UniProtKB - P30679 (GNA15_HUMAN)
Protein
Guanine nucleotide-binding protein subunit alpha-15
Gene
GNA15
Organism
Homo sapiens (Human)
Status
Functioni
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 56 | MagnesiumBy similarity | 1 | |
Metal bindingi | 189 | MagnesiumBy similarity | 1 | |
Binding sitei | 346 | GTP; via amide nitrogenBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 49 – 56 | GTPBy similarity | 8 | |
Nucleotide bindingi | 183 – 189 | GTPBy similarity | 7 | |
Nucleotide bindingi | 208 – 212 | GTPBy similarity | 5 | |
Nucleotide bindingi | 277 – 280 | GTPBy similarity | 4 |
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: GO_Central
- G protein-coupled receptor binding Source: UniProtKB
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- type 2A serotonin receptor binding Source: GO_Central
GO - Biological processi
- action potential Source: GO_Central
- activation of phospholipase C activity Source: ProtInc
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: Reactome
- phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
- phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway Source: ProtInc
- platelet activation Source: Reactome
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Transducer |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P30679 |
Reactomei | R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-416476, G alpha (q) signalling events R-HSA-418592, ADP signalling through P2Y purinoceptor 1 R-HSA-428930, Thromboxane signalling through TP receptor R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs) |
SIGNORi | P30679 |
Names & Taxonomyi
Protein namesi | Recommended name: Guanine nucleotide-binding protein subunit alpha-15Short name: G alpha-15 Short name: G-protein subunit alpha-15 Alternative name(s): Epididymis tissue protein Li 17E Guanine nucleotide-binding protein subunit alpha-16 Short name: G alpha-16 Short name: G-protein subunit alpha-16 |
Gene namesi | Name:GNA15 Synonyms:GNA16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4383, GNA15 |
MIMi | 139314, gene |
neXtProti | NX_P30679 |
VEuPathDBi | HostDB:ENSG00000060558.3 |
Subcellular locationi
Plasma Membrane
- heterotrimeric G-protein complex Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- synapse Source: GOC
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 2769 |
PharmGKBi | PA28768 |
Miscellaneous databases
Pharosi | P30679, Tbio |
Genetic variation databases
BioMutai | GNA15 |
DMDMi | 311033388 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203755 | 1 – 374 | Guanine nucleotide-binding protein subunit alpha-15Add BLAST | 374 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 186 | ADP-ribosylarginine; by cholera toxinBy similarity | 1 |
Keywords - PTMi
ADP-ribosylationProteomic databases
EPDi | P30679 |
jPOSTi | P30679 |
MassIVEi | P30679 |
MaxQBi | P30679 |
PaxDbi | P30679 |
PeptideAtlasi | P30679 |
PRIDEi | P30679 |
ProteomicsDBi | 54731 |
PTM databases
iPTMneti | P30679 |
PhosphoSitePlusi | P30679 |
SwissPalmi | P30679 |
Expressioni
Tissue specificityi
Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000060558, Expressed in lower esophagus mucosa and 168 other tissues |
ExpressionAtlasi | P30679, baseline and differential |
Genevisiblei | P30679, HS |
Organism-specific databases
HPAi | ENSG00000060558, Tissue enhanced (bone marrow, esophagus, lymphoid tissue) |
Interactioni
Subunit structurei
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
GO - Molecular functioni
- G protein-coupled receptor binding Source: UniProtKB
- type 2A serotonin receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109031, 8 interactors |
IntActi | P30679, 14 interactors |
STRINGi | 9606.ENSP00000262958 |
Chemistry databases
BindingDBi | P30679 |
Miscellaneous databases
RNActi | P30679, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 374 | G-alphaPROSITE-ProRule annotationAdd BLAST | 334 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 44 – 57 | G1 motifPROSITE-ProRule annotationAdd BLAST | 14 | |
Regioni | 181 – 189 | G2 motifPROSITE-ProRule annotation | 9 | |
Regioni | 204 – 213 | G3 motifPROSITE-ProRule annotation | 10 | |
Regioni | 273 – 280 | G4 motifPROSITE-ProRule annotation | 8 | |
Regioni | 344 – 349 | G5 motifPROSITE-ProRule annotation | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0085, Eukaryota |
HOGENOMi | CLU_014184_6_0_1 |
InParanoidi | P30679 |
OrthoDBi | 754573at2759 |
PhylomeDBi | P30679 |
TreeFami | TF300673 |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit |
