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UniProtKB - P30595 (CHS2_RHIOL)
Protein
Chitin synthase 2
Gene
CHS2
Organism
Rhizopus oligosporus (Rhizopus microsporus var. oligosporus)
Status
Functioni
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
CuratedCatalytic activityi
- [(1→4)-N-acetyl-β-D-glucosaminyl](n) + UDP-N-acetyl-α-D-glucosamine = [(1→4)-N-acetyl-β-D-glucosaminyl](n+1) + H+ + UDPEC:2.4.1.16
GO - Molecular functioni
- chitin synthase activity Source: UniProtKB-EC
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- chitin biosynthetic process Source: InterPro
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Cell wall biogenesis/degradation |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Names & Taxonomyi
Protein namesi | Recommended name: Chitin synthase 2 (EC:2.4.1.16)Alternative name(s): Chitin-UDP acetyl-glucosaminyl transferase 2 |
Gene namesi | Name:CHS2 |
Organismi | Rhizopus oligosporus (Rhizopus microsporus var. oligosporus) |
Taxonomic identifieri | 4847 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Fungi incertae sedis › Mucoromycota › Mucoromycotina › Mucoromycetes › Mucorales › Mucorineae › Rhizopodaceae › Rhizopus › |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 500 – 517 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 540 – 560 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 586 – 606 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 621 – 641 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 665 – 685 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 799 – 819 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 825 – 845 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193712 | 1 – 858 | Chitin synthase 2Add BLAST | 858 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 116 | DisorderedSequence analysisAdd BLAST | 116 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 52 – 99 | Pro residuesSequence analysisAdd BLAST | 48 |
Sequence similaritiesi
Belongs to the chitin synthase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR004835, Chitin_synth IPR004834, Chitin_synth_fun IPR013616, Chitin_synth_N IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22914, PTHR22914, 1 hit |
Pfami | View protein in Pfam PF01644, Chitin_synth_1, 1 hit PF08407, Chitin_synth_1N, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
P30595-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYPEGPKPEH DQFPLQDTQF SNQPPVHRSP FEDPYPEDQP HFDKQPLLTS
60 70 80 90 100
PAYPPTQYPT SPPPPNFPGS PAVQQPYPPF NNNPSPVSPG VPAYFNPAPP
110 120 130 140 150
SPNMHYGQAP RRQPRRFKTT RQVKLTKGNL VLDCPVPTAY LNDVPIKDGK
160 170 180 190 200
EFTHMRYTAA TCDPKDFASD GYTLRQPMLG RKTELFIVLT MYNEDEVLFA
210 220 230 240 250
RTMHGVMKNI AHLCTRDRSR TWGPNGWEKV VVCIVSDGRN KINQRTLSVL
260 270 280 290 300
ALLGVYQDGI AKNVVHGKPV TAHIYEYTTQ VSVDPNMEVK KAGSKNVVPC
310 320 330 340 350
QILFCLKEKN QKKINSHRWF FQAFGPVIDP HICVLIDVGT KPGGTSIYHL
360 370 380 390 400
WKAFDINSNI AGACGEIRAM AGTRGVALLN PLVAAQNFEY KMSNILDKPL
410 420 430 440 450
ESVFGYISVL PGAFSAYRFK ALQNDVNGHG PLEKYFLGET QHGGDADIFT
460 470 480 490 500
ANMYLAEDRI LCYELVAKKE AHWVLHYVSS SYGETDVPDK VDEFISQRRR
510 520 530 540 550
WLNGSFFAGV YALYHWRKVW QSDHSYLRKM MFMVEDIYNT YNLIFSWFAL
560 570 580 590 600
GNFYLTFFIL TKALGHGVDG STLTDPPFSP DTGETLHTVF NYIYIVLIVI
610 620 630 640 650
QFIMALGNRP QGSKIAYTSS MVFFAILMVY MMFAAIWITV VGVKTVVETS
660 670 680 690 700
GGQFIEMLEQ STFRNIIISL CATYVMYFVS SFMFLDPWHM FTSFIQYILL
710 720 730 740 750
SPSYTNVLNI YAFCNTHDVS WGTKGDNTVA TDLGVVKAKK DGSGDLAVEV
760 770 780 790 800
EVPVEEKDIN AAFIDAQVEL TKKIEPEKSH RDAKTKQEDY YRSFRTRLVL
810 820 830 840 850
AWIISNLALV VAIANTTVID IKGKASIYLG FILWSVAGLS VIRFTGSTLY
LIFKIFTG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10160 Genomic DNA Translation: BAA01024.1 |
PIRi | JC2309 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D10160 Genomic DNA Translation: BAA01024.1 |
PIRi | JC2309 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
CAZyi | GT2, Glycosyltransferase Family 2 |
Family and domain databases
InterProi | View protein in InterPro IPR004835, Chitin_synth IPR004834, Chitin_synth_fun IPR013616, Chitin_synth_N IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR22914, PTHR22914, 1 hit |
Pfami | View protein in Pfam PF01644, Chitin_synth_1, 1 hit PF08407, Chitin_synth_1N, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CHS2_RHIOL | |
Accessioni | P30595Primary (citable) accession number: P30595 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | June 2, 2021 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |