UniProtKB - P30622 (CLIP1_HUMAN)

BLAST

>sp|P30622|CLIP1_HUMAN CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2
MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV
GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR
PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS
ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE
WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM
ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK
QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA
DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEQKSQISEDPENTQTKLEHARIKEL
EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAG
DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK
ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELK
TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKA
EDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR
KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS
EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE
NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE
LQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN
QCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD
KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS
KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLE
EERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLR
GENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQE
SQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCD
ICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF

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History
Entry version 190 (07 Nov 2018)
Sequence version 2 (13 Oct 2009)
Previous versions | rss
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Protein

CAP-Gly domain-containing linker protein 1

Gene

CLIP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1417 – 1434	CCHC-type2 PublicationsAdd BLAST		18

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 17828275
- 17828277
metal ion binding
Source: UniProtKB
Non-traceable author statementⁱ
- 15928712
microtubule binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17889670
microtubule plus-end binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12433698
protein homodimerization activity
Source: UniProtKB
Traceable author statementⁱ
- 15928712
tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17889670
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17828275

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

microtubule bundle formation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17889670
mitotic cell cycle
Source: UniProtKB
Traceable author statementⁱ
- 15928712
positive regulation of microtubule polymerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15262990
- 17889670
protein transport into plasma membrane raft Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transport
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5626467 RHO GTPases activate IQGAPs R-HSA-5663220 RHO GTPases Activate Formins R-HSA-68877 Mitotic Prometaphase
SIGNORⁱ	P30622

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CAP-Gly domain-containing linker protein 1 Alternative name(s): Cytoplasmic linker protein 1 Cytoplasmic linker protein 170 alpha-2 Short name: CLIP-170 Reed-Sternberg intermediate filament-associated protein Restin
Gene namesⁱ	Name:CLIP1 Synonyms:CYLN1, RSN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130779.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10461 CLIP1
MIMⁱ	179838 gene
neXtProtⁱ	NX_P30622

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	98 – 99	KN → EE: Abolishes interaction with tubulin. Abolishes localization at the microtubule plus end. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6249
MalaCards human disease database More...MalaCardsⁱ	CLIP1
Open Targets More...OpenTargetsⁱ	ENSG00000130779
Orphanetⁱ	88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBⁱ	PA162382349

Polymorphism and mutation databases

BioMutaⁱ	CLIP1
DMDMⁱ	261260059

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083527	1 – 1438	CAP-Gly domain-containing linker protein 1Add BLAST		1438

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	48	PhosphoserineCombined sources	1
Modified residueⁱ	50	PhosphothreonineCombined sources	1
Modified residueⁱ	140	PhosphothreonineCombined sources	1
Modified residueⁱ	143	PhosphoserineCombined sources	1
Modified residueⁱ	147	PhosphoserineCombined sources	1
Modified residueⁱ	182	PhosphothreonineCombined sources	1
Modified residueⁱ	195	PhosphoserineCombined sources	1
Modified residueⁱ	197	PhosphoserineCombined sources	1
Modified residueⁱ	200	PhosphoserineCombined sources	1
Modified residueⁱ	204	PhosphoserineCombined sources	1
Modified residueⁱ	310	PhosphoserineBy similarity	1
Modified residueⁱ	312	Phosphoserine; by PKABy similarity	1
Modified residueⁱ	315	PhosphoserineBy similarity	1
Modified residueⁱ	348	PhosphoserineBy similarity	1
Modified residueⁱ	1236	PhosphoserineBy similarity	1
Modified residueⁱ	1310	PhosphothreonineCombined sources	1
Modified residueⁱ	1364	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated. Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons (By similarity). Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules (PubMed:12231510).By similarity1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P30622
PaxDbⁱ	P30622
PeptideAtlas More...PeptideAtlasⁱ	P30622
PRIDEⁱ	P30622
ProteomicsDBⁱ	54727 54728 [P30622-1] 54729 [P30622-2]

PTM databases

GlyConnectⁱ	643
iPTMnetⁱ	P30622
PhosphoSitePlusⁱ	P30622
UniCarbKBⁱ	P30622

Expressionⁱ

Tissue specificityⁱ

Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000130779 Expressed in 234 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_CLIP1
ExpressionAtlasⁱ	P30622 baseline and differential
Genevisibleⁱ	P30622 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004399 HPA026678

