UniProtKB - P30710 (GPX5_RAT)
Protein
Epididymal secretory glutathione peroxidase
Gene
Gpx5
Organism
Rattus norvegicus (Rat)
Status
Functioni
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Catalytic activityi
- EC:1.11.1.9
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | By similarity | 1 |
GO - Molecular functioni
- glutathione peroxidase activity Source: GO_Central
- peroxidase activity Source: GO_Central
GO - Biological processi
- cellular response to oxidative stress Source: RGD
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Enzyme and pathway databases
Reactomei | R-RNO-3299685, Detoxification of Reactive Oxygen Species |
Protein family/group databases
PeroxiBasei | 3735, RnoGPx05 |
Names & Taxonomyi
Protein namesi | Recommended name: Epididymal secretory glutathione peroxidase (EC:1.11.1.9)Alternative name(s): Epididymis-specific glutathione peroxidase-like protein Short name: EGLP Glutathione peroxidase 5 Short name: GPx-5 Short name: GSHPx-5 |
Gene namesi | Name:Gpx5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69227, Gpx5 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: RGD
Plasma Membrane
- sperm plasma membrane Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000013080 | 22 – 221 | Epididymal secretory glutathione peroxidaseAdd BLAST | 200 |
Proteomic databases
PRIDEi | P30710 |
Expressioni
Tissue specificityi
Epididymis.
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
InParanoidi | P30710 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | P30710 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P30710-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIQLRVFYL VPLLLASYVQ TTPRLEKMKM DCYKDVKGTI YNYEALSLNG
60 70 80 90 100
KERIPFKQYA GKHVLFVNVA TYCGLTIQYP ELNALQDDLK QFGLVILGFP
110 120 130 140 150
CNQFGKQEPG DNTEILPGLK YVRPGKGFLP NFQLFAKGDV NGEKEQEIFT
160 170 180 190 200
FLKRSCPHPS ETVVTSKHTF WEPIKVHDIR WNFEKFLVGP NGVPVMRWFH
210 220
QAPVSTVKSD ILAYLNQFKT I
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JU80 | A0A0G2JU80_RAT | Glutathione peroxidase | Gpx5 | 220 | Annotation score: | ||
A0A0G2JVU3 | A0A0G2JVU3_RAT | Glutathione peroxidase | Gpx5 | 220 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62404 mRNA Translation: CAA44274.1 |
PIRi | S24328 |
RefSeqi | NP_001099208.1, NM_001105738.1 |
Genome annotation databases
GeneIDi | 113919 |
KEGGi | rno:113919 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62404 mRNA Translation: CAA44274.1 |
PIRi | S24328 |
RefSeqi | NP_001099208.1, NM_001105738.1 |
3D structure databases
SMRi | P30710 |
ModBasei | Search... |
Protein family/group databases
PeroxiBasei | 3735, RnoGPx05 |
Proteomic databases
PRIDEi | P30710 |
Genome annotation databases
GeneIDi | 113919 |
KEGGi | rno:113919 |
Organism-specific databases
CTDi | 2880 |
RGDi | 69227, Gpx5 |
Phylogenomic databases
InParanoidi | P30710 |
OrthoDBi | 1483113at2759 |
PhylomeDBi | P30710 |
Enzyme and pathway databases
Reactomei | R-RNO-3299685, Detoxification of Reactive Oxygen Species |
Miscellaneous databases
PROi | PR:P30710 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX5_RAT | |
Accessioni | P30710Primary (citable) accession number: P30710 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families