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Protein

Guanine nucleotide-binding protein subunit alpha-15

Gene

GNA15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56MagnesiumBy similarity1
Metal bindingi189MagnesiumBy similarity1
Binding sitei346GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56GTPBy similarity8
Nucleotide bindingi183 – 189GTPBy similarity7
Nucleotide bindingi208 – 212GTPBy similarity5
Nucleotide bindingi277 – 280GTPBy similarity4

GO - Molecular functioni

  • G-protein beta/gamma-subunit complex binding Source: GO_Central
  • G protein-coupled receptor binding Source: UniProtKB
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-416476 G alpha (q) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-15
Short name:
G alpha-15
Short name:
G-protein subunit alpha-15
Alternative name(s):
Epididymis tissue protein Li 17E
Guanine nucleotide-binding protein subunit alpha-16
Short name:
G alpha-16
Short name:
G-protein subunit alpha-16
Gene namesi
Name:GNA15
Synonyms:GNA16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000060558.3
HGNCiHGNC:4383 GNA15
MIMi139314 gene
neXtProtiNX_P30679

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi2769
PharmGKBiPA28768

Polymorphism and mutation databases

BioMutaiGNA15
DMDMi311033388

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002037551 – 374Guanine nucleotide-binding protein subunit alpha-15Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186ADP-ribosylarginine; by cholera toxinBy similarity1

Keywords - PTMi

ADP-ribosylation

Proteomic databases

EPDiP30679
MaxQBiP30679
PaxDbiP30679
PeptideAtlasiP30679
PRIDEiP30679
ProteomicsDBi54731

PTM databases

iPTMnetiP30679
PhosphoSitePlusiP30679
SwissPalmiP30679

Expressioni

Tissue specificityi

Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000060558 Expressed in 158 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_GNA15
ExpressionAtlasiP30679 baseline and differential
GenevisibleiP30679 HS

Organism-specific databases

HPAiHPA043113

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109031, 8 interactors
IntActiP30679, 9 interactors
STRINGi9606.ENSP00000262958

Chemistry databases

BindingDBiP30679

Structurei

3D structure databases

ProteinModelPortaliP30679
SMRiP30679
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0085 Eukaryota
ENOG410XNVQ LUCA
HOGENOMiHOG000038729
HOVERGENiHBG063184
InParanoidiP30679
KOiK04637
OrthoDBiEOG091G0VUT
PhylomeDBiP30679
TreeFamiTF300673

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000654 Gprotein_alpha_Q
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00442 GPROTEINAQ
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P30679-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSLTWRCC PWCLTEDEKA AARVDQEINR ILLEQKKQDR GELKLLLLGP
60 70 80 90 100
GESGKSTFIK QMRIIHGAGY SEEERKGFRP LVYQNIFVSM RAMIEAMERL
110 120 130 140 150
QIPFSRPESK HHASLVMSQD PYKVTTFEKR YAAAMQWLWR DAGIRAYYER
160 170 180 190 200
RREFHLLDSA VYYLSHLERI TEEGYVPTAQ DVLRSRMPTT GINEYCFSVQ
210 220 230 240 250
KTNLRIVDVG GQKSERKKWI HCFENVIALI YLASLSEYDQ CLEENNQENR
260 270 280 290 300
MKESLALFGT ILELPWFKST SVILFLNKTD ILEEKIPTSH LATYFPSFQG
310 320 330 340 350
PKQDAEAAKR FILDMYTRMY TGCVDGPEGS KKGARSRRLF SHYTCATDTQ
360 370
NIRKVFKDVR DSVLARYLDE INLL
Length:374
Mass (Da):43,568
Last modified:November 2, 2010 - v2
Checksum:iF32F8C9198FDC26A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EP74K7EP74_HUMAN
Guanine nucleotide-binding protein ...
GNA15
52Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028000147Y → C6 PublicationsCorresponds to variant dbSNP:rs310680Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63904 mRNA Translation: AAA35860.1
GU727637 mRNA Translation: ADU87639.1
GU727645 mRNA Translation: ADU87646.1
AF493904 mRNA Translation: AAM12618.1
BT009850 mRNA Translation: AAP88852.1
AC005264 Genomic DNA Translation: AAC25612.1
AC005262 Genomic DNA Translation: AAC25616.1
CH471139 Genomic DNA Translation: EAW69338.1
BC013585 mRNA Translation: AAH13585.1
CCDSiCCDS12104.1
PIRiA41096
RefSeqiNP_002059.3, NM_002068.3
UniGeneiHs.73797

Genome annotation databases

EnsembliENST00000262958; ENSP00000262958; ENSG00000060558
GeneIDi2769
KEGGihsa:2769
UCSCiuc002lxf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63904 mRNA Translation: AAA35860.1
GU727637 mRNA Translation: ADU87639.1
GU727645 mRNA Translation: ADU87646.1
AF493904 mRNA Translation: AAM12618.1
BT009850 mRNA Translation: AAP88852.1
AC005264 Genomic DNA Translation: AAC25612.1
AC005262 Genomic DNA Translation: AAC25616.1
CH471139 Genomic DNA Translation: EAW69338.1
BC013585 mRNA Translation: AAH13585.1
CCDSiCCDS12104.1
PIRiA41096
RefSeqiNP_002059.3, NM_002068.3
UniGeneiHs.73797

3D structure databases

ProteinModelPortaliP30679
SMRiP30679
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109031, 8 interactors
IntActiP30679, 9 interactors
STRINGi9606.ENSP00000262958

Chemistry databases

BindingDBiP30679

PTM databases

iPTMnetiP30679
PhosphoSitePlusiP30679
SwissPalmiP30679

Polymorphism and mutation databases

BioMutaiGNA15
DMDMi311033388

Proteomic databases

EPDiP30679
MaxQBiP30679
PaxDbiP30679
PeptideAtlasiP30679
PRIDEiP30679
ProteomicsDBi54731

Protocols and materials databases

DNASUi2769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262958; ENSP00000262958; ENSG00000060558
GeneIDi2769
KEGGihsa:2769
UCSCiuc002lxf.3 human

Organism-specific databases

CTDi2769
DisGeNETi2769
EuPathDBiHostDB:ENSG00000060558.3
GeneCardsiGNA15
H-InvDBiHIX0014634
HGNCiHGNC:4383 GNA15
HPAiHPA043113
MIMi139314 gene
neXtProtiNX_P30679
PharmGKBiPA28768
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0085 Eukaryota
ENOG410XNVQ LUCA
HOGENOMiHOG000038729
HOVERGENiHBG063184
InParanoidiP30679
KOiK04637
OrthoDBiEOG091G0VUT
PhylomeDBiP30679
TreeFamiTF300673

Enzyme and pathway databases

ReactomeiR-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-416476 G alpha (q) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)

Miscellaneous databases

ChiTaRSiGNA15 human
GenomeRNAii2769
PROiPR:P30679
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000060558 Expressed in 158 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_GNA15
ExpressionAtlasiP30679 baseline and differential
GenevisibleiP30679 HS

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR000654 Gprotein_alpha_Q
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00442 GPROTEINAQ
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNA15_HUMAN
AccessioniPrimary (citable) accession number: P30679
Secondary accession number(s): E9KL40
, E9KL47, O75247, Q53XK2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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