UniProtKB - P30613 (KPYR_HUMAN)
Pyruvate kinase PKLR
PKLR
Functioni
Pyruvate kinase that catalyzes the conversion of phosphoenolpyruvate to pyruvate with the synthesis of ATP, and which plays a key role in glycolysis.
1 PublicationMiscellaneous
Catalytic activityi
Cofactori
Protein has several cofactor binding sites:Activity regulationi
: glycolysis Pathwayi
This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.1 Publication This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | SubstrateCombined sources1 Publication | 1 | |
Metal bindingi | 118 | PotassiumCombined sources1 Publication | 1 | |
Metal bindingi | 120 | PotassiumCombined sources1 Publication | 1 | |
Metal bindingi | 156 | PotassiumCombined sources1 Publication | 1 | |
Metal bindingi | 157 | Potassium; via carbonyl oxygenCombined sources1 Publication | 1 | |
Binding sitei | 163 | ATPBy similarity | 1 | |
Binding sitei | 250 | ATPBy similarity | 1 | |
Binding sitei | 313 | Substrate; via amide nitrogenCombined sources1 Publication | 1 | |
Sitei | 313 | Transition state stabilizerBy similarity | 1 | |
Metal bindingi | 315 | ManganeseCombined sources1 Publication | 1 | |
Binding sitei | 338 | Substrate; via amide nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 339 | ManganeseCombined sources1 Publication | 1 | |
Binding sitei | 339 | Substrate; via amide nitrogenCombined sources1 Publication | 1 | |
Binding sitei | 371 | SubstrateCombined sources1 Publication | 1 | |
Binding sitei | 525 | Fructose-1,6-bisphosphate; allosteric activatorCombined sources1 Publication | 1 | |
Binding sitei | 532 | Fructose-1,6-bisphosphate; allosteric activatorCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 118 – 121 | ATPBy similarity | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- kinase activity Source: UniProtKB-KW
- magnesium ion binding Source: InterPro
- potassium ion binding Source: InterPro
- pyruvate kinase activity Source: GO_Central
GO - Biological processi
- ATP biosynthetic process Source: Ensembl
- cellular response to epinephrine stimulus Source: Ensembl
- cellular response to insulin stimulus Source: GO_Central
- glycolytic process Source: GO_Central
- pyruvate biosynthetic process Source: Ensembl
- response to ATP Source: Ensembl
- response to cAMP Source: Ensembl
- response to glucose Source: Ensembl
- response to heat Source: Ensembl
- response to hypoxia Source: Ensembl
- response to lithium ion Source: Ensembl
- response to nutrient Source: Ensembl
Keywordsi
Molecular function | Allosteric enzyme, Kinase, Transferase |
Biological process | Glycolysis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, Potassium, Pyruvate |
Enzyme and pathway databases
BRENDAi | 2.7.1.40, 2681 |
PathwayCommonsi | P30613 |
Reactomei | R-HSA-163765, ChREBP activates metabolic gene expression [P30613-1] R-HSA-210745, Regulation of gene expression in beta cells [P30613-2] R-HSA-70171, Glycolysis |
SABIO-RKi | P30613 |
SignaLinki | P30613 |
SIGNORi | P30613 |
UniPathwayi | UPA00109;UER00188 |
Names & Taxonomyi
Protein namesi | Recommended name: Pyruvate kinase PKLR (EC:2.7.1.401 Publication)Alternative name(s): Pyruvate kinase 1 Pyruvate kinase isozymes L/R R-type/L-type pyruvate kinase Red cell/liver pyruvate kinase |
Gene namesi | Name:PKLR Synonyms:PK1, PKL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9020, PKLR |
MIMi | 609712, gene |
neXtProti | NX_P30613 |
VEuPathDBi | HostDB:ENSG00000143627 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Involvement in diseasei
Pyruvate kinase hyperactivity (PKHYP)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011435 | 37 | G → E in PKHYP. 1 PublicationCorresponds to variant dbSNP:rs118204087EnsemblClinVar. | 1 |
Pyruvate kinase deficiency of red cells (PKRD)17 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_058467 | 40 | R → W in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1484388413Ensembl. | 1 | |
Natural variantiVAR_058468 | 48 – 53 | Missing in PKRD. 1 Publication | 6 | |
Natural variantiVAR_058469 | 73 | L → P in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011436 | 80 | S → P in PKRD. | 1 | |
Natural variantiVAR_011437 | 86 | R → P in PKRD. | 1 | |
Natural variantiVAR_011438 | 90 | I → N in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011439 | 95 | G → R in PKRD. Corresponds to variant dbSNP:rs750857114Ensembl. | 1 | |
Natural variantiVAR_004028 | 107 | M → T in PKRD. | 1 | |
Natural variantiVAR_011440 | 111 | G → R in PKRD. 1 PublicationCorresponds to variant dbSNP:rs918627824EnsemblClinVar. | 1 | |
