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Protein

Sorcin

Gene

SRI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.1 Publication

Miscellaneous

This protein is encoded by an amplified gene in multidrug-resistant cells.
This protein has been shown to bind calcium with high affinity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi83 – 941CuratedAdd BLAST12
Calcium bindingi113 – 1242CuratedAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium channel regulator activity Source: ProtInc
  • calcium ion binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • ion channel binding Source: BHF-UCL
  • protease binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • repressing transcription factor binding Source: Ensembl
  • signaling receptor binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P30626

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sorcin
Alternative name(s):
22 kDa protein
CP-22
Short name:
CP22
V19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000075142.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11292 SRI

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182520 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30626

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi112F → L: Reduces affinity for calcium 5-fold. 1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6717

Open Targets

More...
OpenTargetsi
ENSG00000075142

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36117

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRI

Domain mapping of disease mutations (DMDM)

More...
DMDMi
267021

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000737251 – 198SorcinAdd BLAST198

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P30626

MaxQB - The MaxQuant DataBase

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MaxQBi
P30626

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30626

PeptideAtlas

More...
PeptideAtlasi
P30626

PRoteomics IDEntifications database

More...
PRIDEi
P30626

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54730

Consortium for Top Down Proteomics

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TopDownProteomicsi
P30626-1 [P30626-1]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P30626

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30626

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30626

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P30626

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in cardiac myocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000075142 Expressed in 232 organ(s), highest expression level in colon

CleanEx database of gene expression profiles

More...
CleanExi
HS_SRI

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30626 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P30626 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019004
HPA073666

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with GCA, RYR2 and ANXA7.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112595, 42 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P30626

Database of interacting proteins

More...
DIPi
DIP-40970N

Protein interaction database and analysis system

More...
IntActi
P30626, 17 interactors

Molecular INTeraction database

More...
MINTi
P30626

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265729

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P30626

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30626

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P30626

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 64EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini70 – 103EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini100 – 135EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini134 – 169EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0037 Eukaryota
ENOG410YKQK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153979

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231982

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004492

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30626

Identification of Orthologs from Complete Genome Data

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OMAi
IQCVMSI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0ISY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30626

TreeFam database of animal gene trees

More...
TreeFami
TF314682

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13833 EF-hand_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30626-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID
60 70 80 90 100
ADELQRCLTQ SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA
110 120 130 140 150
VLNGWRQHFI SFDTDRSGTV DPQELQKALT TMGFRLSPQA VNSIAKRYST
160 170 180 190
NGKITFDDYI ACCVKLRALT DSFRRRDTAQ QGVVNFPYDD FIQCVMSV
Length:198
Mass (Da):21,676
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4829C7650A5E3FA
GO
Isoform 2 (identifier: P30626-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAYPGHPGAGGGYYPGG → MQ

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):20,345
Checksum:iA6B23B49FF8B9778
GO
Isoform 3 (identifier: P30626-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAYPGHPGAGGGYYPGG → MQ
     191-198: FIQCVMSV → VSLRN

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,006
Checksum:i2F652A7283896808
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DHQ6B4DHQ6_HUMAN
cDNA FLJ54267, moderately similar t...
SRI
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0K6C9J0K6_HUMAN
Sorcin
SRI
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PG82E9PG82_HUMAN
Sorcin
SRI
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0462771 – 17MAYPG…YYPGG → MQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_054463191 – 198FIQCVMSV → VSLRN in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L12387 mRNA Translation: AAA92155.1
M32886 mRNA Translation: AAA60588.1
AK296601 mRNA Translation: BAG59214.1
BM739144 mRNA No translation available.
AC003991 Genomic DNA No translation available.
AC005075 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76909.1
CH471091 Genomic DNA Translation: EAW76910.1
BC011025 mRNA Translation: AAH11025.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47638.1 [P30626-2]
CCDS5612.1 [P30626-1]
CCDS59063.1 [P30626-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
S52094

