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Protein

Gastrin-releasing peptide receptor

Gene

GRPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity).By similarity1 Publication

GO - Molecular functioni

  • G protein-coupled peptide receptor activity Source: UniProtKB
  • G protein-coupled receptor activity Source: GO_Central
  • neuropeptide binding Source: Ensembl
  • neuropeptide receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP30550

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin-releasing peptide receptor
Short name:
GRP-R
Alternative name(s):
GRP-preferring bombesin receptor
Gene namesi
Name:GRPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000126010.5
HGNCiHGNC:4609 GRPR
MIMi305670 gene
neXtProtiNX_P30550

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 62Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini63 – 76CytoplasmicSequence analysisAdd BLAST14
Transmembranei77 – 96Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini97 – 114ExtracellularSequence analysisAdd BLAST18
Transmembranei115 – 136Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini137 – 152CytoplasmicSequence analysisAdd BLAST16
Transmembranei153 – 174Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini175 – 208ExtracellularSequence analysisAdd BLAST34
Transmembranei209 – 234Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini235 – 264CytoplasmicSequence analysisAdd BLAST30
Transmembranei265 – 285Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini286 – 298ExtracellularSequence analysisAdd BLAST13
Transmembranei299 – 325Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini326 – 384CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2925
OpenTargetsiENSG00000126010
PharmGKBiPA29002

Chemistry databases

ChEMBLiCHEMBL4959
GuidetoPHARMACOLOGYi39

Polymorphism and mutation databases

BioMutaiGRPR
DMDMi232185

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696621 – 384Gastrin-releasing peptide receptorAdd BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi113 ↔ 196PROSITE-ProRule annotation
Lipidationi339S-palmitoyl cysteineBy similarity1
Modified residuei350PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP30550
PaxDbiP30550
PeptideAtlasiP30550
PRIDEiP30550
ProteomicsDBi54720

PTM databases

iPTMnetiP30550
PhosphoSitePlusiP30550

Expressioni

Tissue specificityi

Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.1 Publication

Gene expression databases

BgeeiENSG00000126010 Expressed in 48 organ(s), highest expression level in body of pancreas
CleanExiHS_GRPR
ExpressionAtlasiP30550 baseline and differential
GenevisibleiP30550 HS

Organism-specific databases

HPAiHPA069604

Interactioni

Protein-protein interaction databases

BioGridi109181, 63 interactors
STRINGi9606.ENSP00000369643

Chemistry databases

BindingDBiP30550

Structurei

3D structure databases

ProteinModelPortaliP30550
SMRiP30550
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000230781
HOVERGENiHBG004898
InParanoidiP30550
KOiK04169
OMAiNICHEGY
OrthoDBiEOG091G085Y
PhylomeDBiP30550
TreeFamiTF331292

Family and domain databases

CDDicd15124 7tmA_GRPR, 1 hit
InterProiView protein in InterPro
IPR001556 Bombsn_rcpt-like
IPR001966 Gastrin_pep_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00358 BOMBESINR
PR00640 GASTRINRELPR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30550-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI
60 70 80 90 100
ILIGLIGNIT LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR
110 120 130 140 150
YLADRWLFGR IGCKLIPFIQ LTSVGVSVFT LTALSADRYK AIVRPMDIQA
160 170 180 190 200
SHALMKICLK AAFIWIISML LAIPEAVFSD LHPFHEESTN QTFISCAPYP
210 220 230 240 250
HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS AYNLPVEGNI
260 270 280 290 300
HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH
310 320 330 340 350
FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS
360 370 380
TGRSTTCMTS LKSTNPSVAT FSLINGNICH ERYV
Length:384
Mass (Da):43,199
Last modified:April 1, 1993 - v1
Checksum:i70A75F11D9C82F19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73481 mRNA Translation: AAA88050.1
AF293323, AF293321, AF293322 Genomic DNA Translation: AAL96377.1
AK313588 mRNA Translation: BAG36357.1
CH471074 Genomic DNA Translation: EAW98909.1
BC074733 mRNA Translation: AAH74733.1
CCDSiCCDS14174.1
PIRiA41007
RefSeqiNP_005305.1, NM_005314.2
UniGeneiHs.567282

Genome annotation databases

EnsembliENST00000380289; ENSP00000369643; ENSG00000126010
GeneIDi2925
KEGGihsa:2925

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73481 mRNA Translation: AAA88050.1
AF293323, AF293321, AF293322 Genomic DNA Translation: AAL96377.1
AK313588 mRNA Translation: BAG36357.1
CH471074 Genomic DNA Translation: EAW98909.1
BC074733 mRNA Translation: AAH74733.1
CCDSiCCDS14174.1
PIRiA41007
RefSeqiNP_005305.1, NM_005314.2
UniGeneiHs.567282

3D structure databases

ProteinModelPortaliP30550
SMRiP30550
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109181, 63 interactors
STRINGi9606.ENSP00000369643

Chemistry databases

BindingDBiP30550
ChEMBLiCHEMBL4959
GuidetoPHARMACOLOGYi39

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP30550
PhosphoSitePlusiP30550

Polymorphism and mutation databases

BioMutaiGRPR
DMDMi232185

Proteomic databases

EPDiP30550
PaxDbiP30550
PeptideAtlasiP30550
PRIDEiP30550
ProteomicsDBi54720

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380289; ENSP00000369643; ENSG00000126010
GeneIDi2925
KEGGihsa:2925

Organism-specific databases

CTDi2925
DisGeNETi2925
EuPathDBiHostDB:ENSG00000126010.5
GeneCardsiGRPR
HGNCiHGNC:4609 GRPR
HPAiHPA069604
MIMi305670 gene
neXtProtiNX_P30550
OpenTargetsiENSG00000126010
PharmGKBiPA29002
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119177
HOGENOMiHOG000230781
HOVERGENiHBG004898
InParanoidiP30550
KOiK04169
OMAiNICHEGY
OrthoDBiEOG091G085Y
PhylomeDBiP30550
TreeFamiTF331292

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP30550

Miscellaneous databases

ChiTaRSiGRPR human
GeneWikiiGastrin-releasing_peptide_receptor
GenomeRNAii2925
PROiPR:P30550
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126010 Expressed in 48 organ(s), highest expression level in body of pancreas
CleanExiHS_GRPR
ExpressionAtlasiP30550 baseline and differential
GenevisibleiP30550 HS

Family and domain databases

CDDicd15124 7tmA_GRPR, 1 hit
InterProiView protein in InterPro
IPR001556 Bombsn_rcpt-like
IPR001966 Gastrin_pep_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00358 BOMBESINR
PR00640 GASTRINRELPR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRPR_HUMAN
AccessioniPrimary (citable) accession number: P30550
Secondary accession number(s): B2R910
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 7, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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