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UniProtKB - P30822 (XPO1_YEAST)

Protein

Exportin-1

Gene

CRM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the leucine-rich nuclear export signal (NES).

Miscellaneous

Present with 7080 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • nuclear export signal receptor activity Source: GO_Central
  • protein transporter activity Source: SGD
  • Ran GTPase binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • mRNA export from nucleus Source: SGD
  • protein export from nucleus Source: SGD
  • protein localization to kinetochore Source: SGD
  • regulation of protein export from nucleus Source: GO_Central
  • ribosomal large subunit export from nucleus Source: SGD
  • ribosomal small subunit export from nucleus Source: GO_Central
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30900-MONOMER
ReactomeiR-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition

Protein family/group databases

MoonDBiP30822 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Alternative name(s):
Chromosome region maintenance protein 1
Karyopherin-124
Gene namesi
Name:CRM1
Synonyms:KAP124, XPO1
Ordered Locus Names:YGR218W
ORF Names:G8514
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

SGDiS000003450 CRM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047101 – 1084Exportin-1Add BLAST1084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1080PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP30822
PaxDbiP30822
PRIDEiP30822

PTM databases

iPTMnetiP30822

Interactioni

Subunit structurei

Interacts with GSP1/GSP2, polyadenylate-binding protein PAB1 and PRP40.2 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi33472, 981 interactors
DIPiDIP-2244N
IntActiP30822, 747 interactors
MINTiP30822
STRINGi4932.YGR218W

Structurei

Secondary structure

11084
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP30822
SMRiP30822
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30822

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000000572
HOGENOMiHOG000209012
InParanoidiP30822
KOiK14290
OMAiSEYPEHR
OrthoDBiEOG092C0C5J

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

P30822-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK 
        60         70         80         90        100
ADQILQFSTN PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS 
       110        120        130        140        150
MCQDDEVFKT QKNLINKSDL TLVQILKQEW PQNWPEFIPE LIGSSSSSVN 
       160        170        180        190        200
VCENNMIVLK LLSEEVFDFS AEQMTQAKAL HLKNSMSKEF EQIFKLCFQV 
       210        220        230        240        250
LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST KFMTSPDTRA 
       260        270        280        290        300
ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT 
       310        320        330        340        350
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL 
       360        370        380        390        400
SKIEERELFK TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST 
       410        420        430        440        450
GSGALNPEYM KRFPLKKHIY EEICSQLRLV IIENMVRPEE VLVVENDEGE 
       460        470        480        490        500
IVREFVKESD TIQLYKSERE VLVYLTHLNV IDTEEIMISK LARQIDGSEW 
       510        520        530        540        550
SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV KKRGKDNKAV 
       560        570        580        590        600
VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI 
       610        620        630        640        650
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI 
       660        670        680        690        700
IISEERSVAE RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA 
       710        720        730        740        750
NIIKTNVAVC TSMGADFYPQ LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA 
       760        770        780        790        800
TKTPKVRGLR TIKKEILKLV ETYISKARNL DDVVKVLVEP LLNAVLEDYM 
       810        820        830        840        850
NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC TLDMINKDFT 
       860        870        880        890        900
EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV 
       910        920        930        940        950
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS 
       960        970        980        990       1000
GFSKQALLLM KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS 
      1010       1020       1030       1040       1050
NAFPHLTSEQ IASFLSALTK QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL 
      1060       1070       1080 
FAEDKENALM EQNRLEREKA AKIGGLLKPS ELDD
Length:1,084
Mass (Da):124,104
Last modified:July 1, 1993 - v1
Checksum:iA81833C7F60F5202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA Translation: BAA02371.1
X87941 Genomic DNA Translation: CAA61166.1
Z73003 Genomic DNA Translation: CAA97246.1
BK006941 Genomic DNA Translation: DAA08312.1
PIRiS57681
RefSeqiNP_011734.3, NM_001181347.3

Genome annotation databases

EnsemblFungiiYGR218W; YGR218W; YGR218W
GeneIDi853133
KEGGisce:YGR218W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA Translation: BAA02371.1
X87941 Genomic DNA Translation: CAA61166.1
Z73003 Genomic DNA Translation: CAA97246.1
BK006941 Genomic DNA Translation: DAA08312.1
PIRiS57681
RefSeqiNP_011734.3, NM_001181347.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00C1-1084[»]
3VYCX-ray2.10A1-1084[»]
3WYFX-ray2.22C/F1-1084[»]
3WYGX-ray2.15C1-1084[»]
4GMXX-ray2.10C1-1058[»]
4GPTX-ray2.22C1-1058[»]
4HATX-ray1.78C1-1058[»]
4HAUX-ray2.00C1-1058[»]
4HAVX-ray2.00C1-1058[»]
4HAWX-ray1.90C1-1058[»]
4HAXX-ray2.28C1-1058[»]
4HAYX-ray2.30C1-1058[»]
4HAZX-ray1.90C1-1058[»]
4HB0X-ray2.20C1-1058[»]
4HB2X-ray1.80C1-1058[»]
4HB3X-ray2.80C1-1058[»]
4HB4X-ray2.05C1-1058[»]
5DH9X-ray2.55C1-1058[»]
5DHAX-ray2.95C1-1058[»]
5DHFX-ray2.29C1-1058[»]
5DI9X-ray2.28C1-1058[»]
5DIFX-ray2.09C1-1058[»]
5JLJX-ray2.50C1-1058[»]
5UWHX-ray2.26C1-1058[»]
5UWIX-ray2.14C1-1058[»]
5UWJX-ray2.22C1-1058[»]
5UWOX-ray2.35C1-1058[»]
5UWPX-ray2.05C1-1058[»]
5UWQX-ray2.28C1-1058[»]
5UWRX-ray2.24C1-1058[»]
5UWSX-ray2.40C1-1058[»]
5UWTX-ray2.34C1-1058[»]
5UWUX-ray2.24C1-1058[»]
5UWWX-ray2.15C1-1058[»]
5XOJX-ray2.20C1-1084[»]
6CITX-ray2.03C1-1058[»]
ProteinModelPortaliP30822
SMRiP30822
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33472, 981 interactors
DIPiDIP-2244N
IntActiP30822, 747 interactors
MINTiP30822
STRINGi4932.YGR218W

Protein family/group databases

MoonDBiP30822 Predicted

PTM databases

iPTMnetiP30822

Proteomic databases

MaxQBiP30822
PaxDbiP30822
PRIDEiP30822

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR218W; YGR218W; YGR218W
GeneIDi853133
KEGGisce:YGR218W

Organism-specific databases

SGDiS000003450 CRM1

Phylogenomic databases

GeneTreeiENSGT00390000000572
HOGENOMiHOG000209012
InParanoidiP30822
KOiK14290
OMAiSEYPEHR
OrthoDBiEOG092C0C5J

Enzyme and pathway databases

BioCyciYEAST:G3O-30900-MONOMER
ReactomeiR-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition

Miscellaneous databases

EvolutionaryTraceiP30822
PROiPR:P30822

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXPO1_YEAST
AccessioniPrimary (citable) accession number: P30822
Secondary accession number(s): D6VV01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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