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UniProtKB - P30838 (AL3A1_HUMAN)

Entry version 194 (07 Apr 2021)
Sequence version 3 (02 Nov 2010)
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Protein

Aldehyde dehydrogenase, dimeric NADP-preferring

Gene

ALDH3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).By similarityCurated1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Has a high Km for acetaldehyde.

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2101 Publication1
      Active sitei2441 Publication1

      Regions

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi188 – 193NAD or NADPBy similarity6

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      Complete GO annotation on QuickGO ...

      GO - Biological processi

      Complete GO annotation on QuickGO ...

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionOxidoreductase
      LigandNAD, NADP

      Enzyme and pathway databases

      BRENDA Comprehensive Enzyme Information System

      More...      BRENDAi      		1.2.1.5, 2681

      Pathway Commons web resource for biological pathway data

      More...      PathwayCommonsi      		P30838

      Reactome - a knowledgebase of biological pathways and processes

      More...      Reactomei      		R-HSA-211945, Phase I - Functionalization of compounds

      SABIO-RK: Biochemical Reaction Kinetics Database

      More...      SABIO-RKi      		P30838

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Aldehyde dehydrogenase, dimeric NADP-preferring (EC:1.2.1.52 Publications)
      Alternative name(s):
      ALDHIII
      Aldehyde dehydrogenase 3
      Aldehyde dehydrogenase family 3 member A1
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:ALDH3A1
      Synonyms:ALDH3
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

      Organism-specific databases

      Human Gene Nomenclature Database

      More...      HGNCi      		HGNC:405, ALDH3A1

      Online Mendelian Inheritance in Man (OMIM)

      More...      MIMi      		100660, gene

      neXtProt; the human protein knowledge platform

      More...      neXtProti      		NX_P30838

      Eukaryotic Pathogen, Vector and Host Database Resources

      More...      VEuPathDBi      		HostDB:ENSG00000108602.17

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Keywords - Cellular componenti

      Cytoplasm

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      Mutagenesis

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi244C → S: Abolishes activity. 1 Publication1

      Organism-specific databases

      DisGeNET

      More...      DisGeNETi      		218

      Open Targets

      More...      OpenTargetsi      		ENSG00000108602

      The Pharmacogenetics and Pharmacogenomics Knowledge Base

      More...      PharmGKBi      		PA24697

      Miscellaneous databases

      Pharos NIH Druggable Genome Knowledgebase

      More...      Pharosi      		P30838, Tchem

      Chemistry databases

      ChEMBL database of bioactive drug-like small molecules

      More...      ChEMBLi      		CHEMBL3578

      Drug and drug target database

      More...      DrugBanki      		DB00157, NADH

      Genetic variation databases

      BioMuta curated single-nucleotide variation and disease association database

      More...      BioMutai      		ALDH3A1

      Domain mapping of disease mutations (DMDM)

      More...      DMDMi      		311033473

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000564702 – 453Aldehyde dehydrogenase, dimeric NADP-preferringAdd BLAST452

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
      Modified residuei178N6-acetyllysineCombined sources1
      Modified residuei194N6-acetyllysineCombined sources1

      Keywords - PTMi

      Acetylation

      Proteomic databases

      Encyclopedia of Proteome Dynamics

      More...      EPDi      		P30838

      jPOST - Japan Proteome Standard Repository/Database

      More...      jPOSTi      		P30838

      MassIVE - Mass Spectrometry Interactive Virtual Environment

      More...      MassIVEi      		P30838

      MaxQB - The MaxQuant DataBase

      More...      MaxQBi      		P30838

      PaxDb, a database of protein abundance averages across all three domains of life

      More...      PaxDbi      		P30838

      PeptideAtlas

      More...      PeptideAtlasi      		P30838

      PRoteomics IDEntifications database

      More...      PRIDEi      		P30838

      ProteomicsDB: a multi-organism proteome resource

      More...      ProteomicsDBi      		54741

      PTM databases

      iPTMnet integrated resource for PTMs in systems biology context

      More...      iPTMneti      		P30838

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...      PhosphoSitePlusi      		P30838

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

      High levels in stomach, esophagus and lung; low level in the liver and kidney.

      Gene expression databases

      Bgee dataBase for Gene Expression Evolution

      More...      Bgeei      		ENSG00000108602, Expressed in nasal cavity epithelium and 162 other tissues

      ExpressionAtlas, Differential and Baseline Expression

      More...      ExpressionAtlasi      		P30838, baseline and differential

      Genevisible search portal to normalized and curated expression data from Genevestigator

      More...      Genevisiblei      		P30838, HS

      Organism-specific databases

      Human Protein Atlas

      More...      HPAi      		ENSG00000108602, Tissue enhanced (esophagus, lymphoid tissue, stomach, tongue)

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Homodimer.

