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UniProtKB - P30634 (MPIP3_CAEEL)
Protein
M-phase inducer phosphatase cdc-25.3
Gene
cdc-25.3
Organism
Caenorhabditis elegans
Status
Functioni
Catalytic activityi
- EC:3.1.3.48
GO - Molecular functioni
- phosphoprotein phosphatase activity Source: WormBase
- protein tyrosine phosphatase activity Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- G2/M transition of mitotic cell cycle Source: GO_Central
- mitotic cell cycle Source: WormBase
- positive regulation of G2/MI transition of meiotic cell cycle Source: GO_Central
- positive regulation of G2/M transition of mitotic cell cycle Source: GO_Central
- protein dephosphorylation Source: WormBase
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: M-phase inducer phosphatase cdc-25.3 (EC:3.1.3.48)Alternative name(s): Cell division cycle-related protein 25.3 |
Gene namesi | Name:cdc-25.3 ORF Names:ZK637.11 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | ZK637.11 ; CE00429 ; WBGene00000388 ; cdc-25.3 |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198657 | 1 – 316 | M-phase inducer phosphatase cdc-25.3Add BLAST | 316 |
Proteomic databases
EPDi | P30634 |
PaxDbi | P30634 |
Expressioni
Gene expression databases
Bgeei | WBGene00000388, Expressed in multi-cellular organism and 4 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 41461, 2 interactors |
IntActi | P30634, 2 interactors |
MINTi | P30634 |
STRINGi | 6239.ZK637.11 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 136 – 242 | RhodanesePROSITE-ProRule annotationAdd BLAST | 107 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 65 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the MPI phosphatase family.Curated
Phylogenomic databases
eggNOGi | KOG3772, Eukaryota |
GeneTreei | ENSGT00970000196560 |
HOGENOMi | CLU_931390_0_0_1 |
InParanoidi | P30634 |
OMAi | PCENCIV |
OrthoDBi | 1423329at2759 |
PhylomeDBi | P30634 |
Family and domain databases
CDDi | cd01530, Cdc25, 1 hit |
Gene3Di | 3.40.250.10, 1 hit |
InterProi | View protein in InterPro IPR000751, MPI_Phosphatase IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf |
Pfami | View protein in Pfam PF00581, Rhodanese, 1 hit |
PRINTSi | PR00716, MPIPHPHTASE |
SMARTi | View protein in SMART SM00450, RHOD, 1 hit |
SUPFAMi | SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P30634-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCVDVPCENC IVRNDGLRLK CSECAEGSSK LFPRQNRQHS SAISHISNSS
60 70 80 90 100
PPTRKRSIDG GYTSGTDSAN TSEIVIKKRL TFSKKSHSTS EIETWNAHLQ
110 120 130 140 150
VDYHLETVTP SCSTVYQKIT SETLIEIMQK LSQIEFMQKY ILIDCRYDYE
160 170 180 190 200
YNGGHIKGAQ SLFNPETAAD FFFNKDGSKK INRIPIFYCE YSQKRGPTMA
210 220 230 240 250
NNLREVDRKL NSNIYPRCDY EEIYLLEGGY KNFYAFTRGL EKEQRVQLCE
260 270 280 290 300
PDNYVIMFDD RYKAELRKHQ FHKKNVSKPM KKWSSTTSVI SILTTSGTRI
310
STLRQTCDPI HEHDAH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z11115 Genomic DNA Translation: CAA77456.1 |
PIRi | S15799 |
RefSeqi | NP_498972.1, NM_066571.4 |
Genome annotation databases
EnsemblMetazoai | ZK637.11.1; ZK637.11.1; WBGene00000388 |
GeneIDi | 176260 |
KEGGi | cel:CELE_ZK637.11 |
UCSCi | ZK637.11, c. elegans |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z11115 Genomic DNA Translation: CAA77456.1 |
PIRi | S15799 |
RefSeqi | NP_498972.1, NM_066571.4 |
3D structure databases
SMRi | P30634 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 41461, 2 interactors |
IntActi | P30634, 2 interactors |
MINTi | P30634 |
STRINGi | 6239.ZK637.11 |
Proteomic databases
EPDi | P30634 |
PaxDbi | P30634 |
Genome annotation databases
EnsemblMetazoai | ZK637.11.1; ZK637.11.1; WBGene00000388 |
GeneIDi | 176260 |
KEGGi | cel:CELE_ZK637.11 |
UCSCi | ZK637.11, c. elegans |
Organism-specific databases
CTDi | 176260 |
WormBasei | ZK637.11 ; CE00429 ; WBGene00000388 ; cdc-25.3 |
Phylogenomic databases
eggNOGi | KOG3772, Eukaryota |
GeneTreei | ENSGT00970000196560 |
HOGENOMi | CLU_931390_0_0_1 |
InParanoidi | P30634 |
OMAi | PCENCIV |
OrthoDBi | 1423329at2759 |
PhylomeDBi | P30634 |
Miscellaneous databases
PROi | PR:P30634 |
Gene expression databases
Bgeei | WBGene00000388, Expressed in multi-cellular organism and 4 other tissues |
Family and domain databases
CDDi | cd01530, Cdc25, 1 hit |
Gene3Di | 3.40.250.10, 1 hit |
InterProi | View protein in InterPro IPR000751, MPI_Phosphatase IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf |
Pfami | View protein in Pfam PF00581, Rhodanese, 1 hit |
PRINTSi | PR00716, MPIPHPHTASE |
SMARTi | View protein in SMART SM00450, RHOD, 1 hit |
SUPFAMi | SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MPIP3_CAEEL | |
Accessioni | P30634Primary (citable) accession number: P30634 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families