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Protein

Type-1 angiotensin II receptor

Gene

AGTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • angiotensin type II receptor activity Source: UniProtKB
  • angiotensin type I receptor activity Source: BHF-UCL
  • bradykinin receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  • angiotensin-activated signaling pathway Source: BHF-UCL
  • calcium-mediated signaling Source: BHF-UCL
  • cell chemotaxis Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • kidney development Source: BHF-UCL
  • low-density lipoprotein particle remodeling Source: BHF-UCL
  • phospholipase C-activating angiotensin-activated signaling pathway Source: BHF-UCL
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
  • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
  • positive regulation of cellular protein metabolic process Source: BHF-UCL
  • positive regulation of cholesterol esterification Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • positive regulation of NAD(P)H oxidase activity Source: BHF-UCL
  • positive regulation of phospholipase A2 activity Source: BHF-UCL
  • positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
  • regulation of blood vessel diameter Source: BHF-UCL
  • regulation of blood vessel diameter by renin-angiotensin Source: BHF-UCL
  • regulation of cell growth Source: BHF-UCL
  • regulation of cell proliferation Source: BHF-UCL
  • regulation of inflammatory response Source: BHF-UCL
  • regulation of renal sodium excretion Source: BHF-UCL
  • regulation of systemic arterial blood pressure by renin-angiotensin Source: BHF-UCL
  • regulation of vasoconstriction Source: BHF-UCL
  • renin-angiotensin regulation of aldosterone production Source: BHF-UCL
  • Rho protein signal transduction Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP30556
SIGNORiP30556

Protein family/group databases

TCDBi9.A.14.13.1 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor
Alternative name(s):
AT1AR
AT1BR
Angiotensin II type-1 receptor
Short name:
AT1
Gene namesi
Name:AGTR1
Synonyms:AGTR1A, AGTR1B, AT2R1, AT2R1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144891.17
HGNCiHGNC:336 AGTR1
MIMi106165 gene
neXtProtiNX_P30556

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 52Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini53 – 64CytoplasmicSequence analysisAdd BLAST12
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 102ExtracellularSequence analysisAdd BLAST15
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 142CytoplasmicSequence analysisAdd BLAST18
Transmembranei143 – 162Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 214Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini215 – 240CytoplasmicSequence analysisAdd BLAST26
Transmembranei241 – 262Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Renal tubular dysgenesis (RTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
See also OMIM:267430
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035086282T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi185
MalaCardsiAGTR1
MIMi267430 phenotype
OpenTargetsiENSG00000144891
Orphaneti97369 Renal tubular dysgenesis of genetic origin
PharmGKBiPA43

Chemistry databases

ChEMBLiCHEMBL227
DrugBankiDB08822 Azilsartan medoxomil
DB00796 Candesartan
DB05739 CYT006-AngQb
DB00876 Eprosartan
DB01342 Forasartan
DB01029 Irbesartan
DB00678 Losartan
DB00275 Olmesartan
DB01347 Saprisartan
DB01349 Tasosartan
DB00966 Telmisartan
DB00177 Valsartan
GuidetoPHARMACOLOGYi34

Polymorphism and mutation databases

BioMutaiAGTR1
DMDMi231519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691531 – 359Type-1 angiotensin II receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi355S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP30556
PeptideAtlasiP30556
PRIDEiP30556
ProteomicsDBi54721

PTM databases

iPTMnetiP30556
PhosphoSitePlusiP30556

Expressioni

Tissue specificityi

Liver, lung, adrenal and adrenocortical adenomas.

