ADORA1

Protein namesⁱ	Recommended name: Adenosine receptor A1
Gene namesⁱ	Name:ADORA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163485.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:262 ADORA1
MIMⁱ	102775 gene
neXtProtⁱ	NX_P30542

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 10	ExtracellularSequence analysis	10
Transmembraneⁱ	11 – 33	Helical; Name=1Sequence analysisAdd BLAST	23
Topological domainⁱ	34 – 46	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	47 – 69	Helical; Name=2Sequence analysisAdd BLAST	23
Topological domainⁱ	70 – 80	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	81 – 102	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	103 – 123	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	124 – 146	Helical; Name=4Sequence analysisAdd BLAST	23
Topological domainⁱ	147 – 176	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	177 – 201	Helical; Name=5Sequence analysisAdd BLAST	25
Topological domainⁱ	202 – 235	CytoplasmicSequence analysisAdd BLAST	34
Transmembraneⁱ	236 – 259	Helical; Name=6Sequence analysisAdd BLAST	24
Topological domainⁱ	260 – 267	ExtracellularSequence analysis	8
Transmembraneⁱ	268 – 292	Helical; Name=7Sequence analysisAdd BLAST	25
Topological domainⁱ	293 – 326	CytoplasmicSequence analysisAdd BLAST	34

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	134
Open Targets More...OpenTargetsⁱ	ENSG00000163485
PharmGKBⁱ	PA24583

Chemistry databases

ChEMBLⁱ	CHEMBL226
Drug and drug target database More...DrugBankⁱ	DB00640 Adenosine DB01223 Aminophylline DB00201 Caffeine DB04932 Defibrotide DB00651 Dyphylline DB00824 Enprofylline DB00996 Gabapentin DB05360 KW-3902 DB06471 Naxifylline DB01303 Oxtriphylline DB00806 Pentoxifylline DB04954 Tecadenoson DB01412 Theobromine DB00277 Theophylline
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	18

Polymorphism and mutation databases

BioMutaⁱ	ADORA1
DMDMⁱ	231473

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068991	1 – 326	Adenosine receptor A1Add BLAST		326

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	80 ↔ 169	PROSITE-ProRule annotation
Glycosylationⁱ	159	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	309	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P30542
PeptideAtlas More...PeptideAtlasⁱ	P30542
PRIDEⁱ	P30542
ProteomicsDBⁱ	54718 54719 [P30542-2]

PTM databases

GlyConnectⁱ	992
iPTMnetⁱ	P30542
PhosphoSitePlusⁱ	P30542
SwissPalmⁱ	P30542

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000163485 Expressed in 186 organ(s), highest expression level in metanephric glomerulus
CleanExⁱ	HS_ADORA1
ExpressionAtlasⁱ	P30542 baseline and differential
Genevisibleⁱ	P30542 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044383

HPAⁱ

HPA044383

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ADORA2A	P29274	4	EBI-2903663,EBI-2902702

With

Entry

#Exp.

IntAct

Notes

ADORA2A

P29274

4

EBI-2903663,EBI-2902702

GO - Molecular functionⁱ

G protein-coupled receptor binding Source: Ensembl
heat shock protein binding Source: Ensembl
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106646, 7 interactors
IntActⁱ	P30542, 2 interactors
STRINGⁱ	9606.ENSP00000308549

Chemistry databases

BindingDBⁱ

P30542

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	7 – 36	Combined sources	30
Helixⁱ	38 – 40	Combined sources	3
Helixⁱ	43 – 60	Combined sources	18
Helixⁱ	62 – 71	Combined sources	10
Helixⁱ	77 – 110	Combined sources	34
Turnⁱ	112 – 114	Combined sources	3
Helixⁱ	115 – 118	Combined sources	4
Helixⁱ	121 – 140	Combined sources	20
Helixⁱ	141 – 144	Combined sources	4
Helixⁱ	149 – 159	Combined sources	11
Helixⁱ	171 – 174	Combined sources	4
Helixⁱ	177 – 182	Combined sources	6
Helixⁱ	184 – 188	Combined sources	5
Helixⁱ	190 – 211	Combined sources	22
Helixⁱ	228 – 259	Combined sources	32
Helixⁱ	267 – 291	Combined sources	25
Helixⁱ	293 – 306	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	P30542
SMRⁱ	P30542
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074524
HOVERGENⁱ	HBG106962
InParanoidⁱ	P30542
KEGG Orthology (KO) More...KOⁱ	K04265
OMAⁱ	VYAFRIH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I3U
PhylomeDBⁱ	P30542
TreeFamⁱ	TF325296

Family and domain databases

InterProⁱ	View protein in InterPro IPR001068 Adeno_A1_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00552 ADENOSINEA1R PR00424 ADENOSINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P30542-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS 
        60         70         80         90        100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA 
       110        120        130        140        150
IAVDRYLRVK IPLRYKMVVT PRRAAVAIAG CWILSFVVGL TPMFGWNNLS 
       160        170        180        190        200
AVERAWAANG SMGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY 
       210        220        230        240        250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL 
       260        270        280        290        300
HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL 
       310        320 
KIWNDHFRCQ PAPPIDEDLP EERPDD

Length:326

Mass (Da):36,512

Last modified:April 1, 1993 - v1

Checksum:ⁱ1B555893BCDEC9A6

GO

Isoform 2 (identifier: P30542-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
115-125: YKMVVTPRRAA → RISQCMASTKS
126-326: Missing.