HPAⁱ

CAB004399
HPA026678

Interactionⁱ

Subunit structureⁱ

Interacts with MTOR; phosphorylates and regulates CLIP1 (PubMed:12231510). Interacts (via CAP-Gly domains) with tubulin (PubMed:17563362, PubMed:17889670). Interacts with SLAIN2 (PubMed:21646404). Interacts (via zinc finger) with DCTN1 (PubMed:17828275, PubMed:20679239). Interacts with TUBA1B, MAPRE1 and MAPRE3 (PubMed:17563362). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (By similarity).By similarity7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DCTN1	Q14203	7	EBI-9640673,EBI-724352
MAPRE1	Q15691	4	EBI-6479976,EBI-1004115
TUBA1A	Q71U36	3	EBI-6479976,EBI-302552
TUBA4A	P68366	3	EBI-2683569,EBI-351772

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 17828275
- 17828277
microtubule binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17889670
microtubule plus-end binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12433698
protein homodimerization activity
Source: UniProtKB
Traceable author statementⁱ
- 15928712
tubulin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17889670

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112163, 35 interactors
CORUMⁱ	P30622
Database of interacting proteins More...DIPⁱ	DIP-42826N
ELMⁱ	P30622
IntActⁱ	P30622, 25 interactors
Molecular INTeraction database More...MINTⁱ	P30622
STRINGⁱ	9606.ENSP00000303585

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	37 – 39	Combined sources	3
Beta strandⁱ	63 – 66	Combined sources	4
Turnⁱ	67 – 69	Combined sources	3
Beta strandⁱ	70 – 78	Combined sources	9
Beta strandⁱ	81 – 85	Combined sources	5
Beta strandⁱ	87 – 95	Combined sources	9
Beta strandⁱ	97 – 103	Combined sources	7
Beta strandⁱ	106 – 108	Combined sources	3
Turnⁱ	113 – 115	Combined sources	3
Beta strandⁱ	116 – 119	Combined sources	4
Helixⁱ	121 – 123	Combined sources	3
Beta strandⁱ	124 – 127	Combined sources	4
Beta strandⁱ	193 – 196	Combined sources	4
Beta strandⁱ	217 – 220	Combined sources	4
Turnⁱ	221 – 223	Combined sources	3
Beta strandⁱ	224 – 233	Combined sources	10
Beta strandⁱ	235 – 249	Combined sources	15
Beta strandⁱ	252 – 257	Combined sources	6
Beta strandⁱ	260 – 262	Combined sources	3
Turnⁱ	267 – 269	Combined sources	3
Beta strandⁱ	270 – 274	Combined sources	5
Helixⁱ	275 – 277	Combined sources	3
Beta strandⁱ	278 – 280	Combined sources	3
Beta strandⁱ	295 – 298	Combined sources	4
Turnⁱ	1420 – 1423	Combined sources	4
Beta strandⁱ	1424 – 1427	Combined sources	4
Helixⁱ	1429 – 1431	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P30622
SMRⁱ	P30622
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P30622

EvolutionaryTraceⁱ

P30622

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	78 – 120	CAP-Gly 1PROSITE-ProRule annotationAdd BLAST		43
Domainⁱ	232 – 274	CAP-Gly 2PROSITE-ProRule annotationAdd BLAST		43

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	97 – 101	Important for tubulin binding1 Publication		5

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	350 – 1353	Sequence analysisAdd BLAST		1004

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	143 – 204	Ser-richAdd BLAST		62
Compositional biasⁱ	304 – 331	Ser-richAdd BLAST		28

Domainⁱ

Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.1 Publication

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1417 – 1434	CCHC-type2 PublicationsAdd BLAST		18

Keywords - Domainⁱ

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG4568 Eukaryota COG5244 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119173
HOGENOMⁱ	HOG000092755
HOVERGENⁱ	HBG007123
InParanoidⁱ	P30622
KEGG Orthology (KO) More...KOⁱ	K10421
OMAⁱ	EAKFRER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0J1Y
PhylomeDBⁱ	P30622
TreeFamⁱ	TF326096

