GNA15

Functionⁱ

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	56	MagnesiumBy similarity	1
Metal bindingⁱ	189	MagnesiumBy similarity	1
Binding siteⁱ	346	GTP; via amide nitrogenBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	49 – 56	GTPBy similarity	8
Nucleotide bindingⁱ	183 – 189	GTPBy similarity	7
Nucleotide bindingⁱ	208 – 212	GTPBy similarity	5
Nucleotide bindingⁱ	277 – 280	GTPBy similarity	4

GO - Molecular functionⁱ

G-protein beta/gamma-subunit complex binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10571060
GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of phospholipase C activity
Source: ProtInc
Traceable author statementⁱ
- 7797501
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: Reactome
phospholipase C-activating dopamine receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 7797501
platelet activation Source: Reactome
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Source: UniProtKB
Inferred from physical interactionⁱ
- 10571060

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transducer
Ligand	GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-399997 Acetylcholine regulates insulin secretion R-HSA-416476 G alpha (q) signalling events R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-428930 Thromboxane signalling through TP receptor R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)

Reactomeⁱ

R-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-416476 G alpha (q) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Guanine nucleotide-binding protein subunit alpha-15 Short name: G alpha-15 Short name: G-protein subunit alpha-15 Alternative name(s): Epididymis tissue protein Li 17E Guanine nucleotide-binding protein subunit alpha-16 Short name: G alpha-16 Short name: G-protein subunit alpha-16
Gene namesⁱ	Name:GNA15 Synonyms:GNA16
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000060558.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4383 GNA15
MIMⁱ	139314 gene
neXtProtⁱ	NX_P30679

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2769
PharmGKBⁱ	PA28768

Polymorphism and mutation databases

BioMutaⁱ	GNA15
DMDMⁱ	311033388

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000203755	1 – 374	Guanine nucleotide-binding protein subunit alpha-15Add BLAST		374

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	186	ADP-ribosylarginine; by cholera toxinBy similarity		1

Keywords - PTMⁱ

ADP-ribosylation

Proteomic databases

EPDⁱ	P30679
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P30679
PaxDbⁱ	P30679
PeptideAtlas More...PeptideAtlasⁱ	P30679
PRIDEⁱ	P30679
ProteomicsDBⁱ	54731

PTM databases

iPTMnetⁱ	P30679
PhosphoSitePlusⁱ	P30679
SwissPalmⁱ	P30679

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000060558 Expressed in 158 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_GNA15
ExpressionAtlasⁱ	P30679 baseline and differential
Genevisibleⁱ	P30679 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043113

HPAⁱ

HPA043113

Interactionⁱ

Subunit structureⁱ

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functionⁱ

G protein-coupled receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10571060

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109031, 8 interactors
IntActⁱ	P30679, 9 interactors
STRINGⁱ	9606.ENSP00000262958

Chemistry databases

BindingDBⁱ	P30679

BindingDBⁱ

P30679

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P30679
SMRⁱ	P30679
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0085 Eukaryota ENOG410XNVQ LUCA
HOGENOMⁱ	HOG000038729
HOVERGENⁱ	HBG063184
InParanoidⁱ	P30679
KEGG Orthology (KO) More...KOⁱ	K04637
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VUT
PhylomeDBⁱ	P30679
TreeFamⁱ	TF300673

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00066 G-alpha, 1 hit
Gene3Dⁱ	1.10.400.10, 1 hit
InterProⁱ	View protein in InterPro IPR000654 Gprotein_alpha_Q IPR001019 Gprotein_alpha_su IPR011025 GproteinA_insert IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10218 PTHR10218, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00503 G-alpha, 1 hit
PRINTSⁱ	PR00318 GPROTEINA PR00442 GPROTEINAQ
SMARTⁱ	View protein in SMART SM00275 G_alpha, 1 hit
SUPFAMⁱ	SSF47895 SSF47895, 1 hit SSF52540 SSF52540, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P30679-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARSLTWRCC PWCLTEDEKA AARVDQEINR ILLEQKKQDR GELKLLLLGP 
        60         70         80         90        100
GESGKSTFIK QMRIIHGAGY SEEERKGFRP LVYQNIFVSM RAMIEAMERL 
       110        120        130        140        150
QIPFSRPESK HHASLVMSQD PYKVTTFEKR YAAAMQWLWR DAGIRAYYER 
       160        170        180        190        200
RREFHLLDSA VYYLSHLERI TEEGYVPTAQ DVLRSRMPTT GINEYCFSVQ 
       210        220        230        240        250
KTNLRIVDVG GQKSERKKWI HCFENVIALI YLASLSEYDQ CLEENNQENR 
       260        270        280        290        300
MKESLALFGT ILELPWFKST SVILFLNKTD ILEEKIPTSH LATYFPSFQG 
       310        320        330        340        350
PKQDAEAAKR FILDMYTRMY TGCVDGPEGS KKGARSRRLF SHYTCATDTQ 
       360        370 
NIRKVFKDVR DSVLARYLDE INLL

Length:374

Mass (Da):43,568

Last modified:November 2, 2010 - v2

Checksum:ⁱF32F8C9198FDC26A

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	K7EP74	K7EP74_HUMAN		Guanine nucleotide-binding protein ... Guanine nucleotide-binding protein subunit alpha-15	GNA15	52	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_028000	147	Y → C6 PublicationsCorresponds to variant dbSNP:rs310680Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63904 mRNA Translation: AAA35860.1 GU727637 mRNA Translation: ADU87639.1 GU727645 mRNA Translation: ADU87646.1 AF493904 mRNA Translation: AAM12618.1 BT009850 mRNA Translation: AAP88852.1 AC005264 Genomic DNA Translation: AAC25612.1 AC005262 Genomic DNA Translation: AAC25616.1 CH471139 Genomic DNA Translation: EAW69338.1 BC013585 mRNA Translation: AAH13585.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12104.1
PIRⁱ	A41096
NCBI Reference Sequences More...RefSeqⁱ	NP_002059.3, NM_002068.3
UniGeneⁱ	Hs.73797