« Hide

        10         20         30         40         50
MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS 
        60         70         80         90        100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA 
       110        120 
IAVDRYLRVK IPLRRISQCM ASTKS

Show »

Length:125

Mass (Da):13,348

Checksum:ⁱ37CB91365D17A5F5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087X173	A0A087X173_HUMAN		Adenosine receptor A1 Adenosine receptor A1	ADORA1	210	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	312	A → T in BAF82617 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_044138	43	A → S1 PublicationCorresponds to variant dbSNP:rs11547175Ensembl.	1
Natural variantⁱVAR_044139	50	S → P1 PublicationCorresponds to variant dbSNP:rs11547174Ensembl.	1
Natural variantⁱVAR_044140	105	R → H1 PublicationCorresponds to variant dbSNP:rs11547176Ensembl.	1
Natural variantⁱVAR_035754	170	E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs899207013Ensembl.	1
Natural variantⁱVAR_044141	261	P → Q1 PublicationCorresponds to variant dbSNP:rs17852405Ensembl.	1
Natural variantⁱVAR_078549	279	G → S Found in a family with early-onset autosomal recessive parkinsonism and intellectual disability; unknown pathological significance; does not affect protein abundance; does not affect expression at the cell surface. 1 PublicationCorresponds to variant dbSNP:rs748346254EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034401	115 – 125	YKMVVTPRRAA → RISQCMASTKS in isoform 2. 1 PublicationAdd BLAST		11
Alternative sequenceⁱVSP_034402	126 – 326	Missing in isoform 2. 1 PublicationAdd BLAST		201

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S45235 mRNA Translation: AAB23388.1 S56143 mRNA Translation: AAB25533.2 L22214 mRNA Translation: AAA17544.1 X68485 mRNA Translation: CAA48503.1 AB004662 mRNA Translation: BAA20433.1 EF057066 mRNA Translation: ABO25743.1 AK127752 mRNA Translation: BAG54566.1 AK289928 mRNA Translation: BAF82617.1 AY136746 mRNA Translation: AAN01272.1 BT019854 mRNA Translation: AAV38657.1 CR541749 mRNA Translation: CAG46549.1 AC105940 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91465.1 BC026340 mRNA Translation: AAH26340.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1434.1 [P30542-1]
PIRⁱ	A53005
NCBI Reference Sequences More...RefSeqⁱ	NP_000665.1, NM_000674.2 [P30542-1] NP_001041695.1, NM_001048230.1 [P30542-1]
UniGeneⁱ	Hs.77867

Genome annotation databases

Ensemblⁱ	ENST00000309502; ENSP00000308549; ENSG00000163485 [P30542-1] ENST00000337894; ENSP00000338435; ENSG00000163485 [P30542-1] ENST00000367235; ENSP00000356204; ENSG00000163485 [P30542-2] ENST00000367236; ENSP00000356205; ENSG00000163485 [P30542-1] ENST00000640524; ENSP00000491900; ENSG00000163485 [P30542-2]
GeneIDⁱ	134
KEGGⁱ	hsa:134
UCSC genome browser More...UCSCⁱ	uc001gze.1 human [P30542-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P30542	Adenosine receptor A1		GORGO		326	UniRef100_P30542
P30542-2	Adenosine receptor A1		PANTR		125	UniRef100_A0A2J8QWH5
Adenosine receptor A1		PONAB		125
Adenosine receptor A1		GORGO		125

Protein	Similar proteins		Species	Score	Length	Source
P30542	Adenosine receptor A1		RAT		326	UniRef90_P25099
Adenosine receptor A1		RABIT		328
Adenosine receptor A1		BOVIN		326
Adenosine receptor A1		CANLF		326
Adenosine receptor A1		CAVPO		326
+133
P30542-2	Adenosine receptor A1		PANTR		125	UniRef90_A0A2J8QWH5
Adenosine receptor A1		PONAB		125
Adenosine receptor A1		GORGO		125
Adenosine receptor A1 (Fragment)		NEOVI		152
Adenosine receptor A1		CALJA		125
+13

