UniProtKB - P30785 (NA25_HETCR)
Protein
Delta-stichotoxin-Hcr1d
Gene
N/A
Organism
Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)
Status
Functioni
Binds specifically to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction.By similarity
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- regulation of signal transduction Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Delta-stichotoxin-Hcr1d1 PublicationShort name: Delta-SHTX-Hcr1d1 Publication Alternative name(s): Neurotoxins V1 Publication RTX-V Rm5 |
Organismi | Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus) |
Taxonomic identifieri | 175771 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Stichodactylidae › Heteractis |
Subcellular locationi
Extracellular region or secreted
Other locations
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- nematocyst Source: UniProtKB-SubCell
Keywords - Cellular componenti
Nematocyst, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221526 | 1 – 47 | Delta-stichotoxin-Hcr1d1 PublicationAdd BLAST | 47 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 43 | By similarity | ||
Disulfide bondi | 5 ↔ 33 | By similarity | ||
Disulfide bondi | 26 ↔ 44 | By similarity |
Keywords - PTMi
Disulfide bondStructurei
3D structure databases
ProteinModelPortali | P30785 |
SMRi | P30785 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
Gene3Di | 2.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR000693 Anenome_toxin IPR023355 Myo_ane_neurotoxin_sf |
Pfami | View protein in Pfam PF00706 Toxin_4, 1 hit |
PIRSFi | PIRSF001905 Anenome_toxin, 1 hit |
i Sequence
Sequence statusi: Complete.
P30785-1 [UniParc]FASTAAdd to basket
10 20 30 40
GNCKCDDEGP NVRTAPLTGY VDLGYCNEGW EKCASYYSPI AECCRKK
Sequence databases
PIRi | JN0424 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | JN0424 |
3D structure databases
ProteinModelPortali | P30785 |
SMRi | P30785 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 2.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR000693 Anenome_toxin IPR023355 Myo_ane_neurotoxin_sf |
Pfami | View protein in Pfam PF00706 Toxin_4, 1 hit |
PIRSFi | PIRSF001905 Anenome_toxin, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | NA25_HETCR | |
Accessioni | P30785Primary (citable) accession number: P30785 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1993 |
Last sequence update: | July 1, 1993 | |
Last modified: | November 22, 2017 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families