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UniProtKB - P30556 (AGTR1_HUMAN)

Entry version 204 (25 May 2022)
Sequence version 1 (01 Apr 1993)
Previous versions | rss
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Protein

Type-1 angiotensin II receptor

Gene

AGTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

(Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P30556

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P30556

SIGNOR Signaling Network Open Resource

More...SIGNORi		P30556

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.13.1, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type-1 angiotensin II receptorCurated
Alternative name(s):
AT1AR
AT1BR
Angiotensin II type-1 receptor
Short name:
AT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGTR1Imported
Synonyms:AGTR1A, AGTR1B, AT2R1, AT2R1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:336, AGTR1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		106165, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P30556

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000144891

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 52Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini53 – 64CytoplasmicSequence analysisAdd BLAST12
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 102ExtracellularSequence analysisAdd BLAST15
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 142CytoplasmicSequence analysisAdd BLAST18
Transmembranei143 – 162Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 214Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini215 – 240CytoplasmicSequence analysisAdd BLAST26
Transmembranei241 – 262Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal tubular dysgenesis (RTD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035086282T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		185

MalaCards human disease database

More...MalaCardsi		AGTR1
MIMi267430, phenotype

Open Targets

More...OpenTargetsi		ENSG00000144891

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		243761, NON RARE IN EUROPE: Essential hypertension
97369, Renal tubular dysgenesis of genetic origin

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA43

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P30556, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL227

Drug and drug target database

More...DrugBanki		DB11842, Angiotensin II
DB08822, Azilsartan medoxomil
DB13919, Candesartan
DB00796, Candesartan cilexetil
DB05739, CYT006-AngQb
DB00876, Eprosartan
DB09279, Fimasartan
DB01342, Forasartan
DB01029, Irbesartan
DB00678, Losartan
DB00275, Olmesartan
DB01347, Saprisartan
DB01349, Tasosartan
DB00966, Telmisartan
DB00177, Valsartan

DrugCentral

More...DrugCentrali		P30556

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		34

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AGTR1

Domain mapping of disease mutations (DMDM)

More...DMDMi		231519

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000691531 – 359Type-1 angiotensin II receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) (complex) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi355S-palmitoyl cysteineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P30556

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P30556

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P30556

PeptideAtlas

More...PeptideAtlasi		P30556

PRoteomics IDEntifications database

More...PRIDEi		P30556

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54721

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P30556, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P30556

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P30556

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, lung, adrenal and adrenocortical adenomas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000144891, Expressed in placenta and 184 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P30556, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P30556, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000144891, Tissue enhanced (liver, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAS1 (Probable) (PubMed:15809376).

Interacts with ARRB1 (By similarity).

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

By similarityCurated2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106691, 90 interactors

Protein interaction database and analysis system

More...IntActi		P30556, 74 interactors

Molecular INTeraction database

More...MINTi		P30556

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000419422

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P30556

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P30556, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P30556

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P30556

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni335 – 359DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi335 – 351Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234534

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_8_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P30556

Identification of Orthologs from Complete Genome Data

More...OMAi		QVFHFMQ

Database for complete collections of gene phylogenies

More...PhylomeDBi		P30556

TreeFam database of animal gene trees

More...TreeFami		TF330024

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000190, ATII_AT1_rcpt
IPR000248, ATII_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00241, ANGIOTENSINR
PR00635, ANGIOTENSN1R
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P30556-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV 
        60         70         80         90        100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL 
       110        120        130        140        150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI 
       160        170        180        190        200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN 
       210        220        230        240        250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF 
       260        270        280        290        300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL 
       310        320        330        340        350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK 

