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Protein

Translocator protein

Gene

TSPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).By similarity2 Publications

GO - Molecular functioni

  • androgen binding Source: Ensembl
  • benzodiazepine receptor activity Source: ProtInc
  • cholesterol binding Source: GO_Central
  • cholesterol transporter activity Source: Reactome
  • ion channel binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-196108 Pregnenolone biosynthesis

Protein family/group databases

TCDBi9.A.24.1.1 the mitochondrial cholesterol/porphyrin uptake translocator protein (tspo) family

Names & Taxonomyi

Protein namesi
Recommended name:
Translocator protein
Alternative name(s):
Mitochondrial benzodiazepine receptor
PKBS
Peripheral-type benzodiazepine receptor
Short name:
PBR
Gene namesi
Name:TSPO
Synonyms:BZRP, MBR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100300.17
HGNCiHGNC:1158 TSPO
MIMi109610 gene
neXtProtiNX_P30536

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 5Mitochondrial intermembraneBy similarity4
Transmembranei6 – 26Helical; Name=1By similarityAdd BLAST21
Topological domaini27 – 46CytoplasmicBy similarityAdd BLAST20
Transmembranei47 – 67Helical; Name=2By similarityAdd BLAST21
Topological domaini68 – 79Mitochondrial intermembraneBy similarityAdd BLAST12
Transmembranei80 – 100Helical; Name=3By similarityAdd BLAST21
Topological domaini101 – 105CytoplasmicBy similarity5
Transmembranei106 – 126Helical; Name=4By similarityAdd BLAST21
Topological domaini127 – 134Mitochondrial intermembraneBy similarity8
Transmembranei135 – 155Helical; Name=5By similarityAdd BLAST21
Topological domaini156 – 169CytoplasmicBy similarityAdd BLAST14

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi706
OpenTargetsiENSG00000100300
PharmGKBiPA25473

Chemistry databases

ChEMBLiCHEMBL5742
DrugBankiDB01178 Chlormezanone
DB01068 Clonazepam
DB00628 Clorazepate
DB00829 Diazepam
DB00402 Eszopiclone
DB01544 Flunitrazepam
DB01587 Ketazolam
DB00186 Lorazepam
DB00231 Temazepam
DB00897 Triazolam
DB00962 Zaleplon
DB01198 Zopiclone
GuidetoPHARMACOLOGYi2879

Polymorphism and mutation databases

BioMutaiTSPO
DMDMi313104268

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001909972 – 169Translocator proteinAdd BLAST168

Proteomic databases

EPDiP30536
MaxQBiP30536
PaxDbiP30536
PeptideAtlasiP30536
PRIDEiP30536
ProteomicsDBi54717
TopDownProteomicsiP30536-1 [P30536-1]

PTM databases

iPTMnetiP30536
PhosphoSitePlusiP30536
SwissPalmiP30536

Expressioni

Tissue specificityi

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.1 Publication

Gene expression databases

BgeeiENSG00000100300 Expressed in 217 organ(s), highest expression level in blood
CleanExiHS_TSPO
ExpressionAtlasiP30536 baseline and differential
GenevisibleiP30536 HS

Organism-specific databases

HPAiCAB011232
HPA046260

Interactioni

Subunit structurei

Interacts with TSPOAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA85EBI-6623146,EBI-6942903

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107168, 16 interactors
IntActiP30536, 13 interactors
STRINGi9606.ENSP00000328973

Chemistry databases

BindingDBiP30536

Structurei

3D structure databases

ProteinModelPortaliP30536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TspO/BZRP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3797 Eukaryota
COG3476 LUCA
GeneTreeiENSGT00390000012980
HOGENOMiHOG000224659
InParanoidiP30536
KOiK05770
OMAiPPNWLFA
OrthoDBiEOG091G0W79
PhylomeDBiP30536
TreeFamiTF342852

Family and domain databases

CDDicd15904 TSPO_MBR, 1 hit
Gene3Di1.20.1260.100, 1 hit
InterProiView protein in InterPro
IPR030164 TSPO
IPR038330 TspO/MBR-related_sf
IPR004307 TspO_MBR
PANTHERiPTHR10057 PTHR10057, 1 hit
PTHR10057:SF5 PTHR10057:SF5, 1 hit
PfamiView protein in Pfam
PF03073 TspO_MBR, 1 hit
PIRSFiPIRSF005859 PBR, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30536-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG
60 70 80 90 100
PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF
110 120 130 140 150
GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFTTTL
160
NYCVWRDNHG WRGGRRLPE
Length:169
Mass (Da):18,828
Last modified:November 30, 2010 - v3
Checksum:i6DD741BF99AB89D9
GO
Isoform 2 (identifier: B1AH88-1) [UniParc]FASTAAdd to basket
Also known as: PBR-S
The sequence of this isoform can be found in the external entry B1AH88.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.
Length:102
Mass (Da):10,537
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLD3J3QLD3_HUMAN
Putative peripheral benzodiazepine ...
TSPO
65Annotation score:
B1AH87B1AH87_HUMAN
Putative peripheral benzodiazepine ...
TSPO
107Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013617147T → A Associated with higher levels of pregnenolone production by lymphomonocytes and with increased plasma levels of cholesterol-rich low density lipoprotein. 7 PublicationsCorresponds to variant dbSNP:rs6971Ensembl.1
Natural variantiVAR_013618162R → H5 PublicationsCorresponds to variant dbSNP:rs6972Ensembl.1
Natural variantiVAR_018868169E → Q1 PublicationCorresponds to variant dbSNP:rs9333342Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36035 mRNA Translation: AAA03652.1
U12421 Genomic DNA Translation: AAA83252.1
AY998017 mRNA Translation: AAY45787.1
BT006949 mRNA Translation: AAP35595.1
CR456409 mRNA Translation: CAG30295.1
AY383615 Genomic DNA Translation: AAQ75703.1
Z82214 Genomic DNA No translation available.
BC001110 mRNA Translation: AAH01110.1
CCDSiCCDS33661.1 [P30536-1]
PIRiI38724
JE0149
S14257
RefSeqiNP_000705.2, NM_000714.5 [P30536-1]
NP_001243459.1, NM_001256530.1 [P30536-1]
NP_001243460.1, NM_001256531.1 [P30536-1]
UniGeneiHs.202