Natural variantiVAR_011441 | 115 | A → P in PKRD; Val de Marne. | 1 | |
Natural variantiVAR_011442 | 120 | S → F in PKRD; Beaujon. | 1 | |
Natural variantiVAR_011443 | 130 | S → Y in PKRD; Conakry. 1 PublicationCorresponds to variant dbSNP:rs118204089EnsemblClinVar. | 1 | |
Natural variantiVAR_004029 | 131 | Missing in PKRD. | 1 | |
Natural variantiVAR_004030 | 134 | V → D in PKRD. 1 PublicationCorresponds to variant dbSNP:rs574051756Ensembl. | 1 | |
Natural variantiVAR_011474 | 153 | I → T in PKRD. | 1 | |
Natural variantiVAR_058470 | 154 | A → T in PKRD. 1 PublicationCorresponds to variant dbSNP:rs780192373Ensembl. | 1 | |
Natural variantiVAR_004031 | 155 | L → P in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011444 | 159 | G → V in PKRD. Corresponds to variant dbSNP:rs1239029841Ensembl. | 1 | |
Natural variantiVAR_004033 | 163 | R → C in PKRD; Linz. 1 PublicationCorresponds to variant dbSNP:rs118204083EnsemblClinVar. | 1 | |
Natural variantiVAR_058471 | 163 | R → L in PKRD. 1 Publication | 1 | |
Natural variantiVAR_058472 | 165 | G → V in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004032 | 172 | E → Q in PKRD; Sassari. 1 PublicationCorresponds to variant dbSNP:rs757359024Ensembl. | 1 | |
Natural variantiVAR_011475 | 219 | I → T in PKRD. Corresponds to variant dbSNP:rs200572803Ensembl. | 1 | |
Natural variantiVAR_004034 | 221 | D → DD in PKRD. | 1 | |
Natural variantiVAR_011445 | 222 | G → A in PKRD; Katsushika. | 1 | |
Natural variantiVAR_011447 | 263 | G → R in PKRD. Corresponds to variant dbSNP:rs1253386414Ensembl. | 1 | |
Natural variantiVAR_011448 | 263 | G → W in PKRD. | 1 | |
Natural variantiVAR_058473 | 272 | L → V in PKRD. 1 PublicationCorresponds to variant dbSNP:rs147659527EnsemblClinVar. | 1 | |
Natural variantiVAR_004035 | 275 | G → R in PKRD. Corresponds to variant dbSNP:rs747549978Ensembl. | 1 | |
Natural variantiVAR_004036 | 281 | D → N in PKRD. | 1 | |
Natural variantiVAR_004037 | 287 | F → V in PKRD. | 1 | |
Natural variantiVAR_011449 | 288 | V → L in PKRD; Moriguchi. | 1 | |
Natural variantiVAR_011446 | 293 | D → N in PKRD. Corresponds to variant dbSNP:rs1352610988Ensembl. | 1 | |
Natural variantiVAR_011450 | 295 | A → V in PKRD. Corresponds to variant dbSNP:rs766353400Ensembl. | 1 | |
Natural variantiVAR_011451 | 310 | I → N in PKRD; Dordrecht. 1 Publication | 1 | |
Natural variantiVAR_004038 | 314 | I → T in PKRD; Hong Kong. Corresponds to variant dbSNP:rs981505482Ensembl. | 1 | |
Natural variantiVAR_011452 | 315 | E → K in PKRD. | 1 | |
Natural variantiVAR_058474 | 320 | V → L in PKRD. 1 PublicationCorresponds to variant dbSNP:rs549295725Ensembl. | 1 | |
Natural variantiVAR_004039 | 331 | D → E in PKRD; Parma. 1 PublicationCorresponds to variant dbSNP:rs138476691Ensembl. | 1 | |
Natural variantiVAR_011453 | 331 | D → N in PKRD. Corresponds to variant dbSNP:rs773893686Ensembl. | 1 | |
Natural variantiVAR_004040 | 332 | G → S in PKRD; loss of catalytical activity. 3 PublicationsCorresponds to variant dbSNP:rs773626254EnsemblClinVar. | 1 | |
Natural variantiVAR_011476 | 335 | V → M in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004041 | 336 | A → S in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004042 | 337 | R → P in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004043 | 337 | R → Q in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1167329263Ensembl. | 1 | |
Natural variantiVAR_004044 | 339 | D → H in PKRD. 1 PublicationCorresponds to variant dbSNP:rs747097960Ensembl. | 1 | |
Natural variantiVAR_004045 | 341 | G → A in PKRD. 2 PublicationsCorresponds to variant dbSNP:rs1227427396Ensembl. | 1 | |
Natural variantiVAR_011454 | 341 | G → D in PKRD. | 1 | |
Natural variantiVAR_011455 | 342 | I → F in PKRD. | 1 | |
Natural variantiVAR_011456 | 348 | K → N in PKRD; Kamata. | 1 | |
Natural variantiVAR_011457 | 348 | Missing in PKRD; Brescia. 1 Publication | 1 | |
Natural variantiVAR_011477 | 352 | A → D in PKRD. Corresponds to variant dbSNP:rs1240481888Ensembl. | 1 | |
Natural variantiVAR_004046 | 354 | Missing in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004047 | 357 | I → T in PKRD. 1 PublicationCorresponds to variant dbSNP:rs779152555Ensembl. | 1 | |
Natural variantiVAR_058475 | 358 | G → E in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004048 | 359 | R → C in PKRD; Aomori. Corresponds to variant dbSNP:rs138871700EnsemblClinVar. | 1 | |
Natural variantiVAR_004049 | 359 | R → H in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1376070580Ensembl. | 1 | |
