Adenosine receptor A1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G-protein beta/gamma-subunit complex binding Source: Ensembl
• G protein-coupled adenosine receptor activity Source: Ensembl
• G protein-coupled receptor binding Source: Ensembl
• heat shock protein binding Source: Ensembl
• heterotrimeric G-protein binding Source: Ensembl
• neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• purine nucleoside binding Source: Ensembl

GO - Biological processⁱ

• activation of MAPKK activity Source: Ensembl
• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
• apoptotic signaling pathway Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Adenosine stimulates DNA fragmentation in human thymocytes by Ca(2+)-mediated mechanisms."
    Szondy Z.
    Biochem J 304:877-885(1994) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: ProtIncTraceable author statementⁱ
  • "Adenosine stimulates DNA fragmentation in human thymocytes by Ca(2+)-mediated mechanisms."
    Szondy Z.
    Biochem J 304:877-885(1994) [PubMed] [Europe PMC] [Abstract]
• cognition Source: Ensembl
• detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
• excitatory postsynaptic potential Source: Ensembl
• fatty acid homeostasis Source: Ensembl
• G protein-coupled receptor signaling pathway Source: Reactome
• inflammatory response Source: ProtIncTraceable author statementⁱ
  • "Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function."
    Salmon J.E., Brogle N., Brownlie C., Edberg J.C., Kimberly R.P., Chen B.X., Erlanger B.F.
    J Immunol 151:2775-2785(1993) [PubMed] [Europe PMC] [Abstract]
• lipid catabolic process Source: Ensembl
• negative regulation of acute inflammatory response Source: Ensembl
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
• negative regulation of glutamate secretion Source: Ensembl
• negative regulation of heart contraction Source: Ensembl
• negative regulation of hormone secretion Source: Ensembl
• negative regulation of leukocyte migration Source: Ensembl
• negative regulation of lipid catabolic process Source: Ensembl
• negative regulation of long-term synaptic depression Source: Ensembl
• negative regulation of long-term synaptic potentiation Source: Ensembl
• negative regulation of mucus secretion Source: Ensembl
• negative regulation of neurotrophin production Source: Ensembl
• negative regulation of renal sodium excretion Source: Ensembl
• negative regulation of synaptic transmission, GABAergic Source: Ensembl
• negative regulation of synaptic transmission, glutamatergic Source: Ensembl
• negative regulation of systemic arterial blood pressure Source: Ensembl
• nervous system development Source: ProtIncTraceable author statementⁱ
  • "Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study."
    Ulas J., Brunner L.C., Nguyen L., Cotman C.W.
    Neuroscience 52:843-854(1993) [PubMed] [Europe PMC] [Abstract]
• phagocytosis Source: ProtIncTraceable author statementⁱ
  • "Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function."
    Salmon J.E., Brogle N., Brownlie C., Edberg J.C., Kimberly R.P., Chen B.X., Erlanger B.F.
    J Immunol 151:2775-2785(1993) [PubMed] [Europe PMC] [Abstract]
• positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
• positive regulation of lipid catabolic process Source: Ensembl
• positive regulation of neuron death Source: Ensembl
• positive regulation of nucleoside transport Source: Ensembl
• positive regulation of peptide secretion Source: Ensembl
• positive regulation of potassium ion transport Source: Ensembl
• positive regulation of protein dephosphorylation Source: Ensembl
• positive regulation of systemic arterial blood pressure Source: Ensembl
• protein targeting to membrane Source: Ensembl
• regulation of cardiac muscle cell contraction Source: Ensembl
• regulation of glomerular filtration Source: Ensembl
• regulation of respiratory gaseous exchange by nervous system process Source: Ensembl
• regulation of sensory perception of pain Source: Ensembl
• relaxation of vascular associated smooth muscle Source: Ensembl
• response to hypoxia Source: Ensembl
• signal transduction Source: ProtIncTraceable author statementⁱ
  • Ref.1

    "Cloning and functional characterization of a human A1 adenosine receptor."
    Libert F., van Sande J., Lefort A., Czernilofsky A., Dumont J.E., Vassart G., Ensinger H.A., Mendla K.D.
    Biochem. Biophys. Res. Commun. 187:919-926(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• temperature homeostasis Source: Ensembl
• triglyceride homeostasis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• G protein-coupled receptor binding Source: Ensembl
• heat shock protein binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS 
        60         70         80         90        100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA 
       110        120        130        140        150
IAVDRYLRVK IPLRYKMVVT PRRAAVAIAG CWILSFVVGL TPMFGWNNLS 
       160        170        180        190        200
AVERAWAANG SMGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY 
       210        220        230        240        250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL 
       260        270        280        290        300
HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 
       310        320 
KIWNDHFRCQ PAPPIDEDLP EERPDD                           

        10         20         30         40         50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS 
        60         70         80         90        100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA 
       110        120 
IAVDRYLRVK IPLRRISQCM ASTKS                            

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
3. Human entries with genetic variants
   List of human entries with genetic variants
4. Human variants curated from literature reports
   Index of human variants curated from literature reports
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
7. SIMILARITY comments
   Index of protein domains and families