UniProtKB - P30542 (AA1R_HUMAN)
Protein
Adenosine receptor A1
Gene
ADORA1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: Ensembl
- G protein-coupled adenosine receptor activity Source: Ensembl
- G protein-coupled receptor binding Source: Ensembl
- heat shock protein binding Source: Ensembl
- heterotrimeric G-protein binding Source: Ensembl
- neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- purine nucleoside binding Source: Ensembl
GO - Biological processi
- activation of MAPKK activity Source: Ensembl
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
- apoptotic signaling pathway Source: ProtInc
- cell-cell signaling Source: ProtInc
- cognition Source: Ensembl
- detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
- excitatory postsynaptic potential Source: Ensembl
- fatty acid homeostasis Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- inflammatory response Source: ProtInc
- lipid catabolic process Source: Ensembl
- negative regulation of acute inflammatory response Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of blood vessel diameter Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
- negative regulation of glutamate secretion Source: Ensembl
- negative regulation of heart contraction Source: Ensembl
- negative regulation of hormone secretion Source: Ensembl
- negative regulation of leukocyte migration Source: Ensembl
- negative regulation of lipid catabolic process Source: Ensembl
- negative regulation of long-term synaptic depression Source: Ensembl
- negative regulation of long-term synaptic potentiation Source: Ensembl
- negative regulation of mucus secretion Source: Ensembl
- negative regulation of neurotrophin production Source: Ensembl
- negative regulation of renal sodium excretion Source: Ensembl
- negative regulation of synaptic transmission, GABAergic Source: Ensembl
- negative regulation of synaptic transmission, glutamatergic Source: Ensembl
- negative regulation of systemic arterial blood pressure Source: Ensembl
- nervous system development Source: ProtInc
- phagocytosis Source: ProtInc
- positive regulation of epidermal growth factor-activated receptor activity Source: Ensembl
- positive regulation of lipid catabolic process Source: Ensembl
- positive regulation of neuron death Source: Ensembl
- positive regulation of nucleoside transport Source: Ensembl
- positive regulation of peptide secretion Source: Ensembl
- positive regulation of potassium ion transport Source: Ensembl
- positive regulation of protein dephosphorylation Source: Ensembl
- positive regulation of systemic arterial blood pressure Source: Ensembl
- protein targeting to membrane Source: Ensembl
- regulation of cardiac muscle cell contraction Source: Ensembl
- regulation of glomerular filtration Source: Ensembl
- regulation of respiratory gaseous exchange by nervous system process Source: Ensembl
- regulation of sensory perception of pain Source: Ensembl
- relaxation of vascular smooth muscle Source: Ensembl
- response to hypoxia Source: Ensembl
- signal transduction Source: ProtInc
- temperature homeostasis Source: Ensembl
- triglyceride homeostasis Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-417973 Adenosine P1 receptors R-HSA-418594 G alpha (i) signalling events |
SIGNORi | P30542 |
Protein family/group databases
TCDBi | 9.A.14.3.4 the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Adenosine receptor A1 |
Gene namesi | Name:ADORA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:262 ADORA1 |
MIMi | 102775 gene |
neXtProti | NX_P30542 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Plasma Membrane
- axolemma Source: Ensembl
- basolateral plasma membrane Source: Ensembl
- integral component of plasma membrane Source: ProtInc
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- calyx of Held Source: Ensembl
- dendritic spine Source: Ensembl
- neuronal cell body Source: Ensembl
- postsynaptic density Source: Ensembl
- presynaptic active zone Source: Ensembl
- terminal bouton Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | ExtracellularSequence analysis | 10 | |
Transmembranei | 11 – 33 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 34 – 46 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 47 – 69 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 70 – 80 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 81 – 102 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 103 – 123 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 124 – 146 | Helical; Name=4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 147 – 176 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 177 – 201 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 202 – 235 | CytoplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 236 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 260 – 267 | ExtracellularSequence analysis | 8 | |
