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Protein

Translocator protein

Gene

TSPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • androgen binding Source: Ensembl
  • benzodiazepine receptor activity Source: ProtInc
  • cholesterol binding Source: GO_Central
  • cholesterol transporter activity Source: Reactome
  • ion channel binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processLipid transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196108 Pregnenolone biosynthesis

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.24.1.1 the mitochondrial cholesterol/porphyrin uptake translocator protein (tspo) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translocator protein
Alternative name(s):
Mitochondrial benzodiazepine receptor
PKBS
Peripheral-type benzodiazepine receptor
Short name:
PBR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPO
Synonyms:BZRP, MBR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100300.17

Human Gene Nomenclature Database

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HGNCi
HGNC:1158 TSPO

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109610 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30536

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 5Mitochondrial intermembraneBy similarity4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26Helical; Name=1By similarityAdd BLAST21
Topological domaini27 – 46CytoplasmicBy similarityAdd BLAST20
Transmembranei47 – 67Helical; Name=2By similarityAdd BLAST21
Topological domaini68 – 79Mitochondrial intermembraneBy similarityAdd BLAST12
Transmembranei80 – 100Helical; Name=3By similarityAdd BLAST21
Topological domaini101 – 105CytoplasmicBy similarity5
Transmembranei106 – 126Helical; Name=4By similarityAdd BLAST21
Topological domaini127 – 134Mitochondrial intermembraneBy similarity8
Transmembranei135 – 155Helical; Name=5By similarityAdd BLAST21
Topological domaini156 – 169CytoplasmicBy similarityAdd BLAST14

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
706

Open Targets

More...
OpenTargetsi
ENSG00000100300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25473

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5742

Drug and drug target database

More...
DrugBanki
DB01178 Chlormezanone
DB01068 Clonazepam
DB00628 Clorazepate
DB00829 Diazepam
DB00402 Eszopiclone
DB01544 Flunitrazepam
DB01587 Ketazolam
DB00186 Lorazepam
DB00231 Temazepam
DB00897 Triazolam
DB00962 Zaleplon
DB01198 Zopiclone

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2879

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSPO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104268

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001909972 – 169Translocator proteinAdd BLAST168

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P30536

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P30536

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30536

PeptideAtlas

More...
PeptideAtlasi
P30536

PRoteomics IDEntifications database

More...
PRIDEi
P30536

ProteomicsDB human proteome resource

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ProteomicsDBi
54717

Consortium for Top Down Proteomics

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TopDownProteomicsi
P30536-1 [P30536-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30536

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30536

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P30536

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100300 Expressed in 217 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_TSPO

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30536 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P30536 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB011232
HPA046260

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TSPOAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CREB3L1Q96BA85EBI-6623146,EBI-6942903

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107168, 16 interactors

Protein interaction database and analysis system

More...
IntActi
P30536, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000328973

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P30536

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P30536

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TspO/BZRP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3797 Eukaryota
COG3476 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012980

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000224659

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30536

KEGG Orthology (KO)

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KOi
K05770

Identification of Orthologs from Complete Genome Data

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OMAi
PPNWLFA

Database of Orthologous Groups

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OrthoDBi
EOG091G0W79

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P30536

TreeFam database of animal gene trees

More...
TreeFami
TF342852

Family and domain databases

Conserved Domains Database

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CDDi
cd15904 TSPO_MBR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1260.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030164 TSPO
IPR038330 TspO/MBR-related_sf
IPR004307 TspO_MBR

The PANTHER Classification System

More...
PANTHERi
PTHR10057 PTHR10057, 1 hit
PTHR10057:SF5 PTHR10057:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03073 TspO_MBR, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005859 PBR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30536-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG
60 70 80 90 100
PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF
110 120 130 140 150
GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFTTTL
160
NYCVWRDNHG WRGGRRLPE
Length:169
Mass (Da):18,828
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6DD741BF99AB89D9
GO
Isoform 2 (identifier: B1AH88-1) [UniParc]FASTAAdd to basket
Also known as: PBR-S
The sequence of this isoform can be found in the external entry B1AH88.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.
Length:102
Mass (Da):10,537
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QLD3J3QLD3_HUMAN
Putative peripheral benzodiazepine ...
TSPO
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AH87B1AH87_HUMAN
Putative peripheral benzodiazepine ...
TSPO
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013617147T → A Associated with higher levels of pregnenolone production by lymphomonocytes and with increased plasma levels of cholesterol-rich low density lipoprotein. 7 PublicationsCorresponds to variant dbSNP:rs6971Ensembl.1
Natural variantiVAR_013618162R → H5 PublicationsCorresponds to variant dbSNP:rs6972Ensembl.1
Natural variantiVAR_018868169E → Q1 PublicationCorresponds to variant dbSNP:rs9333342Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M36035 mRNA Translation: AAA03652.1
U12421 Genomic DNA Translation: AAA83252.1
AY998017 mRNA Translation: AAY45787.1
BT006949 mRNA Translation: AAP35595.1
CR456409 mRNA Translation: CAG30295.1
AY383615 Genomic DNA Translation: AAQ75703.1
Z82214 Genomic DNA No translation available.
BC001110 mRNA Translation: AAH01110.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33661.1 [P30536-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38724
JE0149
S14257

