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UniProtKB - P30822 (XPO1_YEAST)
Protein
Exportin-1
Gene
CRM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Receptor for the leucine-rich nuclear export signal (NES).
Miscellaneous
Present with 7080 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- nuclear export signal receptor activity Source: GO_Central
- nuclear import signal receptor activity Source: SGD
- small GTPase binding Source: InterPro
- U1 snRNA binding Source: SGD
- U2 snRNA binding Source: SGD
- U4 snRNA binding Source: SGD
- U5 snRNA binding Source: SGD
- U6 snRNA binding Source: SGD
GO - Biological processi
- mRNA export from nucleus Source: SGD
- nuclear export Source: SGD
- protein export from nucleus Source: SGD
- protein localization to kinetochore Source: SGD
- ribosomal large subunit export from nucleus Source: SGD
- ribosomal small subunit export from nucleus Source: GO_Central
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-5687128, MAPK6/MAPK4 signaling |
Protein family/group databases
MoonDBi | P30822, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Exportin-1Alternative name(s): Chromosome region maintenance protein 1 Karyopherin-124 |
Gene namesi | Name:CRM1 Synonyms:KAP124, XPO1 Ordered Locus Names:YGR218W ORF Names:G8514 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003450, CRM1 |
VEuPathDBi | FungiDB:YGR218W |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- perinuclear region 1 Publication
Note: Localized in the nucleus and at its periphery.
Cytoskeleton
- spindle pole body Source: SGD
Nucleus
- nucleus Source: SGD
Other locations
- cytoplasm Source: GO_Central
- kinetochore Source: SGD
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204710 | 1 – 1084 | Exportin-1Add BLAST | 1084 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1080 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P30822 |
PaxDbi | P30822 |
PRIDEi | P30822 |
PTM databases
iPTMneti | P30822 |
Interactioni
Subunit structurei
Interacts with GSP1/GSP2, polyadenylate-binding protein PAB1 and PRP40.
2 PublicationsBinary interactionsi
P30822
With | #Exp. | IntAct |
---|---|---|
ACE2 [P21192] | 3 | EBI-20589,EBI-2073 |
PKIA [P61925] from Homo sapiens. | 17 | EBI-20589,EBI-2682139 |
GO - Molecular functioni
- small GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 33472, 994 interactors |
DIPi | DIP-2244N |
IntActi | P30822, 747 interactors |
MINTi | P30822 |
STRINGi | 4932.YGR218W |
Miscellaneous databases
RNActi | P30822, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P30822 |
SMRi | P30822 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P30822 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 100 | Importin N-terminalPROSITE-ProRule annotationAdd BLAST | 67 |
Sequence similaritiesi
Belongs to the exportin family.Curated
Phylogenomic databases
eggNOGi | KOG2020, Eukaryota |
GeneTreei | ENSGT00940000153408 |
HOGENOMi | CLU_011906_0_0_1 |
InParanoidi | P30822 |
OMAi | HNINTLC |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
IDEALi | IID50169 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR041123, CRM1_repeat IPR041235, Exp1_repeat_2 IPR013598, Exportin-1/Importin-b-like IPR001494, Importin-beta_N IPR045065, XPO1/5 IPR014877, XPO1_C_dom IPR040485, XPO1_repeat_3 |
PANTHERi | PTHR11223, PTHR11223, 1 hit |
Pfami | View protein in Pfam PF08767, CRM1_C, 1 hit PF18777, CRM1_repeat, 1 hit PF18784, CRM1_repeat_2, 1 hit PF18787, CRM1_repeat_3, 1 hit PF03810, IBN_N, 1 hit PF08389, Xpo1, 1 hit |
SMARTi | View protein in SMART SM01102, CRM1_C, 1 hit SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
i Sequence
Sequence statusi: Complete.