Family and domain databases

Gene3Dⁱ	2.30.30.190, 2 hits
InterProⁱ	View protein in InterPro IPR036859 CAP-Gly_dom_sf IPR000938 CAP-Gly_domain IPR032108 CLIP1_ZNF
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01302 CAP_GLY, 2 hits PF16641 CLIP1_ZNF, 2 hits
SMARTⁱ	View protein in SMART SM01052 CAP_GLY, 2 hits
SUPFAMⁱ	SSF74924 SSF74924, 2 hits
PROSITEⁱ	View protein in PROSITE PS00845 CAP_GLY_1, 2 hits PS50245 CAP_GLY_2, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P30622-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSMLKPSGLK APTKILKPGS TALKTPTAVV APVEKTISSE KASSTPSSET 
        60         70         80         90        100
QEEFVDDFRV GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND 
       110        120        130        140        150
GSVAGVRYFQ CEPLKGIFTR PSKLTRKVQA EDEANGLQTT PASRATSPLC 
       160        170        180        190        200
TSTASMVSSS PSTPSNIPQK PSQPAAKEPS ATPPISNLTK TASESISNLS 
       210        220        230        240        250
EAGSIKKGER ELKIGDRVLV GGTKAGVVRF LGETDFAKGE WCGVELDEPL 
       260        270        280        290        300
GKNDGAVAGT RYFQCQPKYG LFAPVHKVTK IGFPSTTPAK AKANAVRRVM 
       310        320        330        340        350
ATTSASLKRS PSASSLSSMS SVASSVSSRP SRTGLLTETS SRYARKISGT 
       360        370        380        390        400
TALQEALKEK QQHIEQLLAE RDLERAEVAK ATSHVGEIEQ ELALARDGHD 
       410        420        430        440        450
QHVLELEAKM DQLRTMVEAA DREKVELLNQ LEEEKRKVED LQFRVEEESI 
       460        470        480        490        500
TKGDLEQKSQ ISEDPENTQT KLEHARIKEL EQSLLFEKTK ADKLQRELED 
       510        520        530        540        550
TRVATVSEKS RIMELEKDLA LRVQEVAELR RRLESNKPAG DVDMSLSLLQ 
       560        570        580        590        600
EISSLQEKLE VTRTDHQREI TSLKEHFGAR EETHQKEIKA LYTATEKLSK 
       610        620        630        640        650
ENESLKSKLE HANKENSDVI ALWKSKLETA IASHQQAMEE LKVSFSKGLG 
       660        670        680        690        700
TETAEFAELK TQIEKMRLDY QHEIENLQNQ QDSERAAHAK EMEALRAKLM 
       710        720        730        740        750
KVIKEKENSL EAIRSKLDKA EDQHLVEMED TLNKLQEAEI KVKELEVLQA 
       760        770        780        790        800
KCNEQTKVID NFTSQLKATE EKLLDLDALR KASSEGKSEM KKLRQQLEAA 
       810        820        830        840        850
EKQIKHLEIE KNAESSKASS ITRELQGREL KLTNLQENLS EVSQVKETLE 
       860        870        880        890        900
KELQILKEKF AEASEEAVSV QRSMQETVNK LHQKEEQFNM LSSDLEKLRE 
       910        920        930        940        950
NLADMEAKFR EKDEREEQLI KAKEKLENDI AEIMKMSGDN SSQLTKMNDE 
       960        970        980        990       1000
LRLKERDVEE LQLKLTKANE NASFLQKSIE DMTVKAEQSQ QEAAKKHEEE 
      1010       1020       1030       1040       1050
KKELERKLSD LEKKMETSHN QCQELKARYE RATSETKTKH EEILQNLQKT 
      1060       1070       1080       1090       1100
LLDTEDKLKG AREENSGLLQ ELEELRKQAD KAKAAQTAED AMQIMEQMTK 
      1110       1120       1130       1140       1150
EKTETLASLE DTKQTNAKLQ NELDTLKENN LKNVEELNKS KELLTVENQK 
      1160       1170       1180       1190       1200
MEEFRKEIET LKQAAAQKSQ QLSALQEENV KLAEELGRSR DEVTSHQKLE 
      1210       1220       1230       1240       1250
EERSVLNNQL LEMKKRESKF IKDADEEKAS LQKSISITSA LLTEKDAELE 
      1260       1270       1280       1290       1300
KLRNEVTVLR GENASAKSLH SVVQTLESDK VKLELKVKNL ELQLKENKRQ 
      1310       1320       1330       1340       1350
LSSSSGNTDT QADEDERAQE SQIDFLNSVI VDLQRKNQDL KMKVEMMSEA 
      1360       1370       1380       1390       1400
ALNGNGDDLN NYDSDDQEKQ SKKKPRLFCD ICDCFDLHDT EDCPTQAQMS 
      1410       1420       1430 
EDPPHSTHHG SRGEERPYCE ICEMFGHWAT NCNDDETF

