UniProtKB - P30556 (AGTR1_HUMAN)
Type-1 angiotensin II receptor
AGTR1
Functioni
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
(Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
1 PublicationGO - Molecular functioni
- angiotensin type II receptor activity Source: UniProtKB
- angiotensin type I receptor activity Source: BHF-UCL
- bradykinin receptor binding Source: BHF-UCL
- G protein-coupled receptor activity Source: GO_Central
- protein heterodimerization activity Source: BHF-UCL
GO - Biological processi
- angiotensin-activated signaling pathway Source: BHF-UCL
- blood vessel diameter maintenance Source: BHF-UCL
- calcium-mediated signaling Source: BHF-UCL
- cell chemotaxis Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- inflammatory response Source: GO_Central
- kidney development Source: BHF-UCL
- low-density lipoprotein particle remodeling Source: BHF-UCL
- maintenance of blood vessel diameter homeostasis by renin-angiotensin Source: BHF-UCL
- phospholipase C-activating angiotensin-activated signaling pathway Source: BHF-UCL
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
- positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
- positive regulation of cellular protein metabolic process Source: BHF-UCL
- positive regulation of cholesterol esterification Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: BHF-UCL
- positive regulation of inflammatory response Source: BHF-UCL
- positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
- positive regulation of NAD(P)H oxidase activity Source: BHF-UCL
- positive regulation of phospholipase A2 activity Source: BHF-UCL
- positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
- regulation of cell growth Source: BHF-UCL
- regulation of cell population proliferation Source: BHF-UCL
- regulation of inflammatory response Source: BHF-UCL
- regulation of renal sodium excretion Source: BHF-UCL
- regulation of systemic arterial blood pressure by renin-angiotensin Source: BHF-UCL
- regulation of vasoconstriction Source: BHF-UCL
- renin-angiotensin regulation of aldosterone production Source: BHF-UCL
- Rho protein signal transduction Source: UniProtKB
- viral entry into host cell Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P30556 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | P30556 |
SIGNORi | P30556 |
Protein family/group databases
TCDBi | 9.A.14.13.1, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Type-1 angiotensin II receptorCuratedAlternative name(s): AT1AR AT1BR Angiotensin II type-1 receptor Short name: AT1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:336, AGTR1 |
MIMi | 106165, gene |
neXtProti | NX_P30556 |
VEuPathDBi | HostDB:ENSG00000144891 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: BHF-UCL
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 52 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 53 – 64 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 65 – 87 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 88 – 102 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 103 – 124 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 125 – 142 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 143 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 163 – 192 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 193 – 214 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 215 – 240 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 241 – 262 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 263 – 275 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 276 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 359 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Renal tubular dysgenesis (RTD)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035086 | 282 | T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 185 |
MalaCardsi | AGTR1 |
MIMi | 267430, phenotype |
OpenTargetsi | ENSG00000144891 |
Orphaneti | 243761, NON RARE IN EUROPE: Essential hypertension 97369, Renal tubular dysgenesis of genetic origin |
PharmGKBi | PA43 |
Miscellaneous databases
Pharosi | P30556, Tclin |
Chemistry databases
ChEMBLi | CHEMBL227 |