      1 Publication

      <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

      Hide details

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGRID)

      More...      BioGRIDi      		106720, 32 interactors

      Protein interaction database and analysis system

      More...      IntActi      		P30838, 16 interactors

      STRING: functional protein association networks

      More...      STRINGi      		9606.ENSP00000411821

      Chemistry databases

      BindingDB database of measured binding affinities

      More...      BindingDBi      		P30838

      Miscellaneous databases

      RNAct, Protein-RNA interaction predictions for model organisms.

      More...      RNActi      		P30838, protein

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      Secondary structure

      1453
      Legend: HelixTurnBeta strandPDB Structure known for this area
      Show more details

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...      SMRi      		P30838

      Database of comparative protein structure models

      More...      ModBasei      		Search...

      Protein Data Bank in Europe - Knowledge Base

      More...      PDBe-KBi      		Search...

      Miscellaneous databases

      Relative evolutionary importance of amino acids within a protein sequence

      More...      EvolutionaryTracei      		P30838

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Belongs to the aldehyde dehydrogenase family.Curated

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...      eggNOGi      		KOG2456, Eukaryota

      Ensembl GeneTree

      More...      GeneTreei      		ENSGT00940000162101

      InParanoid: Eukaryotic Ortholog Groups

      More...      InParanoidi      		P30838

      Identification of Orthologs from Complete Genome Data

      More...      OMAi      		DFAAQMI

      Database of Orthologous Groups

      More...      OrthoDBi      		646662at2759

      Database for complete collections of gene phylogenies

      More...      PhylomeDBi      		P30838

      TreeFam database of animal gene trees

      More...      TreeFami      		TF314264

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...      Gene3Di      		3.40.309.10, 1 hit
      3.40.605.10, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...      InterProi      		View protein in InterPro
      IPR016161, Ald_DH/histidinol_DH
      IPR016163, Ald_DH_C
      IPR016160, Ald_DH_CS_CYS
      IPR029510, Ald_DH_CS_GLU
      IPR016162, Ald_DH_N
      IPR015590, Aldehyde_DH_dom
      IPR012394, Aldehyde_DH_NAD(P)

      Pfam protein domain database

      More...      Pfami      		View protein in Pfam
      PF00171, Aldedh, 1 hit

      PIRSF; a whole-protein classification database

      More...      PIRSFi      		PIRSF036492, ALDH, 1 hit

      Superfamily database of structural and functional annotation

      More...      SUPFAMi      		SSF53720, SSF53720, 1 hit

      PROSITE; a protein domain and family database

      More...      PROSITEi      		View protein in PROSITE
      PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
      PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

      This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

      P30838-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA 
              60         70         80         90        100
      DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI 
             110        120        130        140        150
      HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNSVVLKPS ELSENMASLL 
             160        170        180        190        200
      ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA 
             210        220        230        240        250
      AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI 
             260        270        280        290        300
      LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG 
             310        320        330        340        350
      QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE 
             360        370        380        390        400
      AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL 
             410        420        430        440        450
      PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM 

      TQH
      Length:453
      Mass (Da):50,395
      Last modified:November 2, 2010 - v3
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD35C488A022FAACA
      GO

      <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

      There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
      EntryEntry nameProtein names
      		Gene namesLengthAnnotation
      A8MYB8A8MYB8_HUMAN
      Aldehyde dehydrogenase, dimeric NAD...
      ALDH3A1
      		389Annotation score:

      Annotation score:2 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      I3L3I9I3L3I9_HUMAN
      Aldehyde dehydrogenase, dimeric NAD...
      ALDH3A1
      		380Annotation score:

