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UniProtKB - P30547 (NK1R_CAVPO)
Protein
Substance-P receptor
Gene
TACR1
Organism
Cavia porcellus (Guinea pig)
Status
Functioni
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
GO - Molecular functioni
- substance P receptor activity Source: Ensembl
GO - Biological processi
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- positive regulation of flagellated sperm motility Source: Ensembl
- regulation of uterine smooth muscle contraction Source: Ensembl
- response to pain Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Substance-P receptorShort name: SPR Alternative name(s): NK-1 receptor Short name: NK-1R Tachykinin receptor 1 |
Gene namesi | Name:TACR1 Synonyms:TAC1R |
Organismi | Cavia porcellus (Guinea pig) |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- sperm head Source: Ensembl
- sperm midpiece Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 32 – 54 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 55 – 64 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 65 – 86 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 87 – 106 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 107 – 128 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 129 – 148 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 149 – 169 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 194 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 195 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 220 – 248 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 249 – 270 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 271 – 283 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 284 – 308 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 309 – 407 | CytoplasmicSequence analysisAdd BLAST | 99 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069884 | 1 – 407 | Substance-P receptorAdd BLAST | 407 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 18 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 105 ↔ 180 | PROSITE-ProRule annotation | ||
Lipidationi | 322 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PRIDEi | P30547 |
Expressioni
Gene expression databases
Bgeei | ENSCPOG00000001484, Expressed in uterine cervix and 10 other tissues |
Interactioni
Subunit structurei
Interacts with ARRB1.
By similarityProtein-protein interaction databases
STRINGi | 10141.ENSCPOP00000001340 |
Chemistry databases
BindingDBi | P30547 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 363 – 407 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 377 – 407 | Polar residuesSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4219, Eukaryota |
GeneTreei | ENSGT00940000153745 |
InParanoidi | P30547 |
OMAi | LPFHVFF |
OrthoDBi | 715197at2759 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001681, Neurokn_rcpt IPR000046, NK1_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01024, NEUROKININ1R PR00244, NEUROKININR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P30547-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDNVLPVDSD LFPNISTNTS EPNQFVQPAW QIVLWAAAYT VIVVTSVVGN
60 70 80 90 100
VVVMWIILAH KRMRTVTNYF LVNLAFAEAS MAAFNTVVNF TYAVHNEWYY
110 120 130 140 150
GLFYCKFHNF FPIAAVFASI YSMTAVAFDR YMAIIHPLQP RLSATATKVV
160 170 180 190 200
ICVIWVLALL LAFPQGYYST TETMPGRVVC MIEWPSHPDK IYEKVYHICV
210 220 230 240 250
TVLIYFLPLL VIGYAYTVVG ITLWASEIPG DSSDRYHEQV SAKRKVVKMM
260 270 280 290 300
IVVVCTFAIC WLPFHIFFLL PYINPDLYLK KFIQQVYLAI MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRLGFKHAF RCCPFISAAD YEGLEMKSTR YFQTQGSVYK
360 370 380 390 400
VSRLETTIST VVGAHEEDPE EGPKATPSSL DLTSNGSSRS NSKTVTESSS
FYSNMLS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64323 mRNA Translation: CAA45608.1 |
PIRi | S23510 |
RefSeqi | NP_001166332.1, NM_001172861.1 XP_013006930.1, XM_013151476.1 |
Genome annotation databases
Ensembli | ENSCPOT00000046226; ENSCPOP00000030949; ENSCPOG00000036008 |
GeneIDi | 100135626 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64323 mRNA Translation: CAA45608.1 |
PIRi | S23510 |
RefSeqi | NP_001166332.1, NM_001172861.1 XP_013006930.1, XM_013151476.1 |
3D structure databases
SMRi | P30547 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000001340 |
Chemistry databases
BindingDBi | P30547 |
ChEMBLi | CHEMBL3942 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PRIDEi | P30547 |
Genome annotation databases
Ensembli | ENSCPOT00000046226; ENSCPOP00000030949; ENSCPOG00000036008 |
GeneIDi | 100135626 |
Organism-specific databases
CTDi | 6869 |
Phylogenomic databases
eggNOGi | KOG4219, Eukaryota |
GeneTreei | ENSGT00940000153745 |
InParanoidi | P30547 |
OMAi | LPFHVFF |
OrthoDBi | 715197at2759 |
TreeFami | TF315303 |
Miscellaneous databases
PROi | PR:P30547 |
Gene expression databases
Bgeei | ENSCPOG00000001484, Expressed in uterine cervix and 10 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001681, Neurokn_rcpt IPR000046, NK1_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01024, NEUROKININ1R PR00244, NEUROKININR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NK1R_CAVPO | |
Accessioni | P30547Primary (citable) accession number: P30547 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families