Natural variantiVAR_004050 | 361 | N → D in PKRD. 1 PublicationCorresponds to variant dbSNP:rs765903674EnsemblClinVar. | 1 | |
Natural variantiVAR_011458 | 364 | G → D in PKRD; Tjaereborg; unstability of the protein and decrease in catalytic activity. 1 PublicationCorresponds to variant dbSNP:rs981579065Ensembl. | 1 | |
Natural variantiVAR_004051 | 368 | V → F in PKRD; Osaka. 1 Publication | 1 | |
Natural variantiVAR_058476 | 374 | L → P in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011459 | 376 | S → I in PKRD. | 1 | |
Natural variantiVAR_004052 | 384 | T → M in PKRD; Tokyo/Beirut; no conformational change. 3 PublicationsCorresponds to variant dbSNP:rs74315362EnsemblClinVar. | 1 | |
Natural variantiVAR_011478 | 385 | R → W in PKRD. | 1 | |
Natural variantiVAR_011460 | 387 | E → G in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011461 | 390 | D → N in PKRD; Mantova; almost complete inactivation. 1 PublicationCorresponds to variant dbSNP:rs147034239Ensembl. | 1 | |
Natural variantiVAR_004053 | 392 | A → T in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1403323591Ensembl. | 1 | |
Natural variantiVAR_004054 | 393 | N → K in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1168490341Ensembl. | 1 | |
Natural variantiVAR_004055 | 393 | N → S in PKRD; Paris. 1 PublicationCorresponds to variant dbSNP:rs776594413Ensembl. | 1 | |
Natural variantiVAR_011462 | 394 | A → D in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1035640530Ensembl. | 1 | |
Natural variantiVAR_011463 | 394 | A → V in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004056 | 401 | C → CS in PKRD. | 1 | |
Natural variantiVAR_011464 | 408 | T → A in PKRD; Hirosaki. | 1 | |
Natural variantiVAR_004057 | 408 | T → I in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004058 | 421 | Q → K in PKRD; Fukushima/Maebashi/Sendai. 1 PublicationCorresponds to variant dbSNP:rs118204084EnsemblClinVar. | 1 | |
Natural variantiVAR_004059 | 426 | R → Q in PKRD; Sapporo. 1 PublicationCorresponds to variant dbSNP:rs768002493Ensembl. | 1 | |
Natural variantiVAR_004060 | 426 | R → W in PKRD; Naniwa. Corresponds to variant dbSNP:rs1023689443Ensembl. | 1 | |
Natural variantiVAR_011465 | 427 | E → A in PKRD. | 1 | |
Natural variantiVAR_011466 | 427 | E → D in PKRD. | 1 | |
Natural variantiVAR_004061 | 431 | A → T in PKRD. 1 PublicationCorresponds to variant dbSNP:rs762591322EnsemblClinVar. | 1 | |
Natural variantiVAR_004062 | 458 | G → D in PKRD. 1 PublicationCorresponds to variant dbSNP:rs755522396Ensembl. | 1 | |
Natural variantiVAR_004063 | 459 | A → V in PKRD. | 1 | |
Natural variantiVAR_004064 | 460 | V → M in PKRD. 1 PublicationCorresponds to variant dbSNP:rs752034960EnsemblClinVar. | 1 | |
Natural variantiVAR_011479 | 468 | A → G in PKRD. Corresponds to variant dbSNP:rs750540943Ensembl. | 1 | |
Natural variantiVAR_004065 | 468 | A → V in PKRD; Hadano. | 1 | |
Natural variantiVAR_011467 | 477 | T → A in PKRD. Corresponds to variant dbSNP:rs759466273Ensembl. | 1 | |
Natural variantiVAR_011480 | 479 | R → H in PKRD; Amish; no conformational change. 2 PublicationsCorresponds to variant dbSNP:rs118204085EnsemblClinVar. | 1 | |
Natural variantiVAR_011468 | 485 | S → F in PKRD. | 1 | |
Natural variantiVAR_004066 | 486 | R → W in PKRD; no conformational change. 4 PublicationsCorresponds to variant dbSNP:rs116100695EnsemblClinVar. | 1 | |
Natural variantiVAR_011469 | 488 | R → Q in PKRD. Corresponds to variant dbSNP:rs369183199EnsemblClinVar. | 1 | |
Natural variantiVAR_004067 | 490 | R → W in PKRD. Corresponds to variant dbSNP:rs200133000EnsemblClinVar. | 1 | |
Natural variantiVAR_011470 | 495 | A → T in PKRD. | 1 | |
Natural variantiVAR_004068 | 495 | A → V in PKRD. 1 PublicationCorresponds to variant dbSNP:rs141560532Ensembl. | 1 | |
Natural variantiVAR_004069 | 498 | R → C in PKRD. 1 PublicationCorresponds to variant dbSNP:rs551883218Ensembl. | 1 | |
Natural variantiVAR_004070 | 498 | R → H in PKRD. 2 PublicationsCorresponds to variant dbSNP:rs758327704Ensembl. | 1 | |
Natural variantiVAR_011471 | 504 | R → L in PKRD; instability of the protein. 1 PublicationCorresponds to variant dbSNP:rs185753709Ensembl. | 1 | |
Natural variantiVAR_004071 | 510 | R → Q in PKRD. 3 PublicationsCorresponds to variant dbSNP:rs113403872EnsemblClinVar. | 1 | |
Natural variantiVAR_011472 | 511 | G → R in PKRD. | 1 | |
Natural variantiVAR_011473 | 531 | R → C in PKRD. | 1 | |
