AGTR1

Functionⁱ

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functionⁱ

angiotensin type II receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15611106
angiotensin type I receptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10993080
bradykinin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10993080
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10993080

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

angiotensin-activated signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 1567413
calcium-mediated signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 1567413
cell chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 15635042
G protein-coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 1378723
kidney development
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16116425
low-density lipoprotein particle remodeling
Source: BHF-UCL
Non-traceable author statementⁱ
- 17069818
phospholipase C-activating angiotensin-activated signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 1378723
phospholipase C-activating G protein-coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 1378723
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Source: BHF-UCL
Inferred from genetic interactionⁱ
- 25850724
positive regulation of cellular protein metabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18971559
positive regulation of cholesterol esterification
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18971559
positive regulation of cytosolic calcium ion concentration
Source: BHF-UCL
Inferred from direct assayⁱ
- 1567413
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 1567413
positive regulation of inflammatory response
Source: BHF-UCL
Traceable author statementⁱ
- 17159080
positive regulation of macrophage derived foam cell differentiation
Source: BHF-UCL
Inferred by curatorⁱ
- 18971559
positive regulation of NAD(P)H oxidase activity
Source: BHF-UCL
Traceable author statementⁱ
- 17159080
positive regulation of phospholipase A2 activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17069818
positive regulation of reactive oxygen species metabolic process
Source: BHF-UCL
Traceable author statementⁱ
- 17159080
regulation of blood vessel diameter
Source: BHF-UCL
Inferred by curatorⁱ
- 1378723
regulation of blood vessel diameter by renin-angiotensin
Source: BHF-UCL
Inferred by curatorⁱ
- 10993080
regulation of cell growth
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
regulation of cell proliferation
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
regulation of inflammatory response
Source: BHF-UCL
Inferred by curatorⁱ
- 1378723
regulation of renal sodium excretion
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
regulation of systemic arterial blood pressure by renin-angiotensin
Source: BHF-UCL
Inferred by curatorⁱ
- 1378723
regulation of vasoconstriction
Source: BHF-UCL
Inferred from direct assayⁱ
- 15117835
renin-angiotensin regulation of aldosterone production
Source: BHF-UCL
Non-traceable author statementⁱ
- 17159080
Rho protein signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 15611106

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	P30556
SIGNORⁱ	P30556

Protein family/group databases

TCDBⁱ

9.A.14.13.1 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Type-1 angiotensin II receptor Alternative name(s): AT1AR AT1BR Angiotensin II type-1 receptor Short name: AT1
Gene namesⁱ	Name:AGTR1 Synonyms:AGTR1A, AGTR1B, AT2R1, AT2R1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144891.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:336 AGTR1
MIMⁱ	106165 gene
neXtProtⁱ	NX_P30556

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 27	ExtracellularSequence analysisAdd BLAST	27
Transmembraneⁱ	28 – 52	Helical; Name=1Sequence analysisAdd BLAST	25
Topological domainⁱ	53 – 64	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	65 – 87	Helical; Name=2Sequence analysisAdd BLAST	23
Topological domainⁱ	88 – 102	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	103 – 124	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	125 – 142	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	143 – 162	Helical; Name=4Sequence analysisAdd BLAST	20
Topological domainⁱ	163 – 192	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	193 – 214	Helical; Name=5Sequence analysisAdd BLAST	22
Topological domainⁱ	215 – 240	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	241 – 262	Helical; Name=6Sequence analysisAdd BLAST	22
Topological domainⁱ	263 – 275	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	276 – 296	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	297 – 359	CytoplasmicSequence analysisAdd BLAST	63

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Renal tubular dysgenesis (RTD)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035086	282	T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677Ensembl.		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	185
MalaCards human disease database More...MalaCardsⁱ	AGTR1
MIMⁱ	267430 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000144891
Orphanetⁱ	243761 NON RARE IN EUROPE: Essential hypertension 97369 Renal tubular dysgenesis of genetic origin
PharmGKBⁱ	PA43

Chemistry databases

ChEMBLⁱ	CHEMBL227
Drug and drug target database More...DrugBankⁱ	DB08822 Azilsartan medoxomil DB00796 Candesartan DB05739 CYT006-AngQb DB00876 Eprosartan DB01342 Forasartan DB01029 Irbesartan DB00678 Losartan DB00275 Olmesartan DB01347 Saprisartan DB01349 Tasosartan DB00966 Telmisartan DB00177 Valsartan
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	34

