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Protein

D(3) dopamine receptor

Gene

Drd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110AgonistBy similarity1

GO - Molecular functioni

GO - Biological processi

  • acid secretion Source: MGI
  • adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  • adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: MGI
  • arachidonic acid secretion Source: MGI
  • autophagy Source: MGI
  • behavioral response to cocaine Source: BHF-UCL
  • cellular calcium ion homeostasis Source: MGI
  • circadian regulation of gene expression Source: MGI
  • dopamine receptor signaling pathway Source: MGI
  • gastric emptying Source: MGI
  • G-protein coupled receptor internalization Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • locomotory behavior Source: MGI
  • musculoskeletal movement, spinal reflex action Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of blood pressure Source: MGI
  • negative regulation of dopamine receptor signaling pathway Source: MGI
  • negative regulation of oligodendrocyte differentiation Source: MGI
  • negative regulation of protein kinase B signaling Source: MGI
  • negative regulation of protein secretion Source: MGI
  • negative regulation of sodium:proton antiporter activity Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of cytokinesis Source: MGI
  • positive regulation of dopamine receptor signaling pathway Source: MGI
  • positive regulation of mitotic nuclear division Source: MGI
  • positive regulation of renal sodium excretion Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • prepulse inhibition Source: MGI
  • regulation of blood volume by renin-angiotensin Source: MGI
  • regulation of cAMP metabolic process Source: MGI
  • regulation of circadian sleep/wake cycle, sleep Source: MGI
  • regulation of dopamine secretion Source: MGI
  • regulation of lipid metabolic process Source: MGI
  • regulation of locomotion Source: MGI
  • regulation of locomotion involved in locomotory behavior Source: MGI
  • regulation of multicellular organism growth Source: MGI
  • response to amphetamine Source: MGI
  • response to cocaine Source: MGI
  • response to drug Source: MGI
  • response to ethanol Source: MGI
  • response to histamine Source: MGI
  • response to morphine Source: MGI
  • synaptic transmission, dopaminergic Source: MGI
  • visual learning Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-390651 Dopamine receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
Gene namesi
Name:Drd3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:94925 Drd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularBy similarityAdd BLAST32
Transmembranei33 – 55Helical; Name=1By similarityAdd BLAST23
Topological domaini56 – 65CytoplasmicBy similarity10
Transmembranei66 – 88Helical; Name=2By similarityAdd BLAST23
Topological domaini89 – 104ExtracellularBy similarityAdd BLAST16
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Topological domaini127 – 149CytoplasmicBy similarityAdd BLAST23
Transmembranei150 – 170Helical; Name=4By similarityAdd BLAST21
Topological domaini171 – 187ExtracellularBy similarityAdd BLAST17
Transmembranei188 – 209Helical; Name=5By similarityAdd BLAST22
Topological domaini210 – 375CytoplasmicBy similarityAdd BLAST166
Transmembranei376 – 397Helical; Name=6By similarityAdd BLAST22
Topological domaini398 – 412ExtracellularBy similarityAdd BLAST15
Transmembranei413 – 432Helical; Name=7By similarityAdd BLAST20
Topological domaini433 – 446CytoplasmicBy similarityAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2111359

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693981 – 446D(3) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi401 ↔ 404PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by GRK4.By similarity
Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP30728
PRIDEiP30728

PTM databases

PhosphoSitePlusiP30728

Expressioni

Gene expression databases

BgeeiENSMUSG00000022705
CleanExiMM_DRD3
ExpressionAtlasiP30728 baseline and differential
GenevisibleiP30728 MM

Interactioni

Subunit structurei

Interacts with CLIC6 (By similarity). Interacts with GRK4. Interacts with PALM. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199307, 1 interactor
CORUMiP30728
STRINGi10090.ENSMUSP00000023390

Chemistry databases

BindingDBiP30728

Structurei

3D structure databases

ProteinModelPortaliP30728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 196Agonist bindingBy similarity8
Regioni388 – 396Agonist bindingBy similarity9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP30728
KOiK04146
OMAiQNSQCIS
OrthoDBiEOG091G06VI
PhylomeDBiP30728
TreeFamiTF334382

Family and domain databases

CDDicd15310 7tmA_D3_dopamine_R, 1 hit
InterProiView protein in InterPro
IPR001620 Dopamine_D3_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00568 DOPAMINED3R
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform D3Long (identifier: P30728-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPLSQISSH INSTCGAENS TGVNRARPHA YYALSYCALI LAIIFGNGLV
60 70 80 90 100
CAAVLRERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR
110 120 130 140 150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV
160 170 180 190 200
ALMITAVWVL AFAVSCPLLF GFNTTGDPSI CSISNPDFVI YSSVVSFYVP
210 220 230 240 250
FGVTVLVYAR IYMVLRQRRR KRILTRQNSQ CISIRPGFPQ QSSCLRLHPI
260 270 280 290 300
RQFSIRARFL SDATGQMEHI EDKPYPQKCQ DPLLSHLQPL SPGQTHGELK
310 320 330 340 350
RYYSICQDTA LRHPNFEGGG GMSQVERTRN SLSPTMAPKL SLEVRKLSNG
360 370 380 390 400
RLSTSLKLGP LQPRGVPLRE KKATQMVVIV LGAFIVCWLP FFLTHVLNTH
410 420 430 440
CQACHVSPEL YRATTWLGYV NSALNPVIYT TFNIEFRKAF LKILSC
Length:446
Mass (Da):49,669
Last modified:April 1, 1993 - v1
Checksum:iB391C2D493B58242
GO
Isoform D3Short (identifier: P30728-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-288: Missing.

Show »
Length:425
Mass (Da):47,168
Checksum:iE4C0EDFB345BAE87
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001873268 – 288Missing in isoform D3Short. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67274 mRNA Translation: CAA47691.1
S78580
, S78574, S78638, S78577, S78578, S78579, S78639 Genomic DNA Translation: AAB35066.2
CCDSiCCDS28179.1 [P30728-1]
PIRiI48322
RefSeqiNP_031903.1, NM_007877.2 [P30728-1]
UniGeneiMm.439735

Genome annotation databases

EnsembliENSMUST00000023390; ENSMUSP00000023390; ENSMUSG00000022705 [P30728-1]
GeneIDi13490
KEGGimmu:13490
UCSCiuc007zgi.1 mouse [P30728-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDRD3_MOUSE
AccessioniPrimary (citable) accession number: P30728
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 20, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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