UniProtKB - P30622 (CLIP1_HUMAN)
CAP-Gly domain-containing linker protein 1
CLIP1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1417 – 1434 | CCHC-type2 PublicationsAdd BLAST | 18 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- microtubule binding Source: UniProtKB
- microtubule plus-end binding Source: UniProtKB
- tubulin binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cytoplasmic microtubule organization Source: GO_Central
- microtubule bundle formation Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
- positive regulation of microtubule polymerization Source: UniProtKB
- protein transport into plasma membrane raft Source: Ensembl
Keywordsi
Biological process | Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P30622 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5626467, RHO GTPases activate IQGAPs R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SIGNORi | P30622 |
Names & Taxonomyi
Protein namesi | Recommended name: CAP-Gly domain-containing linker protein 1Alternative name(s): Cytoplasmic linker protein 1 Cytoplasmic linker protein 170 alpha-2 Short name: CLIP-170 Reed-Sternberg intermediate filament-associated protein Restin |
Gene namesi | Name:CLIP1 Synonyms:CYLN1, RSN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10461, CLIP1 |
MIMi | 179838, gene |
neXtProti | NX_P30622 |
VEuPathDBi | HostDB:ENSG00000130779.19 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 2 Publications
Other locations
- Cytoplasm Curated
- Cytoplasmic vesicle membrane 1 Publication; Peripheral membrane protein ; Cytoplasmic side
- ruffle 1 Publication
Note: Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698).By similarity3 Publications
Cytoskeleton
- centrosome Source: UniProtKB
- intermediate filament Source: ProtInc
- microtubule Source: Alzheimers_University_of_Toronto
- microtubule cytoskeleton Source: UniProtKB
- microtubule plus-end Source: Ensembl
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear envelope Source: Ensembl
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- kinetochore Source: UniProtKB
- ruffle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, MicrotubulePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 98 – 99 | KN → EE: Abolishes interaction with tubulin. Abolishes localization at the microtubule plus end. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 6249 |
MalaCardsi | CLIP1 |
OpenTargetsi | ENSG00000130779 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability |
PharmGKBi | PA162382349 |
Miscellaneous databases
Pharosi | P30622, Tbio |
Genetic variation databases
BioMutai | CLIP1 |
DMDMi | 261260059 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083527 | 1 – 1438 | CAP-Gly domain-containing linker protein 1Add BLAST | 1438 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 48 | PhosphoserineCombined sources | 1 | |
Modified residuei | 50 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 140 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 143 | PhosphoserineCombined sources | 1 | |
Modified residuei | 147 | PhosphoserineCombined sources | 1 | |
Modified residuei | 182 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 195 | PhosphoserineCombined sources | 1 | |
Modified residuei | 197 | PhosphoserineCombined sources | 1 | |
Modified residuei | 200 | PhosphoserineCombined sources | 1 | |
Modified residuei | 204 | PhosphoserineCombined sources | 1 | |
Modified residuei | 310 | PhosphoserineBy similarity | 1 | |
Modified residuei | 312 | Phosphoserine; by PKABy similarity | 1 | |
Modified residuei | 315 | PhosphoserineBy similarity | 1 | |
Modified residuei | 348 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1236 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1310 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1364 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P30622 |
jPOSTi | P30622 |
MassIVEi | P30622 |
PaxDbi | P30622 |
PeptideAtlasi | P30622 |
PRIDEi | P30622 |
ProteomicsDBi | 54727 [P30622-3] 54728 [P30622-1] 54729 [P30622-2] |
PTM databases
GlyConnecti | 643, 6 N-Linked glycans (3 sites) |
GlyGeni | P30622, 4 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (1 site) |
iPTMneti | P30622 |
MetOSitei | P30622 |
PhosphoSitePlusi | P30622 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000130779, Expressed in biceps brachii and 247 other tissues |
ExpressionAtlasi | P30622, baseline and differential |
Genevisiblei | P30622, HS |
Organism-specific databases
HPAi | ENSG00000130779, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Interacts with MTOR; phosphorylates and regulates CLIP1 (PubMed:12231510).
