Type-1 angiotensin II receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• angiotensin type II receptor activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation."
    Barnes W.G., Reiter E., Violin J.D., Ren X.-R., Milligan G., Lefkowitz R.J.
    J. Biol. Chem. 280:8041-8050(2005) [PubMed] [Europe PMC] [Abstract]
• angiotensin type I receptor activity Source: BHF-UCLInferred from direct assayⁱ
  • "AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration."
    AbdAlla S., Lother H., Quitterer U.
    Nature 407:94-98(2000) [PubMed] [Europe PMC] [Abstract]
• bradykinin receptor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration."
    AbdAlla S., Lother H., Quitterer U.
    Nature 407:94-98(2000) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration."
    AbdAlla S., Lother H., Quitterer U.
    Nature 407:94-98(2000) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiotensin-activated signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • Ref.3

    "Cloning and characterization of a human angiotensin II type 1 receptor."
    Bergsma D.J., Ellis C., Kumar C., Nuthalaganti P., Kersten H., Elshourbagy N.A., Griffin E., Stadel J.M., Aiyar N.
    Biochem. Biophys. Res. Commun. 183:989-995(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• calcium-mediated signaling Source: BHF-UCLInferred from direct assayⁱ
  • Ref.3

    "Cloning and characterization of a human angiotensin II type 1 receptor."
    Bergsma D.J., Ellis C., Kumar C., Nuthalaganti P., Kersten H., Elshourbagy N.A., Griffin E., Stadel J.M., Aiyar N.
    Biochem. Biophys. Res. Commun. 183:989-995(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• cell chemotaxis Source: UniProtKBInferred from direct assayⁱ
  • "Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis."
    Hunton D.L., Barnes W.G., Kim J., Ren X.-R., Violin J.D., Reiter E., Milligan G., Patel D.D., Lefkowitz R.J.
    Mol. Pharmacol. 67:1229-1236(2005) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.15

    "Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."
    Gribouval O., Gonzales M., Neuhaus T., Aziza J., Bieth E., Laurent N., Bouton J.M., Feuillet F., Makni S., Ben Amar H., Laube G., Delezoide A.-L., Bouvier R., Dijoud F., Ollagnon-Roman E., Roume J., Joubert M., Antignac C., Gubler M.-C.
    Nat. Genet. 37:964-968(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: VARIANT RTD MET-282.
• low-density lipoprotein particle remodeling Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation."
    Luchtefeld M., Bandlow N., Tietge U.J., Grote K., Pfeilschifter J., Kaszkin M., Beck S., Drexler H., Schieffer B.
    Atherosclerosis 194:62-70(2007) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating angiotensin-activated signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive Neovascularization."
    Pankratz F., Bemtgen X., Zeiser R., Leonhardt F., Kreuzaler S., Hilgendorf I., Smolka C., Helbing T., Hoefer I., Esser J.S., Kustermann M., Moser M., Bode C., Grundmann S.
    Circulation 131:1575-1589(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cellular protein metabolic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages."
    Kanome T., Watanabe T., Nishio K., Takahashi K., Hongo S., Miyazaki A.
    Hypertens. Res. 31:1801-1810(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cholesterol esterification Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages."
    Kanome T., Watanabe T., Nishio K., Takahashi K., Hongo S., Miyazaki A.
    Hypertens. Res. 31:1801-1810(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: BHF-UCLInferred from direct assayⁱ
  • Ref.3

    "Cloning and characterization of a human angiotensin II type 1 receptor."
    Bergsma D.J., Ellis C., Kumar C., Nuthalaganti P., Kersten H., Elshourbagy N.A., Griffin E., Stadel J.M., Aiyar N.
    Biochem. Biophys. Res. Commun. 183:989-995(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • Ref.3

    "Cloning and characterization of a human angiotensin II type 1 receptor."
    Bergsma D.J., Ellis C., Kumar C., Nuthalaganti P., Kersten H., Elshourbagy N.A., Griffin E., Stadel J.M., Aiyar N.
    Biochem. Biophys. Res. Commun. 183:989-995(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of inflammatory response Source: BHF-UCLTraceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages."
    Kanome T., Watanabe T., Nishio K., Takahashi K., Hongo S., Miyazaki A.
    Hypertens. Res. 31:1801-1810(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NAD(P)H oxidase activity Source: BHF-UCLTraceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phospholipase A2 activity Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Angiotensin II type 1-receptor antagonism prevents type IIA secretory phospholipase A2-dependent lipid peroxidation."
    Luchtefeld M., Bandlow N., Tietge U.J., Grote K., Pfeilschifter J., Kaszkin M., Beck S., Drexler H., Schieffer B.
    Atherosclerosis 194:62-70(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of reactive oxygen species metabolic process Source: BHF-UCLTraceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of blood vessel diameter Source: BHF-UCLInferred by curatorⁱ
  • Ref.1

    "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• regulation of blood vessel diameter by renin-angiotensin Source: BHF-UCLInferred by curatorⁱ
  • "AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration."
    AbdAlla S., Lother H., Quitterer U.
    Nature 407:94-98(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of cell growth Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of inflammatory response Source: BHF-UCLInferred by curatorⁱ
  • Ref.1

    "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• regulation of renal sodium excretion Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of systemic arterial blood pressure by renin-angiotensin Source: BHF-UCLInferred by curatorⁱ
  • Ref.1

    "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor."
    Mauzy C.A., Hwang O., Egloff A.M., Wu L.H., Chung F.-Z.
    Biochem. Biophys. Res. Commun. 186:277-284(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
• regulation of vasoconstriction Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries."
    Batenburg W.W., Garrelds I.M., Bernasconi C.C., Juillerat-Jeanneret L., van Kats J.P., Saxena P.R., Danser A.H.
    Circulation 109:2296-2301(2004) [PubMed] [Europe PMC] [Abstract]
• renin-angiotensin regulation of aldosterone production Source: BHF-UCLNon-traceable author statementⁱ
  • "Cross-talk between angiotensin II receptor types 1 and 2: potential role in vascular remodeling in humans."
    Hernandez Schulman I., Zhou M.S., Raij L.
    Hypertension 49:270-271(2007) [PubMed] [Europe PMC] [Abstract]
• Rho protein signal transduction Source: UniProtKBInferred from direct assayⁱ
  • "beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation."
    Barnes W.G., Reiter E., Violin J.D., Ren X.-R., Milligan G., Lefkowitz R.J.
    J. Biol. Chem. 280:8041-8050(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• bradykinin receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration."
    AbdAlla S., Lother H., Quitterer U.
    Nature 407:94-98(2000) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: BHF-UCLInferred from physical interactionⁱ
  • "AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration."
    AbdAlla S., Lother H., Quitterer U.
    Nature 407:94-98(2000) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV 
        60         70         80         90        100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL 
       110        120        130        140        150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI 
       160        170        180        190        200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN 
       210        220        230        240        250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF 
       260        270        280        290        300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL 
       310        320        330        340        350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK 

KPAPCFEVE                                              

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
3. SIMILARITY comments
   Index of protein domains and families
4. Human chromosome 3
   Human chromosome 3: entries, gene names and cross-references to MIM
5. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
6. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
7. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references