      Annotation score:2 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      C9JKT2C9JKT2_HUMAN
      Aldehyde dehydrogenase, dimeric NAD...
      ALDH3A1
      		259Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      C9JMC5C9JMC5_HUMAN
      Aldehyde dehydrogenase, dimeric NAD...
      ALDH3A1
      		372Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      E9PNN6E9PNN6_HUMAN
      Aldehyde dehydrogenase, dimeric NAD...
      ALDH3A1
      		396Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      I3L3W9I3L3W9_HUMAN
      Aldehyde dehydrogenase, dimeric NAD...
      ALDH3A1
      		74Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      I3L1H6I3L1H6_HUMAN
      Aldehyde dehydrogenase, dimeric NAD...
      ALDH3A1
      		131Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      I3L4E5I3L4E5_HUMAN
      Aldehyde dehydrogenase, dimeric NAD...
      ALDH3A1
      		119Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12R → P in AAB46377 (PubMed:1737758).Curated1
      Sequence conflicti12R → P in AAB26658 (PubMed:8493892).Curated1
      Sequence conflicti27I → F in AAA51696 (Ref. 1) Curated1
      Sequence conflicti170V → L AA sequence (PubMed:2037078).Curated1
      Sequence conflicti436D → E AA sequence (PubMed:2037078).Curated1

      Natural variant

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018981134S → A5 PublicationsCorresponds to variant dbSNP:rs887241Ensembl.1
      Natural variantiVAR_018982309G → E. Corresponds to variant dbSNP:rs3744692Ensembl.1
      Natural variantiVAR_011303329P → A in allele ALDH3A1*2. 1 PublicationCorresponds to variant dbSNP:rs2228100Ensembl.1

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...      EMBLi

      GenBank nucleotide sequence database

      More...      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...      DDBJi
      Links Updated
      		M74542 mRNA Translation: AAA51696.1
      M77477 mRNA Translation: AAB46377.1
      S61044 mRNA Translation: AAB26658.1
      BT007102 mRNA Translation: AAP35766.1
      AK292193 mRNA Translation: BAF84882.1
      AK314584 mRNA Translation: BAG37160.1
      AC005722 Genomic DNA No translation available.
      CH471212 Genomic DNA Translation: EAW50909.1
      BC004370 mRNA Translation: AAH04370.1
      BC008892 mRNA Translation: AAH08892.1
      BC021194 mRNA Translation: AAH21194.1

      The Consensus CDS (CCDS) project

      More...      CCDSi      		CCDS11212.1

      Protein sequence database of the Protein Information Resource

      More...      PIRi      		A42584

      NCBI Reference Sequences

      More...      RefSeqi      		NP_000682.3, NM_000691.4
      NP_001128639.1, NM_001135167.1
      NP_001128640.1, NM_001135168.1

      Genome annotation databases

      Ensembl eukaryotic genome annotation project

      More...      Ensembli      		ENST00000225740; ENSP00000225740; ENSG00000108602
      ENST00000444455; ENSP00000388469; ENSG00000108602
      ENST00000457500; ENSP00000411821; ENSG00000108602

      Database of genes from NCBI RefSeq genomes

      More...      GeneIDi      		218

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...      KEGGi      		hsa:218

      UCSC genome browser

      More...      UCSCi      		uc002gwj.4, human

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      		M74542 mRNA Translation: AAA51696.1
      M77477 mRNA Translation: AAB46377.1
      S61044 mRNA Translation: AAB26658.1
      BT007102 mRNA Translation: AAP35766.1
      AK292193 mRNA Translation: BAF84882.1
      AK314584 mRNA Translation: BAG37160.1
      AC005722 Genomic DNA No translation available.
      CH471212 Genomic DNA Translation: EAW50909.1
      BC004370 mRNA Translation: AAH04370.1
      BC008892 mRNA Translation: AAH08892.1
      BC021194 mRNA Translation: AAH21194.1
      CCDSiCCDS11212.1
      PIRiA42584
      RefSeqiNP_000682.3, NM_000691.4
      NP_001128639.1, NM_001135167.1
      NP_001128640.1, NM_001135168.1

      3D structure databases

      Select the link destinations:

      Protein Data Bank Europe

      More...      PDBei

      Protein Data Bank RCSB

      More...      RCSB PDBi

      Protein Data Bank Japan

      More...      PDBji
      Links Updated
      		PDB entryMethodResolution (Å)ChainPositionsPDBsum
      3SZAX-ray1.48A/B1-453[»]
      3SZBX-ray1.51A/B1-453[»]
      4H80X-ray2.50A/B/C/D/E/F/G/H1-453[»]
      4L1OX-ray2.30A/B1-453[»]
      4L2OX-ray1.94A/B/E/G1-453[»]
      SMRiP30838
      ModBaseiSearch...
      PDBe-KBiSearch...