Interacts (via CAP-Gly domains) with tubulin (PubMed:17563362, PubMed:17889670).
Interacts with SLAIN2 (PubMed:21646404).
Interacts (via zinc finger) with DCTN1 (PubMed:17828275, PubMed:20679239).
Interacts with TUBA1B, MAPRE1 and MAPRE3 (PubMed:17563362). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (By similarity).
By similarity7 PublicationsBinary interactionsi
Hide detailsP30622
With | #Exp. | IntAct |
---|---|---|
MAPRE1 [Q15691] | 2 | EBI-2683569,EBI-1004115 |
REL - isoform 2 [Q04864-2] | 3 | EBI-2683569,EBI-10829018 |
TUBA4A [P68366] | 3 | EBI-2683569,EBI-351772 |
CLIP1 - isoform 2 [P30622-1]
With | #Exp. | IntAct |
---|---|---|
itself | 12 | EBI-9640673,EBI-9640673 |
DCTN1 [Q14203] | 7 | EBI-9640673,EBI-724352 |
MAPRE1 [Q15691] | 2 | EBI-9640673,EBI-1004115 |
Isoform 3 [P30622-2]
With | #Exp. | IntAct |
---|---|---|
MAPRE1 [Q15691] | 4 | EBI-6479976,EBI-1004115 |
TUBA1A [Q71U36] | 3 | EBI-6479976,EBI-302552 |
GO - Molecular functioni
- identical protein binding Source: IntAct
- microtubule binding Source: UniProtKB
- microtubule plus-end binding Source: UniProtKB
- tubulin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112163, 44 interactors |
CORUMi | P30622 |
DIPi | DIP-42826N |
ELMi | P30622 |
IntActi | P30622, 33 interactors |
MINTi | P30622 |
STRINGi | 9606.ENSP00000479322 |
Miscellaneous databases
RNActi | P30622, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P30622 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P30622 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 120 | CAP-Gly 1PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 232 – 274 | CAP-Gly 2PROSITE-ProRule annotationAdd BLAST | 43 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 97 – 101 | Important for tubulin binding1 Publication | 5 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 350 – 1353 | Sequence analysisAdd BLAST | 1004 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 143 – 204 | Ser-richAdd BLAST | 62 | |
Compositional biasi | 304 – 331 | Ser-richAdd BLAST | 28 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1417 – 1434 | CCHC-type2 PublicationsAdd BLAST | 18 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG4568, Eukaryota |
GeneTreei | ENSGT00940000155122 |
InParanoidi | P30622 |
OMAi | EGKGHNQ |
OrthoDBi | 1110101at2759 |
PhylomeDBi | P30622 |
TreeFami | TF326096 |
Family and domain databases
Gene3Di | 2.30.30.190, 2 hits |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain IPR032108, CLIP1_ZNF |
Pfami | View protein in Pfam PF01302, CAP_GLY, 2 hits PF16641, CLIP1_ZNF, 2 hits |
SMARTi | View protein in SMART SM01052, CAP_GLY, 2 hits |
SUPFAMi | SSF74924, SSF74924, 2 hits |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 2 hits PS50245, CAP_GLY_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSMLKPSGLK APTKILKPGS TALKTPTAVV APVEKTISSE KASSTPSSET
60 70 80 90 100
QEEFVDDFRV GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND
110 120 130 140 150
GSVAGVRYFQ CEPLKGIFTR PSKLTRKVQA EDEANGLQTT PASRATSPLC
160 170 180 190 200
TSTASMVSSS PSTPSNIPQK PSQPAAKEPS ATPPISNLTK TASESISNLS
210 220 230 240 250
EAGSIKKGER ELKIGDRVLV GGTKAGVVRF LGETDFAKGE WCGVELDEPL
260 270 280 290 300
