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Entry version 195 (08 May 2019)
Sequence version 2 (13 Oct 2009)
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Protein

CAP-Gly domain-containing linker protein 1

Gene

CLIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1417 – 1434CCHC-type2 PublicationsAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P30622

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CAP-Gly domain-containing linker protein 1
Alternative name(s):
Cytoplasmic linker protein 1
Cytoplasmic linker protein 170 alpha-2
Short name:
CLIP-170
Reed-Sternberg intermediate filament-associated protein
Restin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLIP1
Synonyms:CYLN1, RSN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:10461 CLIP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
179838 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30622

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi98 – 99KN → EE: Abolishes interaction with tubulin. Abolishes localization at the microtubule plus end. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
6249

MalaCards human disease database

More...
MalaCardsi
CLIP1

Open Targets

More...
OpenTargetsi
ENSG00000130779

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
88616 Autosomal recessive non-syndromic intellectual disability

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382349

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CLIP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
261260059

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000835271 – 1438CAP-Gly domain-containing linker protein 1Add BLAST1438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48PhosphoserineCombined sources1
Modified residuei50PhosphothreonineCombined sources1
Modified residuei140PhosphothreonineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei310PhosphoserineBy similarity1
Modified residuei312Phosphoserine; by PKABy similarity1
Modified residuei315PhosphoserineBy similarity1
Modified residuei348PhosphoserineBy similarity1
Modified residuei1236PhosphoserineBy similarity1
Modified residuei1310PhosphothreonineCombined sources1
Modified residuei1364PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation induces conformational changes by increasing the affinity of the N-terminus for C-terminus, resulting in inhibition of its function thus decreasing its binding to microtubules and DCTN1. Exhibits a folded, autoinhibited conformation when phosphorylated and an open conformation when dephosphorylated with increased binding affinity to microtubules and DCTN1. Phosphorylation regulates its recruitment to tyrosinated microtubules and the recruitment of vesicular cargo to microtubules in neurons (By similarity). Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules (PubMed:12231510).By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P30622

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P30622

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P30622

PeptideAtlas

More...
PeptideAtlasi
P30622

PRoteomics IDEntifications database

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PRIDEi
P30622

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54727
54728 [P30622-1]
54729 [P30622-2]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
643

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30622

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30622

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P30622

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130779 Expressed in 234 organ(s), highest expression level in biceps brachii

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P30622 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P30622 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB004399
HPA026678

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MTOR; phosphorylates and regulates CLIP1 (PubMed:12231510). Interacts (via CAP-Gly domains) with tubulin (PubMed:17563362, PubMed:17889670). Interacts with SLAIN2 (PubMed:21646404). Interacts (via zinc finger) with DCTN1 (PubMed:17828275, PubMed:20679239). Interacts with TUBA1B, MAPRE1 and MAPRE3 (PubMed:17563362). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (By similarity).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112163, 37 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P30622

Database of interacting proteins

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DIPi
DIP-42826N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P30622

Protein interaction database and analysis system

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IntActi
P30622, 27 interactors

Molecular INTeraction database

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MINTi
P30622

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479322

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11438
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CP5NMR-A1-128[»]
2CP6NMR-A181-339[»]
2E3HX-ray1.45A211-300[»]
2E3IX-ray2.00A56-141[»]
2E4HNMR-A203-300[»]
2HQHX-ray1.80E/F/G/H1416-1438[»]
2QK0X-ray2.00A57-128[»]
3E2UX-ray2.60E/F/G/H1399-1438[»]
3RDVX-ray1.75A/B/C/D56-127[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30622

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P30622

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 120CAP-Gly 1PROSITE-ProRule annotationAdd BLAST43
Domaini232 – 274CAP-Gly 2PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni97 – 101Important for tubulin binding1 Publication5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili350 – 1353Sequence analysisAdd BLAST1004

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 204Ser-richAdd BLAST62
Compositional biasi304 – 331Ser-richAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1417 – 1434CCHC-type2 PublicationsAdd BLAST18

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4568 Eukaryota
COG5244 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155122