NCBI Reference Sequences

More...
RefSeqi
NP_000705.2, NM_000714.5 [P30536-1]
NP_001243459.1, NM_001256530.1 [P30536-1]
NP_001243460.1, NM_001256531.1 [P30536-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.202

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329563; ENSP00000328973; ENSG00000100300 [P30536-1]
ENST00000337554; ENSP00000338004; ENSG00000100300 [P30536-1]
ENST00000396265; ENSP00000379563; ENSG00000100300 [P30536-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
706

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:706

UCSC genome browser

More...
UCSCi
uc003bdn.4 human [P30536-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36035 mRNA Translation: AAA03652.1
U12421 Genomic DNA Translation: AAA83252.1
AY998017 mRNA Translation: AAY45787.1
BT006949 mRNA Translation: AAP35595.1
CR456409 mRNA Translation: CAG30295.1
AY383615 Genomic DNA Translation: AAQ75703.1
Z82214 Genomic DNA No translation available.
BC001110 mRNA Translation: AAH01110.1
CCDSiCCDS33661.1 [P30536-1]
PIRiI38724
JE0149
S14257
RefSeqiNP_000705.2, NM_000714.5 [P30536-1]
NP_001243459.1, NM_001256530.1 [P30536-1]
NP_001243460.1, NM_001256531.1 [P30536-1]
UniGeneiHs.202

3D structure databases

ProteinModelPortaliP30536
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107168, 16 interactors
IntActiP30536, 13 interactors
STRINGi9606.ENSP00000328973

Chemistry databases

BindingDBiP30536
ChEMBLiCHEMBL5742
DrugBankiDB01178 Chlormezanone
DB01068 Clonazepam
DB00628 Clorazepate
DB00829 Diazepam
DB00402 Eszopiclone
DB01544 Flunitrazepam
DB01587 Ketazolam
DB00186 Lorazepam
DB00231 Temazepam
DB00897 Triazolam
DB00962 Zaleplon
DB01198 Zopiclone
GuidetoPHARMACOLOGYi2879

Protein family/group databases

TCDBi9.A.24.1.1 the mitochondrial cholesterol/porphyrin uptake translocator protein (tspo) family

PTM databases

iPTMnetiP30536
PhosphoSitePlusiP30536
SwissPalmiP30536

Polymorphism and mutation databases

BioMutaiTSPO
DMDMi313104268

Proteomic databases

EPDiP30536
MaxQBiP30536
PaxDbiP30536
PeptideAtlasiP30536
PRIDEiP30536
ProteomicsDBi54717
TopDownProteomicsiP30536-1 [P30536-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
706
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329563; ENSP00000328973; ENSG00000100300 [P30536-1]
ENST00000337554; ENSP00000338004; ENSG00000100300 [P30536-1]
ENST00000396265; ENSP00000379563; ENSG00000100300 [P30536-1]
GeneIDi706
KEGGihsa:706
UCSCiuc003bdn.4 human [P30536-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
706
DisGeNETi706
EuPathDBiHostDB:ENSG00000100300.17

GeneCards: human genes, protein and diseases

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GeneCardsi
TSPO
HGNCiHGNC:1158 TSPO
HPAiCAB011232
HPA046260
MIMi109610 gene
neXtProtiNX_P30536
OpenTargetsiENSG00000100300
PharmGKBiPA25473

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3797 Eukaryota
COG3476 LUCA
GeneTreeiENSGT00390000012980
HOGENOMiHOG000224659
InParanoidiP30536
KOiK05770
OMAiPPNWLFA
OrthoDBiEOG091G0W79
PhylomeDBiP30536
TreeFamiTF342852

Enzyme and pathway databases

ReactomeiR-HSA-196108 Pregnenolone biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TSPO human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Translocator_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
706

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100300 Expressed in 217 organ(s), highest expression level in blood
CleanExiHS_TSPO
ExpressionAtlasiP30536 baseline and differential
GenevisibleiP30536 HS

Family and domain databases

CDDicd15904 TSPO_MBR, 1 hit
Gene3Di1.20.1260.100, 1 hit
InterProiView protein in InterPro
IPR030164 TSPO
IPR038330 TspO/MBR-related_sf
IPR004307 TspO_MBR
PANTHERiPTHR10057 PTHR10057, 1 hit
PTHR10057:SF5 PTHR10057:SF5, 1 hit
PfamiView protein in Pfam
PF03073 TspO_MBR, 1 hit
PIRSFiPIRSF005859 PBR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSPO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30536
Secondary accession number(s): Q53Y59, Q6ICF9, Q96TF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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