GKNDGAVAGT RYFQCQPKYG LFAPVHKVTK IGFPSTTPAK AKANAVRRVM
310 320 330 340 350
ATTSASLKRS PSASSLSSMS SVASSVSSRP SRTGLLTETS SRYARKISGT
360 370 380 390 400
TALQEALKEK QQHIEQLLAE RDLERAEVAK ATSHVGEIEQ ELALARDGHD
410 420 430 440 450
QHVLELEAKM DQLRTMVEAA DREKVELLNQ LEEEKRKVED LQFRVEEESI
460 470 480 490 500
TKGDLEQKSQ ISEDPENTQT KLEHARIKEL EQSLLFEKTK ADKLQRELED
510 520 530 540 550
TRVATVSEKS RIMELEKDLA LRVQEVAELR RRLESNKPAG DVDMSLSLLQ
560 570 580 590 600
EISSLQEKLE VTRTDHQREI TSLKEHFGAR EETHQKEIKA LYTATEKLSK
610 620 630 640 650
ENESLKSKLE HANKENSDVI ALWKSKLETA IASHQQAMEE LKVSFSKGLG
660 670 680 690 700
TETAEFAELK TQIEKMRLDY QHEIENLQNQ QDSERAAHAK EMEALRAKLM
710 720 730 740 750
KVIKEKENSL EAIRSKLDKA EDQHLVEMED TLNKLQEAEI KVKELEVLQA
760 770 780 790 800
KCNEQTKVID NFTSQLKATE EKLLDLDALR KASSEGKSEM KKLRQQLEAA
810 820 830 840 850
EKQIKHLEIE KNAESSKASS ITRELQGREL KLTNLQENLS EVSQVKETLE
860 870 880 890 900
KELQILKEKF AEASEEAVSV QRSMQETVNK LHQKEEQFNM LSSDLEKLRE
910 920 930 940 950
NLADMEAKFR EKDEREEQLI KAKEKLENDI AEIMKMSGDN SSQLTKMNDE
960 970 980 990 1000
LRLKERDVEE LQLKLTKANE NASFLQKSIE DMTVKAEQSQ QEAAKKHEEE
1010 1020 1030 1040 1050
KKELERKLSD LEKKMETSHN QCQELKARYE RATSETKTKH EEILQNLQKT
1060 1070 1080 1090 1100
LLDTEDKLKG AREENSGLLQ ELEELRKQAD KAKAAQTAED AMQIMEQMTK
1110 1120 1130 1140 1150
EKTETLASLE DTKQTNAKLQ NELDTLKENN LKNVEELNKS KELLTVENQK
1160 1170 1180 1190 1200
MEEFRKEIET LKQAAAQKSQ QLSALQEENV KLAEELGRSR DEVTSHQKLE
1210 1220 1230 1240 1250
EERSVLNNQL LEMKKRESKF IKDADEEKAS LQKSISITSA LLTEKDAELE
1260 1270 1280 1290 1300
KLRNEVTVLR GENASAKSLH SVVQTLESDK VKLELKVKNL ELQLKENKRQ
1310 1320 1330 1340 1350
LSSSSGNTDT QADEDERAQE SQIDFLNSVI VDLQRKNQDL KMKVEMMSEA
1360 1370 1380 1390 1400
ALNGNGDDLN NYDSDDQEKQ SKKKPRLFCD ICDCFDLHDT EDCPTQAQMS
1410 1420 1430
EDPPHSTHHG SRGEERPYCE ICEMFGHWAT NCNDDETF
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KP58 | J3KP58_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 1,316 | Annotation score: | ||
F5H0N7 | F5H0N7_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 1,063 | Annotation score: | ||
A0A3B3ITA2 | A0A3B3ITA2_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 791 | Annotation score: | ||
F5H6A0 | F5H6A0_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 802 | Annotation score: | ||
F5H1T5 | F5H1T5_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 350 | Annotation score: | ||
F5H270 | F5H270_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 108 | Annotation score: | ||
A0A3B3ISJ8 | A0A3B3ISJ8_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 867 | Annotation score: | ||
A0A3B3IS27 | A0A3B3IS27_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 107 | Annotation score: | ||
F5H367 | F5H367_HUMAN | CAP-Gly domain-containing linker pr... | CLIP1 | 83 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 193 | S → G in AAI14214 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 324 | S → P in AAI14214 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 651 | T → A in AAI14214 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 682 | D → N in AAI14214 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 766 | L → P in AAI14214 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1432 | C → R in AAI14214 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059206 | 162 | S → P. Corresponds to variant dbSNP:rs7963597Ensembl. | 1 | |
