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UniProtKB - P30655 (PSB5_SCHPO)

Entry version 171 (25 May 2022)
Sequence version 3 (15 Jul 1998)
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Protein

Probable proteasome subunit beta type-5

Gene

pts1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of peptide bonds with very broad specificity. EC:3.4.25.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei62NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SPO-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113, SCF-beta-TrCP mediated degradation of Emi1
R-SPO-350562, Regulation of ornithine decarboxylase (ODC)
R-SPO-382556, ABC-family proteins mediated transport
R-SPO-5668541, TNFR2 non-canonical NF-kB pathway
R-SPO-5689603, UCH proteinases
R-SPO-5689880, Ub-specific processing proteases
R-SPO-68949, Orc1 removal from chromatin
R-SPO-69017, CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-75815, Ubiquitin-dependent degradation of Cyclin D
R-SPO-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SPO-8948751, Regulation of PTEN stability and activity
R-SPO-983168, Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPS protease database

More...MEROPSi		T01.012

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable proteasome subunit beta type-5 (EC:3.4.25.1)
Alternative name(s):
Macropain subunit pts1
Multicatalytic endopeptidase complex subunit pts1
Proteasome component pts1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pts1
ORF Names:SPAC4A8.13c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...PomBasei		SPAC4A8.13c, pts1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:SPAC4A8.13c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000266091 – 61Removed in mature formBy similarityAdd BLAST61
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002661062 – 272Probable proteasome subunit beta type-5Add BLAST211

Keywords - PTMi

Zymogen

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P30655

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30655

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30655

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		280037, 5 interactors

STRING: functional protein association networks

More...STRINGi		4896.SPAC4A8.13c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P30655

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30655

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0175, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035750_7_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30655

Identification of Orthologs from Complete Genome Data

More...OMAi		NLGMAMQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30655

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.60.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR000243, Pept_T1A_subB
IPR035705, Proteasome_beta8
IPR016050, Proteasome_bsu_CS
IPR001353, Proteasome_sua/b
IPR023333, Proteasome_suB-type

The PANTHER Classification System

More...PANTHERi		PTHR11599:SF53, PTHR11599:SF53, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00227, Proteasome, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00141, PROTEASOME

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56235, SSF56235, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00854, PROTEASOME_BETA_1, 1 hit
PS51476, PROTEASOME_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P30655-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSIVSKYTQ STNNDDPKKI IEEEGFTNRF DVVPVPQSSL YLRNLTDETK 
        60         70         80         90        100
NKHCLIKMNH GTTTLAFRYQ HGIVVCVDSR ASAGPLIASQ TVKKVIEINP 
       110        120        130        140        150
YLLGTLAGGA ADCQFWETVL GMECRLHQLR NKELISVSAA SKILSNITYS 
       160        170        180        190        200
YKGYGLSMGT MLAGTGKGGT ALYYIDSDGT RLKGDLFSVG SGSTFAYGVL 
       210        220        230        240        250
DSGYRWDLSK QEALYLAQRS IVAATHRDAY SGGSVNLYHI DENGWVFHGN 
       260        270 
FDVDSLIWEA KDNENSFAHI PR
Length:272
Mass (Da):29,987
Last modified:July 15, 1998 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FC37D02A06B5E61
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA58746 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D13094 Genomic DNA Translation: BAA02403.1
CU329670 Genomic DNA Translation: CAB11483.1
X83866 Genomic DNA Translation: CAA58746.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		JS0753
T38783

NCBI Reference Sequences

More...RefSeqi		NP_593825.1, NM_001019254.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPAC4A8.13c.1; SPAC4A8.13c.1:pep; SPAC4A8.13c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2543623

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPAC4A8.13c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13094 Genomic DNA Translation: BAA02403.1
CU329670 Genomic DNA Translation: CAB11483.1
X83866 Genomic DNA Translation: CAA58746.1 Different initiation.
PIRiJS0753
T38783
RefSeqiNP_593825.1, NM_001019254.2

3D structure databases

AlphaFoldDBiP30655
SMRiP30655
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi280037, 5 interactors
STRINGi4896.SPAC4A8.13c.1

Protein family/group databases

MEROPSiT01.012

PTM databases

iPTMnetiP30655

Proteomic databases

MaxQBiP30655
PaxDbiP30655

Genome annotation databases

EnsemblFungiiSPAC4A8.13c.1; SPAC4A8.13c.1:pep; SPAC4A8.13c
GeneIDi2543623
KEGGispo:SPAC4A8.13c

Organism-specific databases

PomBaseiSPAC4A8.13c, pts1
VEuPathDBiFungiDB:SPAC4A8.13c

Phylogenomic databases

eggNOGiKOG0175, Eukaryota
HOGENOMiCLU_035750_7_1_1
InParanoidiP30655
OMAiNLGMAMQ
PhylomeDBiP30655

Enzyme and pathway databases

ReactomeiR-SPO-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113, SCF-beta-TrCP mediated degradation of Emi1
R-SPO-350562, Regulation of ornithine decarboxylase (ODC)
R-SPO-382556, ABC-family proteins mediated transport
R-SPO-5668541, TNFR2 non-canonical NF-kB pathway
R-SPO-5689603, UCH proteinases
R-SPO-5689880, Ub-specific processing proteases
R-SPO-68949, Orc1 removal from chromatin
R-SPO-69017, CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-75815, Ubiquitin-dependent degradation of Cyclin D
R-SPO-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-SPO-8948751, Regulation of PTEN stability and activity
R-SPO-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...PROi		PR:P30655

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055, Ntn_hydrolases_N
IPR000243, Pept_T1A_subB
IPR035705, Proteasome_beta8
IPR016050, Proteasome_bsu_CS
IPR001353, Proteasome_sua/b
IPR023333, Proteasome_suB-type
PANTHERiPTHR11599:SF53, PTHR11599:SF53, 1 hit
PfamiView protein in Pfam
PF00227, Proteasome, 1 hit
PRINTSiPR00141, PROTEASOME
SUPFAMiSSF56235, SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854, PROTEASOME_BETA_1, 1 hit
PS51476, PROTEASOME_BETA_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSB5_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30655
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 15, 1998
Last modified: May 25, 2022
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
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