P30822-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGILDFSND LDIALLDQVV STFYQGSGVQ QKQAQEILTK FQDNPDAWQK
60 70 80 90 100
ADQILQFSTN PQSKFIALSI LDKLITRKWK LLPNDHRIGI RNFVVGMIIS
110 120 130 140 150
MCQDDEVFKT QKNLINKSDL TLVQILKQEW PQNWPEFIPE LIGSSSSSVN
160 170 180 190 200
VCENNMIVLK LLSEEVFDFS AEQMTQAKAL HLKNSMSKEF EQIFKLCFQV
210 220 230 240 250
LEQGSSSSLI VATLESLLRY LHWIPYRYIY ETNILELLST KFMTSPDTRA
260 270 280 290 300
ITLKCLTEVS NLKIPQDNDL IKRQTVLFFQ NTLQQIATSV MPVTADLKAT
310 320 330 340 350
YANANGNDQS FLQDLAMFLT TYLARNRALL ESDESLRELL LNAHQYLIQL
360 370 380 390 400
SKIEERELFK TTLDYWHNLV ADLFYEVQRL PATEMSPLIQ LSVGSQAIST
410 420 430 440 450
GSGALNPEYM KRFPLKKHIY EEICSQLRLV IIENMVRPEE VLVVENDEGE
460 470 480 490 500
IVREFVKESD TIQLYKSERE VLVYLTHLNV IDTEEIMISK LARQIDGSEW
510 520 530 540 550
SWHNINTLSW AIGSISGTMS EDTEKRFVVT VIKDLLDLTV KKRGKDNKAV
560 570 580 590 600
VASDIMYVVG QYPRFLKAHW NFLRTVILKL FEFMHETHEG VQDMACDTFI
610 620 630 640 650
KIVQKCKYHF VIQQPRESEP FIQTIIRDIQ KTTADLQPQQ VHTFYKACGI
660 670 680 690 700
IISEERSVAE RNRLLSDLMQ LPNMAWDTIV EQSTANPTLL LDSETVKIIA
710 720 730 740 750
NIIKTNVAVC TSMGADFYPQ LGHIYYNMLQ LYRAVSSMIS AQVAAEGLIA
760 770 780 790 800
TKTPKVRGLR TIKKEILKLV ETYISKARNL DDVVKVLVEP LLNAVLEDYM
810 820 830 840 850
NNVPDARDAE VLNCMTTVVE KVGHMIPQGV ILILQSVFEC TLDMINKDFT
860 870 880 890 900
EYPEHRVEFY KLLKVINEKS FAAFLELPPA AFKLFVDAIC WAFKHNNRDV
910 920 930 940 950
EVNGLQIALD LVKNIERMGN VPFANEFHKN YFFIFVSETF FVLTDSDHKS
960 970 980 990 1000
GFSKQALLLM KLISLVYDNK ISVPLYQEAE VPQGTSNQVY LSQYLANMLS
1010 1020 1030 1040 1050
NAFPHLTSEQ IASFLSALTK QYKDLVVFKG TLRDFLVQIK EVGGDPTDYL
1060 1070 1080
FAEDKENALM EQNRLEREKA AKIGGLLKPS ELDD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13039 Genomic DNA Translation: BAA02371.1 X87941 Genomic DNA Translation: CAA61166.1 Z73003 Genomic DNA Translation: CAA97246.1 BK006941 Genomic DNA Translation: DAA08312.1 |
PIRi | S57681 |
RefSeqi | NP_011734.3, NM_001181347.3 |
Genome annotation databases
EnsemblFungii | YGR218W_mRNA; YGR218W; YGR218W |
GeneIDi | 853133 |
KEGGi | sce:YGR218W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13039 Genomic DNA Translation: BAA02371.1 X87941 Genomic DNA Translation: CAA61166.1 Z73003 Genomic DNA Translation: CAA97246.1 BK006941 Genomic DNA Translation: DAA08312.1 |
PIRi | S57681 |
RefSeqi | NP_011734.3, NM_001181347.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3M1I | X-ray | 2.00 | C | 1-1084 | [»] | |
3VYC | X-ray | 2.10 | A | 1-1084 | [»] | |
3WYF | X-ray | 2.22 | C/F | 1-1084 | [»] | |
3WYG | X-ray | 2.15 | C | 1-1084 | [»] | |
4GMX | X-ray | 2.10 | C | 1-1058 | [»] | |
4GPT | X-ray | 2.22 | C | 1-1058 | [»] | |
4HAT | X-ray | 1.78 | C | 1-1058 | [»] | |
4HAU | X-ray | 2.00 | C | 1-1058 | [»] | |
4HAV | X-ray | 2.00 | C | 1-1058 | [»] | |
4HAW | X-ray | 1.90 | C | 1-1058 | [»] | |
4HAX | X-ray | 2.28 | C | 1-1058 | [»] | |
4HAY | X-ray | 2.30 | C | 1-1058 | [»] | |
4HAZ | X-ray | 1.90 | C | 1-1058 | [»] | |
4HB0 | X-ray | 2.20 | C | 1-1058 | [»] | |
4HB2 | X-ray | 1.80 | C | 1-1058 | [»] | |
4HB3 | X-ray | 2.80 | C | 1-1058 | [»] | |
4HB4 | X-ray | 2.05 | C | 1-1058 | [»] | |
5DH9 | X-ray | 2.55 | C | 1-1058 | [»] | |
5DHA | X-ray | 2.95 | C | 1-1058 | [»] | |
5DHF | X-ray | 2.29 | C | 1-1058 | [»] | |
5DI9 | X-ray | 2.28 | C | 1-1058 | [»] | |
5DIF | X-ray | 2.09 | C | 1-1058 | [»] | |
5JLJ | X-ray | 2.50 | C | 1-1058 | [»] | |
5UWH | X-ray | 2.26 | C | 1-1058 | [»] | |
5UWI | X-ray | 2.14 | C | 1-1058 | [»] | |
5UWJ | X-ray | 2.22 | C | 1-1058 | [»] | |
5UWO | X-ray | 2.35 | C | 1-1058 | [»] | |