KPAPCFEVE
Length:359
Mass (Da):41,061
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35FC856F53E911A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3DNG8D3DNG8_HUMAN
Type-1 angiotensin II receptor
AGTR1 hCG_2022206
394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSE3A0A0A0MSE3_HUMAN
Type-1 angiotensin II receptor
AGTR1 hCG_2022206
388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187Q → R in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti204 – 205FL → SC in BAA02968 (PubMed:8135787).Curated2
Sequence conflicti232K → N in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti240K → R in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti268L → Q in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti311 – 313RYF → KDI in BAA02968 (PubMed:8135787).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029206163A → T. Corresponds to variant dbSNP:rs12721226EnsemblClinVar.1
Natural variantiVAR_070375222L → V1 PublicationCorresponds to variant dbSNP:rs17852013Ensembl.1
Natural variantiVAR_029207244A → S. Corresponds to variant dbSNP:rs12721225EnsemblClinVar.1
Natural variantiVAR_035086282T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677EnsemblClinVar.1
Natural variantiVAR_011847289C → W1 PublicationCorresponds to variant dbSNP:rs1064533Ensembl.1
Natural variantiVAR_011848336T → P. Corresponds to variant dbSNP:rs1801021Ensembl.1
Natural variantiVAR_070376341P → H1 PublicationCorresponds to variant dbSNP:rs17852012Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M91464 Genomic DNA Translation: AAA35569.1
Z11162 Genomic DNA Translation: CAA77513.1
M87290 mRNA Translation: AAA35535.1
S77410 mRNA Translation: AAB34644.1
M93394 mRNA Translation: AAA58370.1
D13814 mRNA Translation: BAA02968.1
X65699 mRNA Translation: CAA46621.1
AF245699 Genomic DNA Translation: AAF70464.1
AY221090 Genomic DNA Translation: AAO65968.1
BC022447 mRNA Translation: AAH22447.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3137.1
CCDS82854.1
CCDS82855.1

Protein sequence database of the Protein Information Resource

More...PIRi		I39418
JC1104

NCBI Reference Sequences

More...RefSeqi		NP_000676.1, NM_000685.4
NP_004826.5, NM_004835.4
NP_033611.1, NM_009585.3
NP_114038.4, NM_031850.3
NP_114438.2, NM_032049.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000349243.8; ENSP00000273430.3; ENSG00000144891.19
ENST00000402260.2; ENSP00000385641.3; ENSG00000144891.19
ENST00000404754.2; ENSP00000385612.2; ENSG00000144891.19
ENST00000418473.7; ENSP00000398832.4; ENSG00000144891.19
ENST00000461609.1; ENSP00000418851.1; ENSG00000144891.19
ENST00000474935.5; ENSP00000418084.1; ENSG00000144891.19
ENST00000475347.5; ENSP00000419783.1; ENSG00000144891.19
ENST00000497524.5; ENSP00000419422.1; ENSG00000144891.19

Database of genes from NCBI RefSeq genomes

More...GeneIDi		185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:185

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000349243.8; ENSP00000273430.3; NM_000685.5; NP_000676.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91464 Genomic DNA Translation: AAA35569.1
Z11162 Genomic DNA Translation: CAA77513.1
M87290 mRNA Translation: AAA35535.1
S77410 mRNA Translation: AAB34644.1
M93394 mRNA Translation: AAA58370.1
D13814 mRNA Translation: BAA02968.1
X65699 mRNA Translation: CAA46621.1
AF245699 Genomic DNA Translation: AAF70464.1
AY221090 Genomic DNA Translation: AAO65968.1
BC022447 mRNA Translation: AAH22447.1
CCDSiCCDS3137.1
CCDS82854.1
CCDS82855.1
PIRiI39418
JC1104
RefSeqiNP_000676.1, NM_000685.4
NP_004826.5, NM_004835.4
NP_033611.1, NM_009585.3
NP_114038.4, NM_031850.3
NP_114438.2, NM_032049.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YAYX-ray2.90A2-319[»]
4ZUDX-ray2.80A2-315[»]
6DO1X-ray2.90A/B2-319[»]
6OS0X-ray2.90A2-319[»]
6OS1X-ray2.79A2-319[»]
6OS2X-ray2.70A2-319[»]
AlphaFoldDBiP30556
SMRiP30556
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106691, 90 interactors
IntActiP30556, 74 interactors
MINTiP30556
STRINGi9606.ENSP00000419422

