UniProtKB - P30838 (AL3A1_HUMAN)
Protein
Aldehyde dehydrogenase, dimeric NADP-preferring
Gene
ALDH3A1
Organism
Homo sapiens (Human)
Status
Functioni
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).By similarityCurated1 Publication
Catalytic activityi
- EC:1.2.1.52 Publications
Kineticsi
Has a high Km for acetaldehyde.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 210 | 1 Publication | 1 | |
Active sitei | 244 | 1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 188 – 193 | NAD or NADPBy similarity | 6 |
GO - Molecular functioni
- 3-chloroallyl aldehyde dehydrogenase activity Source: GO_Central
- alcohol dehydrogenase (NADP+) activity Source: UniProtKB
- aldehyde dehydrogenase (NAD+) activity Source: UniProtKB
- aldehyde dehydrogenase [NAD(P)+] activity Source: Reactome
- benzaldehyde dehydrogenase (NAD+) activity Source: CACAO
GO - Biological processi
- aging Source: Ensembl
- cellular aldehyde metabolic process Source: UniProtKB
- oxidation-reduction process Source: UniProtKB
- positive regulation of cell population proliferation Source: Ensembl
- response to cAMP Source: Ensembl
- response to drug Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to hypoxia Source: Ensembl
- response to nutrient Source: Ensembl
- xenobiotic metabolic process Source: Reactome
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD, NADP |
Enzyme and pathway databases
BRENDAi | 1.2.1.5, 2681 |
PathwayCommonsi | P30838 |
Reactomei | R-HSA-211945, Phase I - Functionalization of compounds |
SABIO-RKi | P30838 |
Names & Taxonomyi
Protein namesi | Recommended name: Aldehyde dehydrogenase, dimeric NADP-preferring (EC:1.2.1.52 Publications)Alternative name(s): ALDHIII Aldehyde dehydrogenase 3 Aldehyde dehydrogenase family 3 member A1 |
Gene namesi | Name:ALDH3A1 Synonyms:ALDH3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:405, ALDH3A1 |
MIMi | 100660, gene |
neXtProti | NX_P30838 |
VEuPathDBi | HostDB:ENSG00000108602.17 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
Extracellular region or secreted
- extracellular space Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 244 | C → S: Abolishes activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 218 |
OpenTargetsi | ENSG00000108602 |
PharmGKBi | PA24697 |
Miscellaneous databases
Pharosi | P30838, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3578 |
DrugBanki | DB00157, NADH |
Genetic variation databases
BioMutai | ALDH3A1 |
DMDMi | 311033473 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000056470 | 2 – 453 | Aldehyde dehydrogenase, dimeric NADP-preferringAdd BLAST | 452 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 178 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 194 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P30838 |
jPOSTi | P30838 |
MassIVEi | P30838 |
MaxQBi | P30838 |
PaxDbi | P30838 |
PeptideAtlasi | P30838 |
PRIDEi | P30838 |
ProteomicsDBi | 54741 |
PTM databases
iPTMneti | P30838 |
PhosphoSitePlusi | P30838 |
Expressioni
Tissue specificityi
High levels in stomach, esophagus and lung; low level in the liver and kidney.
