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Entry version 175 (03 Jul 2019)
Sequence version 2 (03 Oct 2006)
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Protein

Myo-inositol transporter 2

Gene

ITR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Minor transporter for myo-inositol.1 Publication

Miscellaneous

Present with 468 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • myo-inositol:proton symporter activity Source: GO_Central
  • myo-inositol transmembrane transporter activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33501-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-429593 Inositol transporters

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.1.104 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myo-inositol transporter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITR2
Ordered Locus Names:YOL103W
ORF Names:HRB612
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YOL103W

Saccharomyces Genome Database

More...
SGDi
S000005463 ITR2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 104CytoplasmicSequence analysisAdd BLAST104
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei105 – 125Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini126 – 152ExtracellularSequence analysisAdd BLAST27
Transmembranei153 – 173Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini174 – 179CytoplasmicSequence analysis6
Transmembranei180 – 200Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini201 – 209ExtracellularSequence analysis9
Transmembranei210 – 230Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini231 – 240CytoplasmicSequence analysis10
Transmembranei241 – 261Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini262 – 269ExtracellularSequence analysis8
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 359CytoplasmicSequence analysisAdd BLAST69
Transmembranei360 – 380Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini381 – 396ExtracellularSequence analysisAdd BLAST16
Transmembranei397 – 417Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini418 – 423CytoplasmicSequence analysis6
Transmembranei424 – 444Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini445 – 465ExtracellularSequence analysisAdd BLAST21
Transmembranei466 – 486Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini487 – 506CytoplasmicSequence analysisAdd BLAST20
Transmembranei507 – 527Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini528 – 533ExtracellularSequence analysis6
Transmembranei534 – 554Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini555 – 609CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000504581 – 609Myo-inositol transporter 2Add BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P30606

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30606

PRoteomics IDEntifications database

More...
PRIDEi
P30606

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30606

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34300, 70 interactors

Database of interacting proteins

More...
DIPi
DIP-6553N

Protein interaction database and analysis system

More...
IntActi
P30606, 1 interactor

STRING: functional protein association networks

More...
STRINGi
4932.YOL103W

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155870

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202868

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30606

KEGG Orthology (KO)

More...
KOi
K08150

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSSMNWG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00171 SUGRTRNSPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00879 SP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits
PS00217 SUGAR_TRANSPORT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30606-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNSTAASSR WTKSRLSHFF PSYTNSSGMG AASTDQSSTQ GEELHHRKHC
60 70 80 90 100
EEDNDGQKPK KSPVSTSTMQ IKSRQDEDED DGRIVIKPVN DEDDTSVIIT
110 120 130 140 150
FNQSISPFII TLTFVASISG FMFGYDTGYI SSALISINRD LDNKVLTYGE
160 170 180 190 200
KELITAATSL GALITSVGAG TAADVFGRRP CLMFSNLMFL IGAILQITAH
210 220 230 240 250
KFWQMAAGRL IMGFGVGIGS LISPLFISEI APKMIRGRLT VINSLWLTGG
260 270 280 290 300
QLIAYGCGAG LNHVKNGWRI LVGLSLIPTV LQFSFFCFLP DTPRYYVMKG
310 320 330 340 350
DLKRAKMVLK RSYVNTEDEI IDQKVEELSS LNQSIPGKNP ITKFWNMVKE
360 370 380 390 400
LHTVPSNFRA LIIGCGLQAI QQFTGWNSLM YFSGTIFETV GFKNSSAVSI
410 420 430 440 450
IVSGTNFVFT LIAFFCIDKI GRRYILLIGL PGMTVALVIC AIAFHFLGIK
460 470 480 490 500
FNGADAVVAS DGFSSWGIVI IVFIIVYAAF YALGIGTVPW QQSELFPQNV
510 520 530 540 550
RGVGTSYATA TNWAGSLVIA STFLTMLQNI TPTGTFSFFA GVACLSTIFC
560 570 580 590 600
YFCYPELSGL ELEEVQTILK DGFNIKASKA LAKKRKQQVA EGAAHHKLKF

EPTQEIVES
Length:609
Mass (Da):66,710
Last modified:October 3, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5922363C7DF02EE1
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA14367 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA88159 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA99119 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D90353 Genomic DNA Translation: BAA14367.1 Different initiation.
Z48149 Genomic DNA Translation: CAA88159.1 Different initiation.
Z74845 Genomic DNA Translation: CAA99119.1 Different initiation.
BK006948 Genomic DNA Translation: DAA10681.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B40538

NCBI Reference Sequences

More...
RefSeqi
NP_014538.2, NM_001183357.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOL103W_mRNA; YOL103W_mRNA; YOL103W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOL103W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90353 Genomic DNA Translation: BAA14367.1 Different initiation.
Z48149 Genomic DNA Translation: CAA88159.1 Different initiation.
Z74845 Genomic DNA Translation: CAA99119.1 Different initiation.
BK006948 Genomic DNA Translation: DAA10681.1
PIRiB40538
RefSeqiNP_014538.2, NM_001183357.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi34300, 70 interactors
DIPiDIP-6553N
IntActiP30606, 1 interactor
STRINGi4932.YOL103W

Protein family/group databases

TCDBi2.A.1.1.104 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiP30606

Proteomic databases

MaxQBiP30606
PaxDbiP30606
PRIDEiP30606

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL103W_mRNA; YOL103W_mRNA; YOL103W
GeneIDi854050
KEGGisce:YOL103W

Organism-specific databases

EuPathDBiFungiDB:YOL103W
SGDiS000005463 ITR2

Phylogenomic databases

GeneTreeiENSGT00940000155870
HOGENOMiHOG000202868
InParanoidiP30606
KOiK08150
OMAiTSSMNWG

Enzyme and pathway databases

BioCyciYEAST:G3O-33501-MONOMER
ReactomeiR-SCE-429593 Inositol transporters

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P30606

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 2 hits
PS00217 SUGAR_TRANSPORT_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITR2_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30606
Secondary accession number(s): D6W1W5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 3, 2006
Last modified: July 3, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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