Length:1,438

Mass (Da):162,246

Last modified:October 13, 2009 - v2

Checksum:ⁱA7F125F7A96DBDDB

Isoform 2 (identifier: P30622-1) [UniParc]FASTA Add to basket

Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
457-467: Missing.

« Hide

        10         20         30         40         50
MSMLKPSGLK APTKILKPGS TALKTPTAVV APVEKTISSE KASSTPSSET 
        60         70         80         90        100
QEEFVDDFRV GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND 
       110        120        130        140        150
GSVAGVRYFQ CEPLKGIFTR PSKLTRKVQA EDEANGLQTT PASRATSPLC 
       160        170        180        190        200
TSTASMVSSS PSTPSNIPQK PSQPAAKEPS ATPPISNLTK TASESISNLS 
       210        220        230        240        250
EAGSIKKGER ELKIGDRVLV GGTKAGVVRF LGETDFAKGE WCGVELDEPL 
       260        270        280        290        300
GKNDGAVAGT RYFQCQPKYG LFAPVHKVTK IGFPSTTPAK AKANAVRRVM 
       310        320        330        340        350
ATTSASLKRS PSASSLSSMS SVASSVSSRP SRTGLLTETS SRYARKISGT 
       360        370        380        390        400
TALQEALKEK QQHIEQLLAE RDLERAEVAK ATSHVGEIEQ ELALARDGHD 
       410        420        430        440        450
QHVLELEAKM DQLRTMVEAA DREKVELLNQ LEEEKRKVED LQFRVEEESI 
       460        470        480        490        500
TKGDLETQTK LEHARIKELE QSLLFEKTKA DKLQRELEDT RVATVSEKSR 
       510        520        530        540        550
IMELEKDLAL RVQEVAELRR RLESNKPAGD VDMSLSLLQE ISSLQEKLEV 
       560        570        580        590        600
TRTDHQREIT SLKEHFGARE ETHQKEIKAL YTATEKLSKE NESLKSKLEH 
       610        620        630        640        650
ANKENSDVIA LWKSKLETAI ASHQQAMEEL KVSFSKGLGT ETAEFAELKT 
       660        670        680        690        700
QIEKMRLDYQ HEIENLQNQQ DSERAAHAKE MEALRAKLMK VIKEKENSLE 
       710        720        730        740        750
AIRSKLDKAE DQHLVEMEDT LNKLQEAEIK VKELEVLQAK CNEQTKVIDN 
       760        770        780        790        800
FTSQLKATEE KLLDLDALRK ASSEGKSEMK KLRQQLEAAE KQIKHLEIEK 
       810        820        830        840        850
NAESSKASSI TRELQGRELK LTNLQENLSE VSQVKETLEK ELQILKEKFA 
       860        870        880        890        900
EASEEAVSVQ RSMQETVNKL HQKEEQFNML SSDLEKLREN LADMEAKFRE 
       910        920        930        940        950
KDEREEQLIK AKEKLENDIA EIMKMSGDNS SQLTKMNDEL RLKERDVEEL 
       960        970        980        990       1000
QLKLTKANEN ASFLQKSIED MTVKAEQSQQ EAAKKHEEEK KELERKLSDL 
      1010       1020       1030       1040       1050
EKKMETSHNQ CQELKARYER ATSETKTKHE EILQNLQKTL LDTEDKLKGA 
      1060       1070       1080       1090       1100
REENSGLLQE LEELRKQADK AKAAQTAEDA MQIMEQMTKE KTETLASLED 
      1110       1120       1130       1140       1150
TKQTNAKLQN ELDTLKENNL KNVEELNKSK ELLTVENQKM EEFRKEIETL 
      1160       1170       1180       1190       1200
KQAAAQKSQQ LSALQEENVK LAEELGRSRD EVTSHQKLEE ERSVLNNQLL 
      1210       1220       1230       1240       1250
EMKKRESKFI KDADEEKASL QKSISITSAL LTEKDAELEK LRNEVTVLRG 
      1260       1270       1280       1290       1300
ENASAKSLHS VVQTLESDKV KLELKVKNLE LQLKENKRQL SSSSGNTDTQ 
      1310       1320       1330       1340       1350
ADEDERAQES QIDFLNSVIV DLQRKNQDLK MKVEMMSEAA LNGNGDDLNN 
      1360       1370       1380       1390       1400
YDSDDQEKQS KKKPRLFCDI CDCFDLHDTE DCPTQAQMSE DPPHSTHHGS 
      1410       1420 
RGEERPYCEI CEMFGHWATN CNDDETF

