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UniProtKB - P30608 (CP52F_CANTR)
Protein
Cytochrome P450 52A6
Gene
CYP52A6
Organism
Candida tropicalis (Yeast)
Status
Functioni
Together with an NADPH cytochrome P450 the enzyme system catalyzes the terminal hydroxylation as the first step in the assimilation of alkanes and fatty acids. Preferentially hydroxylates hexadecane.
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 472 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 52A6 (EC:1.14.14.-)Alternative name(s): Alkane-inducible P450-ALK3 CYPLIIA6 |
Gene namesi | Name:CYP52A6 |
Organismi | Candida tropicalis (Yeast) |
Taxonomic identifieri | 5482 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida |
Organism-specific databases
VEuPathDBi | FungiDB:CTRG_02725 |
Subcellular locationi
Other locations
- Membrane Curated
- Membrane ; Single-pass membrane protein
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 17 – 34 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052024 | 1 – 524 | Cytochrome P450 52A6Add BLAST | 524 |
Expressioni
Inductioni
By various alkanes.
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002974, Cyt_P450_E_CYP52 IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01239, EP450IICYP52 PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
P30608-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATQEIIDSA LPYLTKWYTV ITLAALVFLI SSNIKNYVKA KKLKCRDPPY
60 70 80 90 100
FKGAGWTGIS PLIEIIKVKG NGRLARFWPI KTFDDYPNHT FYMSIIGALK
110 120 130 140 150
IVLTVIQENI KAVLATQFTD FSLGTRHAHF YPLLGDGIFT LDGEGWKHSR
160 170 180 190 200
AMLRPQFARD QIGHVKALEP HIQILAKQIK LNKGKTFDIQ ELFFRFTVDT
210 220 230 240 250
ATEFLFGESV HSLYDEKLGI PTPNEIPGRD NFATAFNTSQ HYLATRTYSQ
260 270 280 290 300
TFYFLTNPKE FRDCNAKVHY LAKYFVNKAL NFTPEEIEEK SKSGYVFLYE
310 320 330 340 350
LVKQTRDPKV LQDQLLNIMV AGRDTTAGLL SFAMFELARH PEIWSKLREE
360 370 380 390 400
IEVNFGVGEE SRVEEITFES LKRCEYLKAI LNETLRMYPS VPVNSRTATR
410 420 430 440 450
DTTLPRGGGP NGTDPIFIPK GSTVAYIVYK THRLEEYYGK DADDFRPERW
460 470 480 490 500
FEPSTKKLGW AYVPFNGGPR ICLGQQFALT EASYVITRLV QMFETVSSPP
510 520
DVEYPPPKCI HLTMSHDDGV FVKM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z13010 Genomic DNA Translation: CAA78354.1 |
PIRi | S22972 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z13010 Genomic DNA Translation: CAA78354.1 |
PIRi | S22972 |
3D structure databases
SMRi | P30608 |
ModBasei | Search... |
Organism-specific databases
VEuPathDBi | FungiDB:CTRG_02725 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002974, Cyt_P450_E_CYP52 IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01239, EP450IICYP52 PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CP52F_CANTR | |
Accessioni | P30608Primary (citable) accession number: P30608 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |