UniProtKB - P30561 (AHR_MOUSE)
Aryl hydrocarbon receptor
Ahr
Functioni
Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and cancer (PubMed:10639156, PubMed:10973493, PubMed:1314586, PubMed:7961644, PubMed:7969080, PubMed:8806883, PubMed:9427285).
Upon ligand binding, translocates into the nucleus, where it heterodimerizes with ARNT and induces transcription by binding to xenobiotic response elements (XRE) (By similarity).
Regulates a variety of biological processes, including angiogenesis, hematopoiesis, drug and lipid metabolism, cell motility and immune modulation (PubMed:20106950, PubMed:28396409).
Xenobiotics can act as ligands: upon xenobiotic-binding, activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:10639156, PubMed:10973493, PubMed:1314586, PubMed:7961644, PubMed:7969080, PubMed:8806883, PubMed:9427285).
Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (By similarity).
Next to xenobiotics, natural ligands derived from plants, microbiota, and endogenous metabolism are potent AHR agonists (By similarity).
Tryptophan (Trp) derivatives constitute an important class of endogenous AHR ligands (By similarity).
Acts as a negative regulator of anti-tumor immunity: indoles and kynurenic acid generated by Trp catabolism act as ligand and activate AHR, thereby promoting AHR-driven cancer cell motility and suppressing adaptive immunity (By similarity).
Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (By similarity).
Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1 (PubMed:20106950).
The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).
By similarity9 PublicationsMiscellaneous
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: UniProtKB
- chaperone binding Source: UniProtKB
- cis-regulatory region sequence-specific DNA binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- E-box binding Source: UniProtKB
- Hsp90 protein binding Source: MGI
- identical protein binding Source: MGI
- nuclear receptor activity Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: UniProtKB
- TBP-class protein binding Source: MGI
- TFIID-class transcription factor complex binding Source: MGI
- toxic substance binding Source: MGI
- transcription cis-regulatory region binding Source: MGI
- transcription coactivator binding Source: MGI
GO - Biological processi
- B-1 B cell homeostasis Source: DFLAT
- B cell differentiation Source: DFLAT
- B cell homeostasis Source: DFLAT
- blood circulation Source: DFLAT
- blood vessel development Source: DFLAT
- blood vessel diameter maintenance Source: DFLAT
- blood vessel morphogenesis Source: DFLAT
- blood vessel remodeling Source: DFLAT
- branching involved in blood vessel morphogenesis Source: DFLAT
- camera-type eye development Source: DFLAT
- cAMP-mediated signaling Source: MGI
- cardiac left ventricle morphogenesis Source: DFLAT
- cell cycle Source: UniProtKB-KW
- cell morphogenesis Source: DFLAT
- cellular response to 2,3,7,8-tetrachlorodibenzodioxine Source: MGI
- cellular response to 3-methylcholanthrene Source: UniProtKB
- cellular response to cAMP Source: MGI
- cellular response to forskolin Source: MGI
- circadian regulation of gene expression Source: UniProtKB
- circumferential growth involved in left ventricle morphogenesis Source: DFLAT
- common bile duct development Source: DFLAT
- embryonic hemopoiesis Source: DFLAT
- gland development Source: MGI
- glomerulus morphogenesis Source: DFLAT
- immune system process Source: DFLAT
- kidney morphogenesis Source: DFLAT
- liver development Source: DFLAT
- lymphocyte homeostasis Source: DFLAT
- negative regulation of alkaline phosphatase activity Source: MGI
- negative regulation of calcium ion transmembrane transport Source: MGI
- negative regulation of DNA biosynthetic process Source: MGI
- negative regulation of necrotic cell death Source: DFLAT
- negative regulation of osteoblast differentiation Source: MGI
- negative regulation of osteoblast proliferation Source: MGI
- negative regulation of systemic arterial blood pressure Source: DFLAT
- negative regulation of T cell mediated immune response to tumor cell Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- negative regulation of vasoconstriction Source: DFLAT
- ovarian follicle development Source: MGI
- positive regulation of cell size Source: DFLAT
- positive regulation of growth rate Source: DFLAT
- positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- post-embryonic hemopoiesis Source: DFLAT
- prostate gland development Source: MGI
- regulation of adaptive immune response Source: UniProtKB
- regulation of B cell proliferation Source: MGI
- regulation of blood pressure Source: DFLAT
- regulation of gene expression Source: MGI
- regulation of heart growth Source: DFLAT
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: MGI
- reproductive structure development Source: MGI
- response to organic cyclic compound Source: MGI
