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Entry version 192 (13 Nov 2019)
Sequence version 1 (01 Apr 1993)
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Protein

Type-1 angiotensin II receptor

Gene

AGTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P30556

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P30556

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.13.1 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type-1 angiotensin II receptor
Alternative name(s):
AT1AR
AT1BR
Angiotensin II type-1 receptor
Short name:
AT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGTR1
Synonyms:AGTR1A, AGTR1B, AT2R1, AT2R1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:336 AGTR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
106165 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30556

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 52Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini53 – 64CytoplasmicSequence analysisAdd BLAST12
Transmembranei65 – 87Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini88 – 102ExtracellularSequence analysisAdd BLAST15
Transmembranei103 – 124Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini125 – 142CytoplasmicSequence analysisAdd BLAST18
Transmembranei143 – 162Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini163 – 192ExtracellularSequence analysisAdd BLAST30
Transmembranei193 – 214Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini215 – 240CytoplasmicSequence analysisAdd BLAST26
Transmembranei241 – 262Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini263 – 275ExtracellularSequence analysisAdd BLAST13
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 359CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Renal tubular dysgenesis (RTD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035086282T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
185

MalaCards human disease database

More...
MalaCardsi
AGTR1
MIMi267430 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000144891

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
243761 NON RARE IN EUROPE: Essential hypertension
97369 Renal tubular dysgenesis of genetic origin

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA43

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P30556

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL227

Drug and drug target database

More...
DrugBanki
DB11842 Angiotensin II
DB08822 Azilsartan medoxomil
DB13919 Candesartan
DB00796 Candesartan cilexetil
DB05739 CYT006-AngQb
DB00876 Eprosartan
DB09279 Fimasartan
DB01342 Forasartan
DB01029 Irbesartan
DB00678 Losartan
DB00275 Olmesartan
DB01347 Saprisartan
DB01349 Tasosartan
DB00966 Telmisartan
DB00177 Valsartan

DrugCentral

More...
DrugCentrali
P30556

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
34

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AGTR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
231519

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000691531 – 359Type-1 angiotensin II receptorAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi4N-linked (GlcNAc...) (complex) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi101 ↔ 180PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi355S-palmitoyl cysteineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P30556

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P30556

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30556

PeptideAtlas

More...
PeptideAtlasi
P30556

PRoteomics IDEntifications database

More...
PRIDEi
P30556

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
54721

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30556

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30556

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, lung, adrenal and adrenocortical adenomas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144891 Expressed in 172 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30556 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P30556 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003596

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAS1 (Probable) (PubMed:15809376).

Interacts with ARRB1 (By similarity).

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

By similarityCurated2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106691, 31 interactors

Protein interaction database and analysis system

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IntActi
P30556, 74 interactors

Molecular INTeraction database

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MINTi
P30556

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000419422

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P30556

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30556

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00970000193411

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P30556

KEGG Orthology (KO)

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KOi
K04166

Database of Orthologous Groups

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OrthoDBi
589058at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30556

TreeFam database of animal gene trees

More...
TreeFami
TF330024

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000190 ATII_AT1_rcpt
IPR000248 ATII_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00241 ANGIOTENSINR
PR00635 ANGIOTENSN1R
PR00237 GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P30556-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF
260 270 280 290 300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK

KPAPCFEVE
Length:359
Mass (Da):41,061
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35FC856F53E911A6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3DNG8D3DNG8_HUMAN
Angiotensin II receptor, type 1, is...
AGTR1 hCG_2022206
394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSE3A0A0A0MSE3_HUMAN
Angiotensin II receptor, type 1, is...
AGTR1 hCG_2022206
388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187Q → R in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti204 – 205FL → SC in BAA02968 (PubMed:8135787).Curated2
Sequence conflicti232K → N in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti240K → R in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti268L → Q in BAA02968 (PubMed:8135787).Curated1
Sequence conflicti311 – 313RYF → KDI in BAA02968 (PubMed:8135787).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029206163A → T. Corresponds to variant dbSNP:rs12721226Ensembl.1
Natural variantiVAR_070375222L → V1 PublicationCorresponds to variant dbSNP:rs17852013Ensembl.1
Natural variantiVAR_029207244A → S. Corresponds to variant dbSNP:rs12721225Ensembl.1
Natural variantiVAR_035086282T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677Ensembl.1
Natural variantiVAR_011847289C → W1 PublicationCorresponds to variant dbSNP:rs1064533Ensembl.1
Natural variantiVAR_011848336T → P. Corresponds to variant dbSNP:rs1801021Ensembl.1
Natural variantiVAR_070376341P → H1 PublicationCorresponds to variant dbSNP:rs17852012Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M91464 Genomic DNA Translation: AAA35569.1
Z11162 Genomic DNA Translation: CAA77513.1
M87290 mRNA Translation: AAA35535.1
S77410 mRNA Translation: AAB34644.1
M93394 mRNA Translation: AAA58370.1
D13814 mRNA Translation: BAA02968.1
X65699 mRNA Translation: CAA46621.1
AF245699 Genomic DNA Translation: AAF70464.1
AY221090 Genomic DNA Translation: AAO65968.1
BC022447 mRNA Translation: AAH22447.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3137.1

