UniProtKB - P30559 (OXYR_HUMAN)
Protein
Oxytocin receptor
Gene
OXTR
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- oxytocin receptor activity Source: GO_Central
- peptide binding Source: GO_Central
- peptide hormone binding Source: Ensembl
- vasopressin receptor activity Source: GO_Central
GO - Biological processi
- cell surface receptor signaling pathway Source: ProtInc
- digestive tract development Source: Ensembl
- eating behavior Source: Ensembl
- ERK1 and ERK2 cascade Source: Ensembl
- estrous cycle Source: Ensembl
- female pregnancy Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- heart development Source: Ensembl
- lactation Source: ProtInc
- maternal behavior Source: Ensembl
- maternal process involved in parturition Source: GO_Central
- memory Source: Ensembl
- muscle contraction Source: ProtInc
- negative regulation of gastric acid secretion Source: Ensembl
- positive regulation of blood pressure Source: Ensembl
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of norepinephrine secretion Source: Ensembl
- positive regulation of penile erection Source: Ensembl
- positive regulation of synapse assembly Source: Ensembl
- positive regulation of synaptic transmission, GABAergic Source: Ensembl
- positive regulation of synaptic transmission, glutamatergic Source: Ensembl
- positive regulation of uterine smooth muscle contraction Source: Ensembl
- positive regulation of vasoconstriction Source: GO_Central
- regulation of systemic arterial blood pressure by vasopressin Source: GO_Central
- response to amphetamine Source: Ensembl
- response to anoxia Source: Ensembl
- response to cocaine Source: Ensembl
- response to cytokine Source: Ensembl
- response to drug Source: Ensembl
- response to estradiol Source: Ensembl
- response to peptide hormone Source: Ensembl
- response to progesterone Source: Ensembl
- sleep Source: Ensembl
- social behavior Source: Ensembl
- sperm ejaculation Source: Ensembl
- suckling behavior Source: Ensembl
- telencephalon development Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P30559 |
Reactomei | R-HSA-388479, Vasopressin-like receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P30559 |
SIGNORi | P30559 |
Protein family/group databases
TCDBi | 9.A.14.10.4, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Oxytocin receptorShort name: OT-R |
Gene namesi | Name:OXTR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8529, OXTR |
MIMi | 167055, gene |
neXtProti | NX_P30559 |
VEuPathDBi | HostDB:ENSG00000180914.10 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- apical plasma membrane Source: Ensembl
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- adherens junction Source: Ensembl
- microvillus Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 63 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 64 – 74 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 75 – 97 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 98 – 113 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 114 – 135 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 136 – 154 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 155 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 176 – 202 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 203 – 225 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 226 – 275 | CytoplasmicSequence analysisAdd BLAST | 50 | |
Transmembranei | 276 – 294 | Helical; Name=6Sequence analysisAdd BLAST | 19 | |
Topological domaini | 295 – 309 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 310 – 332 | Helical; Name=7Sequence analysisAdd BLAST | 23 | |
Topological domaini | 333 – 389 | CytoplasmicSequence analysisAdd BLAST | 57 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5021 |
OpenTargetsi | ENSG00000180914 |
PharmGKBi | PA32858 |
Miscellaneous databases
Pharosi | P30559, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2049 |
DrugBanki | DB09059, Atosiban DB01282, Carbetocin DB00107, Oxytocin DB13929, Relcovaptan |
DrugCentrali | P30559 |
GuidetoPHARMACOLOGYi | 369 |
Genetic variation databases
BioMutai | OXTR |
DMDMi | 143811431 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069998 | 1 – 389 | Oxytocin receptorAdd BLAST | 389 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 15 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 112 ↔ 187 | PROSITE-ProRule annotation | ||
Modified residuei | 366 | PhosphoserineBy similarity | 1 | |
Modified residuei | 368 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P30559 |
MaxQBi | P30559 |
PaxDbi | P30559 |
PeptideAtlasi | P30559 |
PRIDEi | P30559 |
ProteomicsDBi | 54722 |
PTM databases
GlyGeni | P30559, 3 sites |
iPTMneti | P30559 |
PhosphoSitePlusi | P30559 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180914, Expressed in myometrium and 163 other tissues |
ExpressionAtlasi | P30559, baseline and differential |
Genevisiblei | P30559, HS |
Organism-specific databases
HPAi | ENSG00000180914, Tissue enriched (breast) |
Interactioni
Protein-protein interaction databases
ELMi | P30559 |
IntActi | P30559, 18 interactors |
MINTi | P30559 |
