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Protein

Exportin-1

Gene

CRM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the leucine-rich nuclear export signal (NES).

Miscellaneous

Present with 7080 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • nuclear export signal receptor activity Source: GO_Central
  • protein transporter activity Source: SGD
  • Ran GTPase binding Source: InterPro

GO - Biological processi

  • mRNA export from nucleus Source: SGD
  • protein export from nucleus Source: SGD
  • protein localization to kinetochore Source: SGD
  • regulation of protein export from nucleus Source: GO_Central
  • ribosomal large subunit export from nucleus Source: SGD
  • ribosomal small subunit export from nucleus Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30900-MONOMER
ReactomeiR-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition

Protein family/group databases

MoonDBiP30822 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-1
Alternative name(s):
Chromosome region maintenance protein 1
Karyopherin-124
Gene namesi
Name:CRM1
Synonyms:KAP124, XPO1
Ordered Locus Names:YGR218W
ORF Names:G8514
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

SGDiS000003450 CRM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047101 – 1084Exportin-1Add BLAST1084

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1080PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP30822
PaxDbiP30822
PRIDEiP30822

PTM databases

iPTMnetiP30822

Interactioni

Subunit structurei

Interacts with GSP1/GSP2, polyadenylate-binding protein PAB1 and PRP40.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33472, 981 interactors
DIPiDIP-2244N
IntActiP30822, 747 interactors
MINTiP30822
STRINGi4932.YGR218W

Structurei

Secondary structure

11084
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP30822
SMRiP30822
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30822

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 100Importin N-terminalPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000000572
HOGENOMiHOG000209012
InParanoidiP30822
KOiK14290
OMAiSEYPEHR
OrthoDBiEOG092C0C5J

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

P30822-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK
60 70 80 90 100
ADQILQFSTN PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS
110 120 130 140 150
MCQDDEVFKT QKNLINKSDL TLVQILKQEW PQNWPEFIPE LIGSSSSSVN
160 170 180 190 200
VCENNMIVLK LLSEEVFDFS AEQMTQAKAL HLKNSMSKEF EQIFKLCFQV
210 220 230 240 250
LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST KFMTSPDTRA
260 270 280 290 300
ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT
310 320 330 340 350
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL
360 370 380 390 400
SKIEERELFK TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST
410 420 430 440 450
GSGALNPEYM KRFPLKKHIY EEICSQLRLV IIENMVRPEE VLVVENDEGE
460 470 480 490 500
IVREFVKESD TIQLYKSERE VLVYLTHLNV IDTEEIMISK LARQIDGSEW
510 520 530 540 550
SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV KKRGKDNKAV
560 570 580 590 600
VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI
610 620 630 640 650
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI
660 670 680 690 700
IISEERSVAE RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA
710 720 730 740 750
NIIKTNVAVC TSMGADFYPQ LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA
760 770 780 790 800
TKTPKVRGLR TIKKEILKLV ETYISKARNL DDVVKVLVEP LLNAVLEDYM
810 820 830 840 850
NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC TLDMINKDFT
860 870 880 890 900
EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV
910 920 930 940 950
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS
960 970 980 990 1000
GFSKQALLLM KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS
1010 1020 1030 1040 1050
NAFPHLTSEQ IASFLSALTK QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL
1060 1070 1080
FAEDKENALM EQNRLEREKA AKIGGLLKPS ELDD
Length:1,084
Mass (Da):124,104
Last modified:July 1, 1993 - v1
Checksum:iA81833C7F60F5202
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA Translation: BAA02371.1
X87941 Genomic DNA Translation: CAA61166.1
Z73003 Genomic DNA Translation: CAA97246.1
BK006941 Genomic DNA Translation: DAA08312.1
PIRiS57681
RefSeqiNP_011734.3, NM_001181347.3

Genome annotation databases

EnsemblFungiiYGR218W; YGR218W; YGR218W
GeneIDi853133
KEGGisce:YGR218W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13039 Genomic DNA Translation: BAA02371.1
X87941 Genomic DNA Translation: CAA61166.1
Z73003 Genomic DNA Translation: CAA97246.1
BK006941 Genomic DNA Translation: DAA08312.1
PIRiS57681
RefSeqiNP_011734.3, NM_001181347.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M1IX-ray2.00C1-1084[»]
3VYCX-ray2.10A1-1084[»]
3WYFX-ray2.22C/F1-1084[»]
3WYGX-ray2.15C1-1084[»]
4GMXX-ray2.10C1-1058[»]
4GPTX-ray2.22C1-1058[»]
4HATX-ray1.78C1-1058[»]
4HAUX-ray2.00C1-1058[»]
4HAVX-ray2.00C1-1058[»]
4HAWX-ray1.90C1-1058[»]
4HAXX-ray2.28C1-1058[»]
4HAYX-ray2.30C1-1058[»]
4HAZX-ray1.90C1-1058[»]
4HB0X-ray2.20C1-1058[»]
4HB2X-ray1.80C1-1058[»]
4HB3X-ray2.80C1-1058[»]
4HB4X-ray2.05C1-1058[»]
5DH9X-ray2.55C1-1058[»]
5DHAX-ray2.95C1-1058[»]
5DHFX-ray2.29C1-1058[»]
5DI9X-ray2.28C1-1058[»]
5DIFX-ray2.09C1-1058[»]
5JLJX-ray2.50C1-1058[»]
5UWHX-ray2.26C1-1058[»]
5UWIX-ray2.14C1-1058[»]
5UWJX-ray2.22C1-1058[»]
5UWOX-ray2.35C1-1058[»]
5UWPX-ray2.05C1-1058[»]
5UWQX-ray2.28C1-1058[»]
5UWRX-ray2.24C1-1058[»]
5UWSX-ray2.40C1-1058[»]
5UWTX-ray2.34C1-1058[»]
5UWUX-ray2.24C1-1058[»]
5UWWX-ray2.15C1-1058[»]
5XOJX-ray2.20C1-1084[»]
6CITX-ray2.03C1-1058[»]
ProteinModelPortaliP30822
SMRiP30822
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33472, 981 interactors
DIPiDIP-2244N
IntActiP30822, 747 interactors
MINTiP30822
STRINGi4932.YGR218W

Protein family/group databases

MoonDBiP30822 Predicted

PTM databases

iPTMnetiP30822

Proteomic databases

MaxQBiP30822
PaxDbiP30822
PRIDEiP30822

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR218W; YGR218W; YGR218W
GeneIDi853133
KEGGisce:YGR218W

Organism-specific databases

SGDiS000003450 CRM1

Phylogenomic databases

GeneTreeiENSGT00390000000572
HOGENOMiHOG000209012
InParanoidiP30822
KOiK14290
OMAiSEYPEHR
OrthoDBiEOG092C0C5J

Enzyme and pathway databases

BioCyciYEAST:G3O-30900-MONOMER
ReactomeiR-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition

Miscellaneous databases

EvolutionaryTraceiP30822
PROiPR:P30822

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
IPR001494 Importin-beta_N
IPR014877 XPO1_C_dom
PfamiView protein in Pfam
PF08767 CRM1_C, 1 hit
PF03810 IBN_N, 1 hit
PF08389 Xpo1, 1 hit
SMARTiView protein in SMART
SM01102 CRM1_C, 1 hit
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXPO1_YEAST
AccessioniPrimary (citable) accession number: P30822
Secondary accession number(s): D6VV01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 7, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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Main funding by: National Institutes of Health

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