Gene expression databases
Bgeei | ENSG00000108602, Expressed in nasal cavity epithelium and 162 other tissues |
ExpressionAtlasi | P30838, baseline and differential |
Genevisiblei | P30838, HS |
Organism-specific databases
HPAi | ENSG00000108602, Tissue enhanced (esophagus, lymphoid tissue, stomach, tongue) |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 106720, 22 interactors |
IntActi | P30838, 16 interactors |
STRINGi | 9606.ENSP00000411821 |
Chemistry databases
BindingDBi | P30838 |
Miscellaneous databases
RNActi | P30838, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P30838 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P30838 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Phylogenomic databases
eggNOGi | KOG2456, Eukaryota |
GeneTreei | ENSGT00940000162101 |
InParanoidi | P30838 |
OMAi | DFAAQMI |
OrthoDBi | 646662at2759 |
PhylomeDBi | P30838 |
TreeFami | TF314264 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR012394, Aldehyde_DH_NAD(P) |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
PIRSFi | PIRSF036492, ALDH, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
P30838-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA
60 70 80 90 100
DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI
110 120 130 140 150
HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNSVVLKPS ELSENMASLL
160 170 180 190 200
ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA
210 220 230 240 250
AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI
260 270 280 290 300
LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG
310 320 330 340 350
QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE
360 370 380 390 400
AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL
410 420 430 440 450
PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM
TQH
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MYB8 | A8MYB8_HUMAN | Aldehyde dehydrogenase, dimeric NAD... | ALDH3A1 | 389 | Annotation score: | ||
I3L3I9 | I3L3I9_HUMAN | Aldehyde dehydrogenase, dimeric NAD... | ALDH3A1 | 380 | Annotation score: | ||
C9JKT2 | C9JKT2_HUMAN | Aldehyde dehydrogenase, dimeric NAD... | ALDH3A1 | 259 | Annotation score: | ||
C9JMC5 | C9JMC5_HUMAN | Aldehyde dehydrogenase, dimeric NAD... | ALDH3A1 | 372 | Annotation score: | ||
E9PNN6 | E9PNN6_HUMAN | Aldehyde dehydrogenase, dimeric NAD... | ALDH3A1 | 396 | Annotation score: | ||
I3L3W9 | I3L3W9_HUMAN | Aldehyde dehydrogenase, dimeric NAD... | ALDH3A1 | 74 | Annotation score: | ||
I3L1H6 | I3L1H6_HUMAN | Aldehyde dehydrogenase, dimeric NAD... | ALDH3A1 | 131 | Annotation score: | ||
I3L4E5 | I3L4E5_HUMAN | Aldehyde dehydrogenase, dimeric NAD... | ALDH3A1 | 119 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | R → P in AAB46377 (PubMed:1737758).Curated | 1 | |
Sequence conflicti | 12 | R → P in AAB26658 (PubMed:8493892).Curated | 1 | |
Sequence conflicti | 27 | I → F in AAA51696 (Ref. 1) Curated | 1 | |
Sequence conflicti | 170 | V → L AA sequence (PubMed:2037078).Curated | 1 | |
Sequence conflicti | 436 | D → E AA sequence (PubMed:2037078).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018981 | 134 | S → A5 PublicationsCorresponds to variant dbSNP:rs887241Ensembl. | 1 | |
Natural variantiVAR_018982 | 309 | G → E. Corresponds to variant dbSNP:rs3744692Ensembl. | 1 | |
Natural variantiVAR_011303 | 329 | P → A in allele ALDH3A1*2. 1 PublicationCorresponds to variant dbSNP:rs2228100Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74542 mRNA Translation: AAA51696.1 M77477 mRNA Translation: AAB46377.1 S61044 mRNA Translation: AAB26658.1 BT007102 mRNA Translation: AAP35766.1 AK292193 mRNA Translation: BAF84882.1 AK314584 mRNA Translation: BAG37160.1 AC005722 Genomic DNA No translation available. CH471212 Genomic DNA Translation: EAW50909.1 BC004370 mRNA Translation: AAH04370.1 BC008892 mRNA Translation: AAH08892.1 BC021194 mRNA Translation: AAH21194.1 |
