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Protein

Sorcin

Gene

SRI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.1 Publication

Miscellaneous

This protein is encoded by an amplified gene in multidrug-resistant cells.
This protein has been shown to bind calcium with high affinity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi83 – 941CuratedAdd BLAST12
Calcium bindingi113 – 1242CuratedAdd BLAST12

GO - Molecular functioni

  • calcium channel regulator activity Source: ProtInc
  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • calcium ion binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • ion channel binding Source: BHF-UCL
  • protease binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • repressing transcription factor binding Source: Ensembl
  • signaling receptor binding Source: ProtInc

GO - Biological processi

  • action potential Source: ProtInc
  • calcium ion transport Source: Ensembl
  • cytoplasmic sequestering of transcription factor Source: Ensembl
  • heart development Source: ProtInc
  • intracellular sequestering of iron ion Source: ProtInc
  • muscle organ development Source: ProtInc
  • negative regulation of cardiac muscle contraction Source: Ensembl
  • negative regulation of heart rate Source: BHF-UCL
  • negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
  • negative regulation of transcription regulatory region DNA binding Source: Ensembl
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
  • positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  • proteolysis Source: GO_Central
  • regulation of calcium ion transport Source: BHF-UCL
  • regulation of cardiac muscle cell contraction Source: BHF-UCL
  • regulation of cell communication by electrical coupling Source: BHF-UCL
  • regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
  • regulation of heart contraction Source: ProtInc
  • regulation of high voltage-gated calcium channel activity Source: BHF-UCL
  • regulation of relaxation of muscle Source: BHF-UCL
  • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
  • regulation of striated muscle contraction Source: ProtInc
  • signal transduction Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases
SIGNORiP30626

Names & Taxonomyi

Protein namesi
Recommended name:
Sorcin
Alternative name(s):
22 kDa protein
CP-22
Short name:
CP22
V19
Gene namesi
Name:SRI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000075142.13
HGNCiHGNC:11292 SRI
MIMi182520 gene
neXtProtiNX_P30626

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi112F → L: Reduces affinity for calcium 5-fold. 1

Organism-specific databases

DisGeNETi6717
OpenTargetsiENSG00000075142
PharmGKBiPA36117

Polymorphism and mutation databases

BioMutaiSRI
DMDMi267021

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737251 – 198SorcinAdd BLAST198

Proteomic databases

EPDiP30626
MaxQBiP30626
PaxDbiP30626
PeptideAtlasiP30626
PRIDEiP30626
ProteomicsDBi54730
TopDownProteomicsiP30626-1 [P30626-1]

2D gel databases

OGPiP30626

PTM databases

iPTMnetiP30626
PhosphoSitePlusiP30626
SwissPalmiP30626

Expressioni

Tissue specificityi

Detected in cardiac myocytes.

Gene expression databases

BgeeiENSG00000075142
CleanExiHS_SRI
ExpressionAtlasiP30626 baseline and differential
GenevisibleiP30626 HS

Organism-specific databases

HPAiHPA019004
HPA073666

Interactioni

Subunit structurei

Homodimer. Interacts with GCA, RYR2 and ANXA7.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • ion channel binding Source: BHF-UCL
  • protease binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • repressing transcription factor binding Source: Ensembl
  • signaling receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi112595, 40 interactors
CORUMiP30626
DIPiDIP-40970N
IntActiP30626, 18 interactors
MINTiP30626
STRINGi9606.ENSP00000265729

Structurei

Secondary structure

1198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 32Combined sources5
Helixi36 – 43Combined sources8
Helixi44 – 46Combined sources3
Helixi51 – 60Combined sources10
Turni61 – 64Combined sources4
Beta strandi66 – 68Combined sources3
Helixi72 – 82Combined sources11
Beta strandi84 – 86Combined sources3
Beta strandi88 – 90Combined sources3
Helixi92 – 112Combined sources21
Beta strandi118 – 120Combined sources3
Helixi122 – 131Combined sources10
Helixi138 – 147Combined sources10
Beta strandi149 – 152Combined sources4
Beta strandi153 – 155Combined sources3
Helixi156 – 176Combined sources21
Helixi178 – 180Combined sources3
Beta strandi182 – 187Combined sources6
Helixi188 – 196Combined sources9

3D structure databases

ProteinModelPortaliP30626
SMRiP30626
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP30626

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 64EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini70 – 103EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini100 – 135EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini134 – 169EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00620000087734
HOGENOMiHOG000231982
HOVERGENiHBG004492
InParanoidiP30626
OMAiIQCVMSI
OrthoDBiEOG091G0ISY
PhylomeDBiP30626
TreeFamiTF314682

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 4 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P30626-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAYPGHPGAG GGYYPGGYGG APGGPAFPGQ TQDPLYGYFA AVAGQDGQID
60 70 80 90 100
ADELQRCLTQ SGIAGGYKPF NLETCRLMVS MLDRDMSGTM GFNEFKELWA
110 120 130 140 150
VLNGWRQHFI SFDTDRSGTV DPQELQKALT TMGFRLSPQA VNSIAKRYST
160 170 180 190
NGKITFDDYI ACCVKLRALT DSFRRRDTAQ QGVVNFPYDD FIQCVMSV
Length:198
Mass (Da):21,676
Last modified:April 1, 1993 - v1
Checksum:iA4829C7650A5E3FA
GO
Isoform 2 (identifier: P30626-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAYPGHPGAGGGYYPGG → MQ

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):20,345
Checksum:iA6B23B49FF8B9778
GO
Isoform 3 (identifier: P30626-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAYPGHPGAGGGYYPGG → MQ
     191-198: FIQCVMSV → VSLRN

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,006
Checksum:i2F652A7283896808
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462771 – 17MAYPG…YYPGG → MQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_054463191 – 198FIQCVMSV → VSLRN in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12387 mRNA Translation: AAA92155.1
M32886 mRNA Translation: AAA60588.1
AK296601 mRNA Translation: BAG59214.1
BM739144 mRNA No translation available.
AC003991 Genomic DNA No translation available.
AC005075 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76909.1
CH471091 Genomic DNA Translation: EAW76910.1
BC011025 mRNA Translation: AAH11025.1
CCDSiCCDS47638.1 [P30626-2]
CCDS5612.1 [P30626-1]
CCDS59063.1 [P30626-3]
PIRiS52094
RefSeqiNP_001243820.1, NM_001256891.1
NP_001243821.1, NM_001256892.1 [P30626-3]
NP_003121.1, NM_003130.3 [P30626-1]
NP_944490.1, NM_198901.1 [P30626-2]
UniGeneiHs.489040

Genome annotation databases

EnsembliENST00000265729; ENSP00000265729; ENSG00000075142 [P30626-1]
ENST00000394641; ENSP00000378137; ENSG00000075142 [P30626-2]
ENST00000431660; ENSP00000391148; ENSG00000075142 [P30626-3]
GeneIDi6717
KEGGihsa:6717
UCSCiuc003ujq.3 human [P30626-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSORCN_HUMAN
AccessioniPrimary (citable) accession number: P30626
Secondary accession number(s): A8MTH6, B4DKK2, D6W5Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 18, 2018
This is version 192 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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