Show »

Length:1,427

Mass (Da):160,990

Checksum:ⁱ0A4F166DD94254E8

Isoform 3 (identifier: P30622-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
457-502: Missing.

« Hide

        10         20         30         40         50
MSMLKPSGLK APTKILKPGS TALKTPTAVV APVEKTISSE KASSTPSSET 
        60         70         80         90        100
QEEFVDDFRV GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND 
       110        120        130        140        150
GSVAGVRYFQ CEPLKGIFTR PSKLTRKVQA EDEANGLQTT PASRATSPLC 
       160        170        180        190        200
TSTASMVSSS PSTPSNIPQK PSQPAAKEPS ATPPISNLTK TASESISNLS 
       210        220        230        240        250
EAGSIKKGER ELKIGDRVLV GGTKAGVVRF LGETDFAKGE WCGVELDEPL 
       260        270        280        290        300
GKNDGAVAGT RYFQCQPKYG LFAPVHKVTK IGFPSTTPAK AKANAVRRVM 
       310        320        330        340        350
ATTSASLKRS PSASSLSSMS SVASSVSSRP SRTGLLTETS SRYARKISGT 
       360        370        380        390        400
TALQEALKEK QQHIEQLLAE RDLERAEVAK ATSHVGEIEQ ELALARDGHD 
       410        420        430        440        450
QHVLELEAKM DQLRTMVEAA DREKVELLNQ LEEEKRKVED LQFRVEEESI 
       460        470        480        490        500
TKGDLEVATV SEKSRIMELE KDLALRVQEV AELRRRLESN KPAGDVDMSL 
       510        520        530        540        550
SLLQEISSLQ EKLEVTRTDH QREITSLKEH FGAREETHQK EIKALYTATE 
       560        570        580        590        600
KLSKENESLK SKLEHANKEN SDVIALWKSK LETAIASHQQ AMEELKVSFS 
       610        620        630        640        650
KGLGTETAEF AELKTQIEKM RLDYQHEIEN LQNQQDSERA AHAKEMEALR 
       660        670        680        690        700
AKLMKVIKEK ENSLEAIRSK LDKAEDQHLV EMEDTLNKLQ EAEIKVKELE 
       710        720        730        740        750
VLQAKCNEQT KVIDNFTSQL KATEEKLLDL DALRKASSEG KSEMKKLRQQ 
       760        770        780        790        800
LEAAEKQIKH LEIEKNAESS KASSITRELQ GRELKLTNLQ ENLSEVSQVK 
       810        820        830        840        850
ETLEKELQIL KEKFAEASEE AVSVQRSMQE TVNKLHQKEE QFNMLSSDLE 
       860        870        880        890        900
KLRENLADME AKFREKDERE EQLIKAKEKL ENDIAEIMKM SGDNSSQLTK 
       910        920        930        940        950
MNDELRLKER DVEELQLKLT KANENASFLQ KSIEDMTVKA EQSQQEAAKK 
       960        970        980        990       1000
HEEEKKELER KLSDLEKKME TSHNQCQELK ARYERATSET KTKHEEILQN 
      1010       1020       1030       1040       1050
LQKTLLDTED KLKGAREENS GLLQELEELR KQADKAKAAQ TAEDAMQIME 
      1060       1070       1080       1090       1100
QMTKEKTETL ASLEDTKQTN AKLQNELDTL KENNLKNVEE LNKSKELLTV 
      1110       1120       1130       1140       1150
ENQKMEEFRK EIETLKQAAA QKSQQLSALQ EENVKLAEEL GRSRDEVTSH 
      1160       1170       1180       1190       1200
QKLEEERSVL NNQLLEMKKR ESKFIKDADE EKASLQKSIS ITSALLTEKD 
      1210       1220       1230       1240       1250
AELEKLRNEV TVLRGENASA KSLHSVVQTL ESDKVKLELK VKNLELQLKE 
      1260       1270       1280       1290       1300
NKRQLSSSSG NTDTQADEDE RAQESQIDFL NSVIVDLQRK NQDLKMKVEM 
      1310       1320       1330       1340       1350
MSEAALNGNG DDLNNYDSDD QEKQSKKKPR LFCDICDCFD LHDTEDCPTQ 
      1360       1370       1380       1390 
AQMSEDPPHS THHGSRGEER PYCEICEMFG HWATNCNDDE TF