DrugBanki | DB11842, Angiotensin II DB08822, Azilsartan medoxomil DB13919, Candesartan DB00796, Candesartan cilexetil DB05739, CYT006-AngQb DB00876, Eprosartan DB09279, Fimasartan DB01342, Forasartan DB01029, Irbesartan DB00678, Losartan DB00275, Olmesartan DB01347, Saprisartan DB01349, Tasosartan DB00966, Telmisartan DB00177, Valsartan |
DrugCentrali | P30556 |
GuidetoPHARMACOLOGYi | 34 |
Genetic variation databases
BioMutai | AGTR1 |
DMDMi | 231519 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069153 | 1 – 359 | Type-1 angiotensin II receptorAdd BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Disulfide bondi | 101 ↔ 180 | PROSITE-ProRule annotation | ||
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 355 | S-palmitoyl cysteineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
jPOSTi | P30556 |
MassIVEi | P30556 |
PaxDbi | P30556 |
PeptideAtlasi | P30556 |
PRIDEi | P30556 |
ProteomicsDBi | 54721 |
PTM databases
GlyGeni | P30556, 3 sites |
iPTMneti | P30556 |
PhosphoSitePlusi | P30556 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000144891, Expressed in placenta and 184 other tissues |
ExpressionAtlasi | P30556, baseline and differential |
Genevisiblei | P30556, HS |
Organism-specific databases
HPAi | ENSG00000144891, Tissue enhanced (liver, placenta) |
Interactioni
Subunit structurei
Binary interactionsi
P30556
GO - Molecular functioni
- bradykinin receptor binding Source: BHF-UCL
- protein heterodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 106691, 90 interactors |
IntActi | P30556, 74 interactors |
MINTi | P30556 |
STRINGi | 9606.ENSP00000419422 |
Chemistry databases
BindingDBi | P30556 |
Miscellaneous databases
RNActi | P30556, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P30556 |
SMRi | P30556 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 335 – 359 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 335 – 351 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234534 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P30556 |
OMAi | QVFHFMQ |
PhylomeDBi | P30556 |
TreeFami | TF330024 |
Family and domain databases
InterProi | View protein in InterPro IPR000190, ATII_AT1_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00635, ANGIOTENSN1R PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF
260 270 280 290 300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK
KPAPCFEVE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3DNG8 | D3DNG8_HUMAN | Type-1 angiotensin II receptor | AGTR1 hCG_2022206 | 394 | Annotation score: | ||
A0A0A0MSE3 | A0A0A0MSE3_HUMAN | Type-1 angiotensin II receptor | AGTR1 hCG_2022206 | 388 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 187 | Q → R in BAA02968 (PubMed:8135787).Curated | 1 | |
Sequence conflicti | 204 – 205 | FL → SC in BAA02968 (PubMed:8135787).Curated | 2 | |
Sequence conflicti | 232 | K → N in BAA02968 (PubMed:8135787).Curated | 1 | |
Sequence conflicti | 240 | K → R in BAA02968 (PubMed:8135787).Curated | 1 | |
Sequence conflicti | 268 | L → Q in BAA02968 (PubMed:8135787).Curated | 1 | |
Sequence conflicti | 311 – 313 | RYF → KDI in BAA02968 (PubMed:8135787).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029206 | 163 | A → T. Corresponds to variant dbSNP:rs12721226EnsemblClinVar. | 1 | |
Natural variantiVAR_070375 | 222 | L → V1 PublicationCorresponds to variant dbSNP:rs17852013Ensembl. | 1 | |
Natural variantiVAR_029207 | 244 | A → S. Corresponds to variant dbSNP:rs12721225EnsemblClinVar. | 1 | |
Natural variantiVAR_035086 | 282 | T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677EnsemblClinVar. | 1 | |
Natural variantiVAR_011847 | 289 | C → W1 PublicationCorresponds to variant dbSNP:rs1064533Ensembl. | 1 | |
Natural variantiVAR_011848 | 336 | T → P. Corresponds to variant dbSNP:rs1801021Ensembl. | 1 | |
Natural variantiVAR_070376 | 341 | P → H1 PublicationCorresponds to variant dbSNP:rs17852012Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91464 Genomic DNA Translation: AAA35569.1 Z11162 Genomic DNA Translation: CAA77513.1 M87290 mRNA Translation: AAA35535.1 S77410 mRNA Translation: AAB34644.1 M93394 mRNA Translation: AAA58370.1 D13814 mRNA Translation: BAA02968.1 X65699 mRNA Translation: CAA46621.1 AF245699 Genomic DNA Translation: AAF70464.1 AY221090 Genomic DNA Translation: AAO65968.1 BC022447 mRNA Translation: AAH22447.1 |