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000092755

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30622

KEGG Orthology (KO)

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KOi
K10421

Identification of Orthologs from Complete Genome Data

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OMAi
SHNQCQD

Database of Orthologous Groups

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OrthoDBi
794531at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P30622

TreeFam database of animal gene trees

More...
TreeFami
TF326096

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR032108 CLIP1_ZNF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01302 CAP_GLY, 2 hits
PF16641 CLIP1_ZNF, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01052 CAP_GLY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74924 SSF74924, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30622-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMLKPSGLK APTKILKPGS TALKTPTAVV APVEKTISSE KASSTPSSET
60 70 80 90 100
QEEFVDDFRV GERVWVNGNK PGFIQFLGET QFAPGQWAGI VLDEPIGKND
110 120 130 140 150
GSVAGVRYFQ CEPLKGIFTR PSKLTRKVQA EDEANGLQTT PASRATSPLC
160 170 180 190 200
TSTASMVSSS PSTPSNIPQK PSQPAAKEPS ATPPISNLTK TASESISNLS
210 220 230 240 250
EAGSIKKGER ELKIGDRVLV GGTKAGVVRF LGETDFAKGE WCGVELDEPL
260 270 280 290 300
GKNDGAVAGT RYFQCQPKYG LFAPVHKVTK IGFPSTTPAK AKANAVRRVM
310 320 330 340 350
ATTSASLKRS PSASSLSSMS SVASSVSSRP SRTGLLTETS SRYARKISGT
360 370 380 390 400
TALQEALKEK QQHIEQLLAE RDLERAEVAK ATSHVGEIEQ ELALARDGHD
410 420 430 440 450
QHVLELEAKM DQLRTMVEAA DREKVELLNQ LEEEKRKVED LQFRVEEESI
460 470 480 490 500
TKGDLEQKSQ ISEDPENTQT KLEHARIKEL EQSLLFEKTK ADKLQRELED
510 520 530 540 550
TRVATVSEKS RIMELEKDLA LRVQEVAELR RRLESNKPAG DVDMSLSLLQ
560 570 580 590 600
EISSLQEKLE VTRTDHQREI TSLKEHFGAR EETHQKEIKA LYTATEKLSK
610 620 630 640 650
ENESLKSKLE HANKENSDVI ALWKSKLETA IASHQQAMEE LKVSFSKGLG
660 670 680 690 700
TETAEFAELK TQIEKMRLDY QHEIENLQNQ QDSERAAHAK EMEALRAKLM
710 720 730 740 750
KVIKEKENSL EAIRSKLDKA EDQHLVEMED TLNKLQEAEI KVKELEVLQA
760 770 780 790 800
KCNEQTKVID NFTSQLKATE EKLLDLDALR KASSEGKSEM KKLRQQLEAA
810 820 830 840 850
EKQIKHLEIE KNAESSKASS ITRELQGREL KLTNLQENLS EVSQVKETLE
860 870 880 890 900
KELQILKEKF AEASEEAVSV QRSMQETVNK LHQKEEQFNM LSSDLEKLRE
910 920 930 940 950
NLADMEAKFR EKDEREEQLI KAKEKLENDI AEIMKMSGDN SSQLTKMNDE
960 970 980 990 1000
LRLKERDVEE LQLKLTKANE NASFLQKSIE DMTVKAEQSQ QEAAKKHEEE
1010 1020 1030 1040 1050
KKELERKLSD LEKKMETSHN QCQELKARYE RATSETKTKH EEILQNLQKT
1060 1070 1080 1090 1100
LLDTEDKLKG AREENSGLLQ ELEELRKQAD KAKAAQTAED AMQIMEQMTK
1110 1120 1130 1140 1150
EKTETLASLE DTKQTNAKLQ NELDTLKENN LKNVEELNKS KELLTVENQK
1160 1170 1180 1190 1200
MEEFRKEIET LKQAAAQKSQ QLSALQEENV KLAEELGRSR DEVTSHQKLE
1210 1220 1230 1240 1250
EERSVLNNQL LEMKKRESKF IKDADEEKAS LQKSISITSA LLTEKDAELE
1260 1270 1280 1290 1300
KLRNEVTVLR GENASAKSLH SVVQTLESDK VKLELKVKNL ELQLKENKRQ
1310 1320 1330 1340 1350
LSSSSGNTDT QADEDERAQE SQIDFLNSVI VDLQRKNQDL KMKVEMMSEA
1360 1370 1380 1390 1400
ALNGNGDDLN NYDSDDQEKQ SKKKPRLFCD ICDCFDLHDT EDCPTQAQMS
1410 1420 1430
EDPPHSTHHG SRGEERPYCE ICEMFGHWAT NCNDDETF
Length:1,438
Mass (Da):162,246
Last modified:October 13, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7F125F7A96DBDDB
GO
Isoform 2 (identifier: P30622-1) [UniParc]FASTAAdd to basket
Also known as: Long