Natural variantiVAR_004072 | 532 | R → Q in PKRD. 1 PublicationCorresponds to variant dbSNP:rs758278200Ensembl. | 1 | |
Natural variantiVAR_004073 | 532 | R → W in PKRD; Complete loss in the responsiveness to fructose 1,6-bisphosphate, FBP. 2 PublicationsCorresponds to variant dbSNP:rs201255024EnsemblClinVar. | 1 | |
Natural variantiVAR_004074 | 552 | V → M in PKRD. Corresponds to variant dbSNP:rs370316462Ensembl. | 1 | |
Natural variantiVAR_011481 | 557 | G → A in PKRD. | 1 | |
Natural variantiVAR_004075 | 559 | R → G in PKRD. | 1 | |
Natural variantiVAR_004076 | 566 | N → K in PKRD. | 1 | |
Natural variantiVAR_011482 | 569 | R → Q in PKRD. 1 PublicationCorresponds to variant dbSNP:rs61755431EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Hereditary hemolytic anemiaOrganism-specific databases
DisGeNETi | 5313 |
MalaCardsi | PKLR |
MIMi | 102900, phenotype 266200, phenotype |
OpenTargetsi | ENSG00000143627 |
Orphaneti | 766, Hemolytic anemia due to red cell pyruvate kinase deficiency |
PharmGKBi | PA33352 |
Miscellaneous databases
Pharosi | P30613, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1075126 |
DrugBanki | DB02726, 2-Phosphoglycolic Acid DB00787, Acyclovir DB04551, beta-D-fructofuranose 1,6-bisphosphate DB00119, Pyruvic acid |
Genetic variation databases
BioMutai | PKLR |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000112094 | 1 – 574 | Pyruvate kinase PKLRAdd BLAST | 574 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 19 | PhosphoserineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 43 | PhosphoserineCombined sources | 1 | |
Modified residuei | 292 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P30613 |
jPOSTi | P30613 |
MassIVEi | P30613 |
MaxQBi | P30613 |
PaxDbi | P30613 |
PeptideAtlasi | P30613 |
PRIDEi | P30613 |
ProteomicsDBi | 54725 [P30613-1] 54726 [P30613-2] |
2D gel databases
REPRODUCTION-2DPAGEi | P30613 |
SWISS-2DPAGEi | P30613 |
PTM databases
GlyGeni | P30613, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P30613 |
PhosphoSitePlusi | P30613 |
SwissPalmi | P30613 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143627, Expressed in liver and 139 other tissues |
ExpressionAtlasi | P30613, baseline and differential |
Genevisiblei | P30613, HS |
Organism-specific databases
HPAi | ENSG00000143627, Tissue enhanced (bone marrow, kidney, liver) |
Interactioni
Subunit structurei
Homotetramer.
1 PublicationBinary interactionsi
P30613
With | #Exp. | IntAct |
---|---|---|
CPNE7 - isoform 2 [Q9UBL6-2] | 3 | EBI-2117450,EBI-12012272 |
Protein-protein interaction databases
BioGRIDi | 111330, 48 interactors |
ComplexPortali | CPX-3094, PKL pyruvate kinase complex [P30613-2] CPX-3095, PKR pyruvate kinase complex [P30613-1] |
IntActi | P30613, 12 interactors |
STRINGi | 9606.ENSP00000339933 |
Chemistry databases
BindingDBi | P30613 |
Miscellaneous databases
RNActi | P30613, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P30613 |
SMRi | P30613 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P30613 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 475 – 480 | Fructose-1,6-bisphosphate binding; allosteric activatorCombined sources1 Publication | 6 | |
Regioni | 559 – 564 | Fructose-1,6-bisphosphate binding; allosteric activatorCombined sources1 Publication | 6 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2323, Eukaryota |
GeneTreei | ENSGT00390000008859 |
HOGENOMi | CLU_015439_0_1_1 |
InParanoidi | P30613 |
OMAi | MVRVHHL |
OrthoDBi | 933620at2759 |
PhylomeDBi | P30613 |
TreeFami | TF300390 |
Family and domain databases
CDDi | cd00288, Pyruvate_Kinase, 1 hit |
Gene3Di | 2.40.33.10, 1 hit 3.20.20.60, 1 hit 3.40.1380.20, 1 hit |
InterProi | View protein in InterPro IPR001697, Pyr_Knase IPR015813, Pyrv/PenolPyrv_Kinase-like_dom IPR040442, Pyrv_Kinase-like_dom_sf IPR011037, Pyrv_Knase-like_insert_dom_sf IPR018209, Pyrv_Knase_AS IPR015793, Pyrv_Knase_brl IPR015795, Pyrv_Knase_C IPR036918, Pyrv_Knase_C_sf IPR015806, Pyrv_Knase_insert_dom_sf |
PANTHERi | PTHR11817, PTHR11817, 1 hit |
Pfami | View protein in Pfam PF00224, PK, 1 hit PF02887, PK_C, 1 hit |
PRINTSi | PR01050, PYRUVTKNASE |
SUPFAMi | SSF50800, SSF50800, 1 hit SSF51621, SSF51621, 1 hit SSF52935, SSF52935, 1 hit |
TIGRFAMsi | TIGR01064, pyruv_kin, 1 hit |
PROSITEi | View protein in PROSITE PS00110, PYRUVATE_KINASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSIQENISSL QLRSWVSKSQ RDLAKSILIG APGGPAGYLR RASVAQLTQE
60 70 80 90 100
LGTAFFQQQQ LPAAMADTFL EHLCLLDIDS EPVAARSTSI IATIGPASRS
110 120 130 140 150
VERLKEMIKA GMNIARLNFS HGSHEYHAES IANVREAVES FAGSPLSYRP