Genome annotation databases

Ensemblⁱ	ENST00000262958; ENSP00000262958; ENSG00000060558
GeneIDⁱ	2769
KEGGⁱ	hsa:2769
UCSC genome browser More...UCSCⁱ	uc002lxf.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P30679	Guanine nucleotide-binding protein subunit alpha-15		FUKDA		454	UniRef90_P30679
G protein subunit alpha 15		AOTNA		374
G protein subunit alpha 15		SAIBB		374
Uncharacterized protein		MUSPF		374
guanine nucleotide-binding protein subunit alpha-15		Enhydra lutris kenyoni		374
+63

Protein	Similar proteins		Species	Score	Length	Source
P30679	Guanine nucleotide-binding protein subunit alpha-15		FUKDA		454	UniRef50_P30679
G protein subunit alpha 15		AOTNA		374
Uncharacterized protein		AILME		374
GNA15 isoform 1		PONAB		374
Guanine nucleotide-binding protein subunit alpha-15		MYODS		374
+80

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63904 mRNA Translation: AAA35860.1 GU727637 mRNA Translation: ADU87639.1 GU727645 mRNA Translation: ADU87646.1 AF493904 mRNA Translation: AAM12618.1 BT009850 mRNA Translation: AAP88852.1 AC005264 Genomic DNA Translation: AAC25612.1 AC005262 Genomic DNA Translation: AAC25616.1 CH471139 Genomic DNA Translation: EAW69338.1 BC013585 mRNA Translation: AAH13585.1
CCDSⁱ	CCDS12104.1
PIRⁱ	A41096
RefSeqⁱ	NP_002059.3, NM_002068.3
UniGeneⁱ	Hs.73797

3D structure databases

ProteinModelPortalⁱ	P30679
SMRⁱ	P30679
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109031, 8 interactors
IntActⁱ	P30679, 9 interactors
STRINGⁱ	9606.ENSP00000262958

Chemistry databases

BindingDBⁱ	P30679

BindingDBⁱ

P30679

PTM databases

iPTMnetⁱ	P30679
PhosphoSitePlusⁱ	P30679
SwissPalmⁱ	P30679

Polymorphism and mutation databases

BioMutaⁱ	GNA15
DMDMⁱ	311033388

Proteomic databases

EPDⁱ	P30679
MaxQBⁱ	P30679
PaxDbⁱ	P30679
PeptideAtlasⁱ	P30679
PRIDEⁱ	P30679
ProteomicsDBⁱ	54731

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2769
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262958; ENSP00000262958; ENSG00000060558
GeneIDⁱ	2769
KEGGⁱ	hsa:2769
UCSCⁱ	uc002lxf.3 human

Organism-specific databases

CTDⁱ	2769
DisGeNETⁱ	2769
EuPathDBⁱ	HostDB:ENSG00000060558.3
GeneCardsⁱ	GNA15
H-InvDBⁱ	HIX0014634
HGNCⁱ	HGNC:4383 GNA15
HPAⁱ	HPA043113
MIMⁱ	139314 gene
neXtProtⁱ	NX_P30679
PharmGKBⁱ	PA28768
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0085 Eukaryota ENOG410XNVQ LUCA
HOGENOMⁱ	HOG000038729
HOVERGENⁱ	HBG063184
InParanoidⁱ	P30679
KOⁱ	K04637
OrthoDBⁱ	EOG091G0VUT
PhylomeDBⁱ	P30679
TreeFamⁱ	TF300673

Enzyme and pathway databases

Reactomeⁱ	R-HSA-399997 Acetylcholine regulates insulin secretion R-HSA-416476 G alpha (q) signalling events R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-428930 Thromboxane signalling through TP receptor R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)

Reactomeⁱ

R-HSA-399997 Acetylcholine regulates insulin secretion
R-HSA-416476 G alpha (q) signalling events
R-HSA-418592 ADP signalling through P2Y purinoceptor 1
R-HSA-428930 Thromboxane signalling through TP receptor
R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs)

Miscellaneous databases

ChiTaRSⁱ	GNA15 human
GenomeRNAiⁱ	2769
Protein Ontology More...PROⁱ	PR:P30679
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000060558 Expressed in 158 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_GNA15
ExpressionAtlasⁱ	P30679 baseline and differential
Genevisibleⁱ	P30679 HS

Family and domain databases

CDDⁱ	cd00066 G-alpha, 1 hit
Gene3Dⁱ	1.10.400.10, 1 hit
InterProⁱ	View protein in InterPro IPR000654 Gprotein_alpha_Q IPR001019 Gprotein_alpha_su IPR011025 GproteinA_insert IPR027417 P-loop_NTPase
PANTHERⁱ	PTHR10218 PTHR10218, 1 hit
Pfamⁱ	View protein in Pfam PF00503 G-alpha, 1 hit
PRINTSⁱ	PR00318 GPROTEINA PR00442 GPROTEINAQ
SMARTⁱ	View protein in SMART SM00275 G_alpha, 1 hit
SUPFAMⁱ	SSF47895 SSF47895, 1 hit SSF52540 SSF52540, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GNA15_HUMAN
Accessionⁱ	P30679Primary (citable) accession number: P30679 Secondary accession number(s): E9KL40 , E9KL47, O75247, Q53XK2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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UniProtKB - P30679 (GNA15_HUMAN)

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Guanine nucleotide-binding protein subunit alpha-15

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