Show »

Length:1,392

Mass (Da):156,781

Checksum:ⁱ959DF99064762A10

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H6A0	F5H6A0_HUMAN	CAP-Gly domain-containing linker pr... CAP-Gly domain-containing linker protein 1	CLIP1	803	Annotation score:
F6VGP8	F6VGP8_HUMAN	CAP-Gly domain-containing linker pr... CAP-Gly domain-containing linker protein 1	CLIP1	428	Annotation score:
J3KP58	J3KP58_HUMAN	CAP-Gly domain-containing linker pr... CAP-Gly domain-containing linker protein 1	CLIP1	1,316	Annotation score:
F5H0N7	F5H0N7_HUMAN	CAP-Gly domain-containing linker pr... CAP-Gly domain-containing linker protein 1	CLIP1	1,013	Annotation score:
F5H6H4	F5H6H4_HUMAN	CAP-Gly domain-containing linker pr... CAP-Gly domain-containing linker protein 1	CLIP1	117	Annotation score:
F5H1T5	F5H1T5_HUMAN	CAP-Gly domain-containing linker pr... CAP-Gly domain-containing linker protein 1	CLIP1	350	Annotation score:
F5H270	F5H270_HUMAN	CAP-Gly domain-containing linker pr... CAP-Gly domain-containing linker protein 1	CLIP1	108	Annotation score:
F5H367	F5H367_HUMAN	CAP-Gly domain-containing linker pr... CAP-Gly domain-containing linker protein 1	CLIP1	83	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	193	S → G in AAI14214 (PubMed:15489334).Curated	1
Sequence conflictⁱ	324	S → P in AAI14214 (PubMed:15489334).Curated	1
Sequence conflictⁱ	651	T → A in AAI14214 (PubMed:15489334).Curated	1
Sequence conflictⁱ	682	D → N in AAI14214 (PubMed:15489334).Curated	1
Sequence conflictⁱ	766	L → P in AAI14214 (PubMed:15489334).Curated	1
Sequence conflictⁱ	1432	C → R in AAI14214 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_059206	162	S → P. Corresponds to variant dbSNP:rs7963597Ensembl.	1
Natural variantⁱVAR_048672	780	R → W. Corresponds to variant dbSNP:rs3741447Ensembl.	1
Natural variantⁱVAR_048673	941	S → P1 PublicationCorresponds to variant dbSNP:rs17883517Ensembl.	1
Natural variantⁱVAR_020398	1080	D → E2 PublicationsCorresponds to variant dbSNP:rs1129167Ensembl.	1
Natural variantⁱVAR_036446	1213	M → I in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1183319975Ensembl.	1
Natural variantⁱVAR_048674	1224	A → S. Corresponds to variant dbSNP:rs17881033Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_000765	457 – 502	Missing in isoform 3. 2 PublicationsAdd BLAST		46
Alternative sequenceⁱVSP_038201	457 – 467	Missing in isoform 2. 1 PublicationAdd BLAST		11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64838 mRNA Translation: CAA46050.1 M97501 mRNA Translation: AAA35693.1 BC114213 mRNA Translation: AAI14214.1 BC117209 mRNA Translation: AAI17210.1 BC126305 mRNA Translation: AAI26306.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS58285.1 [P30622-3] CCDS9232.1 [P30622-1] CCDS9233.1 [P30622-2]
PIRⁱ	A43336 S22695
NCBI Reference Sequences More...RefSeqⁱ	NP_001234926.1, NM_001247997.1 [P30622-3] NP_002947.1, NM_002956.2 [P30622-1] NP_937883.1, NM_198240.1 [P30622-2] XP_016875275.1, XM_017019786.1 [P30622-1] XP_016875279.1, XM_017019790.1 [P30622-2]
UniGeneⁱ	Hs.524809