Polymorphism and mutation databases

BioMutaⁱ	AGTR1
DMDMⁱ	231519

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069153	1 – 359	Type-1 angiotensin II receptorAdd BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	4	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Disulfide bondⁱ	101 ↔ 180	PROSITE-ProRule annotation
Glycosylationⁱ	176	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	188	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	355	S-palmitoyl cysteineSequence analysis	1

Post-translational modificationⁱ

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbⁱ	P30556
PeptideAtlas More...PeptideAtlasⁱ	P30556
PRIDEⁱ	P30556
ProteomicsDBⁱ	54721

PTM databases

iPTMnetⁱ	P30556
PhosphoSitePlusⁱ	P30556

Expressionⁱ

Tissue specificityⁱ

Liver, lung, adrenal and adrenocortical adenomas.

Gene expression databases

Bgeeⁱ	ENSG00000144891 Expressed in 172 organ(s), highest expression level in placenta
CleanExⁱ	HS_AGTR1
ExpressionAtlasⁱ	P30556 baseline and differential
Genevisibleⁱ	P30556 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003596

HPAⁱ

HPA003596

Interactionⁱ

Subunit structureⁱ

Interacts with MAS1 (Probable) (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).By similarityCurated2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AGT	P01019	2	EBI-6623016,EBI-6622938

With

Entry

#Exp.

IntAct

Notes

AGT

P01019

2

EBI-6623016,EBI-6622938

GO - Molecular functionⁱ

bradykinin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10993080
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10993080

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106691, 31 interactors
IntActⁱ	P30556, 5 interactors
Molecular INTeraction database More...MINTⁱ	P30556
STRINGⁱ	9606.ENSP00000273430

Chemistry databases

BindingDBⁱ

P30556

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	17 – 20	Combined sources	4
Helixⁱ	27 – 55	Combined sources	29
Turnⁱ	56 – 59	Combined sources	4
Helixⁱ	62 – 80	Combined sources	19
Helixⁱ	82 – 89	Combined sources	8
Helixⁱ	98 – 131	Combined sources	34
Helixⁱ	142 – 159	Combined sources	18
Helixⁱ	161 – 166	Combined sources	6
Beta strandⁱ	167 – 174	Combined sources	8
Beta strandⁱ	178 – 182	Combined sources	5
Helixⁱ	191 – 194	Combined sources	4
Helixⁱ	198 – 203	Combined sources	6
Helixⁱ	205 – 221	Combined sources	17
Helixⁱ	236 – 267	Combined sources	32
Beta strandⁱ	269 – 271	Combined sources	3
Helixⁱ	274 – 292	Combined sources	19
Helixⁱ	294 – 303	Combined sources	10
Helixⁱ	306 – 316	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P30556
SMRⁱ	P30556
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119055
HOVERGENⁱ	HBG104998
InParanoidⁱ	P30556
KEGG Orthology (KO) More...KOⁱ	K04166
PhylomeDBⁱ	P30556
TreeFamⁱ	TF330024

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15192 7tmA_AT1R, 1 hit
InterProⁱ	View protein in InterPro IPR000190 ATII_AT1_rcpt IPR000248 ATII_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00241 ANGIOTENSINR PR00635 ANGIOTENSN1R PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P30556-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MILNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV 
        60         70         80         90        100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNYL 
       110        120        130        140        150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI 
       160        170        180        190        200
IIWLLAGLAS LPAIIHRNVF FIENTNITVC AFHYESQNST LPIGLGLTKN 
       210        220        230        240        250
ILGFLFPFLI ILTSYTLIWK ALKKAYEIQK NKPRNDDIFK IIMAIVLFFF 
       260        270        280        290        300
FSWIPHQIFT FLDVLIQLGI IRDCRIADIV DTAMPITICI AYFNNCLNPL 
       310        320        330        340        350
FYGFLGKKFK RYFLQLLKYI PPKAKSHSNL STKMSTLSYR PSDNVSSSTK 

