30838
PeptideAtlasⁱ	P30838
PRIDEⁱ	P30838
ProteomicsDBⁱ	54741

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	218
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000225740; ENSP00000225740; ENSG00000108602 ENST00000444455; ENSP00000388469; ENSG00000108602 ENST00000457500; ENSP00000411821; ENSG00000108602
GeneIDⁱ	218
KEGGⁱ	hsa:218
UCSCⁱ	uc002gwj.4 human

Organism-specific databases

CTDⁱ	218
DisGeNETⁱ	218
EuPathDBⁱ	HostDB:ENSG00000108602.17
GeneCardsⁱ	ALDH3A1
H-InvDBⁱ	HIX0013622
HGNCⁱ	HGNC:405 ALDH3A1
HPAⁱ	CAB045957 HPA051150 HPA063783
MIMⁱ	100660 gene
neXtProtⁱ	NX_P30838
OpenTargetsⁱ	ENSG00000108602
PharmGKBⁱ	PA24697
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2456 Eukaryota COG1012 LUCA
GeneTreeⁱ	ENSGT00390000002825
HOGENOMⁱ	HOG000271515
HOVERGENⁱ	HBG050483
InParanoidⁱ	P30838
KOⁱ	K00129
OMAⁱ	QKLPEWA
OrthoDBⁱ	EOG091G05HC
PhylomeDBⁱ	P30838
TreeFamⁱ	TF314264

Enzyme and pathway databases

BRENDAⁱ	1.2.1.5 2681
Reactomeⁱ	R-HSA-211945 Phase I - Functionalization of compounds
SABIO-RKⁱ	P30838

Miscellaneous databases

ChiTaRSⁱ	ALDH3A1 human
EvolutionaryTraceⁱ	P30838
GeneWikiⁱ	Aldehyde_dehydrogenase_3_family,_member_A1
GenomeRNAiⁱ	218
Protein Ontology More...PROⁱ	PR:P30838
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108602 Expressed in 141 organ(s), highest expression level in nasal cavity epithelium
CleanExⁱ	HS_ALDH3A1
ExpressionAtlasⁱ	P30838 baseline and differential
Genevisibleⁱ	P30838 HS

Family and domain databases

Gene3Dⁱ	3.40.309.10, 1 hit 3.40.605.10, 2 hits
InterProⁱ	View protein in InterPro IPR016161 Ald_DH/histidinol_DH IPR016163 Ald_DH_C IPR016160 Ald_DH_CS_CYS IPR029510 Ald_DH_CS_GLU IPR016162 Ald_DH_N IPR015590 Aldehyde_DH_dom IPR012394 Aldehyde_DH_NAD(P)
Pfamⁱ	View protein in Pfam PF00171 Aldedh, 1 hit
PIRSFⁱ	PIRSF036492 ALDH, 1 hit
SUPFAMⁱ	SSF53720 SSF53720, 1 hit
PROSITEⁱ	View protein in PROSITE PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AL3A1_HUMAN
Accessionⁱ	P30838Primary (citable) accession number: P30838 Secondary accession number(s): A8K828, Q9BT37
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	November 2, 2010
	Last modified:	September 12, 2018
	This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P30838 (AL3A1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Aldehyde dehydrogenase, dimeric NADP-preferring

ALDH3A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