160 170 180 190 200
VAIALDTKGP EIRTGILQGG PESEVELVKG SQVLVTVDPA FRTRGNANTV
210 220 230 240 250
WVDYPNIVRV VPVGGRIYID DGLISLVVQK IGPEGLVTQV ENGGVLGSRK
260 270 280 290 300
GVNLPGAQVD LPGLSEQDVR DLRFGVEHGV DIVFASFVRK ASDVAAVRAA
310 320 330 340 350
LGPEGHGIKI ISKIENHEGV KRFDEILEVS DGIMVARGDL GIEIPAEKVF
360 370 380 390 400
LAQKMMIGRC NLAGKPVVCA TQMLESMITK PRPTRAETSD VANAVLDGAD
410 420 430 440 450
CIMLSGETAK GNFPVEAVKM QHAIAREAEA AVYHRQLFEE LRRAAPLSRD
460 470 480 490 500
PTEVTAIGAV EAAFKCCAAA IIVLTTTGRS AQLLSRYRPR AAVIAVTRSA
510 520 530 540 550
QAARQVHLCR GVFPLLYREP PEAIWADDVD RRVQFGIESG KLRGFLRVGD
560 570
LVIVVTGWRP GSGYTNIMRV LSIS
The sequence of this isoform differs from the canonical sequence as follows:
1-33: MSIQENISSLQLRSWVSKSQRDLAKSILIGAPG → ME
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W6W2 | F8W6W2_HUMAN | Pyruvate kinase | PKLR | 161 | Annotation score: | ||
A0A0G2JLC7 | A0A0G2JLC7_HUMAN | Pyruvate kinase PKLR | PKLR | 46 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 381 | P → A in BAA02515 (Ref. 3) Curated | 1 | |
Sequence conflicti | 423 | A → R in AAA60104 (PubMed:3126495).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011435 | 37 | G → E in PKHYP. 1 PublicationCorresponds to variant dbSNP:rs118204087EnsemblClinVar. | 1 | |
Natural variantiVAR_058467 | 40 | R → W in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1484388413Ensembl. | 1 | |
Natural variantiVAR_058468 | 48 – 53 | Missing in PKRD. 1 Publication | 6 | |
Natural variantiVAR_058469 | 73 | L → P in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011436 | 80 | S → P in PKRD. | 1 | |
Natural variantiVAR_011437 | 86 | R → P in PKRD. | 1 | |
Natural variantiVAR_011438 | 90 | I → N in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011439 | 95 | G → R in PKRD. Corresponds to variant dbSNP:rs750857114Ensembl. | 1 | |
Natural variantiVAR_004028 | 107 | M → T in PKRD. | 1 | |
Natural variantiVAR_011440 | 111 | G → R in PKRD. 1 PublicationCorresponds to variant dbSNP:rs918627824EnsemblClinVar. | 1 | |
Natural variantiVAR_011441 | 115 | A → P in PKRD; Val de Marne. | 1 | |
Natural variantiVAR_011442 | 120 | S → F in PKRD; Beaujon. | 1 | |
Natural variantiVAR_011443 | 130 | S → Y in PKRD; Conakry. 1 PublicationCorresponds to variant dbSNP:rs118204089EnsemblClinVar. | 1 | |
Natural variantiVAR_004029 | 131 | Missing in PKRD. | 1 | |
Natural variantiVAR_004030 | 134 | V → D in PKRD. 1 PublicationCorresponds to variant dbSNP:rs574051756Ensembl. | 1 | |
Natural variantiVAR_011474 | 153 | I → T in PKRD. | 1 | |
Natural variantiVAR_058470 | 154 | A → T in PKRD. 1 PublicationCorresponds to variant dbSNP:rs780192373Ensembl. | 1 | |
Natural variantiVAR_004031 | 155 | L → P in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011444 | 159 | G → V in PKRD. Corresponds to variant dbSNP:rs1239029841Ensembl. | 1 | |
Natural variantiVAR_004033 | 163 | R → C in PKRD; Linz. 1 PublicationCorresponds to variant dbSNP:rs118204083EnsemblClinVar. | 1 | |
Natural variantiVAR_058471 | 163 | R → L in PKRD. 1 Publication | 1 | |
Natural variantiVAR_058472 | 165 | G → V in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004032 | 172 | E → Q in PKRD; Sassari. 1 PublicationCorresponds to variant dbSNP:rs757359024Ensembl. | 1 | |
Natural variantiVAR_011475 | 219 | I → T in PKRD. Corresponds to variant dbSNP:rs200572803Ensembl. | 1 | |
Natural variantiVAR_004034 | 221 | D → DD in PKRD. | 1 | |
Natural variantiVAR_011445 | 222 | G → A in PKRD; Katsushika. | 1 | |
Natural variantiVAR_011447 | 263 | G → R in PKRD. Corresponds to variant dbSNP:rs1253386414Ensembl. | 1 | |
Natural variantiVAR_011448 | 263 | G → W in PKRD. | 1 | |
Natural variantiVAR_058473 | 272 | L → V in PKRD. 1 PublicationCorresponds to variant dbSNP:rs147659527EnsemblClinVar. | 1 | |
Natural variantiVAR_004035 | 275 | G → R in PKRD. Corresponds to variant dbSNP:rs747549978Ensembl. | 1 | |
Natural variantiVAR_004036 | 281 | D → N in PKRD. | 1 | |
Natural variantiVAR_004037 | 287 | F → V in PKRD. | 1 | |
Natural variantiVAR_011449 | 288 | V → L in PKRD; Moriguchi. | 1 | |
Natural variantiVAR_011446 | 293 | D → N in PKRD. Corresponds to variant dbSNP:rs1352610988Ensembl. | 1 | |
Natural variantiVAR_011450 | 295 | A → V in PKRD. Corresponds to variant dbSNP:rs766353400Ensembl. | 1 | |
Natural variantiVAR_011451 | 310 | I → N in PKRD; Dordrecht. 1 Publication | 1 | |
Natural variantiVAR_004038 | 314 | I → T in PKRD; Hong Kong. Corresponds to variant dbSNP:rs981505482Ensembl. | 1 | |