      Protein-protein interaction databases

      BioGRIDi106720, 32 interactors
      IntActiP30838, 16 interactors
      STRINGi9606.ENSP00000411821

      Chemistry databases

      BindingDBiP30838
      ChEMBLiCHEMBL3578
      DrugBankiDB00157, NADH

      PTM databases

      iPTMnetiP30838
      PhosphoSitePlusiP30838

      Genetic variation databases

      BioMutaiALDH3A1
      DMDMi311033473

      Proteomic databases

      EPDiP30838
      jPOSTiP30838
      MassIVEiP30838
      MaxQBiP30838
      PaxDbiP30838
      PeptideAtlasiP30838
      PRIDEiP30838
      ProteomicsDBi54741

      Protocols and materials databases

      Antibodypedia a portal for validated antibodies

      More...      Antibodypediai      		26030, 466 antibodies

      The DNASU plasmid repository

      More...      DNASUi      		218

      Genome annotation databases

      EnsembliENST00000225740; ENSP00000225740; ENSG00000108602
      ENST00000444455; ENSP00000388469; ENSG00000108602
      ENST00000457500; ENSP00000411821; ENSG00000108602
      GeneIDi218
      KEGGihsa:218
      UCSCiuc002gwj.4, human

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...      CTDi      		218
      DisGeNETi218

      GeneCards: human genes, protein and diseases

      More...      GeneCardsi      		ALDH3A1
      HGNCiHGNC:405, ALDH3A1
      HPAiENSG00000108602, Tissue enhanced (esophagus, lymphoid tissue, stomach, tongue)
      MIMi100660, gene
      neXtProtiNX_P30838
      OpenTargetsiENSG00000108602
      PharmGKBiPA24697
      VEuPathDBiHostDB:ENSG00000108602.17

      GenAtlas: human gene database

      More...      GenAtlasi      		Search...

      Phylogenomic databases

      eggNOGiKOG2456, Eukaryota
      GeneTreeiENSGT00940000162101
      InParanoidiP30838
      OMAiDFAAQMI
      OrthoDBi646662at2759
      PhylomeDBiP30838
      TreeFamiTF314264

      Enzyme and pathway databases

      BRENDAi1.2.1.5, 2681
      PathwayCommonsiP30838
      ReactomeiR-HSA-211945, Phase I - Functionalization of compounds
      SABIO-RKiP30838

      Miscellaneous databases

      BioGRID ORCS database of CRISPR phenotype screens

      More...      BioGRID-ORCSi      		218, 2 hits in 985 CRISPR screens

      ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

      More...      ChiTaRSi      		ALDH3A1, human
      EvolutionaryTraceiP30838

      The Gene Wiki collection of pages on human genes and proteins

      More...      GeneWikii      		Aldehyde_dehydrogenase_3_family,_member_A1

      Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

      More...      GenomeRNAii      		218
      PharosiP30838, Tchem

      Protein Ontology

      More...      PROi      		PR:P30838
      RNActiP30838, protein

      The Stanford Online Universal Resource for Clones and ESTs

      More...      SOURCEi      		Search...

      Gene expression databases

      BgeeiENSG00000108602, Expressed in nasal cavity epithelium and 162 other tissues
      ExpressionAtlasiP30838, baseline and differential
      GenevisibleiP30838, HS

      Family and domain databases

      Gene3Di3.40.309.10, 1 hit
      3.40.605.10, 1 hit
      InterProiView protein in InterPro
      IPR016161, Ald_DH/histidinol_DH
      IPR016163, Ald_DH_C
      IPR016160, Ald_DH_CS_CYS
      IPR029510, Ald_DH_CS_GLU
      IPR016162, Ald_DH_N
      IPR015590, Aldehyde_DH_dom
      IPR012394, Aldehyde_DH_NAD(P)
      PfamiView protein in Pfam
      PF00171, Aldedh, 1 hit
      PIRSFiPIRSF036492, ALDH, 1 hit
      SUPFAMiSSF53720, SSF53720, 1 hit
      PROSITEiView protein in PROSITE
      PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit
      PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...      ProtoNeti      		Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...      MobiDBi      		Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAL3A1_HUMAN
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30838
      Secondary accession number(s): A8K828, Q9BT37
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
      Last sequence update: November 2, 2010
      Last modified: April 7, 2021
      This is version 194 of the entry and version 3 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      3D-structure, Direct protein sequencing, Reference proteome

      Documents

      1. Human chromosome 17
        Human chromosome 17: entries, gene names and cross-references to MIM
      2. Human entries with genetic variants
        List of human entries with genetic variants
      3. Human variants curated from literature reports
        Index of human variants curated from literature reports
      4. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      5. PDB cross-references
        Index of Protein Data Bank (PDB) cross-references
      6. SIMILARITY comments
        Index of protein domains and families
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