- response to toxic substance Source: MGI
- response to xenobiotic stimulus Source: UniProtKB
- smooth muscle tissue development Source: DFLAT
- spleen development Source: DFLAT
- T cell homeostasis Source: DFLAT
- transcription by RNA polymerase II Source: UniProtKB
- venous blood vessel development Source: DFLAT
- xenobiotic metabolic process Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Receptor, Repressor |
Biological process | Biological rhythms, Cell cycle, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-211945, Phase I - Functionalization of compounds R-MMU-211976, Endogenous sterols R-MMU-211981, Xenobiotics R-MMU-8937144, Aryl hydrocarbon receptor signalling |
Names & Taxonomyi
Protein namesi | Recommended name: Aryl hydrocarbon receptorShort name: Ah receptor Short name: AhR |
Gene namesi | Name:Ahr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105043, Ahr |
Subcellular locationi
Cytosol
- cytosol Source: DFLAT
- cytosolic aryl hydrocarbon receptor complex Source: DFLAT
Nucleus
- nuclear aryl hydrocarbon receptor complex Source: DFLAT
- nucleus Source: UniProtKB
Other locations
- aryl hydrocarbon receptor complex Source: GO_Central
- cytoplasm Source: UniProtKB
- protein-containing complex Source: MGI
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 39 | R → D: Drastically reduces the binding affinity of AHR?ARNT to dioxin response element (DRE). Impairs ligand-induced nuclear translocation of AHR. 1 Publication | 1 | |
Mutagenesisi | 42 | L → E: Significantly reduces binding affinities of the AHR?ARNT heterodimer to DRE. 1 Publication | 1 | |
Mutagenesisi | 43 | N → A: Reduces the binding affinity of AHR?ARNT to the DRE by more than 10-fold. 1 Publication | 1 | |
Mutagenesisi | 49 | L → E: Reduces the AHR induction transcription activity by 50%. Increases ligand-induced nuclear translocation of AHR. 1 Publication | 1 | |
Mutagenesisi | 65 | K → E: Reduces the binding affinity of AHR?ARNT to the DRE by more than 10-fold. 1 Publication | 1 | |
Mutagenesisi | 70 | R → D: Drastically reduces the AHR transcription activity inductiona. Increases constitutive AHR nuclear translocation in the absence of ligands. Reduces binding affinity for the DRE by more than 30-fold in vitro. 1 Publication | 1 | |
Mutagenesisi | 112 | E → A: Reduces transcription activity. Decreases interaction with ARNT. 1 Publication | 1 | |
Mutagenesisi | 115 | F → A: Highly disrupts the dimerization ability of AHR. 1 Publication | 1 | |
Mutagenesisi | 115 | F → D: Highly disrupts the dimerization ability of AHR. Reduces the AHR transcription factor activity induction by 50%. 2 Publications | 1 | |
Mutagenesisi | 116 | L → E: Highly disrupts the dimerization ability of AHR. Reduces transcription activity. Decreases interaction with ARNT. 1 Publication | 1 | |
Mutagenesisi | 119 | A → D: Highly disrupts the dimerization ability of AHR. Reduces transcription activity. Impairs interaction with ARNT. 1 Publication | 1 | |
Mutagenesisi | 120 | L → D: Significantly reduces binding affinities of the AHR?ARNT heterodimer to DRE. 1 Publication | 1 | |
Mutagenesisi | 120 | L → E: Highly disrupts the dimerization ability of AHR. Reduces transcription activity. Impairs interaction with ARNT. 1 Publication | 1 | |
Mutagenesisi | 124 | V → D: Highly disrupts the dimerization ability of AHR. Reduces transcription activity. Impairs interaction with ARNT. 1 Publication | 1 | |
Mutagenesisi | 134 | F → D: Reduces the AHR induction activity by ?50%. Translocate to thee nucleus at a high level. 1 Publication | 1 | |
Mutagenesisi | 152 | I → D: Completely abolished the AHR induction activity, the ligand-induced nuclear translocation of AHR, and drastically reduced DRE-binding in vitro. 1 Publication | 1 | |
Mutagenesisi | 238 | K → D: Significantly reduces binding affinities of the AHR?ARNT heterodimer to DRE. 1 Publication | 1 | |
Mutagenesisi | 240 | L → D: Significantly reduces binding affinities of the AHR?ARNT heterodimer to DRE. 1 Publication | 1 | |
Mutagenesisi | 260 | F → D: Reduces transcription activity. Impairs interaction with ARNT. 1 Publication | 1 | |
Mutagenesisi | 262 | I → D: Reduces transcription activity. Decreases interaction with ARNT. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL6099 |
GuidetoPHARMACOLOGYi | 2951 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000013452 | 1 – 9 | 2 Publications | 9 | |
ChainiPRO_0000013453 | 10 – 848 | Aryl hydrocarbon receptorAdd BLAST | 839 |
Post-translational modificationi
Keywords - PTMi
ADP-ribosylationProteomic databases
MaxQBi | P30561 |
PaxDbi | P30561 |
PRIDEi | P30561 |
ProteomicsDBi | 281961 |
PTM databases
iPTMneti | P30561 |
PhosphoSitePlusi | P30561 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Interactioni
Subunit structurei
Homodimer (PubMed:24001774). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (By similarity).