STRINGi | 9606.ENSP00000324270 |
Chemistry databases
BindingDBi | P30559 |
Miscellaneous databases
RNActi | P30559, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222344 |
HOGENOMi | CLU_009579_15_3_1 |
InParanoidi | P30559 |
OMAi | IHTTRQK |
OrthoDBi | 243095at2759 |
PhylomeDBi | P30559 |
TreeFami | TF106499 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002062, Oxytocn_rcpt IPR001817, Vasoprsn_rcpt |
PANTHERi | PTHR24241:SF89, PTHR24241:SF89, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00665, OXYTOCINR PR00896, VASOPRESSINR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P30559-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL
60 70 80 90 100
LLALSGNACV LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD
110 120 130 140 150
ITFRFYGPDL LCRLVKYLQV VGMFASTYLL LLMSLDRCLA ICQPLRSLRR
160 170 180 190 200
RTDRLAVLAT WLGCLVASAP QVHIFSLREV ADGVFDCWAV FIQPWGPKAY
210 220 230 240 250
ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA AEAPEGAAAG
260 270 280 290 300
DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW
310 320 330 340 350
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS
360 370 380
YLKGRRLGET SASKKSNSSS FVLSHRSSSQ RSCSQPSTA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JN09 | C9JN09_HUMAN | Oxytocin receptor | OXTR | 92 | Annotation score: | ||
C9JQC4 | C9JQC4_HUMAN | Oxytocin receptor | OXTR | 43 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 308 | A → G in CAA56562 (PubMed:7798245).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031570 | 16 | A → S. Corresponds to variant dbSNP:rs237906Ensembl. | 1 | |
Natural variantiVAR_031571 | 218 | A → T2 PublicationsCorresponds to variant dbSNP:rs4686302Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64878 mRNA Translation: CAA46097.1 AY389507 mRNA Translation: AAQ91333.1 X80282 Genomic DNA Translation: CAA56562.1 |
CCDSi | CCDS2570.1 |
PIRi | A55493 |
RefSeqi | NP_000907.2, NM_000916.3 XP_011532064.1, XM_011533762.2 |
Genome annotation databases
Ensembli | ENST00000316793; ENSP00000324270; ENSG00000180914 |
GeneIDi | 5021 |
KEGGi | hsa:5021 |
UCSCi | uc003brc.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Oxytocin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64878 mRNA Translation: CAA46097.1 AY389507 mRNA Translation: AAQ91333.1 X80282 Genomic DNA Translation: CAA56562.1 |
CCDSi | CCDS2570.1 |
PIRi | A55493 |
RefSeqi | NP_000907.2, NM_000916.3 XP_011532064.1, XM_011533762.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6TPK | X-ray | 3.20 | A | 35-356 | [»] | |
SMRi | P30559 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ELMi | P30559 |
IntActi | P30559, 18 interactors |
MINTi | P30559 |
STRINGi | 9606.ENSP00000324270 |
Chemistry databases
BindingDBi | P30559 |
ChEMBLi | CHEMBL2049 |
DrugBanki | DB09059, Atosiban DB01282, Carbetocin DB00107, Oxytocin DB13929, Relcovaptan |
DrugCentrali | P30559 |
GuidetoPHARMACOLOGYi | 369 |
Protein family/group databases
TCDBi | 9.A.14.10.4, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P30559, 3 sites |
iPTMneti | P30559 |
PhosphoSitePlusi | P30559 |
Genetic variation databases
BioMutai | OXTR |
DMDMi | 143811431 |
Proteomic databases
MassIVEi | P30559 |
MaxQBi | P30559 |
PaxDbi | P30559 |
PeptideAtlasi | P30559 |
PRIDEi | P30559 |
ProteomicsDBi | 54722 |
Protocols and materials databases
Antibodypediai | 10144, 370 antibodies |
Genome annotation databases
Ensembli | ENST00000316793; ENSP00000324270; ENSG00000180914 |
GeneIDi | 5021 |
KEGGi | hsa:5021 |
UCSCi | uc003brc.4, human |
Organism-specific databases
CTDi | 5021 |
DisGeNETi | 5021 |
GeneCardsi | OXTR |
HGNCi | HGNC:8529, OXTR |
HPAi | ENSG00000180914, Tissue enriched (breast) |
MIMi | 167055, gene |
neXtProti | NX_P30559 |
OpenTargetsi | ENSG00000180914 |
PharmGKBi | PA32858 |
VEuPathDBi | HostDB:ENSG00000180914.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222344 |
HOGENOMi | CLU_009579_15_3_1 |
InParanoidi | P30559 |
OMAi | IHTTRQK |
OrthoDBi | 243095at2759 |
PhylomeDBi | P30559 |
TreeFami | TF106499 |
Enzyme and pathway databases
PathwayCommonsi | P30559 |
Reactomei | R-HSA-388479, Vasopressin-like receptors R-HSA-416476, G alpha (q) signalling events |
SignaLinki | P30559 |
SIGNORi | P30559 |
Miscellaneous databases
BioGRID-ORCSi | 5021, 5 hits in 878 CRISPR screens |
GeneWikii | Oxytocin_receptor |
GenomeRNAii | 5021 |
Pharosi | P30559, Tclin |
PROi | PR:P30559 |
RNActi | P30559, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180914, Expressed in myometrium and 163 other tissues |
ExpressionAtlasi | P30559, baseline and differential |
Genevisiblei | P30559, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002062, Oxytocn_rcpt IPR001817, Vasoprsn_rcpt |
PANTHERi | PTHR24241:SF89, PTHR24241:SF89, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00665, OXYTOCINR PR00896, VASOPRESSINR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OXYR_HUMAN | |
Accessioni | P30559Primary (citable) accession number: P30559 Secondary accession number(s): Q15071 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 10, 2021 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families