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UniProtKB - P30605 (ITR1_YEAST)
Protein
Myo-inositol transporter 1
Gene
ITR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Major transporter for myo-inositol.
1 PublicationCatalytic activityi
GO - Molecular functioni
- myo-inositol:proton symporter activity Source: GO_Central
- myo-inositol transmembrane transporter activity Source: SGD
GO - Biological processi
- myo-inositol transport Source: SGD
- pseudohyphal growth Source: SGD
- transmembrane transport Source: SGD
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-SCE-429593, Inositol transporters |
Protein family/group databases
TCDBi | 2.A.1.1.8, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Myo-inositol transporter 1 |
Gene namesi | Name:ITR1 Ordered Locus Names:YDR497C ORF Names:D9719.3 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002905, ITR1 |
VEuPathDBi | FungiDB:YDR497C |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: SGD
Vacuole
- fungal-type vacuole Source: SGD
- fungal-type vacuole membrane Source: SGD
Other locations
- cell periphery Source: SGD
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 81 | CytoplasmicSequence analysisAdd BLAST | 81 | |
Transmembranei | 82 – 102 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 129 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 130 – 150 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 151 – 163 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 164 – 184 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 186 | ExtracellularSequence analysis | 2 | |
Transmembranei | 187 – 207 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 208 – 215 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 216 – 236 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 237 – 246 | ExtracellularSequence analysis | 10 | |
Transmembranei | 247 – 267 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 268 – 349 | CytoplasmicSequence analysisAdd BLAST | 82 | |
Transmembranei | 350 – 370 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 371 – 376 | ExtracellularSequence analysis | 6 | |
Transmembranei | 377 – 397 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 398 – 400 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 401 – 421 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 422 – 441 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 442 – 462 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 463 – 486 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 487 – 507 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 508 – 510 | ExtracellularSequence analysis | 3 | |
Transmembranei | 511 – 531 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 532 – 584 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050455 | 1 – 584 | Myo-inositol transporter 1Add BLAST | 584 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | PhosphoserineCombined sources | 1 | |
Modified residuei | 35 | PhosphoserineCombined sources | 1 | |
Modified residuei | 37 | PhosphoserineCombined sources | 1 | |
Modified residuei | 46 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 371 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Cross-linki | 573 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources |
Keywords - PTMi
Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P30605 |
PaxDbi | P30605 |
PRIDEi | P30605 |
TopDownProteomicsi | P30605 |
PTM databases
iPTMneti | P30605 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 32548, 124 interactors |
DIPi | DIP-7406N |
IntActi | P30605, 25 interactors |
MINTi | P30605 |
STRINGi | 4932.YDR497C |
Miscellaneous databases
RNActi | P30605, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 13 – 42 | DisorderedSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
GeneTreei | ENSGT00940000155870 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P30605 |
OMAi | GRKMAIY |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits PS00217, SUGAR_TRANSPORT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P30605-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGIHIPYLTS KTSQSNVGDA VGNADSVEFN SEHDSPSKRG KITLESHEIQ
60 70 80 90 100
RAPASDDEDR IQIKPVNDED DTSVMITFNQ SLSPFIITLT FVASISGFMF
110 120 130 140 150
GYDTGYISSA LISIGTDLDH KVLTYGEKEI VTAATSLGAL ITSIFAGTAA
160 170 180 190 200
DIFGRKRCLM GSNLMFVIGA ILQVSAHTFW QMAVGRLIMG FGVGIGSLIA
210 220 230 240 250
PLFISEIAPK MIRGRLTVIN SLWLTGGQLV AYGCGAGLNY VNNGWRILVG
260 270 280 290 300
LSLIPTAVQF TCLCFLPDTP RYYVMKGDLA RATEVLKRSY TDTSEEIIER
310 320 330 340 350
KVEELVTLNQ SIPGKNVPEK VWNTIKELHT VPSNLRALII GCGLQAIQQF
360 370 380 390 400
TGWNSLMYFS GTIFETVGFK NSSAVSIIVS GTNFIFTLVA FFSIDKIGRR
410 420 430 440 450
TILLIGLPGM TMALVVCSIA FHFLGIKFDG AVAVVVSSGF SSWGIVIIVF
460 470 480 490 500
IIVFAAFYAL GIGTVPWQQS ELFPQNVRGI GTSYATATNW AGSLVIASTF
510 520 530 540 550
LTMLQNITPA GTFAFFAGLS CLSTIFCYFC YPELSGLELE EVQTILKDGF
560 570 580
NIKASKALAK KRKQQVARVH ELKYEPTQEI IEDI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 43 – 44 | TL → HI in BAA14366 (PubMed:2040626).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D90352 Genomic DNA Translation: BAA14366.1 U33057 Genomic DNA Translation: AAB64939.1 BK006938 Genomic DNA Translation: DAA12329.1 |
PIRi | S69555 |
RefSeqi | NP_010785.1, NM_001180805.1 |
Genome annotation databases
EnsemblFungii | YDR497C_mRNA; YDR497C; YDR497C |
GeneIDi | 852108 |
KEGGi | sce:YDR497C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D90352 Genomic DNA Translation: BAA14366.1 U33057 Genomic DNA Translation: AAB64939.1 BK006938 Genomic DNA Translation: DAA12329.1 |
PIRi | S69555 |
RefSeqi | NP_010785.1, NM_001180805.1 |
3D structure databases
AlphaFoldDBi | P30605 |
SMRi | P30605 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 32548, 124 interactors |
DIPi | DIP-7406N |
IntActi | P30605, 25 interactors |
MINTi | P30605 |
STRINGi | 4932.YDR497C |
Protein family/group databases
TCDBi | 2.A.1.1.8, the major facilitator superfamily (mfs) |
PTM databases
iPTMneti | P30605 |
Proteomic databases
MaxQBi | P30605 |
PaxDbi | P30605 |
PRIDEi | P30605 |
TopDownProteomicsi | P30605 |
Genome annotation databases
EnsemblFungii | YDR497C_mRNA; YDR497C; YDR497C |
GeneIDi | 852108 |
KEGGi | sce:YDR497C |
Organism-specific databases
SGDi | S000002905, ITR1 |
VEuPathDBi | FungiDB:YDR497C |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
GeneTreei | ENSGT00940000155870 |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P30605 |
OMAi | GRKMAIY |
Enzyme and pathway databases
Reactomei | R-SCE-429593, Inositol transporters |
Miscellaneous databases
PROi | PR:P30605 |
RNActi | P30605, protein |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits PS00217, SUGAR_TRANSPORT_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ITR1_YEAST | |
Accessioni | P30605Primary (citable) accession number: P30605 Secondary accession number(s): D6VTB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - SIMILARITY comments
Index of protein domains and families