Transmembranei | 268 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 293 – 326 | CytoplasmicSequence analysisAdd BLAST | 34 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 134 |
OpenTargetsi | ENSG00000163485 |
PharmGKBi | PA24583 |
Miscellaneous databases
Pharosi | P30542 |
Chemistry databases
ChEMBLi | CHEMBL226 |
DrugBanki | DB00640 Adenosine DB01223 Aminophylline DB00201 Caffeine DB09061 Cannabidiol DB04932 Defibrotide DB00651 Dyphylline DB00824 Enprofylline DB00996 Gabapentin DB00555 Lamotrigine DB06471 Naxifylline DB01303 Oxtriphylline DB00806 Pentoxifylline DB12670 Rolofylline DB04954 Tecadenoson DB01412 Theobromine DB00277 Theophylline DB12569 Tonapofylline |
DrugCentrali | P30542 |
GuidetoPHARMACOLOGYi | 18 |
Polymorphism and mutation databases
BioMutai | ADORA1 |
DMDMi | 231473 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068991 | 1 – 326 | Adenosine receptor A1Add BLAST | 326 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 80 ↔ 169 | PROSITE-ProRule annotation | ||
Glycosylationi | 159 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 309 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
MassIVEi | P30542 |
PaxDbi | P30542 |
PeptideAtlasi | P30542 |
PRIDEi | P30542 |
ProteomicsDBi | 54718 [P30542-1] 54719 [P30542-2] |
PTM databases
GlyConnecti | 992 |
iPTMneti | P30542 |
PhosphoSitePlusi | P30542 |
SwissPalmi | P30542 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163485 Expressed in 186 organ(s), highest expression level in metanephric glomerulus |
ExpressionAtlasi | P30542 baseline and differential |
Genevisiblei | P30542 HS |
Organism-specific databases
HPAi | HPA044383 |
Interactioni
Binary interactionsi
GO - Molecular functioni
- G protein-coupled receptor binding Source: Ensembl
- heat shock protein binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
Protein-protein interaction databases
BioGridi | 106646, 8 interactors |
IntActi | P30542, 6 interactors |
MINTi | P30542 |
STRINGi | 9606.ENSP00000356205 |
Chemistry databases
BindingDBi | P30542 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P30542 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00950000182731 |
InParanoidi | P30542 |
KOi | K04265 |
OMAi | CWTVAFI |
OrthoDBi | 550297at2759 |
PhylomeDBi | P30542 |
TreeFami | TF325296 |
Family and domain databases
InterProi | View protein in InterPro IPR001068 Adeno_A1_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00552 ADENOSINEA1R PR00424 ADENOSINER PR00237 GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P30542-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKMVVT PRRAAVAIAG CWILSFVVGL TPMFGWNNLS
160 170 180 190 200
AVERAWAANG SMGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL
310 320
KIWNDHFRCQ PAPPIDEDLP EERPDD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X173 | A0A087X173_HUMAN | Adenosine receptor A1 | ADORA1 | 210 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 312 | A → T in BAF82617 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044138 | 43 | A → S1 PublicationCorresponds to variant dbSNP:rs11547175Ensembl. | 1 | |
Natural variantiVAR_044139 | 50 | S → P1 PublicationCorresponds to variant dbSNP:rs11547174Ensembl. | 1 | |
Natural variantiVAR_044140 | 105 | R → H1 PublicationCorresponds to variant dbSNP:rs11547176Ensembl. | 1 | |
Natural variantiVAR_035754 | 170 | E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs899207013Ensembl. | 1 | |
Natural variantiVAR_044141 | 261 | P → Q1 PublicationCorresponds to variant dbSNP:rs17852405Ensembl. | 1 | |
Natural variantiVAR_078549 | 279 | G → S Found in a family with early-onset autosomal recessive parkinsonism and intellectual disability; unknown pathological significance; does not affect protein abundance; does not affect expression at the cell surface. 1 PublicationCorresponds to variant dbSNP:rs748346254EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034401 | 115 – 125 | YKMVVTPRRAA → RISQCMASTKS in isoform 2. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_034402 | 126 – 326 | Missing in isoform 2. 1 PublicationAdd BLAST | 201 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S45235 mRNA Translation: AAB23388.1 S56143 mRNA Translation: AAB25533.2 L22214 mRNA Translation: AAA17544.1 X68485 mRNA Translation: CAA48503.1 AB004662 mRNA Translation: BAA20433.1 EF057066 mRNA Translation: ABO25743.1 AK127752 mRNA Translation: BAG54566.1 AK289928 mRNA Translation: BAF82617.1 AY136746 mRNA Translation: AAN01272.1 BT019854 mRNA Translation: AAV38657.1 CR541749 mRNA Translation: CAG46549.1 AC105940 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91465.1 BC026340 mRNA Translation: AAH26340.1 |
