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Entry version 83 (03 Jul 2019)
Sequence version 2 (15 Jul 1999)
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Protein

Chitin synthase 2

Gene

CHS2

Organism
Exophiala dermatitidis (Black yeast) (Wangiella dermatitidis)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in cell wall biogenesis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2 Glycosyltransferase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitin synthase 2 (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 2
Class-I chitin synthase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiExophiala dermatitidis (Black yeast) (Wangiella dermatitidis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5970 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesChaetothyriomycetidaeChaetothyrialesHerpotrichiellaceaeExophiala

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Transmembranei570 – 589HelicalSequence analysisAdd BLAST20
Transmembranei613 – 633HelicalSequence analysisAdd BLAST21
Transmembranei644 – 664HelicalSequence analysisAdd BLAST21
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Transmembranei723 – 743HelicalSequence analysisAdd BLAST21
Transmembranei753 – 773HelicalSequence analysisAdd BLAST21
Transmembranei854 – 874HelicalSequence analysisAdd BLAST21
Transmembranei893 – 913HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001936951 – 928Chitin synthase 2Add BLAST928

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P30601

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004835 Chitin_synth
IPR004834 Chitin_synth_fun
IPR013616 Chitin_synth_N
IPR029044 Nucleotide-diphossugar_trans

The PANTHER Classification System

More...
PANTHERi
PTHR22914 PTHR22914, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01644 Chitin_synth_1, 1 hit
PF08407 Chitin_synth_1N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30601-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYNRLGSPQ RDGPYSPSAQ PQYDSRSPSP GRPLQPYIHP DEAYARQQPL
60 70 80 90 100
HLQMPTASDD RLAMQPTYSV ENVHNPQAYG QQYGQHLPDS GDMGYGRNDY
110 120 130 140 150
IVSPEEHHDA YYTQPYSPHP QGDYALDPYP SHDEPYRPDT DNVPILQPDS
160 170 180 190 200
AYGPDPHTQP GMDYDDYQEE PRPTPSPAPI RRWKTVKEVQ LFNGNLVLDC
210 220 230 240 250
PVPPKLLANV PHAKPPERDE FTHMRYSAAT CDPSDFHNER FTLRQRLFAK
260 270 280 290 300
PRQTELFIVV TMYNEDEFLF ARTMIGVFKN IEFMCNRSSS KTWGKEAWKK
310 320 330 340 350
IVVCIVSDGR AKINPRTRAV LAGLGVYQDG IAKQQVNGKD VTAHIYEYTT
360 370 380 390 400
QVGLELKGTQ VSLKPRSATP VQLLFCLKEK NQKKINSHRW FFQAFGRVLD
410 420 430 440 450
PNICVLIDAG TKPGKDSIYQ LWKAFDLEPM CGGACGEIKV MLDHGKKLLN
460 470 480 490 500
PLVATQNFEY KMSNILDKPL ESAFGFISVL PGAFCAYRYV ALQNDKNGVG
510 520 530 540 550
PLEKYFKGET MHADAGVFTA NMYLAEDRIL CFELVSKRNC RWILQYVKSA
560 570 580 590 600
TGETDVPDRI PEFVLQRRRW LNGSFFAAVY AVAHVYQLWR TDHSFLRKLM
610 620 630 640 650
FLIEFTYQTI NMLFAWFAIG NFFLVFRLLT ASLGTKETLG TAGTVLGVVF
660 670 680 690 700
EFVYLGTLLY CFILSMGNRP QGNPKSYMMM VIFWSVLMVW LTFASIFLTV
710 720 730 740 750
KSIETEVQQK DFSFSTIFNN STFFGLIVSL ASTYVLWFVA SFLFFDPWHM
760 770 780 790 800
FTCFLQYIVL TPTYINVLNI YAFCNTHDIT WGTKGDDKAE KLPSANVKPG
810 820 830 840 850
GKVDVLIPQD DGDLNAQYDS ELKKFATKPP KEVKAPNPAD KQEDYYKSFR
860 870 880 890 900
SNVVTAWMIT NFILVAAVLN IAGFDRINVH DTQQQNSTIY LAVILWSVAG
910 920
LSLFRFTGAC WFLVVRMVSL EIWSVCKV
Length:928
Mass (Da):105,713
Last modified:July 15, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i001AF053F8873C9B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti259 – 260VV → KL in AAA30335 (PubMed:1731323).Curated2
Sequence conflicti462M → L in AAA30335 (PubMed:1731323).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF052606 Genomic DNA Translation: AAC34496.1
M81906 Genomic DNA Translation: AAA30335.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45188

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052606 Genomic DNA Translation: AAC34496.1
M81906 Genomic DNA Translation: AAA30335.1
PIRiA45188

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

Proteomic databases

PRIDEiP30601

Family and domain databases

InterProiView protein in InterPro
IPR004835 Chitin_synth
IPR004834 Chitin_synth_fun
IPR013616 Chitin_synth_N
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR22914 PTHR22914, 1 hit
PfamiView protein in Pfam
PF01644 Chitin_synth_1, 1 hit
PF08407 Chitin_synth_1N, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHS2_EXODE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30601
Secondary accession number(s): O74210
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: July 15, 1999
Last modified: July 3, 2019
This is version 83 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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