Natural variantiVAR_011452 | 315 | E → K in PKRD. | 1 | |
Natural variantiVAR_058474 | 320 | V → L in PKRD. 1 PublicationCorresponds to variant dbSNP:rs549295725Ensembl. | 1 | |
Natural variantiVAR_004039 | 331 | D → E in PKRD; Parma. 1 PublicationCorresponds to variant dbSNP:rs138476691Ensembl. | 1 | |
Natural variantiVAR_011453 | 331 | D → N in PKRD. Corresponds to variant dbSNP:rs773893686Ensembl. | 1 | |
Natural variantiVAR_004040 | 332 | G → S in PKRD; loss of catalytical activity. 3 PublicationsCorresponds to variant dbSNP:rs773626254EnsemblClinVar. | 1 | |
Natural variantiVAR_011476 | 335 | V → M in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004041 | 336 | A → S in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004042 | 337 | R → P in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004043 | 337 | R → Q in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1167329263Ensembl. | 1 | |
Natural variantiVAR_004044 | 339 | D → H in PKRD. 1 PublicationCorresponds to variant dbSNP:rs747097960Ensembl. | 1 | |
Natural variantiVAR_004045 | 341 | G → A in PKRD. 2 PublicationsCorresponds to variant dbSNP:rs1227427396Ensembl. | 1 | |
Natural variantiVAR_011454 | 341 | G → D in PKRD. | 1 | |
Natural variantiVAR_011455 | 342 | I → F in PKRD. | 1 | |
Natural variantiVAR_011456 | 348 | K → N in PKRD; Kamata. | 1 | |
Natural variantiVAR_011457 | 348 | Missing in PKRD; Brescia. 1 Publication | 1 | |
Natural variantiVAR_011477 | 352 | A → D in PKRD. Corresponds to variant dbSNP:rs1240481888Ensembl. | 1 | |
Natural variantiVAR_004046 | 354 | Missing in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004047 | 357 | I → T in PKRD. 1 PublicationCorresponds to variant dbSNP:rs779152555Ensembl. | 1 | |
Natural variantiVAR_058475 | 358 | G → E in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004048 | 359 | R → C in PKRD; Aomori. Corresponds to variant dbSNP:rs138871700EnsemblClinVar. | 1 | |
Natural variantiVAR_004049 | 359 | R → H in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1376070580Ensembl. | 1 | |
Natural variantiVAR_004050 | 361 | N → D in PKRD. 1 PublicationCorresponds to variant dbSNP:rs765903674EnsemblClinVar. | 1 | |
Natural variantiVAR_011458 | 364 | G → D in PKRD; Tjaereborg; unstability of the protein and decrease in catalytic activity. 1 PublicationCorresponds to variant dbSNP:rs981579065Ensembl. | 1 | |
Natural variantiVAR_004051 | 368 | V → F in PKRD; Osaka. 1 Publication | 1 | |
Natural variantiVAR_058476 | 374 | L → P in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011459 | 376 | S → I in PKRD. | 1 | |
Natural variantiVAR_004052 | 384 | T → M in PKRD; Tokyo/Beirut; no conformational change. 3 PublicationsCorresponds to variant dbSNP:rs74315362EnsemblClinVar. | 1 | |
Natural variantiVAR_011478 | 385 | R → W in PKRD. | 1 | |
Natural variantiVAR_011460 | 387 | E → G in PKRD. 1 Publication | 1 | |
Natural variantiVAR_011461 | 390 | D → N in PKRD; Mantova; almost complete inactivation. 1 PublicationCorresponds to variant dbSNP:rs147034239Ensembl. | 1 | |
Natural variantiVAR_004053 | 392 | A → T in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1403323591Ensembl. | 1 | |
Natural variantiVAR_004054 | 393 | N → K in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1168490341Ensembl. | 1 | |
Natural variantiVAR_004055 | 393 | N → S in PKRD; Paris. 1 PublicationCorresponds to variant dbSNP:rs776594413Ensembl. | 1 | |
Natural variantiVAR_011462 | 394 | A → D in PKRD. 1 PublicationCorresponds to variant dbSNP:rs1035640530Ensembl. | 1 | |
Natural variantiVAR_011463 | 394 | A → V in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004056 | 401 | C → CS in PKRD. | 1 | |
Natural variantiVAR_011464 | 408 | T → A in PKRD; Hirosaki. | 1 | |
Natural variantiVAR_004057 | 408 | T → I in PKRD. 1 Publication | 1 | |
Natural variantiVAR_004058 | 421 | Q → K in PKRD; Fukushima/Maebashi/Sendai. 1 PublicationCorresponds to variant dbSNP:rs118204084EnsemblClinVar. | 1 | |
Natural variantiVAR_004059 | 426 | R → Q in PKRD; Sapporo. 1 PublicationCorresponds to variant dbSNP:rs768002493Ensembl. | 1 | |
Natural variantiVAR_004060 | 426 | R → W in PKRD; Naniwa. Corresponds to variant dbSNP:rs1023689443Ensembl. | 1 | |
Natural variantiVAR_011465 | 427 | E → A in PKRD. | 1 | |
Natural variantiVAR_011466 | 427 | E → D in PKRD. | 1 | |
Natural variantiVAR_004061 | 431 | A → T in PKRD. 1 PublicationCorresponds to variant dbSNP:rs762591322EnsemblClinVar. | 1 | |