Genome annotation databases

EnsembliENST00000329563; ENSP00000328973; ENSG00000100300 [P30536-1]
ENST00000337554; ENSP00000338004; ENSG00000100300 [P30536-1]
ENST00000396265; ENSP00000379563; ENSG00000100300 [P30536-1]
GeneIDi706
KEGGihsa:706
UCSCiuc003bdn.4 human [P30536-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36035 mRNA Translation: AAA03652.1
U12421 Genomic DNA Translation: AAA83252.1
AY998017 mRNA Translation: AAY45787.1
BT006949 mRNA Translation: AAP35595.1
CR456409 mRNA Translation: CAG30295.1
AY383615 Genomic DNA Translation: AAQ75703.1
Z82214 Genomic DNA No translation available.
BC001110 mRNA Translation: AAH01110.1
CCDSiCCDS33661.1 [P30536-1]
PIRiI38724
JE0149
S14257
RefSeqiNP_000705.2, NM_000714.5 [P30536-1]
NP_001243459.1, NM_001256530.1 [P30536-1]
NP_001243460.1, NM_001256531.1 [P30536-1]
UniGeneiHs.202

3D structure databases

ProteinModelPortaliP30536
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107168, 16 interactors
IntActiP30536, 13 interactors
STRINGi9606.ENSP00000328973

Chemistry databases

BindingDBiP30536
ChEMBLiCHEMBL5742
DrugBankiDB01178 Chlormezanone
DB01068 Clonazepam
DB00628 Clorazepate
DB00829 Diazepam
DB00402 Eszopiclone
DB01544 Flunitrazepam
DB01587 Ketazolam
DB00186 Lorazepam
DB00231 Temazepam
DB00897 Triazolam
DB00962 Zaleplon
DB01198 Zopiclone
GuidetoPHARMACOLOGYi2879

Protein family/group databases

TCDBi9.A.24.1.1 the mitochondrial cholesterol/porphyrin uptake translocator protein (tspo) family

PTM databases

iPTMnetiP30536
PhosphoSitePlusiP30536
SwissPalmiP30536

Polymorphism and mutation databases

BioMutaiTSPO
DMDMi313104268

Proteomic databases

EPDiP30536
MaxQBiP30536
PaxDbiP30536
PeptideAtlasiP30536
PRIDEiP30536
ProteomicsDBi54717
TopDownProteomicsiP30536-1 [P30536-1]

Protocols and materials databases

DNASUi706
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329563; ENSP00000328973; ENSG00000100300 [P30536-1]
ENST00000337554; ENSP00000338004; ENSG00000100300 [P30536-1]
ENST00000396265; ENSP00000379563; ENSG00000100300 [P30536-1]
GeneIDi706
KEGGihsa:706
UCSCiuc003bdn.4 human [P30536-1]

Organism-specific databases

CTDi706
DisGeNETi706
EuPathDBiHostDB:ENSG00000100300.17
GeneCardsiTSPO
HGNCiHGNC:1158 TSPO
HPAiCAB011232
HPA046260
MIMi109610 gene
neXtProtiNX_P30536
OpenTargetsiENSG00000100300
PharmGKBiPA25473
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3797 Eukaryota
COG3476 LUCA
GeneTreeiENSGT00390000012980
HOGENOMiHOG000224659
InParanoidiP30536
KOiK05770
OMAiPPNWLFA
OrthoDBiEOG091G0W79
PhylomeDBiP30536
TreeFamiTF342852

Enzyme and pathway databases

ReactomeiR-HSA-196108 Pregnenolone biosynthesis

Miscellaneous databases

ChiTaRSiTSPO human
GeneWikiiTranslocator_protein
GenomeRNAii706
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100300 Expressed in 217 organ(s), highest expression level in blood
CleanExiHS_TSPO
ExpressionAtlasiP30536 baseline and differential
GenevisibleiP30536 HS

Family and domain databases

CDDicd15904 TSPO_MBR, 1 hit
Gene3Di1.20.1260.100, 1 hit
InterProiView protein in InterPro
IPR030164 TSPO
IPR038330 TspO/MBR-related_sf
IPR004307 TspO_MBR
PANTHERiPTHR10057 PTHR10057, 1 hit
PTHR10057:SF5 PTHR10057:SF5, 1 hit
PfamiView protein in Pfam
PF03073 TspO_MBR, 1 hit
PIRSFiPIRSF005859 PBR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSPO_HUMAN
AccessioniPrimary (citable) accession number: P30536
Secondary accession number(s): Q53Y59, Q6ICF9, Q96TF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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