The sequence of this isoform differs from the canonical sequence as follows:
     457-467: Missing.

Show »
Length:1,427
Mass (Da):160,990
Checksum:i0A4F166DD94254E8
GO
Isoform 3 (identifier: P30622-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     457-502: Missing.

Show »
Length:1,392
Mass (Da):156,781
Checksum:i959DF99064762A10
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H0N7F5H0N7_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
1,063Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KP58J3KP58_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
1,316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITA2A0A3B3ITA2_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
791Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISJ8A0A3B3ISJ8_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
867Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS27A0A3B3IS27_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1T5F5H1T5_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6A0F5H6A0_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
802Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H270F5H270_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H367F5H367_HUMAN
CAP-Gly domain-containing linker pr...
CLIP1
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti193S → G in AAI14214 (PubMed:15489334).Curated1
Sequence conflicti324S → P in AAI14214 (PubMed:15489334).Curated1
Sequence conflicti651T → A in AAI14214 (PubMed:15489334).Curated1
Sequence conflicti682D → N in AAI14214 (PubMed:15489334).Curated1
Sequence conflicti766L → P in AAI14214 (PubMed:15489334).Curated1
Sequence conflicti1432C → R in AAI14214 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059206162S → P. Corresponds to variant dbSNP:rs7963597Ensembl.1
Natural variantiVAR_048672780R → W. Corresponds to variant dbSNP:rs3741447Ensembl.1
Natural variantiVAR_048673941S → P1 PublicationCorresponds to variant dbSNP:rs17883517Ensembl.1
Natural variantiVAR_0203981080D → E2 PublicationsCorresponds to variant dbSNP:rs1129167Ensembl.1
Natural variantiVAR_0364461213M → I in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1183319975Ensembl.1
Natural variantiVAR_0486741224A → S. Corresponds to variant dbSNP:rs17881033Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000765457 – 502Missing in isoform 3. 2 PublicationsAdd BLAST46
Alternative sequenceiVSP_038201457 – 467Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X64838 mRNA Translation: CAA46050.1
M97501 mRNA Translation: AAA35693.1
BC114213 mRNA Translation: AAI14214.1
BC117209 mRNA Translation: AAI17210.1
BC126305 mRNA Translation: AAI26306.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58285.1 [P30622-3]
CCDS9232.1 [P30622-1]
CCDS9233.1 [P30622-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A43336
S22695

NCBI Reference Sequences

More...
RefSeqi
NP_001234926.1, NM_001247997.1 [P30622-3]
NP_002947.1, NM_002956.2 [P30622-1]
NP_937883.1, NM_198240.1 [P30622-2]
XP_016875275.1, XM_017019786.1 [P30622-1]
XP_016875279.1, XM_017019790.1 [P30622-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302528; ENSP00000303585; ENSG00000130779 [P30622-1]
ENST00000358808; ENSP00000351665; ENSG00000130779 [P30622-1]
ENST00000537178; ENSP00000445531; ENSG00000130779 [P30622-2]
ENST00000540338; ENSP00000439093; ENSG00000130779 [P30622-3]
ENST00000620786; ENSP00000479322; ENSG00000130779 [P30622-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6249