Interacts with ARNT; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:24001774, PubMed:28396409). Binds MYBBP1A (PubMed:11956195).
Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT.
Interacts with NEDD8 and IVNS1ABP (PubMed:12215427).
Interacts with ARNTL/BMAL1 (PubMed:20106950).
Interacts with HSP90AB1 (PubMed:15581363).
Interacts with TIPARP; leading to mono-ADP-ribosylation of AHR and subsequent inhibition of AHR (By similarity).
By similarity6 PublicationsBinary interactionsi
P30561
With | #Exp. | IntAct |
---|---|---|
arnt [P79832] from Oncorhynchus mykiss. | 2 | EBI-78863,EBI-958635 |
URI1 [O94763] from Homo sapiens. | 2 | EBI-78863,EBI-357067 |
GO - Molecular functioni
- aryl hydrocarbon receptor binding Source: UniProtKB
- chaperone binding Source: UniProtKB
- Hsp90 protein binding Source: MGI
- identical protein binding Source: MGI
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II-specific DNA-binding transcription factor binding Source: MGI
- TBP-class protein binding Source: MGI
- TFIID-class transcription factor complex binding Source: MGI
- transcription coactivator binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 198037, 8 interactors |
CORUMi | P30561 |
DIPi | DIP-222N |
IntActi | P30561, 8 interactors |
STRINGi | 10090.ENSMUSP00000112137 |
Chemistry databases
BindingDBi | P30561 |
Miscellaneous databases
RNActi | P30561, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P30561 |
SMRi | P30561 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 79 | bHLHPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 116 – 179 | PAS 1PROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 269 – 336 | PAS 2PROSITE-ProRule annotationAdd BLAST | 68 | |
Domaini | 342 – 380 | PACAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 37 – 65 | DNA-bindingBy similarityAdd BLAST | 29 | |
Regioni | 116 – 124 | Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity1 Publication | 9 | |
Regioni | 260 – 262 | Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity1 Publication | 3 | |
Regioni | 421 – 449 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 422 – 449 | Polar residuesSequence analysisAdd BLAST | 28 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG3560, Eukaryota |
InParanoidi | P30561 |
OrthoDBi | 174264at2759 |
PhylomeDBi | P30561 |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR033348, AHR IPR039091, AHR/AHRR IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 |
PANTHERi | PTHR10649, PTHR10649, 1 hit PTHR10649:SF9, PTHR10649:SF9, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSSGANITYA SRKRRKPVQK TVKPIPAEGI KSNPSKRHRD RLNTELDRLA
60 70 80 90 100
SLLPFPQDVI NKLDKLSVLR LSVSYLRAKS FFDVALKSTP ADRNGGQDQC
110 120 130 140 150
RAQIRDWQDL QEGEFLLQAL NGFVLVVTAD ALVFYASSTI QDYLGFQQSD
160 170 180 190 200
VIHQSVYELI HTEDRAEFQR QLHWALNPDS AQGVDEAHGP PQAAVYYTPD
210 220 230 240 250
QLPPENASFM ERCFRCRLRC LLDNSSGFLA MNFQGRLKYL HGQNKKGKDG
260 270 280 290 300
ALLPPQLALF AIATPLQPPS ILEIRTKNFI FRTKHKLDFT PIGCDAKGQL
310 320 330 340 350
ILGYTEVELC TRGSGYQFIH AADMLHCAES HIRMIKTGES GMTVFRLFAK
360 370 380 390 400
HSRWRWVQSN ARLIYRNGRP DYIIATQRPL TDEEGREHLQ KRSTSLPFMF
410 420 430 440 450
ATGEAVLYEI SSPFSPIMDP LPIRTKSNTS RKDWAPQSTP SKDSFHPSSL
460 470 480 490 500
MSALIQQDES IYLCPPSSPA PLDSHFLMGS VSKCGSWQDS FAAAGSEAAL
510 520 530 540 550
KHEQIGHAQD VNLALSGGPS ELFPDNKNND LYNIMRNLGI DFEDIRSMQN
560 570 580 590 600
EEFFRTDSTA AGEVDFKDID ITDEILTYVQ DSLNNSTLMN SACQQQPVTQ
