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Protein

Adenosine receptor A2a

Gene

Adora2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-417973 Adenosine P1 receptors
R-RNO-5683826 Surfactant metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2a
Gene namesi
Name:Adora2a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi2049 Adora2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4ExtracellularBy similarity4
Transmembranei5 – 29Helical; Name=1By similarityAdd BLAST25
Topological domaini30 – 39CytoplasmicBy similarity10
Transmembranei40 – 63Helical; Name=2By similarityAdd BLAST24
Topological domaini64 – 74ExtracellularBy similarityAdd BLAST11
Transmembranei75 – 97Helical; Name=3By similarityAdd BLAST23
Topological domaini98 – 117CytoplasmicBy similarityAdd BLAST20
Transmembranei118 – 140Helical; Name=4By similarityAdd BLAST23
Topological domaini141 – 168ExtracellularBy similarityAdd BLAST28
Transmembranei169 – 193Helical; Name=5By similarityAdd BLAST25
Topological domaini194 – 229CytoplasmicBy similarityAdd BLAST36
Transmembranei230 – 253Helical; Name=6By similarityAdd BLAST24
Topological domaini254 – 261ExtracellularBy similarity8
Transmembranei262 – 285Helical; Name=7By similarityAdd BLAST24
Topological domaini286 – 410CytoplasmicBy similarityAdd BLAST125

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL302
GuidetoPHARMACOLOGYi19

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690011 – 410Adenosine receptor A2aAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 154PROSITE-ProRule annotation
Disulfide bondi71 ↔ 143PROSITE-ProRule annotation
Disulfide bondi74 ↔ 161PROSITE-ProRule annotation
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 257PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiP30543
PRIDEiP30543

PTM databases

PhosphoSitePlusiP30543

Expressioni

Gene expression databases

BgeeiENSRNOG00000001302 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiP30543 RN

Interactioni

Subunit structurei

Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct. May interact with DRD4. Interacts with NECAB2 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247408, 2 interactors
IntActiP30543, 6 interactors
STRINGi10116.ENSRNOP00000001759

Chemistry databases

BindingDBiP30543

Structurei

3D structure databases

ProteinModelPortaliP30543
SMRiP30543
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 172Agonist bindingBy similarity10
Regioni241 – 248Agonist bindingBy similarity8
Regioni259 – 269Agonist bindingBy similarityAdd BLAST11

Domaini

The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiP30543
KOiK04266
OMAiMESQPLP
OrthoDBiEOG091G0I3U
PhylomeDBiP30543
TreeFamiTF325296

Family and domain databases

CDDicd15068 7tmA_Adenosine_R_A2A, 1 hit
InterProiView protein in InterPro
IPR001513 Adeno_A2A_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00553 ADENOSINA2AR
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P30543-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSSVYITVE LAIAVLAILG NVLVCWAVWI NSNLQNVTNF FVVSLAAADI
60 70 80 90 100
AVGVLAIPFA ITISTGFCAA CHGCLFFACF VLVLTQSSIF SLLAIAIDRY
110 120 130 140 150
IAIRIPLRYN GLVTGVRAKG IIAICWVLSF AIGLTPMLGW NNCSQKDGNS
160 170 180 190 200
TKTCGEGRVT CLFEDVVPMN YMVYYNFFAF VLLPLLLMLA IYLRIFLAAR
210 220 230 240 250
RQLKQMESQP LPGERTRSTL QKEVHAAKSL AIIVGLFALC WLPLHIINCF
260 270 280 290 300
TFFCSTCRHA PPWLMYLAII LSHSNSVVNP FIYAYRIREF RQTFRKIIRT
310 320 330 340 350
HVLRRQEPFQ AGGSSAWALA AHSTEGEQVS LRLNGHPLGV WANGSATHSG
360 370 380 390 400
RRPNGYTLGL GGGGSAQGSP RDVELPTQER QEGQEHPGLR GHLVQARVGA
410
SSWSSEFAPS
Length:410
Mass (Da):44,999
Last modified:December 1, 2000 - v2
Checksum:iD87B256CD2336BAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268A → T in AAA70305 (PubMed:1599465).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91214 mRNA Translation: AAA70305.2
L08102 mRNA No translation available.
S47609 mRNA Translation: AAA11888.1
AF228684 mRNA Translation: AAF61924.1
BC081727 mRNA Translation: AAH81727.1
PIRiA48974
RefSeqiNP_445746.3, NM_053294.4
XP_017457041.1, XM_017601552.1
XP_017457042.1, XM_017601553.1
XP_017457043.1, XM_017601554.1
XP_017457044.1, XM_017601555.1
UniGeneiRn.11180

Genome annotation databases

EnsembliENSRNOT00000001759; ENSRNOP00000001759; ENSRNOG00000001302
GeneIDi25369
KEGGirno:25369
UCSCiRGD:2049 rat

Similar proteinsi

Entry informationi

Entry nameiAA2AR_RAT
AccessioniPrimary (citable) accession number: P30543
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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