Natural variantiVAR_004062 | 458 | G → D in PKRD. 1 PublicationCorresponds to variant dbSNP:rs755522396Ensembl. | 1 | |
Natural variantiVAR_004063 | 459 | A → V in PKRD. | 1 | |
Natural variantiVAR_004064 | 460 | V → M in PKRD. 1 PublicationCorresponds to variant dbSNP:rs752034960EnsemblClinVar. | 1 | |
Natural variantiVAR_011479 | 468 | A → G in PKRD. Corresponds to variant dbSNP:rs750540943Ensembl. | 1 | |
Natural variantiVAR_004065 | 468 | A → V in PKRD; Hadano. | 1 | |
Natural variantiVAR_011467 | 477 | T → A in PKRD. Corresponds to variant dbSNP:rs759466273Ensembl. | 1 | |
Natural variantiVAR_011480 | 479 | R → H in PKRD; Amish; no conformational change. 2 PublicationsCorresponds to variant dbSNP:rs118204085EnsemblClinVar. | 1 | |
Natural variantiVAR_011468 | 485 | S → F in PKRD. | 1 | |
Natural variantiVAR_004066 | 486 | R → W in PKRD; no conformational change. 4 PublicationsCorresponds to variant dbSNP:rs116100695EnsemblClinVar. | 1 | |
Natural variantiVAR_011469 | 488 | R → Q in PKRD. Corresponds to variant dbSNP:rs369183199EnsemblClinVar. | 1 | |
Natural variantiVAR_004067 | 490 | R → W in PKRD. Corresponds to variant dbSNP:rs200133000EnsemblClinVar. | 1 | |
Natural variantiVAR_011470 | 495 | A → T in PKRD. | 1 | |
Natural variantiVAR_004068 | 495 | A → V in PKRD. 1 PublicationCorresponds to variant dbSNP:rs141560532Ensembl. | 1 | |
Natural variantiVAR_004069 | 498 | R → C in PKRD. 1 PublicationCorresponds to variant dbSNP:rs551883218Ensembl. | 1 | |
Natural variantiVAR_004070 | 498 | R → H in PKRD. 2 PublicationsCorresponds to variant dbSNP:rs758327704Ensembl. | 1 | |
Natural variantiVAR_011471 | 504 | R → L in PKRD; instability of the protein. 1 PublicationCorresponds to variant dbSNP:rs185753709Ensembl. | 1 | |
Natural variantiVAR_018848 | 506 | V → I1 PublicationCorresponds to variant dbSNP:rs8177988EnsemblClinVar. | 1 | |
Natural variantiVAR_004071 | 510 | R → Q in PKRD. 3 PublicationsCorresponds to variant dbSNP:rs113403872EnsemblClinVar. | 1 | |
Natural variantiVAR_011472 | 511 | G → R in PKRD. | 1 | |
Natural variantiVAR_011473 | 531 | R → C in PKRD. | 1 | |
Natural variantiVAR_004072 | 532 | R → Q in PKRD. 1 PublicationCorresponds to variant dbSNP:rs758278200Ensembl. | 1 | |
Natural variantiVAR_004073 | 532 | R → W in PKRD; Complete loss in the responsiveness to fructose 1,6-bisphosphate, FBP. 2 PublicationsCorresponds to variant dbSNP:rs201255024EnsemblClinVar. | 1 | |
Natural variantiVAR_004074 | 552 | V → M in PKRD. Corresponds to variant dbSNP:rs370316462Ensembl. | 1 | |
Natural variantiVAR_011481 | 557 | G → A in PKRD. | 1 | |
Natural variantiVAR_004075 | 559 | R → G in PKRD. | 1 | |
Natural variantiVAR_004076 | 566 | N → K in PKRD. | 1 | |
Natural variantiVAR_011482 | 569 | R → Q in PKRD. 1 PublicationCorresponds to variant dbSNP:rs61755431EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002883 | 1 – 33 | MSIQE…IGAPG → ME in isoform L-type. CuratedAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015983 mRNA Translation: BAA31706.1 M15465 mRNA Translation: AAA60104.1 D13243 Genomic DNA Translation: BAA02515.1 Sequence problems. AY316591 Genomic DNA Translation: AAP69527.1 BC025737 mRNA Translation: AAH25737.1 S60712 mRNA Translation: AAB26262.1 |
CCDSi | CCDS1109.1 [P30613-1] CCDS44240.1 [P30613-2] |
PIRi | I52269, KIHUPR |
RefSeqi | NP_000289.1, NM_000298.5 [P30613-1] NP_870986.1, NM_181871.3 [P30613-2] |
Genome annotation databases
Ensembli | ENST00000342741.6; ENSP00000339933.4; ENSG00000143627.19 ENST00000392414.7; ENSP00000376214.3; ENSG00000143627.19 [P30613-2] ENST00000571194.5; ENSP00000461487.1; ENSG00000262785.5 [P30613-2] ENST00000572740.1; ENSP00000459921.1; ENSG00000262785.5 |
GeneIDi | 5313 |
KEGGi | hsa:5313 |
MANE-Selecti | ENST00000342741.6; ENSP00000339933.4; NM_000298.6; NP_000289.1 |
UCSCi | uc001fka.5, human [P30613-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Pyruvate kinase entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB015983 mRNA Translation: BAA31706.1 M15465 mRNA Translation: AAA60104.1 D13243 Genomic DNA Translation: BAA02515.1 Sequence problems. AY316591 Genomic DNA Translation: AAP69527.1 BC025737 mRNA Translation: AAH25737.1 S60712 mRNA Translation: AAB26262.1 |
CCDSi | CCDS1109.1 [P30613-1] CCDS44240.1 [P30613-2] |
PIRi | I52269, KIHUPR |
RefSeqi | NP_000289.1, NM_000298.5 [P30613-1] NP_870986.1, NM_181871.3 [P30613-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VGB | X-ray | 2.73 | A/B/C/D | 47-574 | [»] | |
2VGF | X-ray | 2.75 | A/B/C/D | 47-574 | [»] | |