Protein sequence database of the Protein Information Resource

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PIRi
I39418
JC1104

NCBI Reference Sequences

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RefSeqi
NP_000676.1, NM_000685.4
NP_004826.5, NM_004835.4
NP_033611.1, NM_009585.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000349243; ENSP00000273430; ENSG00000144891
ENST00000404754; ENSP00000385612; ENSG00000144891
ENST00000461609; ENSP00000418851; ENSG00000144891
ENST00000474935; ENSP00000418084; ENSG00000144891
ENST00000475347; ENSP00000419783; ENSG00000144891
ENST00000497524; ENSP00000419422; ENSG00000144891

Database of genes from NCBI RefSeq genomes

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GeneIDi
185

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:185

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91464 Genomic DNA Translation: AAA35569.1
Z11162 Genomic DNA Translation: CAA77513.1
M87290 mRNA Translation: AAA35535.1
S77410 mRNA Translation: AAB34644.1
M93394 mRNA Translation: AAA58370.1
D13814 mRNA Translation: BAA02968.1
X65699 mRNA Translation: CAA46621.1
AF245699 Genomic DNA Translation: AAF70464.1
AY221090 Genomic DNA Translation: AAO65968.1
BC022447 mRNA Translation: AAH22447.1
CCDSiCCDS3137.1
PIRiI39418
JC1104
RefSeqiNP_000676.1, NM_000685.4
NP_004826.5, NM_004835.4
NP_033611.1, NM_009585.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZV0model-B1-359[»]
4YAYX-ray2.90A2-319[»]
4ZUDX-ray2.80A2-315[»]
6DO1X-ray2.90A/B2-319[»]
SMRiP30556
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi106691, 31 interactors
IntActiP30556, 74 interactors
MINTiP30556
STRINGi9606.ENSP00000419422

Chemistry databases

BindingDBiP30556
ChEMBLiCHEMBL227
DrugBankiDB11842 Angiotensin II
DB08822 Azilsartan medoxomil
DB13919 Candesartan
DB00796 Candesartan cilexetil
DB05739 CYT006-AngQb
DB00876 Eprosartan
DB09279 Fimasartan
DB01342 Forasartan
DB01029 Irbesartan
DB00678 Losartan
DB00275 Olmesartan
DB01347 Saprisartan
DB01349 Tasosartan
DB00966 Telmisartan
DB00177 Valsartan
DrugCentraliP30556
GuidetoPHARMACOLOGYi34

Protein family/group databases

TCDBi9.A.14.13.1 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP30556
PhosphoSitePlusiP30556

Polymorphism and mutation databases

BioMutaiAGTR1
DMDMi231519

Proteomic databases

jPOSTiP30556
MassIVEiP30556
PaxDbiP30556
PeptideAtlasiP30556
PRIDEiP30556
ProteomicsDBi54721

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
185

Genome annotation databases

EnsembliENST00000349243; ENSP00000273430; ENSG00000144891
ENST00000404754; ENSP00000385612; ENSG00000144891
ENST00000461609; ENSP00000418851; ENSG00000144891
ENST00000474935; ENSP00000418084; ENSG00000144891
ENST00000475347; ENSP00000419783; ENSG00000144891
ENST00000497524; ENSP00000419422; ENSG00000144891
GeneIDi185
KEGGihsa:185

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
185
DisGeNETi185

GeneCards: human genes, protein and diseases

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GeneCardsi
AGTR1
HGNCiHGNC:336 AGTR1
HPAiHPA003596
MalaCardsiAGTR1
MIMi106165 gene
267430 phenotype
neXtProtiNX_P30556
OpenTargetsiENSG00000144891
Orphaneti243761 NON RARE IN EUROPE: Essential hypertension
97369 Renal tubular dysgenesis of genetic origin
PharmGKBiPA43

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00970000193411
InParanoidiP30556
KOiK04166
OrthoDBi589058at2759
PhylomeDBiP30556
TreeFamiTF330024

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP30556
SIGNORiP30556

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AGTR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Angiotensin_II_receptor_type_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
185
PharosiP30556

Protein Ontology

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PROi
PR:P30556

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144891 Expressed in 172 organ(s), highest expression level in placenta
ExpressionAtlasiP30556 baseline and differential
GenevisibleiP30556 HS

Family and domain databases

InterProiView protein in InterPro
IPR000190 ATII_AT1_rcpt
IPR000248 ATII_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00241 ANGIOTENSINR
PR00635 ANGIOTENSN1R
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGTR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30556
Secondary accession number(s): Q13725, Q8TBK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 13, 2019
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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