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Protein

Proto-oncogene Mas

Gene

Mas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (By similarity). Receptor for angiotensin 1-7.By similarity1 Publication

GO - Molecular functioni

  • angiotensin receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: MGI
  • peptide binding Source: UniProtKB
  • peptide hormone binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Proto-oncogene Mas
Gene namesi
Name:Mas1
Synonyms:Mas, Mas-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:96918 Mas1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 60Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini61 – 64CytoplasmicSequence analysis4
Transmembranei65 – 86Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini87 – 103ExtracellularSequence analysisAdd BLAST17
Transmembranei104 – 127Helical; Name=3Sequence analysisAdd BLAST24
Topological domaini128 – 148CytoplasmicSequence analysisAdd BLAST21
Transmembranei149 – 171Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini172 – 184ExtracellularSequence analysisAdd BLAST13
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 223CytoplasmicSequence analysisAdd BLAST18
Transmembranei224 – 244Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini245 – 262ExtracellularSequence analysisAdd BLAST18
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 324CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Chemistry databases

GuidetoPHARMACOLOGYi150

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697151 – 324Proto-oncogene MasAdd BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP30554
PRIDEiP30554

PTM databases

iPTMnetiP30554
PhosphoSitePlusiP30554

Expressioni

Gene expression databases

BgeeiENSMUSG00000068037
CleanExiMM_MAS1
ExpressionAtlasiP30554 baseline and differential
GenevisibleiP30554 MM

Interactioni

Subunit structurei

Interacts with AGTR1. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086409

Structurei

3D structure databases

ProteinModelPortaliP30554
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFZP Eukaryota
ENOG410YK5N LUCA
GeneTreeiENSGT00550000074531
HOGENOMiHOG000015412
HOVERGENiHBG098384
InParanoidiP30554
KOiK04303
OMAiPLGFVEN
OrthoDBiEOG091G0BGC
PhylomeDBiP30554
TreeFamiTF336336

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR026234 MRGPCRFAMILY
IPR000820 Proto-oncogene_Mas
PANTHERiPTHR11334 PTHR11334, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00533 MASONCOGENE
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30554-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSNMTSLA EEKAMNTSSR NASLGSSHPP IPIVHWVIMS ISPLGFVENG
60 70 80 90 100
ILLWFLCFRM RRNPFTVYIT HLSIADISLL FCIFILSIDY ALDYELSSGH
110 120 130 140 150
HYTIVTLSVT FLFGYNTGLY LLTAISVERC LSVLYPIWYR CHRPKHQSAF
160 170 180 190 200
VCALLWALSC LVTTMEYVMC IDSGEESHSR SDCRAVIIFI AILSFLVFTP
210 220 230 240 250
LMLVSSTILV VKIRKNTWAS HSSKLYIVIM VTIIIFLIFA MPMRVLYLLY
260 270 280 290 300
YEYWSAFGNL HNISLLFSTI NSSANPFIYF FVGSSKKKRF RESLKVVLTR
310 320
AFKDEMQPRR QEGNGNTVSI ETVV
Length:324
Mass (Da):37,055
Last modified:December 6, 2005 - v2
Checksum:i1708FCECAF4656A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19S → I in AAB69120 (PubMed:16141072).Curated1
Sequence conflicti74I → M in CAA47964 (PubMed:8001672).Curated1
Sequence conflicti140 – 141RC → TS in CAA47964 (PubMed:8001672).Curated2
Sequence conflicti156W → C in CAA47964 (PubMed:8001672).Curated1
Sequence conflicti207T → S in CAA47964 (PubMed:8001672).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67735 Genomic DNA Translation: CAA47964.1
AK030261 mRNA Translation: BAC26865.1
AK030265 mRNA Translation: BAC26868.1
U96273 mRNA Translation: AAB69120.1
CCDSiCCDS28394.1
PIRiS51001
RefSeqiNP_032578.2, NM_008552.5
XP_006523356.1, XM_006523293.3
XP_006523357.1, XM_006523294.3
XP_006523359.1, XM_006523296.3
XP_006523360.1, XM_006523297.3
XP_006523362.1, XM_006523299.3
XP_011244492.1, XM_011246190.2
XP_011244493.1, XM_011246191.2
XP_011244494.1, XM_011246192.2
XP_011244495.1, XM_011246193.2
XP_017172759.1, XM_017317270.1
XP_017172760.1, XM_017317271.1
XP_017172761.1, XM_017317272.1
XP_017172762.1, XM_017317273.1
XP_017172763.1, XM_017317274.1
UniGeneiMm.425994

Genome annotation databases

EnsembliENSMUST00000089015; ENSMUSP00000086409; ENSMUSG00000068037
ENSMUST00000161747; ENSMUSP00000123902; ENSMUSG00000068037
ENSMUST00000162333; ENSMUSP00000125108; ENSMUSG00000068037
ENSMUST00000165020; ENSMUSP00000132300; ENSMUSG00000068037
ENSMUST00000167152; ENSMUSP00000131341; ENSMUSG00000068037
GeneIDi17171
KEGGimmu:17171
UCSCiuc008ald.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMAS_MOUSE
AccessioniPrimary (citable) accession number: P30554
Secondary accession number(s): O35944, Q8BHI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 6, 2005
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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