KPAPCFEVE

Length:359

Mass (Da):41,061

Last modified:April 1, 1993 - v1

Checksum:ⁱ35FC856F53E911A6

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3DNG8	D3DNG8_HUMAN	Angiotensin II receptor, type 1, is... Angiotensin II receptor, type 1, isoform CRA_a (Type-1 angiotensin II receptor)	AGTR1 hCG_2022206	394	Annotation score:
A0A0A0MSE3	A0A0A0MSE3_HUMAN	Angiotensin II receptor, type 1, is... Angiotensin II receptor, type 1, isoform CRA_c (Type-1 angiotensin II receptor)	AGTR1 hCG_2022206	388	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	187	Q → R in BAA02968 (PubMed:8135787).Curated	1
Sequence conflictⁱ	204 – 205	FL → SC in BAA02968 (PubMed:8135787).Curated	2
Sequence conflictⁱ	232	K → N in BAA02968 (PubMed:8135787).Curated	1
Sequence conflictⁱ	240	K → R in BAA02968 (PubMed:8135787).Curated	1
Sequence conflictⁱ	268	L → Q in BAA02968 (PubMed:8135787).Curated	1
Sequence conflictⁱ	311 – 313	RYF → KDI in BAA02968 (PubMed:8135787).Curated	3

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029206	163	A → T. Corresponds to variant dbSNP:rs12721226Ensembl.	1
Natural variantⁱVAR_070375	222	L → V1 PublicationCorresponds to variant dbSNP:rs17852013Ensembl.	1
Natural variantⁱVAR_029207	244	A → S. Corresponds to variant dbSNP:rs12721225Ensembl.	1
Natural variantⁱVAR_035086	282	T → M in RTD. 1 PublicationCorresponds to variant dbSNP:rs104893677Ensembl.	1
Natural variantⁱVAR_011847	289	C → W1 PublicationCorresponds to variant dbSNP:rs1064533Ensembl.	1
Natural variantⁱVAR_011848	336	T → P. Corresponds to variant dbSNP:rs1801021Ensembl.	1
Natural variantⁱVAR_070376	341	P → H1 PublicationCorresponds to variant dbSNP:rs17852012Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M91464 Genomic DNA Translation: AAA35569.1 Z11162 Genomic DNA Translation: CAA77513.1 M87290 mRNA Translation: AAA35535.1 S77410 mRNA Translation: AAB34644.1 M93394 mRNA Translation: AAA58370.1 D13814 mRNA Translation: BAA02968.1 X65699 mRNA Translation: CAA46621.1 AF245699 Genomic DNA Translation: AAF70464.1 AY221090 Genomic DNA Translation: AAO65968.1 BC022447 mRNA Translation: AAH22447.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3137.1
PIRⁱ	I39418 JC1104
NCBI Reference Sequences More...RefSeqⁱ	NP_000676.1, NM_000685.4 NP_004826.5, NM_004835.4 NP_033611.1, NM_009585.3
UniGeneⁱ	Hs.477887 Hs.744837

Genome annotation databases

Ensemblⁱ	ENST00000349243; ENSP00000273430; ENSG00000144891 ENST00000404754; ENSP00000385612; ENSG00000144891 ENST00000461609; ENSP00000418851; ENSG00000144891 ENST00000474935; ENSP00000418084; ENSG00000144891 ENST00000475347; ENSP00000419783; ENSG00000144891 ENST00000497524; ENSP00000419422; ENSG00000144891
GeneIDⁱ	185
KEGGⁱ	hsa:185

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30556	Angiotensin II receptor, type 1, isoform CRA_a		HUMAN		394	UniRef100_P30556
Angiotensin II receptor, type 1		HUMAN		359
Type 1 angiotensin II receptor isoform (Fragment)		HUMAN		43

Protein	Similar proteins		Species	Score	Length	Source
P30556	Type-1A angiotensin II receptor	)	RAT		359	UniRef90_P25095
Type-1 angiotensin II receptor		CAVPO		359
Type-1 angiotensin II receptor		CANLF		359
Type-1 angiotensin II receptor		BOVIN		359
Type-1 angiotensin II receptor		MERUN		359
+173

Protein	Similar proteins		Species	Score	Length	Source
P30556	Type-1A angiotensin II receptor	)	RAT		359	UniRef50_P25095
Type-1 angiotensin II receptor		BOVIN		359
Type-1 angiotensin II receptor		CANLF		359
Type-1 angiotensin II receptor		SHEEP		359
Type-1 angiotensin II receptor		MERUN		359
+213