InterProi | View protein in InterPro IPR000654, Gprotein_alpha_Q IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00442, GPROTEINAQ |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P30679-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARSLTWRCC PWCLTEDEKA AARVDQEINR ILLEQKKQDR GELKLLLLGP
60 70 80 90 100
GESGKSTFIK QMRIIHGAGY SEEERKGFRP LVYQNIFVSM RAMIEAMERL
110 120 130 140 150
QIPFSRPESK HHASLVMSQD PYKVTTFEKR YAAAMQWLWR DAGIRAYYER
160 170 180 190 200
RREFHLLDSA VYYLSHLERI TEEGYVPTAQ DVLRSRMPTT GINEYCFSVQ
210 220 230 240 250
KTNLRIVDVG GQKSERKKWI HCFENVIALI YLASLSEYDQ CLEENNQENR
260 270 280 290 300
MKESLALFGT ILELPWFKST SVILFLNKTD ILEEKIPTSH LATYFPSFQG
310 320 330 340 350
PKQDAEAAKR FILDMYTRMY TGCVDGPEGS KKGARSRRLF SHYTCATDTQ
360 370
NIRKVFKDVR DSVLARYLDE INLL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7EP74 | K7EP74_HUMAN | Guanine nucleotide-binding protein ... | GNA15 | 52 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028000 | 147 | Y → C6 PublicationsCorresponds to variant dbSNP:rs310680Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63904 mRNA Translation: AAA35860.1 GU727637 mRNA Translation: ADU87639.1 GU727645 mRNA Translation: ADU87646.1 AF493904 mRNA Translation: AAM12618.1 BT009850 mRNA Translation: AAP88852.1 AC005264 Genomic DNA Translation: AAC25612.1 AC005262 Genomic DNA Translation: AAC25616.1 CH471139 Genomic DNA Translation: EAW69338.1 BC013585 mRNA Translation: AAH13585.1 |
CCDSi | CCDS12104.1 |
PIRi | A41096 |
RefSeqi | NP_002059.3, NM_002068.3 |
Genome annotation databases
Ensembli | ENST00000262958; ENSP00000262958; ENSG00000060558 |
GeneIDi | 2769 |
KEGGi | hsa:2769 |
UCSCi | uc002lxf.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63904 mRNA Translation: AAA35860.1 GU727637 mRNA Translation: ADU87639.1 GU727645 mRNA Translation: ADU87646.1 AF493904 mRNA Translation: AAM12618.1 BT009850 mRNA Translation: AAP88852.1 AC005264 Genomic DNA Translation: AAC25612.1 AC005262 Genomic DNA Translation: AAC25616.1 CH471139 Genomic DNA Translation: EAW69338.1 BC013585 mRNA Translation: AAH13585.1 |
CCDSi | CCDS12104.1 |
PIRi | A41096 |
RefSeqi | NP_002059.3, NM_002068.3 |
3D structure databases
SMRi | P30679 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109031, 8 interactors |
IntActi | P30679, 14 interactors |
STRINGi | 9606.ENSP00000262958 |
Chemistry databases
BindingDBi | P30679 |
PTM databases
iPTMneti | P30679 |
PhosphoSitePlusi | P30679 |
SwissPalmi | P30679 |
Genetic variation databases
BioMutai | GNA15 |
DMDMi | 311033388 |
Proteomic databases
EPDi | P30679 |
jPOSTi | P30679 |
MassIVEi | P30679 |
MaxQBi | P30679 |
PaxDbi | P30679 |
PeptideAtlasi | P30679 |
PRIDEi | P30679 |
ProteomicsDBi | 54731 |
Protocols and materials databases
Antibodypediai | 23159, 249 antibodies |
DNASUi | 2769 |
Genome annotation databases
Ensembli | ENST00000262958; ENSP00000262958; ENSG00000060558 |
GeneIDi | 2769 |
KEGGi | hsa:2769 |
UCSCi | uc002lxf.3, human |
Organism-specific databases
CTDi | 2769 |
DisGeNETi | 2769 |
GeneCardsi | GNA15 |
HGNCi | HGNC:4383, GNA15 |
HPAi | ENSG00000060558, Tissue enhanced (bone marrow, esophagus, lymphoid tissue) |
MIMi | 139314, gene |
neXtProti | NX_P30679 |
PharmGKBi | PA28768 |
VEuPathDBi | HostDB:ENSG00000060558.3 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0085, Eukaryota |
HOGENOMi | CLU_014184_6_0_1 |
InParanoidi | P30679 |
OrthoDBi | 754573at2759 |
PhylomeDBi | P30679 |
TreeFami | TF300673 |
Enzyme and pathway databases
PathwayCommonsi | P30679 |
Reactomei | R-HSA-399997, Acetylcholine regulates insulin secretion R-HSA-416476, G alpha (q) signalling events R-HSA-418592, ADP signalling through P2Y purinoceptor 1 R-HSA-428930, Thromboxane signalling through TP receptor R-HSA-434316, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs) |
SIGNORi | P30679 |
Miscellaneous databases
BioGRID-ORCSi | 2769, 4 hits in 869 CRISPR screens |
ChiTaRSi | GNA15, human |
GenomeRNAii | 2769 |
Pharosi | P30679, Tbio |
PROi | PR:P30679 |
RNActi | P30679, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000060558, Expressed in lower esophagus mucosa and 168 other tissues |
ExpressionAtlasi | P30679, baseline and differential |
Genevisiblei | P30679, HS |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit |
InterProi | View protein in InterPro IPR000654, Gprotein_alpha_Q IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00442, GPROTEINAQ |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GNA15_HUMAN | |
Accessioni | P30679Primary (citable) accession number: P30679 Secondary accession number(s): E9KL40 Q53XK2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 10, 2021 | |
This is version 199 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families