UCSC genome browser

More...
UCSCi
uc001ucg.2 human [P30622-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64838 mRNA Translation: CAA46050.1
M97501 mRNA Translation: AAA35693.1
BC114213 mRNA Translation: AAI14214.1
BC117209 mRNA Translation: AAI17210.1
BC126305 mRNA Translation: AAI26306.1
CCDSiCCDS58285.1 [P30622-3]
CCDS9232.1 [P30622-1]
CCDS9233.1 [P30622-2]
PIRiA43336
S22695
RefSeqiNP_001234926.1, NM_001247997.1 [P30622-3]
NP_002947.1, NM_002956.2 [P30622-1]
NP_937883.1, NM_198240.1 [P30622-2]
XP_016875275.1, XM_017019786.1 [P30622-1]
XP_016875279.1, XM_017019790.1 [P30622-2]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CP5NMR-A1-128[»]
2CP6NMR-A181-339[»]
2E3HX-ray1.45A211-300[»]
2E3IX-ray2.00A56-141[»]
2E4HNMR-A203-300[»]
2HQHX-ray1.80E/F/G/H1416-1438[»]
2QK0X-ray2.00A57-128[»]
3E2UX-ray2.60E/F/G/H1399-1438[»]
3RDVX-ray1.75A/B/C/D56-127[»]
SMRiP30622
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112163, 37 interactors
CORUMiP30622
DIPiDIP-42826N
ELMiP30622
IntActiP30622, 27 interactors
MINTiP30622
STRINGi9606.ENSP00000479322

PTM databases

GlyConnecti643
iPTMnetiP30622
PhosphoSitePlusiP30622
UniCarbKBiP30622

Polymorphism and mutation databases

BioMutaiCLIP1
DMDMi261260059

Proteomic databases

EPDiP30622
jPOSTiP30622
PaxDbiP30622
PeptideAtlasiP30622
PRIDEiP30622
ProteomicsDBi54727
54728 [P30622-1]
54729 [P30622-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302528; ENSP00000303585; ENSG00000130779 [P30622-1]
ENST00000358808; ENSP00000351665; ENSG00000130779 [P30622-1]
ENST00000537178; ENSP00000445531; ENSG00000130779 [P30622-2]
ENST00000540338; ENSP00000439093; ENSG00000130779 [P30622-3]
ENST00000620786; ENSP00000479322; ENSG00000130779 [P30622-3]
GeneIDi6249
KEGGihsa:6249
UCSCiuc001ucg.2 human [P30622-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6249
DisGeNETi6249

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CLIP1
HGNCiHGNC:10461 CLIP1
HPAiCAB004399
HPA026678
MalaCardsiCLIP1
MIMi179838 gene
neXtProtiNX_P30622
OpenTargetsiENSG00000130779
Orphaneti88616 Autosomal recessive non-syndromic intellectual disability
PharmGKBiPA162382349

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4568 Eukaryota
COG5244 LUCA
GeneTreeiENSGT00940000155122
HOGENOMiHOG000092755
InParanoidiP30622
KOiK10421
OMAiSHNQCQD
OrthoDBi794531at2759
PhylomeDBiP30622
TreeFamiTF326096

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-68877 Mitotic Prometaphase
SIGNORiP30622

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLIP1 human
EvolutionaryTraceiP30622

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CLIP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6249

Protein Ontology

More...
PROi
PR:P30622

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130779 Expressed in 234 organ(s), highest expression level in biceps brachii
ExpressionAtlasiP30622 baseline and differential
GenevisibleiP30622 HS

Family and domain databases

Gene3Di2.30.30.190, 2 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR032108 CLIP1_ZNF
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
PF16641 CLIP1_ZNF, 2 hits
SMARTiView protein in SMART
SM01052 CAP_GLY, 2 hits
SUPFAMiSSF74924 SSF74924, 2 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLIP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30622
Secondary accession number(s): A0AVD3, Q17RS4, Q29RG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 13, 2009
Last modified: May 8, 2019
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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