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Entry version 121 (02 Jun 2021)
Sequence version 4 (19 Mar 2014)
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Protein

Chitin synthase 2

Gene

chs-2

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chitin synthase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.1.16, 3627

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2, Glycosyltransferase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitin synthase 2 (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chs-2
ORF Names:NCU05239
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 4, Linkage Group IV, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:NCU05239

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 748ExtracellularSequence analysisAdd BLAST748
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Topological domaini770 – 786CytoplasmicSequence analysisAdd BLAST17
Transmembranei787 – 807HelicalSequence analysisAdd BLAST21
Topological domaini808 – 821ExtracellularSequence analysisAdd BLAST14
Transmembranei822 – 842HelicalSequence analysisAdd BLAST21
Topological domaini843 – 865CytoplasmicSequence analysisAdd BLAST23
Transmembranei866 – 886HelicalSequence analysisAdd BLAST21
Topological domaini887 – 894ExtracellularSequence analysis8
Transmembranei895 – 915HelicalSequence analysisAdd BLAST21
Topological domaini916 – 993CytoplasmicSequence analysisAdd BLAST78
Transmembranei994 – 1014HelicalSequence analysisAdd BLAST21
Topological domaini1015 – 1025ExtracellularSequence analysisAdd BLAST11
Transmembranei1026 – 1046HelicalSequence analysisAdd BLAST21
Topological domaini1047 – 1097CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937021 – 1097Chitin synthase 2Add BLAST1097

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni148 – 217DisorderedSequence analysisAdd BLAST70
Regioni259 – 322DisorderedSequence analysisAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi269 – 283Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi303 – 322Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chitin synthase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004760_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30589

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004835, Chitin_synth
IPR004834, Chitin_synth_fun
IPR013616, Chitin_synth_N

The PANTHER Classification System

More...
PANTHERi
PTHR22914, PTHR22914, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01644, Chitin_synth_1, 1 hit
PF08407, Chitin_synth_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P30589-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGYGHSTAG GFGSGSGSGP PGPQYMLPQY DEGDDPDADA TPAGQGVRLL
60 70 80 90 100
TNLDNSSYIS VSEITSQSSH RDNIRPSRLR QAYEPSIDAR TYEPSLDTRT
110 120 130 140 150
YEPSISDRRH MYEPSIDERS SYMDPPRIPP PDGGSYVSSY MGTESMVSGH
160 170 180 190 200
GRPWSPESAT GYRVPPQGRY EPSEIDGHAR PGTPGSSYGN ARRPLPSAPA
210 220 230 240 250
PLHYNSPSRA ASHYPRYHGG YADDVTVSMG PDDDRTDIFG PETDLSETRH
260 270 280 290 300
LNDAYGFRSS QITLSEDPHG THARSRYDDE DDVSTTYSSN TGTSASGVDK
310 320 330 340 350
FEHYGPIPEE GKHERRGVRP PQMSRKEVQL INGELVLECK IPTILYSFLP
360 370 380 390 400
RRDEVEFTHM RYTAVTCDPD DFVARGYKLR QNIGRTARET ELFICVTMYN
410 420 430 440 450
EDEFGFTRTM HAVMKNISHF CSRNKSRTWG ADGWQKIVVC VVSDGREIIH
460 470 480 490 500
PRTLDALAAM GVYQHGIAKN FVNQKAVQAH VYEYTTQVSL DSDLKFKGAE
510 520 530 540 550
KGIVPCQMIF CLKEKNQKKL NSHRWFFNAF GKALNPNVCI LLDVGTRPGG
560 570 580 590 600
TSLYHLWKAF DTDSNVAGAC GEIKAMKGRF GGNLLNPLVA SQNFEYKMSN
610 620 630 640 650
ILDKPLESVF GYITVLPGAL SAYRYHALQN DETGHGPLSQ YFKGETLHGQ
660 670 680 690 700
HADVFTANMY LAEDRILCWE LVAKRGERWV LKYVKGCTGE TDVPDTVPEF
710 720 730 740 750
VSQRRRWLNG AFFAAVYSLV HFRQIWKTDH TFMRKALLHV EFLYHLLQLL
760 770 780 790 800
FTYFSLANFY LAFYFIAGGL ADPHVDPFNS DGHVARIIFN ILRYVCVLLI
810 820 830 840 850
CTQFILSLGN RPQGAKRMYL ASMIIYAVIM VYTTFATIFI VVRQIQPSQK
860 870 880 890 900
SDDKPDLELG NNVFTNLIVS VASTLGLYFV MSFLYLDPWH MFTSAIQYFV
910 920 930 940 950
LLPSYICTLQ IYAFCNTHDV TWGTKGDNVM RTDLGGAIGK GSTVELEMPS
960 970 980 990 1000
DQLDIDSGYD ECLRNLRDRV MVPAVPVSED QLQQDYYKSV RTYMVVSWMV
1010 1020 1030 1040 1050
ANATLAMAVS EAYGDSEIGD NFYLRFILWA VAALALFRAL GSTTFAAINL
1060 1070 1080 1090
VSALVEGRVR LRLNMKGFRW IKEKWGDADV KGKFEGLGDR ARGLARR
Length:1,097
Mass (Da):123,135
Last modified:March 19, 2014 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EF4FC97A6663EE8
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA54816 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti495K → M in CAA54816 (PubMed:7952169).Curated1
Sequence conflicti495K → M in AAA33582 (PubMed:1731323).Curated1
Sequence conflicti939G → V in CAA54816 (PubMed:7952169).Curated1
Sequence conflicti974 – 977AVPV → CRSL in CAA54816 (PubMed:7952169).Curated4
Sequence conflicti1096R → K in CAA54816 (PubMed:7952169).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM002239 Genomic DNA Translation: EAA32767.3
X77782 Genomic DNA Translation: CAA54816.1 Frameshift.
M82951 Genomic DNA Translation: AAA33582.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B45189
T47246

NCBI Reference Sequences

More...
RefSeqi
XP_962003.3, XM_956910.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA32767; EAA32767; NCU05239

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3878151

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU05239

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM002239 Genomic DNA Translation: EAA32767.3
X77782 Genomic DNA Translation: CAA54816.1 Frameshift.
M82951 Genomic DNA Translation: AAA33582.1
PIRiB45189
T47246
RefSeqiXP_962003.3, XM_956910.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

CAZyiGT2, Glycosyltransferase Family 2

Genome annotation databases

EnsemblFungiiEAA32767; EAA32767; NCU05239
GeneIDi3878151
KEGGincr:NCU05239

Organism-specific databases

VEuPathDBiFungiDB:NCU05239

Phylogenomic databases

HOGENOMiCLU_004760_1_0_1
InParanoidiP30589

Enzyme and pathway databases

BRENDAi2.4.1.16, 3627

Family and domain databases

InterProiView protein in InterPro
IPR004835, Chitin_synth
IPR004834, Chitin_synth_fun
IPR013616, Chitin_synth_N
PANTHERiPTHR22914, PTHR22914, 1 hit
PfamiView protein in Pfam
PF01644, Chitin_synth_1, 1 hit
PF08407, Chitin_synth_1N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHS2_NEUCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30589
Secondary accession number(s): Q7RVF4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 19, 2014
Last modified: June 2, 2021
This is version 121 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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