NCBI Reference Sequences

More...
RefSeqi
NP_001243820.1, NM_001256891.1
NP_001243821.1, NM_001256892.1 [P30626-3]
NP_003121.1, NM_003130.3 [P30626-1]
NP_944490.1, NM_198901.1 [P30626-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.489040

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265729; ENSP00000265729; ENSG00000075142 [P30626-1]
ENST00000394641; ENSP00000378137; ENSG00000075142 [P30626-2]
ENST00000431660; ENSP00000391148; ENSG00000075142 [P30626-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6717

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6717

UCSC genome browser

More...
UCSCi
uc003ujq.3 human [P30626-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12387 mRNA Translation: AAA92155.1
M32886 mRNA Translation: AAA60588.1
AK296601 mRNA Translation: BAG59214.1
BM739144 mRNA No translation available.
AC003991 Genomic DNA No translation available.
AC005075 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76909.1
CH471091 Genomic DNA Translation: EAW76910.1
BC011025 mRNA Translation: AAH11025.1
CCDSiCCDS47638.1 [P30626-2]
CCDS5612.1 [P30626-1]
CCDS59063.1 [P30626-3]
PIRiS52094
RefSeqiNP_001243820.1, NM_001256891.1
NP_001243821.1, NM_001256892.1 [P30626-3]
NP_003121.1, NM_003130.3 [P30626-1]
NP_944490.1, NM_198901.1 [P30626-2]
UniGeneiHs.489040

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JUOX-ray2.20A/B1-198[»]
2JC2X-ray2.50A/B/C/D1-198[»]
4U8DX-ray2.30A/B1-198[»]
4UPGX-ray2.10A30-198[»]
4USLX-ray1.65A1-198[»]
D1-32[»]
5MRAX-ray3.74A/B/C/D32-198[»]
ProteinModelPortaliP30626
SMRiP30626
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112595, 42 interactors
CORUMiP30626
DIPiDIP-40970N
IntActiP30626, 17 interactors
MINTiP30626
STRINGi9606.ENSP00000265729

PTM databases

iPTMnetiP30626
PhosphoSitePlusiP30626
SwissPalmiP30626

Polymorphism and mutation databases

BioMutaiSRI
DMDMi267021

2D gel databases

OGPiP30626

Proteomic databases

EPDiP30626
MaxQBiP30626
PaxDbiP30626
PeptideAtlasiP30626
PRIDEiP30626
ProteomicsDBi54730
TopDownProteomicsiP30626-1 [P30626-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265729; ENSP00000265729; ENSG00000075142 [P30626-1]
ENST00000394641; ENSP00000378137; ENSG00000075142 [P30626-2]
ENST00000431660; ENSP00000391148; ENSG00000075142 [P30626-3]
GeneIDi6717
KEGGihsa:6717
UCSCiuc003ujq.3 human [P30626-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6717
DisGeNETi6717
EuPathDBiHostDB:ENSG00000075142.13

GeneCards: human genes, protein and diseases

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GeneCardsi
SRI
HGNCiHGNC:11292 SRI
HPAiHPA019004
HPA073666
MIMi182520 gene
neXtProtiNX_P30626
OpenTargetsiENSG00000075142
PharmGKBiPA36117

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00940000153979
HOGENOMiHOG000231982
HOVERGENiHBG004492
InParanoidiP30626
OMAiIQCVMSI
OrthoDBiEOG091G0ISY
PhylomeDBiP30626
TreeFamiTF314682

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases
SIGNORiP30626

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SRI human
EvolutionaryTraceiP30626

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SRI_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6717

Protein Ontology

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PROi
PR:P30626

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000075142 Expressed in 232 organ(s), highest expression level in colon
CleanExiHS_SRI
ExpressionAtlasiP30626 baseline and differential
GenevisibleiP30626 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSORCN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30626
Secondary accession number(s): A8MTH6, B4DKK2, D6W5Q0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: December 5, 2018
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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