Cross-referencesⁱ

Web resourcesⁱ

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Angiotensin receptor entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M91464 Genomic DNA Translation: AAA35569.1 Z11162 Genomic DNA Translation: CAA77513.1 M87290 mRNA Translation: AAA35535.1 S77410 mRNA Translation: AAB34644.1 M93394 mRNA Translation: AAA58370.1 D13814 mRNA Translation: BAA02968.1 X65699 mRNA Translation: CAA46621.1 AF245699 Genomic DNA Translation: AAF70464.1 AY221090 Genomic DNA Translation: AAO65968.1 BC022447 mRNA Translation: AAH22447.1
CCDSⁱ	CCDS3137.1
PIRⁱ	I39418 JC1104
RefSeqⁱ	NP_000676.1, NM_000685.4 NP_004826.5, NM_004835.4 NP_033611.1, NM_009585.3
UniGeneⁱ	Hs.477887 Hs.744837

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ZV0	model	-	B	1-359	[»]
	4YAY	X-ray	2.90	A	2-319	[»]
	4ZUD	X-ray	2.80	A	2-315	[»]
ProteinModelPortalⁱ	P30556
SMRⁱ	P30556
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106691, 31 interactors
IntActⁱ	P30556, 5 interactors
MINTⁱ	P30556
STRINGⁱ	9606.ENSP00000273430

Chemistry databases

BindingDBⁱ	P30556
ChEMBLⁱ	CHEMBL227
DrugBankⁱ	DB08822 Azilsartan medoxomil DB00796 Candesartan DB05739 CYT006-AngQb DB00876 Eprosartan DB01342 Forasartan DB01029 Irbesartan DB00678 Losartan DB00275 Olmesartan DB01347 Saprisartan DB01349 Tasosartan DB00966 Telmisartan DB00177 Valsartan
GuidetoPHARMACOLOGYⁱ	34

Protein family/group databases

TCDBⁱ	9.A.14.13.1 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	P30556
PhosphoSitePlusⁱ	P30556

Polymorphism and mutation databases

BioMutaⁱ	AGTR1
DMDMⁱ	231519

Proteomic databases

PaxDbⁱ	P30556
PeptideAtlasⁱ	P30556
PRIDEⁱ	P30556
ProteomicsDBⁱ	54721

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	185
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000349243; ENSP00000273430; ENSG00000144891 ENST00000404754; ENSP00000385612; ENSG00000144891 ENST00000461609; ENSP00000418851; ENSG00000144891 ENST00000474935; ENSP00000418084; ENSG00000144891 ENST00000475347; ENSP00000419783; ENSG00000144891 ENST00000497524; ENSP00000419422; ENSG00000144891
GeneIDⁱ	185
KEGGⁱ	hsa:185

Organism-specific databases

CTDⁱ	185
DisGeNETⁱ	185
EuPathDBⁱ	HostDB:ENSG00000144891.17
GeneCardsⁱ	AGTR1
HGNCⁱ	HGNC:336 AGTR1
HPAⁱ	HPA003596
MalaCardsⁱ	AGTR1
MIMⁱ	106165 gene 267430 phenotype
neXtProtⁱ	NX_P30556
OpenTargetsⁱ	ENSG00000144891
Orphanetⁱ	243761 NON RARE IN EUROPE: Essential hypertension 97369 Renal tubular dysgenesis of genetic origin
PharmGKBⁱ	PA43
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000119055
HOVERGENⁱ	HBG104998
InParanoidⁱ	P30556
KOⁱ	K04166
PhylomeDBⁱ	P30556
TreeFamⁱ	TF330024

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkⁱ	P30556
SIGNORⁱ	P30556

Miscellaneous databases

GeneWikiⁱ	Angiotensin_II_receptor_type_1
GenomeRNAiⁱ	185
Protein Ontology More...PROⁱ	PR:P30556
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144891 Expressed in 172 organ(s), highest expression level in placenta
CleanExⁱ	HS_AGTR1
ExpressionAtlasⁱ	P30556 baseline and differential
Genevisibleⁱ	P30556 HS

Family and domain databases

CDDⁱ	cd15192 7tmA_AT1R, 1 hit
InterProⁱ	View protein in InterPro IPR000190 ATII_AT1_rcpt IPR000248 ATII_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00241 ANGIOTENSINR PR00635 ANGIOTENSN1R PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGTR1_HUMAN
Accessionⁱ	P30556Primary (citable) accession number: P30556 Secondary accession number(s): Q13725, Q8TBK4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	April 1, 1993
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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Supporting data

UniProtKB - P30556 (AGTR1_HUMAN)

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Type-1 angiotensin II receptor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