Natural variantiVAR_048672 | 780 | R → W. Corresponds to variant dbSNP:rs3741447Ensembl. | 1 | |
Natural variantiVAR_048673 | 941 | S → P1 PublicationCorresponds to variant dbSNP:rs17883517Ensembl. | 1 | |
Natural variantiVAR_020398 | 1080 | D → E2 PublicationsCorresponds to variant dbSNP:rs1129167Ensembl. | 1 | |
Natural variantiVAR_036446 | 1213 | M → I in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1183319975Ensembl. | 1 | |
Natural variantiVAR_048674 | 1224 | A → S. Corresponds to variant dbSNP:rs17881033Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000765 | 457 – 502 | Missing in isoform 3. 2 PublicationsAdd BLAST | 46 | |
Alternative sequenceiVSP_038201 | 457 – 467 | Missing in isoform 2. 1 PublicationAdd BLAST | 11 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64838 mRNA Translation: CAA46050.1 M97501 mRNA Translation: AAA35693.1 BC114213 mRNA Translation: AAI14214.1 BC117209 mRNA Translation: AAI17210.1 BC126305 mRNA Translation: AAI26306.1 |
CCDSi | CCDS58285.1 [P30622-3] CCDS9232.1 [P30622-1] CCDS9233.1 [P30622-2] |
PIRi | A43336 S22695 |
RefSeqi | NP_001234926.1, NM_001247997.1 [P30622-3] NP_002947.1, NM_002956.2 [P30622-1] NP_937883.1, NM_198240.1 [P30622-2] XP_016875275.1, XM_017019786.1 [P30622-1] XP_016875279.1, XM_017019790.1 [P30622-2] |
Genome annotation databases
Ensembli | ENST00000302528; ENSP00000303585; ENSG00000130779 [P30622-1] ENST00000358808; ENSP00000351665; ENSG00000130779 [P30622-1] ENST00000537178; ENSP00000445531; ENSG00000130779 [P30622-2] ENST00000540338; ENSP00000439093; ENSG00000130779 [P30622-3] ENST00000620786; ENSP00000479322; ENSG00000130779 [P30622-3] |
GeneIDi | 6249 |
KEGGi | hsa:6249 |
UCSCi | uc001ucg.2, human [P30622-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64838 mRNA Translation: CAA46050.1 M97501 mRNA Translation: AAA35693.1 BC114213 mRNA Translation: AAI14214.1 BC117209 mRNA Translation: AAI17210.1 BC126305 mRNA Translation: AAI26306.1 |
CCDSi | CCDS58285.1 [P30622-3] CCDS9232.1 [P30622-1] CCDS9233.1 [P30622-2] |
PIRi | A43336 S22695 |
RefSeqi | NP_001234926.1, NM_001247997.1 [P30622-3] NP_002947.1, NM_002956.2 [P30622-1] NP_937883.1, NM_198240.1 [P30622-2] XP_016875275.1, XM_017019786.1 [P30622-1] XP_016875279.1, XM_017019790.1 [P30622-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CP5 | NMR | - | A | 1-128 | [»] | |
2CP6 | NMR | - | A | 181-339 | [»] | |
2E3H | X-ray | 1.45 | A | 211-300 | [»] | |
2E3I | X-ray | 2.00 | A | 56-141 | [»] | |
2E4H | NMR | - | A | 203-300 | [»] | |
2HQH | X-ray | 1.80 | E/F/G/H | 1416-1438 | [»] | |
2QK0 | X-ray | 2.00 | A | 57-128 | [»] | |
3E2U | X-ray | 2.60 | E/F/G/H | 1399-1438 | [»] | |
3RDV | X-ray | 1.75 | A/B/C/D | 56-127 | [»] | |
SMRi | P30622 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112163, 44 interactors |
CORUMi | P30622 |
DIPi | DIP-42826N |
ELMi | P30622 |
IntActi | P30622, 33 interactors |
MINTi | P30622 |
STRINGi | 9606.ENSP00000479322 |
PTM databases
GlyConnecti | 643, 6 N-Linked glycans (3 sites) |