Gene expression databases

BgeeiENSG00000144891
CleanExiHS_AGTR1
ExpressionAtlasiP30556 baseline and differential
GenevisibleiP30556 HS

Organism-specific databases

HPAiHPA003596

Interactioni

Subunit structurei

Interacts with MAS1 (Probable) (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).By similarityCurated2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTP010192EBI-6623016,EBI-6622938

GO - Molecular functioni

  • bradykinin receptor binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi106691, 31 interactors
IntActiP30556, 5 interactors
MINTiP30556
STRINGi9606.ENSP00000273430

Chemistry databases

BindingDBiP30556

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 20Combined sources4
Helixi27 – 55Combined sources29
Turni56 – 59Combined sources4
Helixi62 – 80Combined sources19
Helixi82 – 89Combined sources8
Helixi98 – 131Combined sources34
Helixi142 – 159Combined sources18
Helixi161 – 166Combined sources6
Beta strandi167 – 174Combined sources8
Beta strandi178 – 182Combined sources5
Helixi191 – 194Combined sources4
Helixi198 – 203Combined sources6
Helixi205 – 221Combined sources17
Helixi236 – 267Combined sources32
Beta strandi269 – 271Combined sources3
Helixi274 – 292Combined sources19
Helixi294 – 303Combined sources10
Helixi306 – 316Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZV0model-B1-359[»]
4YAYX-ray2.90A2-319[»]
4ZUDX-ray2.80A2-315[»]
ProteinModelPortaliP30556
SMRiP30556
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOVERGENiHBG104998
InParanoidiP30556
KOiK04166
PhylomeDBiP30556
TreeFamiTF330024

Family and domain databases

CDDicd15192 7tmA_AT1R, 1 hit
InterProiView protein in InterPro
IPR000190 ATII_AT1_rcpt
IPR000248 ATII_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00241 ANGIOTENSINR
PR00635 ANGIOTENSN1R
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF
260 270 280 290 300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK

KPAPCFEVE
Length:359
Mass (Da):41,061
Last modified:April 1, 1993 - v1
Checksum:i35FC856F53E911A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187Q → R in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti204 – 205FL → SC in BAA02968 (PubMed:8135787).Curated2
Sequence conflicti232K → N in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti240K → R in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti268L → Q in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti311 – 313RYF → KDI in BAA02968 (PubMed:8135787).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029206163A → T. Corresponds to variant dbSNP:rs12721226Ensembl.1
Natural variantiVAR_070375222L → V1 PublicationCorresponds to variant dbSNP:rs17852013Ensembl.1
Natural variantiVAR_029207244A → S. Corresponds to variant dbSNP:rs12721225Ensembl.1
Natural variantiVAR_035086282T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677Ensembl.1
Natural variantiVAR_011847289C → W1 PublicationCorresponds to variant dbSNP:rs1064533Ensembl.1
Natural variantiVAR_011848336T → P. Corresponds to variant dbSNP:rs1801021Ensembl.1
Natural variantiVAR_070376341P → H1 PublicationCorresponds to variant dbSNP:rs17852012Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91464 Genomic DNA Translation: AAA35569.1
Z11162 Genomic DNA Translation: CAA77513.1
M87290 mRNA Translation: AAA35535.1
S77410 mRNA Translation: AAB34644.1
M93394 mRNA Translation: AAA58370.1
D13814 mRNA Translation: BAA02968.1
X65699 mRNA Translation: CAA46621.1
AF245699 Genomic DNA Translation: AAF70464.1
AY221090 Genomic DNA Translation: AAO65968.1
BC022447 mRNA Translation: AAH22447.1
CCDSiCCDS3137.1
PIRiI39418
JC1104
RefSeqiNP_000676.1, NM_000685.4
NP_004826.5, NM_004835.4
NP_033611.1, NM_009585.3
UniGeneiHs.477887
Hs.744837

Genome annotation databases

EnsembliENST00000349243; ENSP00000273430; ENSG00000144891
ENST00000404754; ENSP00000385612; ENSG00000144891
ENST00000461609; ENSP00000418851; ENSG00000144891
ENST00000474935; ENSP00000418084; ENSG00000144891
ENST00000475347; ENSP00000419783; ENSG00000144891
ENST00000497524; ENSP00000419422; ENSG00000144891
GeneIDi185
KEGGihsa:185

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAGTR1_HUMAN
AccessioniPrimary (citable) accession number: P30556
Secondary accession number(s): Q13725, Q8TBK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 20, 2018
This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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