2VGG | X-ray | 2.74 | A/B/C/D | 47-574 | [»] | |
2VGI | X-ray | 2.87 | A/B/C/D | 47-574 | [»] | |
4IMA | X-ray | 1.95 | A/B/C/D | 34-574 | [»] | |
4IP7 | X-ray | 1.80 | A/B/C/D | 34-574 | [»] | |
6NN4 | X-ray | 2.15 | A/B/C/D | 34-574 | [»] | |
6NN5 | X-ray | 2.26 | A/B/C/D | 34-574 | [»] | |
6NN7 | X-ray | 2.32 | A/B/C/D/E/F/G/H | 34-574 | [»] | |
6NN8 | X-ray | 2.42 | A/B/C/D/E/F/G/H | 34-574 | [»] | |
AlphaFoldDBi | P30613 | |||||
SMRi | P30613 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111330, 48 interactors |
ComplexPortali | CPX-3094, PKL pyruvate kinase complex [P30613-2] CPX-3095, PKR pyruvate kinase complex [P30613-1] |
IntActi | P30613, 12 interactors |
STRINGi | 9606.ENSP00000339933 |
Chemistry databases
BindingDBi | P30613 |
ChEMBLi | CHEMBL1075126 |
DrugBanki | DB02726, 2-Phosphoglycolic Acid DB00787, Acyclovir DB04551, beta-D-fructofuranose 1,6-bisphosphate DB00119, Pyruvic acid |
PTM databases
GlyGeni | P30613, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P30613 |
PhosphoSitePlusi | P30613 |
SwissPalmi | P30613 |
Genetic variation databases
BioMutai | PKLR |
2D gel databases
REPRODUCTION-2DPAGEi | P30613 |
SWISS-2DPAGEi | P30613 |
Proteomic databases
EPDi | P30613 |
jPOSTi | P30613 |
MassIVEi | P30613 |
MaxQBi | P30613 |
PaxDbi | P30613 |
PeptideAtlasi | P30613 |
PRIDEi | P30613 |
ProteomicsDBi | 54725 [P30613-1] 54726 [P30613-2] |
Protocols and materials databases
Antibodypediai | 1670, 537 antibodies from 37 providers |
DNASUi | 5313 |
Genome annotation databases
Ensembli | ENST00000342741.6; ENSP00000339933.4; ENSG00000143627.19 ENST00000392414.7; ENSP00000376214.3; ENSG00000143627.19 [P30613-2] ENST00000571194.5; ENSP00000461487.1; ENSG00000262785.5 [P30613-2] ENST00000572740.1; ENSP00000459921.1; ENSG00000262785.5 |
GeneIDi | 5313 |
KEGGi | hsa:5313 |
MANE-Selecti | ENST00000342741.6; ENSP00000339933.4; NM_000298.6; NP_000289.1 |
UCSCi | uc001fka.5, human [P30613-1] |
Organism-specific databases
CTDi | 5313 |
DisGeNETi | 5313 |
GeneCardsi | PKLR |
HGNCi | HGNC:9020, PKLR |
HPAi | ENSG00000143627, Tissue enhanced (bone marrow, kidney, liver) |
MalaCardsi | PKLR |
MIMi | 102900, phenotype 266200, phenotype 609712, gene |
neXtProti | NX_P30613 |
OpenTargetsi | ENSG00000143627 |
Orphaneti | 766, Hemolytic anemia due to red cell pyruvate kinase deficiency |
PharmGKBi | PA33352 |
VEuPathDBi | HostDB:ENSG00000143627 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2323, Eukaryota |
GeneTreei | ENSGT00390000008859 |
HOGENOMi | CLU_015439_0_1_1 |
InParanoidi | P30613 |
OMAi | MVRVHHL |
OrthoDBi | 933620at2759 |
PhylomeDBi | P30613 |
TreeFami | TF300390 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00188 |
BRENDAi | 2.7.1.40, 2681 |
PathwayCommonsi | P30613 |
Reactomei | R-HSA-163765, ChREBP activates metabolic gene expression [P30613-1] R-HSA-210745, Regulation of gene expression in beta cells [P30613-2] R-HSA-70171, Glycolysis |
SABIO-RKi | P30613 |
SignaLinki | P30613 |
SIGNORi | P30613 |
Miscellaneous databases
BioGRID-ORCSi | 5313, 14 hits in 1079 CRISPR screens |
EvolutionaryTracei | P30613 |
GeneWikii | PKLR |
GenomeRNAii | 5313 |
Pharosi | P30613, Tbio |
PROi | PR:P30613 |
RNActi | P30613, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143627, Expressed in liver and 139 other tissues |
ExpressionAtlasi | P30613, baseline and differential |
Genevisiblei | P30613, HS |
Family and domain databases
CDDi | cd00288, Pyruvate_Kinase, 1 hit |
Gene3Di | 2.40.33.10, 1 hit 3.20.20.60, 1 hit 3.40.1380.20, 1 hit |
InterProi | View protein in InterPro IPR001697, Pyr_Knase IPR015813, Pyrv/PenolPyrv_Kinase-like_dom IPR040442, Pyrv_Kinase-like_dom_sf IPR011037, Pyrv_Knase-like_insert_dom_sf IPR018209, Pyrv_Knase_AS IPR015793, Pyrv_Knase_brl IPR015795, Pyrv_Knase_C IPR036918, Pyrv_Knase_C_sf IPR015806, Pyrv_Knase_insert_dom_sf |
PANTHERi | PTHR11817, PTHR11817, 1 hit |
Pfami | View protein in Pfam PF00224, PK, 1 hit PF02887, PK_C, 1 hit |
PRINTSi | PR01050, PYRUVTKNASE |
SUPFAMi | SSF50800, SSF50800, 1 hit SSF51621, SSF51621, 1 hit SSF52935, SSF52935, 1 hit |
TIGRFAMsi | TIGR01064, pyruv_kin, 1 hit |
PROSITEi | View protein in PROSITE PS00110, PYRUVATE_KINASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KPYR_HUMAN | |
Accessioni | P30613Primary (citable) accession number: P30613 Secondary accession number(s): O75758, P11973 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | May 30, 2000 | |
Last modified: | May 25, 2022 | |
This is version 241 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families