610 620 630 640 650
HLSCMLQERL QLEQQQQLQQ PPPQALEPQQ QLCQMVCPQQ DLGPKHTQIN
660 670 680 690 700
GTFASWNPTP PVSFNCPQQE LKHYQLFSSL QGTAQEFPYK PEVDSVPYTQ
710 720 730 740 750
NFAPCNQPLL PEHSKSVQLD FPGRDFEPSL HPTTSNLDFV SCLQVPENQS
760 770 780 790 800
HGINSQSTMV SPQAYYAGAM SMYQCQPGPQ RTPVDQTQYS SEIPGSQAFL
810 820 830 840
SKVQSRGIFN ETYSSDLSSI GHAAQTTGHL HHLAEARPLP DITPGGFL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3U5D9 | Q3U5D9_MOUSE | Aryl hydrocarbon receptor | Ahr | 805 | Annotation score: | ||
A0A0B4J1L1 | A0A0B4J1L1_MOUSE | Aryl hydrocarbon receptor | Ahr | 114 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 74 | S → T (PubMed:1325649).Curated | 1 | |
Sequence conflicti | 74 | S → T (PubMed:8148872).Curated | 1 | |
Sequence conflicti | 132 – 133 | LV → FL (PubMed:1314586).Curated | 2 | |
Sequence conflicti | 132 – 133 | LV → FL (PubMed:8408082).Curated | 2 | |
Sequence conflicti | 171 – 172 | QL → HV (PubMed:1314586).Curated | 2 | |
Sequence conflicti | 171 – 172 | QL → HV (PubMed:8408082).Curated | 2 | |
Sequence conflicti | 351 | H → N in D38416 (PubMed:7961644).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 324 | M → I in allele AHRB1; no increase in specific ligand binding. 6 Publications | 1 | |
Natural varianti | 348 | F → L in allele AHRB1 and allele AHRD; no reduction in specific ligand binding. 7 Publications | 1 | |
Natural varianti | 375 | A → V in allele AHRD; reduced specific ligand binding. 5 Publications | 1 | |
Natural varianti | 471 | P → L in allele AHRB1; no increase in specific ligand binding. 6 Publications | 1 | |
Natural varianti | 533 | N → S in allele AHRB1; no increase in specific ligand binding. 6 Publications | 1 | |
Natural varianti | 589 | M → I in allele AHRD. 2 Publications | 1 | |
Natural varianti | 589 | M → L in allele AHRB1; no increase in specific ligand binding. 5 Publications | 1 | |
Natural varianti | 758 | T → A in allele AHRB1 and allele AHRD. 7 Publications | 1 | |
Natural varianti | 806 – 848 | Missing in allele AHRB1. Add BLAST | 43 | |
Natural varianti | 808 | I → V in allele AHRB3. 1 Publication | 1 | |
Natural varianti | 821 | G → D in allele AHRB3. 1 Publication | 1 | |
Natural varianti | 824 | A → V in allele AHRB3. 1 Publication | 1 | |
Natural varianti | 843 – 848 | TPGGFL → SHLVGSCSSHARMKFIQEQD TGTVRVGHQYYFSKTFDSCI in allele AHRB3. | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38417 mRNA Translation: BAA07469.1 M94623 Unassigned DNA Translation: AAA02896.1 L19749 Unassigned DNA No translation available. L19750 Unassigned DNA No translation available. L19751 Unassigned DNA No translation available. L19752 Unassigned DNA No translation available. L19753 Unassigned DNA No translation available. L19754 Unassigned DNA No translation available. L19755 Unassigned DNA No translation available. L19756 Unassigned DNA No translation available. L19757 Unassigned DNA No translation available. L19758 Unassigned DNA No translation available. L19759 Unassigned DNA No translation available. D38416 mRNA No translation available. AF325111 Genomic DNA Translation: AAK13443.1 AF405560 mRNA Translation: AAL89725.1 AF405561 mRNA Translation: AAL89726.1 AF405562 mRNA Translation: AAL89727.1 AF405563 mRNA Translation: AAL89728.1 AF405566 mRNA Translation: AAL89731.1 AF405567 mRNA Translation: AAL89732.1 AF405570 mRNA Translation: AAL89735.1 |
PIRi | A46266 |
RefSeqi | NP_038492.1, NM_013464.4 |