Genome annotation databases

Ensemblⁱ	ENST00000302528; ENSP00000303585; ENSG00000130779 [P30622-1] ENST00000358808; ENSP00000351665; ENSG00000130779 [P30622-1] ENST00000537178; ENSP00000445531; ENSG00000130779 [P30622-2] ENST00000540338; ENSP00000439093; ENSG00000130779 [P30622-3] ENST00000620786; ENSP00000479322; ENSG00000130779 [P30622-3]
GeneIDⁱ	6249
KEGGⁱ	hsa:6249
UCSC genome browser More...UCSCⁱ	uc001ucg.2 human [P30622-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30622	CAP-Gly domain-containing linker protein 1 isoform X1		DELLE		1440	UniRef90_P30622
CAP-Gly domain containing linker protein 1		CALJA		1440
CAP-Gly domain-containing linker protein 1 isoform X1		BALAS		1440
CAP-Gly domain containing linker protein 1		SAIBB		1440
CAP-Gly domain-containing linker protein 1 isoform X1		LIPVE		1440
+247
P30622-2	CAP-Gly domain-containing linker protein 1 isoform b		CALJA		1394	UniRef90_P30622-2
CAP-Gly domain-containing linker protein 1 isoform X4		TARSY		1394
CAP-Gly domain-containing linker protein 1 isoform b		MACMU		1392
Uncharacterized protein		MACFA		1392
Uncharacterized protein		PROCO		1392
+57

Protein	Similar proteins		Species	Score	Length	Source
P30622	CAP-Gly domain-containing linker protein 1		CHICK		1433	UniRef50_P30622
CAP-Gly domain-containing linker protein 1		RAT		1320
CAP-Gly domain containing linker protein 1		CALJA		1440
CAP-Gly domain-containing linker protein 1 isoform X1		DELLE		1440
CAP-Gly domain-containing linker protein 1 isoform X1		LIPVE		1440
+727
P30622-2	CAP-Gly domain-containing linker protein 1 isoform b		CALJA		1394	UniRef50_P30622-2
CAP-Gly domain-containing linker protein 1 isoform X4		TARSY		1394
Uncharacterized protein		COLAP		1392
Uncharacterized protein		PROCO		1392
CAP-Gly domain containing linker protein 1		GORGO		1392
+266

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64838 mRNA Translation: CAA46050.1 M97501 mRNA Translation: AAA35693.1 BC114213 mRNA Translation: AAI14214.1 BC117209 mRNA Translation: AAI17210.1 BC126305 mRNA Translation: AAI26306.1
CCDSⁱ	CCDS58285.1 [P30622-3] CCDS9232.1 [P30622-1] CCDS9233.1 [P30622-2]
PIRⁱ	A43336 S22695
RefSeqⁱ	NP_001234926.1, NM_001247997.1 [P30622-3] NP_002947.1, NM_002956.2 [P30622-1] NP_937883.1, NM_198240.1 [P30622-2] XP_016875275.1, XM_017019786.1 [P30622-1] XP_016875279.1, XM_017019790.1 [P30622-2]
UniGeneⁱ	Hs.524809

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CP5	NMR	-	A	1-128	[»]
	2CP6	NMR	-	A	181-339	[»]
	2E3H	X-ray	1.45	A	211-300	[»]
	2E3I	X-ray	2.00	A	56-141	[»]
	2E4H	NMR	-	A	203-300	[»]
	2HQH	X-ray	1.80	E/F/G/H	1416-1438	[»]
	2QK0	X-ray	2.00	A	57-128	[»]
	3E2U	X-ray	2.60	E/F/G/H	1399-1438	[»]
	3RDV	X-ray	1.75	A/B/C/D	56-127	[»]
ProteinModelPortalⁱ	P30622
SMRⁱ	P30622
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112163, 35 interactors
CORUMⁱ	P30622
DIPⁱ	DIP-42826N
ELMⁱ	P30622
IntActⁱ	P30622, 25 interactors
MINTⁱ	P30622
STRINGⁱ	9606.ENSP00000303585