Chemistry databases

BindingDBiP30556
ChEMBLiCHEMBL227
DrugBankiDB11842, Angiotensin II
DB08822, Azilsartan medoxomil
DB13919, Candesartan
DB00796, Candesartan cilexetil
DB05739, CYT006-AngQb
DB00876, Eprosartan
DB09279, Fimasartan
DB01342, Forasartan
DB01029, Irbesartan
DB00678, Losartan
DB00275, Olmesartan
DB01347, Saprisartan
DB01349, Tasosartan
DB00966, Telmisartan
DB00177, Valsartan
DrugCentraliP30556
GuidetoPHARMACOLOGYi34

Protein family/group databases

TCDBi9.A.14.13.1, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP30556, 3 sites
iPTMnetiP30556
PhosphoSitePlusiP30556

Genetic variation databases

BioMutaiAGTR1
DMDMi231519

Proteomic databases

jPOSTiP30556
MassIVEiP30556
PaxDbiP30556
PeptideAtlasiP30556
PRIDEiP30556
ProteomicsDBi54721

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P30556, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1002, 548 antibodies from 41 providers

The DNASU plasmid repository

More...DNASUi		185

Genome annotation databases

EnsembliENST00000349243.8; ENSP00000273430.3; ENSG00000144891.19
ENST00000402260.2; ENSP00000385641.3; ENSG00000144891.19
ENST00000404754.2; ENSP00000385612.2; ENSG00000144891.19
ENST00000418473.7; ENSP00000398832.4; ENSG00000144891.19
ENST00000461609.1; ENSP00000418851.1; ENSG00000144891.19
ENST00000474935.5; ENSP00000418084.1; ENSG00000144891.19
ENST00000475347.5; ENSP00000419783.1; ENSG00000144891.19
ENST00000497524.5; ENSP00000419422.1; ENSG00000144891.19
GeneIDi185
KEGGihsa:185
MANE-SelectiENST00000349243.8; ENSP00000273430.3; NM_000685.5; NP_000676.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		185
DisGeNETi185

GeneCards: human genes, protein and diseases

More...GeneCardsi		AGTR1
HGNCiHGNC:336, AGTR1
HPAiENSG00000144891, Tissue enhanced (liver, placenta)
MalaCardsiAGTR1
MIMi106165, gene
267430, phenotype
neXtProtiNX_P30556
OpenTargetsiENSG00000144891
Orphaneti243761, NON RARE IN EUROPE: Essential hypertension
97369, Renal tubular dysgenesis of genetic origin
PharmGKBiPA43
VEuPathDBiHostDB:ENSG00000144891

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT01030000234534
HOGENOMiCLU_009579_8_3_1
InParanoidiP30556
OMAiQVFHFMQ
PhylomeDBiP30556
TreeFamiTF330024

Enzyme and pathway databases

PathwayCommonsiP30556
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
SignaLinkiP30556
SIGNORiP30556

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		185, 17 hits in 1066 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AGTR1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Angiotensin_II_receptor_type_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		185
PharosiP30556, Tclin

Protein Ontology

More...PROi		PR:P30556
RNActiP30556, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000144891, Expressed in placenta and 184 other tissues
ExpressionAtlasiP30556, baseline and differential
GenevisibleiP30556, HS

Family and domain databases

InterProiView protein in InterPro
IPR000190, ATII_AT1_rcpt
IPR000248, ATII_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00241, ANGIOTENSINR
PR00635, ANGIOTENSN1R
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGTR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30556
Secondary accession number(s): Q13725, Q8TBK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 25, 2022
This is version 204 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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