GlyGeni | P30622, 4 sites, 6 N-linked glycans (3 sites), 1 O-linked glycan (1 site) |
iPTMneti | P30622 |
MetOSitei | P30622 |
PhosphoSitePlusi | P30622 |
Genetic variation databases
BioMutai | CLIP1 |
DMDMi | 261260059 |
Proteomic databases
EPDi | P30622 |
jPOSTi | P30622 |
MassIVEi | P30622 |
PaxDbi | P30622 |
PeptideAtlasi | P30622 |
PRIDEi | P30622 |
ProteomicsDBi | 54727 [P30622-3] 54728 [P30622-1] 54729 [P30622-2] |
Protocols and materials databases
Antibodypediai | 3829, 300 antibodies |
Genome annotation databases
Ensembli | ENST00000302528; ENSP00000303585; ENSG00000130779 [P30622-1] ENST00000358808; ENSP00000351665; ENSG00000130779 [P30622-1] ENST00000537178; ENSP00000445531; ENSG00000130779 [P30622-2] ENST00000540338; ENSP00000439093; ENSG00000130779 [P30622-3] ENST00000620786; ENSP00000479322; ENSG00000130779 [P30622-3] |
GeneIDi | 6249 |
KEGGi | hsa:6249 |
UCSCi | uc001ucg.2, human [P30622-3] |
Organism-specific databases
CTDi | 6249 |
DisGeNETi | 6249 |
GeneCardsi | CLIP1 |
HGNCi | HGNC:10461, CLIP1 |
HPAi | ENSG00000130779, Tissue enhanced (skeletal) |
MalaCardsi | CLIP1 |
MIMi | 179838, gene |
neXtProti | NX_P30622 |
OpenTargetsi | ENSG00000130779 |
Orphaneti | 88616, Autosomal recessive non-syndromic intellectual disability |
PharmGKBi | PA162382349 |
VEuPathDBi | HostDB:ENSG00000130779.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4568, Eukaryota |
GeneTreei | ENSGT00940000155122 |
InParanoidi | P30622 |
OMAi | EGKGHNQ |
OrthoDBi | 1110101at2759 |
PhylomeDBi | P30622 |
TreeFami | TF326096 |
Enzyme and pathway databases
PathwayCommonsi | P30622 |
Reactomei | R-HSA-141444, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-2467813, Separation of Sister Chromatids R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-5626467, RHO GTPases activate IQGAPs R-HSA-5663220, RHO GTPases Activate Formins R-HSA-68877, Mitotic Prometaphase R-HSA-9648025, EML4 and NUDC in mitotic spindle formation |
SIGNORi | P30622 |
Miscellaneous databases
BioGRID-ORCSi | 6249, 2 hits in 879 CRISPR screens |
ChiTaRSi | CLIP1, human |
EvolutionaryTracei | P30622 |
GeneWikii | CLIP1 |
GenomeRNAii | 6249 |
Pharosi | P30622, Tbio |
PROi | PR:P30622 |
RNActi | P30622, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130779, Expressed in biceps brachii and 247 other tissues |
ExpressionAtlasi | P30622, baseline and differential |
Genevisiblei | P30622, HS |
Family and domain databases
Gene3Di | 2.30.30.190, 2 hits |
InterProi | View protein in InterPro IPR036859, CAP-Gly_dom_sf IPR000938, CAP-Gly_domain IPR032108, CLIP1_ZNF |
Pfami | View protein in Pfam PF01302, CAP_GLY, 2 hits PF16641, CLIP1_ZNF, 2 hits |
SMARTi | View protein in SMART SM01052, CAP_GLY, 2 hits |
SUPFAMi | SSF74924, SSF74924, 2 hits |
PROSITEi | View protein in PROSITE PS00845, CAP_GLY_1, 2 hits PS50245, CAP_GLY_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLIP1_HUMAN | |
Accessioni | P30622Primary (citable) accession number: P30622 Secondary accession number(s): A0AVD3, Q17RS4, Q29RG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | October 13, 2009 | |
Last modified: | February 10, 2021 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references