CCDSi | CCDS1434.1 [P30542-1] |
PIRi | A53005 |
RefSeqi | NP_000665.1, NM_000674.2 [P30542-1] NP_001041695.1, NM_001048230.1 [P30542-1] |
Genome annotation databases
Ensembli | ENST00000309502; ENSP00000308549; ENSG00000163485 [P30542-1] ENST00000337894; ENSP00000338435; ENSG00000163485 [P30542-1] ENST00000367235; ENSP00000356204; ENSG00000163485 [P30542-2] ENST00000367236; ENSP00000356205; ENSG00000163485 [P30542-1] ENST00000640524; ENSP00000491900; ENSG00000163485 [P30542-2] |
GeneIDi | 134 |
KEGGi | hsa:134 |
UCSCi | uc001gze.1 human [P30542-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S45235 mRNA Translation: AAB23388.1 S56143 mRNA Translation: AAB25533.2 L22214 mRNA Translation: AAA17544.1 X68485 mRNA Translation: CAA48503.1 AB004662 mRNA Translation: BAA20433.1 EF057066 mRNA Translation: ABO25743.1 AK127752 mRNA Translation: BAG54566.1 AK289928 mRNA Translation: BAF82617.1 AY136746 mRNA Translation: AAN01272.1 BT019854 mRNA Translation: AAV38657.1 CR541749 mRNA Translation: CAG46549.1 AC105940 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91465.1 BC026340 mRNA Translation: AAH26340.1 |
CCDSi | CCDS1434.1 [P30542-1] |
PIRi | A53005 |
RefSeqi | NP_000665.1, NM_000674.2 [P30542-1] NP_001041695.1, NM_001048230.1 [P30542-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5N2S | X-ray | 3.30 | A | 4-316 | [»] | |
5UEN | X-ray | 3.20 | A/B | 2-211 | [»] | |
A/B | 228-311 | [»] | ||||
6D9H | electron microscopy | 3.60 | R | 2-326 | [»] | |
SMRi | P30542 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 106646, 8 interactors |
IntActi | P30542, 6 interactors |
MINTi | P30542 |
STRINGi | 9606.ENSP00000356205 |
Chemistry databases
BindingDBi | P30542 |
ChEMBLi | CHEMBL226 |
DrugBanki | DB00640 Adenosine DB01223 Aminophylline DB00201 Caffeine DB09061 Cannabidiol DB04932 Defibrotide DB00651 Dyphylline DB00824 Enprofylline DB00996 Gabapentin DB00555 Lamotrigine DB06471 Naxifylline DB01303 Oxtriphylline DB00806 Pentoxifylline DB12670 Rolofylline DB04954 Tecadenoson DB01412 Theobromine DB00277 Theophylline DB12569 Tonapofylline |
DrugCentrali | P30542 |
GuidetoPHARMACOLOGYi | 18 |
Protein family/group databases
TCDBi | 9.A.14.3.4 the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyConnecti | 992 |
iPTMneti | P30542 |
PhosphoSitePlusi | P30542 |
SwissPalmi | P30542 |
Polymorphism and mutation databases
BioMutai | ADORA1 |
DMDMi | 231473 |
Proteomic databases
MassIVEi | P30542 |
PaxDbi | P30542 |
PeptideAtlasi | P30542 |
PRIDEi | P30542 |
ProteomicsDBi | 54718 [P30542-1] 54719 [P30542-2] |
Protocols and materials databases
DNASUi | 134 |
Genome annotation databases
Ensembli | ENST00000309502; ENSP00000308549; ENSG00000163485 [P30542-1] ENST00000337894; ENSP00000338435; ENSG00000163485 [P30542-1] ENST00000367235; ENSP00000356204; ENSG00000163485 [P30542-2] ENST00000367236; ENSP00000356205; ENSG00000163485 [P30542-1] ENST00000640524; ENSP00000491900; ENSG00000163485 [P30542-2] |
GeneIDi | 134 |
KEGGi | hsa:134 |
UCSCi | uc001gze.1 human [P30542-1] |
Organism-specific databases
CTDi | 134 |
DisGeNETi | 134 |
GeneCardsi | ADORA1 |
HGNCi | HGNC:262 ADORA1 |
HPAi | HPA044383 |
MIMi | 102775 gene |
neXtProti | NX_P30542 |
OpenTargetsi | ENSG00000163485 |
PharmGKBi | PA24583 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00950000182731 |
InParanoidi | P30542 |
KOi | K04265 |
OMAi | CWTVAFI |
OrthoDBi | 550297at2759 |
PhylomeDBi | P30542 |
TreeFami | TF325296 |
Enzyme and pathway databases
Reactomei | R-HSA-417973 Adenosine P1 receptors R-HSA-418594 G alpha (i) signalling events |
SIGNORi | P30542 |
Miscellaneous databases
ChiTaRSi | ADORA1 human |
GeneWikii | Adenosine_A1_receptor |
GenomeRNAii | 134 |
Pharosi | P30542 |
PROi | PR:P30542 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163485 Expressed in 186 organ(s), highest expression level in metanephric glomerulus |
ExpressionAtlasi | P30542 baseline and differential |
Genevisiblei | P30542 HS |
Family and domain databases
InterProi | View protein in InterPro IPR001068 Adeno_A1_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00552 ADENOSINEA1R PR00424 ADENOSINER PR00237 GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AA1R_HUMAN | |
Accessioni | P30542Primary (citable) accession number: P30542 Secondary accession number(s): A6NFY5 Q8TAM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | November 13, 2019 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references