Protein	Similar proteins		Species	Score	Length	Source
P30542	Adenosine receptor A1		RAT		326	UniRef50_P25099
Adenosine receptor A1		RABIT		328
Adenosine receptor A1		CAVPO		326
Adenosine receptor A1		BOVIN		326
Adenosine receptor A1		PONAB		326
+292
P30542-2	Adenosine receptor A1		PANTR		125	UniRef50_A0A2J8QWH5
Adenosine receptor A1		PONAB		125
Adenosine receptor A1		GORGO		125
Adenosine receptor A1 (Fragment)		NEOVI		152
Adenosine receptor A1		CALJA		125
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S45235 mRNA Translation: AAB23388.1 S56143 mRNA Translation: AAB25533.2 L22214 mRNA Translation: AAA17544.1 X68485 mRNA Translation: CAA48503.1 AB004662 mRNA Translation: BAA20433.1 EF057066 mRNA Translation: ABO25743.1 AK127752 mRNA Translation: BAG54566.1 AK289928 mRNA Translation: BAF82617.1 AY136746 mRNA Translation: AAN01272.1 BT019854 mRNA Translation: AAV38657.1 CR541749 mRNA Translation: CAG46549.1 AC105940 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91465.1 BC026340 mRNA Translation: AAH26340.1
CCDSⁱ	CCDS1434.1 [P30542-1]
PIRⁱ	A53005
RefSeqⁱ	NP_000665.1, NM_000674.2 [P30542-1] NP_001041695.1, NM_001048230.1 [P30542-1]
UniGeneⁱ	Hs.77867

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5N2S	X-ray	3.30	A	4-316	[»]
	5UEN	X-ray	3.20	A/B	2-211	[»]
				A/B	228-311	[»]
	6D9H	electron microscopy	3.60	R	2-326	[»]
ProteinModelPortalⁱ	P30542
SMRⁱ	P30542
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106646, 7 interactors
IntActⁱ	P30542, 2 interactors
STRINGⁱ	9606.ENSP00000308549

Chemistry databases

BindingDBⁱ	P30542
ChEMBLⁱ	CHEMBL226
DrugBankⁱ	DB00640 Adenosine DB01223 Aminophylline DB00201 Caffeine DB04932 Defibrotide DB00651 Dyphylline DB00824 Enprofylline DB00996 Gabapentin DB05360 KW-3902 DB06471 Naxifylline DB01303 Oxtriphylline DB00806 Pentoxifylline DB04954 Tecadenoson DB01412 Theobromine DB00277 Theophylline
GuidetoPHARMACOLOGYⁱ	18

Protein family/group databases

TCDBⁱ	9.A.14.3.4 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

GlyConnectⁱ	992
iPTMnetⁱ	P30542
PhosphoSitePlusⁱ	P30542
SwissPalmⁱ	P30542

Polymorphism and mutation databases

BioMutaⁱ	ADORA1
DMDMⁱ	231473

Proteomic databases

PaxDbⁱ	P30542
PeptideAtlasⁱ	P30542
PRIDEⁱ	P30542
ProteomicsDBⁱ	54718 54719 [P30542-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	134
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000309502; ENSP00000308549; ENSG00000163485 [P30542-1] ENST00000337894; ENSP00000338435; ENSG00000163485 [P30542-1] ENST00000367235; ENSP00000356204; ENSG00000163485 [P30542-2] ENST00000367236; ENSP00000356205; ENSG00000163485 [P30542-1] ENST00000640524; ENSP00000491900; ENSG00000163485 [P30542-2]
GeneIDⁱ	134
KEGGⁱ	hsa:134
UCSCⁱ	uc001gze.1 human [P30542-1]

Organism-specific databases

CTDⁱ	134
DisGeNETⁱ	134
EuPathDBⁱ	HostDB:ENSG00000163485.15
GeneCardsⁱ	ADORA1
HGNCⁱ	HGNC:262 ADORA1
HPAⁱ	HPA044383
MIMⁱ	102775 gene
neXtProtⁱ	NX_P30542
OpenTargetsⁱ	ENSG00000163485
PharmGKBⁱ	PA24583
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00550000074524
HOVERGENⁱ	HBG106962
InParanoidⁱ	P30542
KOⁱ	K04265
OMAⁱ	VYAFRIH
OrthoDBⁱ	EOG091G0I3U
PhylomeDBⁱ	P30542
TreeFamⁱ	TF325296

Enzyme and pathway databases

Reactomeⁱ	R-HSA-417973 Adenosine P1 receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-417973 Adenosine P1 receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSⁱ	ADORA1 human
GeneWikiⁱ	Adenosine_A1_receptor
GenomeRNAiⁱ	134
Protein Ontology More...PROⁱ	PR:P30542
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163485 Expressed in 186 organ(s), highest expression level in metanephric glomerulus
CleanExⁱ	HS_ADORA1
ExpressionAtlasⁱ	P30542 baseline and differential
Genevisibleⁱ	P30542 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001068 Adeno_A1_rcpt IPR001634 Adenosn_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00552 ADENOSINEA1R PR00424 ADENOSINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AA1R_HUMAN
Accessionⁱ	P30542Primary (citable) accession number: P30542 Secondary accession number(s): A6NFY5 Q8TAM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
	Last sequence update:	April 1, 1993
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - P30542 (AA1R_HUMAN)

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Adenosine receptor A1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