PTM databases

GlyConnectⁱ	643
iPTMnetⁱ	P30622
PhosphoSitePlusⁱ	P30622
UniCarbKBⁱ	P30622

Polymorphism and mutation databases

BioMutaⁱ	CLIP1
DMDMⁱ	261260059

Proteomic databases

EPDⁱ	P30622
PaxDbⁱ	P30622
PeptideAtlasⁱ	P30622
PRIDEⁱ	P30622
ProteomicsDBⁱ	54727 54728 [P30622-1] 54729 [P30622-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000302528; ENSP00000303585; ENSG00000130779 [P30622-1] ENST00000358808; ENSP00000351665; ENSG00000130779 [P30622-1] ENST00000537178; ENSP00000445531; ENSG00000130779 [P30622-2] ENST00000540338; ENSP00000439093; ENSG00000130779 [P30622-3] ENST00000620786; ENSP00000479322; ENSG00000130779 [P30622-3]
GeneIDⁱ	6249
KEGGⁱ	hsa:6249
UCSCⁱ	uc001ucg.2 human [P30622-3]

Organism-specific databases

CTDⁱ	6249
DisGeNETⁱ	6249
EuPathDBⁱ	HostDB:ENSG00000130779.19
GeneCardsⁱ	CLIP1
HGNCⁱ	HGNC:10461 CLIP1
HPAⁱ	CAB004399 HPA026678
MalaCardsⁱ	CLIP1
MIMⁱ	179838 gene
neXtProtⁱ	NX_P30622
OpenTargetsⁱ	ENSG00000130779
Orphanetⁱ	88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBⁱ	PA162382349
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4568 Eukaryota COG5244 LUCA
GeneTreeⁱ	ENSGT00760000119173
HOGENOMⁱ	HOG000092755
HOVERGENⁱ	HBG007123
InParanoidⁱ	P30622
KOⁱ	K10421
OMAⁱ	EAKFRER
OrthoDBⁱ	EOG091G0J1Y
PhylomeDBⁱ	P30622
TreeFamⁱ	TF326096

Enzyme and pathway databases

Reactomeⁱ	R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813 Separation of Sister Chromatids R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-5626467 RHO GTPases activate IQGAPs R-HSA-5663220 RHO GTPases Activate Formins R-HSA-68877 Mitotic Prometaphase
SIGNORⁱ	P30622

Miscellaneous databases

ChiTaRSⁱ	CLIP1 human
EvolutionaryTraceⁱ	P30622
GeneWikiⁱ	CLIP1
GenomeRNAiⁱ	6249
Protein Ontology More...PROⁱ	PR:P30622
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130779 Expressed in 234 organ(s), highest expression level in biceps brachii
CleanExⁱ	HS_CLIP1
ExpressionAtlasⁱ	P30622 baseline and differential
Genevisibleⁱ	P30622 HS

Family and domain databases

Gene3Dⁱ	2.30.30.190, 2 hits
InterProⁱ	View protein in InterPro IPR036859 CAP-Gly_dom_sf IPR000938 CAP-Gly_domain IPR032108 CLIP1_ZNF
Pfamⁱ	View protein in Pfam PF01302 CAP_GLY, 2 hits PF16641 CLIP1_ZNF, 2 hits
SMARTⁱ	View protein in SMART SM01052 CAP_GLY, 2 hits
SUPFAMⁱ	SSF74924 SSF74924, 2 hits
PROSITEⁱ	View protein in PROSITE PS00845 CAP_GLY_1, 2 hits PS50245 CAP_GLY_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLIP1_HUMAN
Accessionⁱ	P30622Primary (citable) accession number: P30622 Secondary accession number(s): A0AVD3, Q17RS4, Q29RG0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	October 13, 2009
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - P30622 (CLIP1_HUMAN)

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CAP-Gly domain-containing linker protein 1

CLIP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Endosome

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