CCDSi | CCDS11212.1 |
PIRi | A42584 |
RefSeqi | NP_000682.3, NM_000691.4 NP_001128639.1, NM_001135167.1 NP_001128640.1, NM_001135168.1 |
Genome annotation databases
Ensembli | ENST00000225740; ENSP00000225740; ENSG00000108602 ENST00000444455; ENSP00000388469; ENSG00000108602 ENST00000457500; ENSP00000411821; ENSG00000108602 |
GeneIDi | 218 |
KEGGi | hsa:218 |
UCSCi | uc002gwj.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74542 mRNA Translation: AAA51696.1 M77477 mRNA Translation: AAB46377.1 S61044 mRNA Translation: AAB26658.1 BT007102 mRNA Translation: AAP35766.1 AK292193 mRNA Translation: BAF84882.1 AK314584 mRNA Translation: BAG37160.1 AC005722 Genomic DNA No translation available. CH471212 Genomic DNA Translation: EAW50909.1 BC004370 mRNA Translation: AAH04370.1 BC008892 mRNA Translation: AAH08892.1 BC021194 mRNA Translation: AAH21194.1 |
CCDSi | CCDS11212.1 |
PIRi | A42584 |
RefSeqi | NP_000682.3, NM_000691.4 NP_001128639.1, NM_001135167.1 NP_001128640.1, NM_001135168.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3SZA | X-ray | 1.48 | A/B | 1-453 | [»] | |
3SZB | X-ray | 1.51 | A/B | 1-453 | [»] | |
4H80 | X-ray | 2.50 | A/B/C/D/E/F/G/H | 1-453 | [»] | |
4L1O | X-ray | 2.30 | A/B | 1-453 | [»] | |
4L2O | X-ray | 1.94 | A/B/E/G | 1-453 | [»] | |
SMRi | P30838 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106720, 22 interactors |
IntActi | P30838, 16 interactors |
STRINGi | 9606.ENSP00000411821 |
Chemistry databases
BindingDBi | P30838 |
ChEMBLi | CHEMBL3578 |
DrugBanki | DB00157, NADH |
PTM databases
iPTMneti | P30838 |
PhosphoSitePlusi | P30838 |
Genetic variation databases
BioMutai | ALDH3A1 |
DMDMi | 311033473 |
Proteomic databases
EPDi | P30838 |
jPOSTi | P30838 |
MassIVEi | P30838 |
MaxQBi | P30838 |
PaxDbi | P30838 |
PeptideAtlasi | P30838 |
PRIDEi | P30838 |
ProteomicsDBi | 54741 |
Protocols and materials databases
Antibodypediai | 26030, 455 antibodies |
DNASUi | 218 |
Genome annotation databases
Ensembli | ENST00000225740; ENSP00000225740; ENSG00000108602 ENST00000444455; ENSP00000388469; ENSG00000108602 ENST00000457500; ENSP00000411821; ENSG00000108602 |
GeneIDi | 218 |
KEGGi | hsa:218 |
UCSCi | uc002gwj.4, human |
Organism-specific databases
CTDi | 218 |
DisGeNETi | 218 |
GeneCardsi | ALDH3A1 |
HGNCi | HGNC:405, ALDH3A1 |
HPAi | ENSG00000108602, Tissue enhanced (esophagus, lymphoid tissue, stomach, tongue) |
MIMi | 100660, gene |
neXtProti | NX_P30838 |
OpenTargetsi | ENSG00000108602 |
PharmGKBi | PA24697 |
VEuPathDBi | HostDB:ENSG00000108602.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2456, Eukaryota |
GeneTreei | ENSGT00940000162101 |
InParanoidi | P30838 |
OMAi | DFAAQMI |
OrthoDBi | 646662at2759 |
PhylomeDBi | P30838 |
TreeFami | TF314264 |
Enzyme and pathway databases
BRENDAi | 1.2.1.5, 2681 |
PathwayCommonsi | P30838 |
Reactomei | R-HSA-211945, Phase I - Functionalization of compounds |
SABIO-RKi | P30838 |
Miscellaneous databases
BioGRID-ORCSi | 218, 2 hits in 871 CRISPR screens |
ChiTaRSi | ALDH3A1, human |
EvolutionaryTracei | P30838 |
GeneWikii | Aldehyde_dehydrogenase_3_family,_member_A1 |
GenomeRNAii | 218 |
Pharosi | P30838, Tchem |
PROi | PR:P30838 |
RNActi | P30838, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108602, Expressed in nasal cavity epithelium and 162 other tissues |
ExpressionAtlasi | P30838, baseline and differential |
Genevisiblei | P30838, HS |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR012394, Aldehyde_DH_NAD(P) |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
PIRSFi | PIRSF036492, ALDH, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AL3A1_HUMAN | |
Accessioni | P30838Primary (citable) accession number: P30838 Secondary accession number(s): A8K828, Q9BT37 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 10, 2021 | |
This is version 193 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families