5UWP | X-ray | 2.05 | C | 1-1058 | [»] | |
5UWQ | X-ray | 2.28 | C | 1-1058 | [»] | |
5UWR | X-ray | 2.24 | C | 1-1058 | [»] | |
5UWS | X-ray | 2.40 | C | 1-1058 | [»] | |
5UWT | X-ray | 2.34 | C | 1-1058 | [»] | |
5UWU | X-ray | 2.24 | C | 1-1058 | [»] | |
5UWW | X-ray | 2.15 | C | 1-1058 | [»] | |
5XOJ | X-ray | 2.20 | C | 1-1084 | [»] | |
5YRO | X-ray | 2.40 | C | 1-1058 | [»] | |
5YST | X-ray | 2.04 | C | 1-1052 | [»] | |
5YSU | X-ray | 2.30 | C | 1-1055 | [»] | |
5YTB | X-ray | 2.30 | C | 1-1052 | [»] | |
5ZPU | X-ray | 2.60 | C | 1-1058 | [»] | |
6A38 | X-ray | 2.69 | C | 1-1058 | [»] | |
6A3A | X-ray | 2.30 | C | 1-1058 | [»] | |
6A3B | X-ray | 2.51 | C | 1-1058 | [»] | |
6A3C | X-ray | 2.35 | C | 1-1058 | [»] | |
6A3E | X-ray | 2.70 | C | 1-1058 | [»] | |
6CIT | X-ray | 2.03 | C | 1-1058 | [»] | |
6KFT | X-ray | 2.51 | C | 1-1058 | [»] | |
6LQ9 | X-ray | 2.50 | C | 1-1058 | [»] | |
6M60 | X-ray | 2.17 | C | 1-1058 | [»] | |
6M6X | X-ray | 2.88 | C | 1-1058 | [»] | |
6X2M | X-ray | 2.35 | C | 1-1058 | [»] | |
6X2O | X-ray | 2.55 | C | 1-1058 | [»] | |
6X2P | X-ray | 2.40 | C | 1-1058 | [»] | |
6X2R | X-ray | 2.30 | C | 1-1058 | [»] | |
6X2S | X-ray | 2.50 | C | 1-1058 | [»] | |
6X2U | X-ray | 2.20 | C | 1-1058 | [»] | |
6X2V | X-ray | 2.82 | C | 1-1058 | [»] | |
6X2W | X-ray | 3.00 | C | 1-1058 | [»] | |
6X2X | X-ray | 2.46 | C | 1-1058 | [»] | |
6X2Y | X-ray | 2.30 | C | 1-1058 | [»] | |
6XJP | X-ray | 2.80 | C | 1-1058 | [»] | |
6XJR | X-ray | 1.94 | C | 1-1058 | [»] | |
6XJS | X-ray | 1.94 | C | 1-1058 | [»] | |
6XJT | X-ray | 2.41 | C | 1-1058 | [»] | |
6XJU | X-ray | 2.19 | C | 1-1058 | [»] | |
7CND | X-ray | 1.80 | C | 1-1058 | [»] | |
7L5E | X-ray | 1.94 | C | 1-1058 | [»] | |
AlphaFoldDBi | P30822 | |||||
SMRi | P30822 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33472, 994 interactors |
DIPi | DIP-2244N |
IntActi | P30822, 747 interactors |
MINTi | P30822 |
STRINGi | 4932.YGR218W |
Chemistry databases
ChEMBLi | CHEMBL4630873 |
Protein family/group databases
MoonDBi | P30822, Predicted |
PTM databases
iPTMneti | P30822 |
Proteomic databases
MaxQBi | P30822 |
PaxDbi | P30822 |
PRIDEi | P30822 |
Genome annotation databases
EnsemblFungii | YGR218W_mRNA; YGR218W; YGR218W |
GeneIDi | 853133 |
KEGGi | sce:YGR218W |
Organism-specific databases
SGDi | S000003450, CRM1 |
VEuPathDBi | FungiDB:YGR218W |
Phylogenomic databases
eggNOGi | KOG2020, Eukaryota |
GeneTreei | ENSGT00940000153408 |
HOGENOMi | CLU_011906_0_0_1 |
InParanoidi | P30822 |
OMAi | HNINTLC |
Enzyme and pathway databases
Reactomei | R-SCE-5687128, MAPK6/MAPK4 signaling |
Miscellaneous databases
EvolutionaryTracei | P30822 |
PROi | PR:P30822 |
RNActi | P30822, protein |
Family and domain databases
Gene3Di | 1.25.10.10, 2 hits |
IDEALi | IID50169 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR041123, CRM1_repeat IPR041235, Exp1_repeat_2 IPR013598, Exportin-1/Importin-b-like IPR001494, Importin-beta_N IPR045065, XPO1/5 IPR014877, XPO1_C_dom IPR040485, XPO1_repeat_3 |
PANTHERi | PTHR11223, PTHR11223, 1 hit |
Pfami | View protein in Pfam PF08767, CRM1_C, 1 hit PF18777, CRM1_repeat, 1 hit PF18784, CRM1_repeat_2, 1 hit PF18787, CRM1_repeat_3, 1 hit PF03810, IBN_N, 1 hit PF08389, Xpo1, 1 hit |
SMARTi | View protein in SMART SM01102, CRM1_C, 1 hit SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50166, IMPORTIN_B_NT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | XPO1_YEAST | |
Accessioni | P30822Primary (citable) accession number: P30822 Secondary accession number(s): D6VV01 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families