CCDSi | CCDS3137.1 CCDS82854.1 CCDS82855.1 |
PIRi | I39418 JC1104 |
RefSeqi | NP_000676.1, NM_000685.4 NP_004826.5, NM_004835.4 NP_033611.1, NM_009585.3 NP_114038.4, NM_031850.3 NP_114438.2, NM_032049.3 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia Angiotensin receptor entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M91464 Genomic DNA Translation: AAA35569.1 Z11162 Genomic DNA Translation: CAA77513.1 M87290 mRNA Translation: AAA35535.1 S77410 mRNA Translation: AAB34644.1 M93394 mRNA Translation: AAA58370.1 D13814 mRNA Translation: BAA02968.1 X65699 mRNA Translation: CAA46621.1 AF245699 Genomic DNA Translation: AAF70464.1 AY221090 Genomic DNA Translation: AAO65968.1 BC022447 mRNA Translation: AAH22447.1 |
CCDSi | CCDS3137.1 CCDS82854.1 CCDS82855.1 |
PIRi | I39418 JC1104 |
RefSeqi | NP_000676.1, NM_000685.4 NP_004826.5, NM_004835.4 NP_033611.1, NM_009585.3 NP_114038.4, NM_031850.3 NP_114438.2, NM_032049.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4YAY | X-ray | 2.90 | A | 2-319 | [»] | |
4ZUD | X-ray | 2.80 | A | 2-315 | [»] | |
6DO1 | X-ray | 2.90 | A/B | 2-319 | [»] | |
6OS0 | X-ray | 2.90 | A | 2-319 | [»] | |
6OS1 | X-ray | 2.79 | A | 2-319 | [»] | |
6OS2 | X-ray | 2.70 | A | 2-319 | [»] | |
AlphaFoldDBi | P30556 | |||||
SMRi | P30556 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106691, 90 interactors |
IntActi | P30556, 74 interactors |
MINTi | P30556 |
STRINGi | 9606.ENSP00000419422 |
Chemistry databases
BindingDBi | P30556 |
ChEMBLi | CHEMBL227 |
DrugBanki | DB11842, Angiotensin II DB08822, Azilsartan medoxomil DB13919, Candesartan DB00796, Candesartan cilexetil DB05739, CYT006-AngQb DB00876, Eprosartan DB09279, Fimasartan DB01342, Forasartan DB01029, Irbesartan DB00678, Losartan DB00275, Olmesartan DB01347, Saprisartan DB01349, Tasosartan DB00966, Telmisartan DB00177, Valsartan |
DrugCentrali | P30556 |
GuidetoPHARMACOLOGYi | 34 |
Protein family/group databases
TCDBi | 9.A.14.13.1, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P30556, 3 sites |
iPTMneti | P30556 |
PhosphoSitePlusi | P30556 |
Genetic variation databases
BioMutai | AGTR1 |
DMDMi | 231519 |
Proteomic databases
jPOSTi | P30556 |
MassIVEi | P30556 |
PaxDbi | P30556 |
PeptideAtlasi | P30556 |
PRIDEi | P30556 |
ProteomicsDBi | 54721 |
Protocols and materials databases
ABCDi | P30556, 3 sequenced antibodies |
Antibodypediai | 1002, 548 antibodies from 41 providers |
DNASUi | 185 |
Genome annotation databases
Organism-specific databases
CTDi | 185 |
DisGeNETi | 185 |
GeneCardsi | AGTR1 |
HGNCi | HGNC:336, AGTR1 |
HPAi | ENSG00000144891, Tissue enhanced (liver, placenta) |
MalaCardsi | AGTR1 |
MIMi | 106165, gene 267430, phenotype |
neXtProti | NX_P30556 |
OpenTargetsi | ENSG00000144891 |
Orphaneti | 243761, NON RARE IN EUROPE: Essential hypertension 97369, Renal tubular dysgenesis of genetic origin |
PharmGKBi | PA43 |
VEuPathDBi | HostDB:ENSG00000144891 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234534 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P30556 |
OMAi | QVFHFMQ |
PhylomeDBi | P30556 |
TreeFami | TF330024 |
Enzyme and pathway databases
PathwayCommonsi | P30556 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis |
SignaLinki | P30556 |
SIGNORi | P30556 |
Miscellaneous databases
BioGRID-ORCSi | 185, 17 hits in 1066 CRISPR screens |
ChiTaRSi | AGTR1, human |
GeneWikii | Angiotensin_II_receptor_type_1 |
GenomeRNAii | 185 |
Pharosi | P30556, Tclin |
PROi | PR:P30556 |
RNActi | P30556, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144891, Expressed in placenta and 184 other tissues |
ExpressionAtlasi | P30556, baseline and differential |
Genevisiblei | P30556, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000190, ATII_AT1_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00635, ANGIOTENSN1R PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGTR1_HUMAN | |
Accessioni | P30556Primary (citable) accession number: P30556 Secondary accession number(s): Q13725, Q8TBK4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families