Genome annotation databases
GeneIDi | 11622 |
KEGGi | mmu:11622 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D38417 mRNA Translation: BAA07469.1 M94623 Unassigned DNA Translation: AAA02896.1 L19749 Unassigned DNA No translation available. L19750 Unassigned DNA No translation available. L19751 Unassigned DNA No translation available. L19752 Unassigned DNA No translation available. L19753 Unassigned DNA No translation available. L19754 Unassigned DNA No translation available. L19755 Unassigned DNA No translation available. L19756 Unassigned DNA No translation available. L19757 Unassigned DNA No translation available. L19758 Unassigned DNA No translation available. L19759 Unassigned DNA No translation available. D38416 mRNA No translation available. AF325111 Genomic DNA Translation: AAK13443.1 AF405560 mRNA Translation: AAL89725.1 AF405561 mRNA Translation: AAL89726.1 AF405562 mRNA Translation: AAL89727.1 AF405563 mRNA Translation: AAL89728.1 AF405566 mRNA Translation: AAL89731.1 AF405567 mRNA Translation: AAL89732.1 AF405570 mRNA Translation: AAL89735.1 |
PIRi | A46266 |
RefSeqi | NP_038492.1, NM_013464.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4M4X | X-ray | 2.55 | A/B | 110-267 | [»] | |
5V0L | X-ray | 4.00 | B | 29-267 | [»] | |
AlphaFoldDBi | P30561 | |||||
SMRi | P30561 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 198037, 8 interactors |
CORUMi | P30561 |
DIPi | DIP-222N |
IntActi | P30561, 8 interactors |
STRINGi | 10090.ENSMUSP00000112137 |
Chemistry databases
BindingDBi | P30561 |
ChEMBLi | CHEMBL6099 |
GuidetoPHARMACOLOGYi | 2951 |
PTM databases
iPTMneti | P30561 |
PhosphoSitePlusi | P30561 |
Proteomic databases
MaxQBi | P30561 |
PaxDbi | P30561 |
PRIDEi | P30561 |
ProteomicsDBi | 281961 |
Protocols and materials databases
DNASUi | 11622 |
Genome annotation databases
GeneIDi | 11622 |
KEGGi | mmu:11622 |
Organism-specific databases
CTDi | 196 |
MGIi | MGI:105043, Ahr |
Phylogenomic databases
eggNOGi | KOG3560, Eukaryota |
InParanoidi | P30561 |
OrthoDBi | 174264at2759 |
PhylomeDBi | P30561 |
Enzyme and pathway databases
Reactomei | R-MMU-211945, Phase I - Functionalization of compounds R-MMU-211976, Endogenous sterols R-MMU-211981, Xenobiotics R-MMU-8937144, Aryl hydrocarbon receptor signalling |
Miscellaneous databases
BioGRID-ORCSi | 11622, 2 hits in 77 CRISPR screens |
ChiTaRSi | Ahr, mouse |
PROi | PR:P30561 |
RNActi | P30561, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd00130, PAS, 2 hits |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR033348, AHR IPR039091, AHR/AHRR IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR001610, PAC IPR000014, PAS IPR035965, PAS-like_dom_sf IPR013767, PAS_fold IPR013655, PAS_fold_3 |
PANTHERi | PTHR10649, PTHR10649, 1 hit PTHR10649:SF9, PTHR10649:SF9, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit PF00989, PAS, 1 hit PF08447, PAS_3, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit SM00086, PAC, 1 hit SM00091, PAS, 2 hits |
SUPFAMi | SSF47459, SSF47459, 1 hit SSF55785, SSF55785, 2 hits |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit PS50112, PAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AHR_MOUSE | |
Accessioni | P30561Primary (citable) accession number: P30561 Secondary accession number(s): Q8QZX6 Q9QVY1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | March 25, 2003 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references